-often suffer from cartilage injuries. Cartilage surgery is available in India to cure cartilage problems and prevent them from developing knee osteoarthritis. Autologous cartilage cell implantation is being done by Madras Joint replacement center at an affordable cost. This biological intervention will hopefully avoid a knee replacement in young individuals.

8. Patient lifetime Overall quality of life Severity of the disease Lifestyle changes Pharmaceuticals IA – Steroids / HA Total Joint Replacement Revision joint Replacement PAIN RELIEF REPLACEMENT

9. Patient lifetime Before ACI Overall quality of life Severity of the disease Lifestyle changes Pharmaceuticals IA – Steroids / HA Total Joint Replacement Revision joint Replacement PAIN RELIEF REPLACEMENT GAP For many Patients relief is no longer effective but too young for replacement

10. Patient lifetime Overall quality of life Severity of the disease Lifestyle changes Pharmaceuticals IA – Steroids / HA Total Joint Replacement Revision joint Replacement PAIN RELIEF REPLACEMENT CELL THERAPY Biologics REGENERATION

16. Cell Isolation & Cultivation Cell implantation & rehabilitation Cell Collection & Growth Autologous Chondrocyte Implantation Arthroscopic view after ACI

24. Process isolated cells from the harvested tissue for approx. 4 weeks Debride damaged cartilage. The cartilage being regenerated . Implant Procedure Cell Culture Operation Rehabilitation Rehabilitation Tissue Harvest Obtain cartilage specimen from the superior aspect of the medial or lateral femoral condyle Diagnosis Chondral defect

31. Thank you