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Dr. ABHIJEET

VITAMIN-D & HEALTH
What is Vitamin D?

-Vitamin D is one of the four fat soluble
  vitamins and one vitamin that can be
  obtained through exposure to the sun.
- Vitamin D is also nick named the
  sunshine vitamin for obvious reasons.
- There are 5 forms of vitamin D, but only
  two are physiologically relevant to us.
  Forms D2 (ergocalciferol) and
  D3(cholecalciferol)
- D3 is produced from our skin.
  Vitamin D is carried in the blood to
  the liver where it is then converted
  to calcidiol, which can then be
  converted in the kidneys to the
  biologically active form of vitamin D
  called calcitriol.
Vitamin D and Bone Strength

-Vitamin D increases bone strength by
 increasing the calcium absorption
 from intestines, increasing osteoclast
 (bone building)
 numbers, maintaining phosphate and
 calcium levels, and helping the
 parathyroid hormone to maintain
 calcium levels
Immune System and Vitamin D

• A study done at University of Copenhagen
  has come to the conclusion that vitamin D
  aids
  T cells activation in our body.
• “When a T cell is exposed to a foreign
  pathogen, it extends a signaling device or
  ‘antenna’ known as a vitamin D
  receptor, which searches for vitamin D. If the
  T cells cannot find enough vitamin D in the
  blood, they won’t even begin to mobilize. ”
Multiple Sclerosis and Vitamin D

• An autoimmune disease that destroy the
  protective sheath of the nerves.
• The body cannot distinguish between
  itself and a foreign substance or
  infection. This turns the body’s normally
  effective defense system against itself.
  Vitamin D pills are now being used as a
  treatment for MS
Vitamin D and Asthma Control

• According to a study, published in
  the ‘American Journal of Respiratory
  and Critical Care Medicine’, children
  who had lower serum vitamin D
  levels were more likely to have been
  hospitalized from asthma, and use
  more inhaled medicine.
Other Benefits

• Vitamin D has been casually linked to other
   benefits such as
 - healthy brain aging,
 - helping maintain a healthy body weight,
 -protection against low levels of radiation etc.
• some studies have shown that people with
   appropriate levels of vitamin D are at lower
   risk to develop cancer.
Vitamin D Requirements

•   Birth to 12 months – 400 IU
•   1-13 years – 600 IU
•   14-18 years – 600 IU
•   19-70 years – 600 IU
•   71+ years – 800 IU
•   Pregnant/Breastfeeding women – 600IU
• Australian, researchers found that mothers
  who had the lowest vitamin D levels in their
  blood during their second trimester had
  almost double the risk of their babies
  developing language problems.
• A recent review article published by
  researchers from Loyola University Chicago
  concluded that adequate intake of vitamin D
  may prevent or delay the onset of diabetes
  and reduce complications for those who have
  already been diagnosed.
• vitamin D plays an integral role in insulin
  sensitivity and secretion.
• Vitamin D deficiency also may be associated
  with hyperglycemia, insulin
  resistance,hypertension and heart disease.
• an increased risk of depression may be related
  to several vitamin D–sensitive diseases. For
  example: cancer, cardiovascular disease,
  and multiple sclerosis.
• It reduces the production of cytokines which
  are proteins that increase inflammation and
  are the possible risk factor for depression.
• In some recent studies it has also shown great
  promise in assisting psoriasis, the immune
  system, thyroid function as well as normal
  blood clotting.
Vitamin D and Heart-Health Benefits
                of Weight Loss
• A study from the American Journal of Clinical
  Nutrition suggests Vitamin D may enhance
  some positive effects of weight loss scientists
  discovered that those who took 400 IU of
  vitamin D and 1,200 mg of calcium in
  supplement form daily during the course of
  their 15-week diet had greater improvements
  in cholesterol levels (compared to those given
  a placebo for the same time period).
• Experiments show that vitamin D can inhibit the
  growth of human prostate cancer and breast
  cancer cells.
• Lung cancer and pancreatic cancer cells may also
  be susceptible to the effects of vitamin D.
• High fat diet, which normally would produce a
  higher incidence of colon cancer, supplements of
  calcium and vitamin D blocked this carcinogenic
  effect of the diet.
THANK YOU!!!

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Vitamin d & health By Dr Abhijeet

  • 2. What is Vitamin D? -Vitamin D is one of the four fat soluble vitamins and one vitamin that can be obtained through exposure to the sun. - Vitamin D is also nick named the sunshine vitamin for obvious reasons. - There are 5 forms of vitamin D, but only two are physiologically relevant to us. Forms D2 (ergocalciferol) and D3(cholecalciferol)
  • 3. - D3 is produced from our skin. Vitamin D is carried in the blood to the liver where it is then converted to calcidiol, which can then be converted in the kidneys to the biologically active form of vitamin D called calcitriol.
  • 4. Vitamin D and Bone Strength -Vitamin D increases bone strength by increasing the calcium absorption from intestines, increasing osteoclast (bone building) numbers, maintaining phosphate and calcium levels, and helping the parathyroid hormone to maintain calcium levels
  • 5. Immune System and Vitamin D • A study done at University of Copenhagen has come to the conclusion that vitamin D aids T cells activation in our body. • “When a T cell is exposed to a foreign pathogen, it extends a signaling device or ‘antenna’ known as a vitamin D receptor, which searches for vitamin D. If the T cells cannot find enough vitamin D in the blood, they won’t even begin to mobilize. ”
  • 6. Multiple Sclerosis and Vitamin D • An autoimmune disease that destroy the protective sheath of the nerves. • The body cannot distinguish between itself and a foreign substance or infection. This turns the body’s normally effective defense system against itself. Vitamin D pills are now being used as a treatment for MS
  • 7. Vitamin D and Asthma Control • According to a study, published in the ‘American Journal of Respiratory and Critical Care Medicine’, children who had lower serum vitamin D levels were more likely to have been hospitalized from asthma, and use more inhaled medicine.
  • 8. Other Benefits • Vitamin D has been casually linked to other benefits such as - healthy brain aging, - helping maintain a healthy body weight, -protection against low levels of radiation etc. • some studies have shown that people with appropriate levels of vitamin D are at lower risk to develop cancer.
  • 9. Vitamin D Requirements • Birth to 12 months – 400 IU • 1-13 years – 600 IU • 14-18 years – 600 IU • 19-70 years – 600 IU • 71+ years – 800 IU • Pregnant/Breastfeeding women – 600IU
  • 10. • Australian, researchers found that mothers who had the lowest vitamin D levels in their blood during their second trimester had almost double the risk of their babies developing language problems.
  • 11. • A recent review article published by researchers from Loyola University Chicago concluded that adequate intake of vitamin D may prevent or delay the onset of diabetes and reduce complications for those who have already been diagnosed. • vitamin D plays an integral role in insulin sensitivity and secretion.
  • 12. • Vitamin D deficiency also may be associated with hyperglycemia, insulin resistance,hypertension and heart disease. • an increased risk of depression may be related to several vitamin D–sensitive diseases. For example: cancer, cardiovascular disease, and multiple sclerosis.
  • 13. • It reduces the production of cytokines which are proteins that increase inflammation and are the possible risk factor for depression.
  • 14. • In some recent studies it has also shown great promise in assisting psoriasis, the immune system, thyroid function as well as normal blood clotting.
  • 15. Vitamin D and Heart-Health Benefits of Weight Loss • A study from the American Journal of Clinical Nutrition suggests Vitamin D may enhance some positive effects of weight loss scientists discovered that those who took 400 IU of vitamin D and 1,200 mg of calcium in supplement form daily during the course of their 15-week diet had greater improvements in cholesterol levels (compared to those given a placebo for the same time period).
  • 16. • Experiments show that vitamin D can inhibit the growth of human prostate cancer and breast cancer cells. • Lung cancer and pancreatic cancer cells may also be susceptible to the effects of vitamin D. • High fat diet, which normally would produce a higher incidence of colon cancer, supplements of calcium and vitamin D blocked this carcinogenic effect of the diet.
  • 17.