1. ANA MILENA SÁNCHEZ HENAO
MEDICINE STUDENT
III SEMESTER
TEACHER:
LINA MARÍA MARTÍNEZ
SÁNCHEZ
MOLECULAR BIOLOGY
AUGUST 27

4. The place where the assembly is made
of proteins is the ribosome, which in order to
provide ideal structures and genetically
altered not to remain in perfect condition
and have been properly synthesized
without bad replication of RNAs requiring
programmed control part of the cells to
destroy it if necessary and so prevent a
number of malformations and diseases of
this origin that cause mortality or decreased
quality of life for the population

6. To find out whether medicines are
effective, you need to understand how
the receptors in the cell wall work. An
important means of achieving this is to
crystallize the protein, so that it can be
examined with x-rays.
“Since then, a handful of
structures of other receptors have
appeared in the scientific
literature, but at such a low
resolution that in some cases it
was even difficult to determine
how medicines bind to such
receptors” “With our new
structure, we have achieved the
highest resolution ever for any
protein in the human cell wall”

7. Degree of detail
of the new high-
resolution
crystal
structure makes
it possible to see
This gives an
insight into the way
natrium ions affect
the working of
hormones and
neurotransmitters
in the body

8. By binding the receptor protein, that is oily
and therefore does not easily crystallize, to
another protein that crystallizes readily, the
researchers were able to produce minuscule
crystals of the fusion product.
Previously, they had used the protein
lysozyme for this process
But this time they used
proteins that crystallize even
more easily and that are a
better match for the receptor
Research indicates that coffee drinkers
are less susceptible to developing
Parkinson's disease. Caffeine has been
shown to inhibit the effect of the
receptor, adenosine A2A, associated
with this disorder.

9. I believe the future that this research will therefore
have a clear objective and the results obtained have
been very important and contributors. It seems very
interesting , since it is a breakthrough that supports and
strengthens the scientific studies about the
intervention and modification of proteins that serves
as a molecular target for pharmaceutical treatment of
pathologies related, in addition, these studies can
understand the origins of many diseases and be defined
accuracy from molecular biology.

11. "The existing knowledge about relatives from
the so-called rhomboid protease family did
not help us in our quest for the molecules
processed by the enzyme we discovered,"
says Dr. Lemberg. Unlike all rhomboid
proteases that had been studied so far, the
new rhomboid localizes to the Endoplasmic
Reticulum (ER), the site in the cell where
new membrane proteins are produced.

13. "WE NOW HAVE REVEALED
THAT THE ER RHOMBOID
PROTEASE CLEAVES
ABERRANT MEMBRANE
PROTEINS WITHIN THEIR
MEMBRANE ANCHOR”, SAYS
DR. LEMBERG
The scientists demonstrated that this
protease cooperates directly with
components of the so-called ER-
associated degradation (ERAD)
pathway to dispose of the faulty
protein.

14. These new insights now provide the basis
for a molecular understanding of how
membrane proteins that the make up a
large fraction of cellular proteins are
extracted from these membranes for
degradation without getting into each
other’s way

15. Recognize and detect each protein forms a
structure that contributes to better
management of it and thus to better
techniques to modify, create or transform,
this being a good target for treating deadly
diseases

16. Recognize and detect each protein forms a
structure that contributes to better
management of it and thus to better
techniques to modify, create or transform,
this being a good target for treating deadly
diseases may, in this notice are working
with a receiver A2A adenosine receptor
that is a caffeine from the body, work and
handling of the 2A2 receiver released an
important preventive method on
Parkinson's disease since it was
discovered that A2A receptor inhibition by
caffeine drinkers in people coffee the risk
of suffering from the disease diminishes
what excellent advances patents on
knowledge and control of diseases that are
becoming increasingly more common in
our society.

17. This new is very important because
discovering how to degrade defective
proteins believed to cause metabolic
disorders, cellular and systemic reduces
mortality in human population and the
qualityof life improves and some way to
prolong life

18. Recognize that the accumulation of misfolded proteins
can seriously damage cells causing Alzheimer's and
Parkinson causes the genetic material can be
manipulated to reduce the risk of such diseases or
proteins that are targets of destruction or treatment,
which decreases the incidence of these diseases if
detected early.

19.  Martinez
Sánchez, Lina Maria.
“Biología Molecular” 7ª edition UPB
medical faculty
 “Highest Resolution Ever for Human
Protein” .Science daily , July 11 /2012
 “HowCells Degrade Aberrant
membrane”. Science daily, July 13 /2012