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Charles Edouard Brown Sequard (1817- 1894)
Science 1997
& GH
GH-IGF1-Insulin ,[object Object]
INSULIN / IGFs Signaling
INSULIN / IGFs Signaling KO GH KO GHRH KO GHR KO KO IGF1 KO IGF1-R KO IRS 1 & 2, PI3 K Yeasts, caenorhabditis elegans, insects, mice & centenarial model
Endocrine Reviews 2011
Des taux bas d ’IGF1 sont associés à une longévité accrue ,[object Object],[object Object],[object Object]
 
 
 
 
 
+ 18 %
 
GH-IGF1-Insulin ,[object Object]
 
Endocrine Reviews 2010, 31: 301-342.
 
JCEM 18: 901- 903, 1958 NATURE 1979
There is now a substantial body of evidence that indicates that GH Replacement Therapy has a beneficial effect upon many parameters: Body composition improves, lean mass increases, and fat mass decreases sgnificantly. ,[object Object],[object Object],[object Object],[object Object]
Swerdlow AJ, Higgins CD, Adlard P, Preece MA 2002 Risk of cancer in patients treated with 17 human pituitary growth hormone in the UK, 1959-85: a cohort study. Lancet 360:273-277 ,[object Object],[object Object],[object Object],[object Object],[object Object],HOWEVER
JCEM 2012 SAGhE : Safety and Appropriateness of Growth hormone treatments in Europe
 
 
 
 
 
Les Fondamentaux ,[object Object],[object Object],[object Object]
www.ice-ece2012.com

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