2. Atopic dermatitis
(AD) is a highly pruritic, recurring
inflammatory skin disease. It usually
develops in early childhood and is frequently
seen in children with a personal history of
respiratory allergy and/or a family history of
atopic disease.
4. Skin barrier dysfunction
1. Ceramide deficiency
• Ceramides are main source of essential FA, a
key role in epidermal barrier function.
• Acts as a water modulator and permeability
barrier
• Decrease in ceramide level is main
attributable factor in barrier disrupted dry
skin of AD