No hay notas en la diapositiva.
Stages of neurofibrillary tangle formation in Alzheimer’s disease. Stage 0 (S0) neurons show fine cytoplasmic reaction for the tangle-associated protein Tau (red). In stage 1 (S1) tangles, the abnormal tangles fill part of the neuronal cytoplasm. Stage 2 (S2) tangles fill the neuronal cytoplasm and displace the nucleus. In stage 3 (S3) the neuron has died, leaving the tangle free in the brain