Human metapneumovirus

Human Metapneumovirus Prof. Dr. Saad S Al Ani Senior Pediatric Consultant Head of Pediatric Department Khorfakkan Hospital Sharjah ,UAE [email_address]

Human Metapneumovirus (hMPV) ,[object Object],Williams JV, Wang CK, Yang CF, et al : The role of human metapneumovirus in upper respiratory tract infections in children: a 20-year experience. J Infect Dis 2006; 193:387-395

Cont. ,[object Object],[object Object],( 1)van den Hoogen BG, de Jong JC, Groen J, et al: A newly discovered human pneumovirus isolated from young children with respiratory tract disease. Nat Med 2001; 7:719-724.

Cont. ,[object Object],[object Object],[object Object],van den Hoogen BG, de Jong JC, Groen J, et al : A newly discovered human pneumovirus isolated from young children with respiratory tract disease . Nat Med 2001; 7:719-724.

Cont. ,[object Object],[object Object],[object Object],[object Object],[object Object],Osterhaus A, Fouchier R : Human metapneumovirus in the community. Lancet 2003; 361:890-891.

Cont. ,[object Object],[object Object],[object Object],[object Object],[object Object],Williams JV, Tollefson SJ, Heymann PW, et al : Human metapneumovirus infection in children hospitalized for wheezing. J Allergy Clin Immunol 2005; 115:1311-1312

Bar in the image represents 10 nm. Glycoprotein spikes are visible in viral membrane and extruded nucleocapsid is visible below Human Metapneumovirus

Epidemiology ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

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Clinical Manifestations ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Noyola DE, Alpuche - Solis AG, Herrera - Diaz A, et al : Human metapneumovirus infections in Mexico: epidemiological and clinical characteristics. J Med Microbiol 2005; 54:969-974

Cont. ,[object Object],[object Object],[object Object],[object Object],[object Object],Noyola DE, Alpuche - Solis AG, Herrera - Diaz A, et al : Human metapneumovirus infections in Mexico: epidemiological and clinical characteristics. J Med Microbiol 2005; 54:969-974

[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Clinical Manifestations at Various Ages Takao S, Shimozono H, Kashiwa H, et al : Clinical study of pediatric cases of acute respiratory diseases associated with human metapneumovirus in Japan. Jpn J Infect Dis 2003; 56:127-129.

Cont. ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Takao S, Shimozono H, Kashiwa H, et al : Clinical study of pediatric cases of acute respiratory diseases associated with human metapneumovirus in Japan. Jpn J Infect Dis 2003; 56:127-129.

Diagnosis ,[object Object],[object Object],[object Object],[object Object]

Treatment ,[object Object],[object Object],[object Object],[object Object],(1)Hamelin ME, Prince GA, Boivin G : Effect of ribavirin and glucocorticoid treatment in a mouse model of human metapneumovirus infection. Antimicrob Agents Chemother 2006; 50:774-777.

Prevention ,[object Object],[object Object],[object Object],[object Object],[object Object]

Human metapneumovirus

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Human metapneumovirus