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522psychdepre08[2]
1.
2.
3.
4.
5.
6.
Need Drugs?
7.
Normal State
8.
Monoamine theory
(iproniazid, 1950-irreversible MAO I) [NE] low Depressive State
9.
Biosynthesis of
Neurotransmitters (acetylcholine and monoamines)
10.
Projections of Norepinephrine
Containing Neurons in the Locus Coeruleus
11.
[NE] Treatment State
(I)
12.
[NE] Treatment State
(II) *Increase [NE], [5-HT] or [DA]
13.
Monoamine transporter NE
14.
Serotonin (5-HT) Transporter
Polymorphism Missense mutation Obsessive-compulsive disorder (Molecular Psychiatry 2003: 8, 933-936)
15.
Autoreceptor Desensitization
16.
17.
3 5 4
1 2 R S R N R D
18.
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