http://www.advancedbionutritionals.com/Products/CircO2.htm | Nitric oxide plays a critical role in several biological processes in the body and has been found to improve circulation and brain function, among other benefits. The most effective way to take nitric oxide is through a dissolvable lozenge, such as CircO2™, distributed by Advanced Bionutritionals.

1. The Science Behind and Health Benefits of Nitric Oxide Supplement CircO2
Nitric oxide (NO), also called nitrogen oxide (and not to be confused with the anesthetic nitrous oxide),
is a signaling molecule that plays an important role in many biological processes, including circulation
and brain function. Three men won the Nobel Prize in Physiology in 1998 for their discovery of how
nitric oxide affects the cardiovascular system1, and researchers at MIT have since discovered how nitric
oxide is most effectively supplemented in the diet.
Nitric Oxide Improves Circulation, Brain Function, Bone Density—Even Sex Drive
Nitric oxide has been found to support a healthy heart and circulation, boost brain power and even
improve sexual health2. Nitric oxide protects organs such as the liver from ischemia, a restriction in
blood supply to tissues. NO has also been found to reduce triglycerides in certain patients3 , and a study
published by the Journal of the American Medical Association (JAMA) found a link between nitric oxide
and bone health4.
The JAMA study compared two groups of women—one who took a nitric oxide supplement, and one
who took a placebo—and found that the group of women who took the NO supplement had improved
bone density. Conversely, the group who took the placebo actually lost bone density in their hips.
Reduced bone density in the hips is especially troublesome, as this increases the chance of a hip
fracture, a common cause of disability and even death in older individuals.
MIT Researchers Find Nitric Oxide Supplements in Pill Form Ineffective
Given the multiple benefits of nitric oxide, the question is how to effectively supplement NO in the diet.
Researchers at MIT discovered that most nitric oxide is actually produced in the mouth when the
nutrients in food interact with natural bacteria found in the saliva5. These findings led the researchers
to conclude that taking nitric oxide via pill form—the most common means of administration—is much
less effective, if not ineffective.
The Most Effective Way to Take a Nitric Oxide Supplement
People are commonly advised to take L-arginine to boost nitric oxide, but it is difficult for the body to
convert L-arginine to nitric oxide, especially for those over age 40. As people age it becomes more
difficult for the body to produce nitric oxide6. Additionally, taking nitric oxide in pill, tablet or powder
form is almost completely ineffective—recall the MIT researchers who discovered that nitric oxide is
produced in the mouth when food nutrients react with bacteria in the saliva.
The most effective way to boost nitric oxide is via a dissolvable lozenge such as CircO2™, the dissolvable
lozenge developed by the nutrition professionals at Advanced Bionutritionals. Nitric oxide lozenges
interact with the saliva and bacteria in your mouth, converting the nutrients in the lozenge into nitric
oxide. Unlike a pill, tablet or powder, in lozenge form your body gets a boost of NO with every swallow.

2. Summary
Nitric oxide plays a critical role in several biological processes in the body and has been found to
improve circulation and brain function, among other benefits. The most effective way to take nitric
oxide is through a dissolvable lozenge, such as CircO2™, distributed by Advanced Bionutritionals.
Company Bio
Advanced Bionutritionals is a cutting edge line of nutraceuticals. We work closely with our suppliers and
our manufacturers to ensure that your supplements are made with fresh, quality ingredients following
good manufacturing practice guidelines. Our highly qualified team is always researching new and better
ingredients to ensure safe, effective health solutions for you. Visit our website at
http://www.advancedbionutritionals.com or call us toll free at 1-800-791-3395.
Sources:
1. http://www.nobelprize.org/nobel_prizes/medicine/laureates/1998/index.html
2. http://www.advancedbionutritionals.com/Products/CircO2.htm
3. http://www.nrjournal.com/article/S0271-5317%2811%2900046-7/abstract
4. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3606948/
5. http://www.sciencedirect.com/science/article/pii/S0015626476800065
6. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3018552/