22. *If he was getting home ON a bus, this would express location, and therefore require the prepositional. “By bus” or the more heavy-handed “by means of bus” requires the instrumental.
43. Instrumental Case Masculine Feminine Neuter Nominative авт о бус в о дка пер о стол маш и на окн о Instrumental авт о бусом в о дкой пер о м стол о м маш и ной окн о м