Cromolyn sodium is a first-line treatment for mild to moderate asthma. It works by stabilizing mast cells and inhibiting the release of inflammatory mediators. Common side effects include headache, cough, and diarrhea. It is used prophylactically to prevent asthma symptoms and exercise-induced bronchospasm. Cromolyn sodium has a good safety profile and fewer side effects than other asthma medications. It comes in a nebulizer solution or metered-dose inhaler and should be taken 4 times daily for maintenance treatment of asthma.

1. CROMOLYN SODIUM
Amitsinh Vihol
Exam No-43
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2. CROMOLYN SODIUM
According to WHO,
• Worldwide 235 millions patient of asthma
• In India, 15-20 million patient
(15-20% are 5-11 year old children)
• 1,80,000 death every year in the world.
• First line agent into mild to moderate asthma
• Safer treatment, less adverse effect.
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3. CROMOLYN SODIUM
PHARMACOLOGY
• Pharmacologic class: Chromone derivative
• Therapeutic class: Mast cell
stabilizer, antiasthmatic, ophthalmic decongestant.
• Pregnancy risk category B
• Mechanism of Action-Inhibits release of histamine and
reacting substances of anaphylaxis from mast cells, stabilizing
the cell membrane and reducing the allergic response and
inflammatory reaction.
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4. CROMOLYN SODIUM
Adverse reactions
• CNS: headache, dizziness
• Respiratory: wheezing, cough, nasal irritation, stuffy
nose, sneezing, sore throat
• GI: nausea, diarrhea, stomachache
• Urinay: difficult or painful urination
• Skin: rash
• Other: altered taste, substernal burning, allergic
reactions.
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5. CROMOLYN SODIUM
INDICATION-
• Prophylactic in the management of patients with bronchial
asthma.
• Prevention of exercise-induced bronchospasm;
• Adjunct in prevention of allergic disorders including rhinitis
CONTRAINDICATIONS-
• Contraindicated in those patients who have shown
hypersensitivity to cromolyn sodium.
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6. CROMOLYN SODIUM
DOSAGE-
Usual Adult Dose for Asthma -- Maintenance:
• Nebulization solution: 20 mg 4 times a day at regular intervals.
• Metered dose inhaler: 2 puffs 4 times a day at regular
intervals.
Usual Pediatric Dose for Asthma -- Maintenance:
• Nebulization solution:
> 2 years: 20 mg 4 times a day at regular intervals.
• Metered dose inhaler:
> 5 years: 2 puffs 4 times a day at regular intervals.
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7. CROMOLYN SODIUM
COMPETITOR-
• Fintal(Abbot)-(94RS/5 vial of each 2ml)
• Nalcrom (Sanofi-Aventis)-($10/20ml)
• Nasalcrom(Prestige Brands)-($9/13ml)
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8. CROMOLYN SODIUM
STORAGE & LABELLING-
• Store at 20°-25°C (68°-77°F).
• Do not use if solution is discolored or contains a precipitate.
• Retain in foil pouch until time of use.
• PROTECT FROM LIGHT.
• KEEP THIS AND ALL MEDICATIONS OUT OF THE REACH OF
CHILDREN.
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9. CROMOLYN SODIUM
PACKAGING & AVAILABLE DOSAGE FORM-
• Packed in vial which is made from a low density polyethylene
(LDPE) resin.
• Cromolyn Sodium Inhalation Solution Unit-Dose 2 mL Vial is
supplied as a colorless to pale yellow solution containing 20
mg cromolyn sodium, USP, in water for injection, USP, with 5
vials per foil pouch in cartons as listed below.
• 60 vials per carton.
• 120 vials per carton.
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10. CROMOLYN SODIUM
PRICING
• 90Rs/5 vial Each contain 2ml
• 999Rs/Cartoon of 60 Vials
• 1999Rs/Cartoon of 120 vials
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12. CROMOLYN SODIUM
• REFRENCE-
• Rang & Dale’s Pharmacology by H.P.Rang, M.M.Dale, et all.,6th
edition, Page no-364-365
• http://www.nlm.nih.gov/medlineplus/druginfo/meds/a60104
2.html
• http://www.drugs.com/mtm/cromolyn-sodium-
inhalation.html
• http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=AEC
8F12A-B778-4AB5-A932-FDFB620FD50B#section-10
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