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A	
  brief	
  introduc.on	
  to	
  
                            current	
  efforts	
  in
                  scien.fic	
  discourse	
  annota.on	
  

                                         Anita	
  de	
  Waard
                  Disrup/ve	
  Technology	
  Director,	
  Elsevier	
  Labs
                        -­‐	
  also	
  on	
  behalf	
  of	
  HCLS/UU/D2S...
                        hEp://elsatglabs.com/labs/anita	
  

Thursday, October 20, 2011
One	
  way	
  of	
  subdividing	
  the	
  field	
  of
                              Scien/fic	
  Discourse	
  Annota/on:




                                                                                    2

Thursday, October 20, 2011
One	
  way	
  of	
  subdividing	
  the	
  field	
  of
                              Scien/fic	
  Discourse	
  Annota/on:
      Five	
  levels	
  of	
  markup:	
  




                                                                                    2

Thursday, October 20, 2011
One	
  way	
  of	
  subdividing	
  the	
  field	
  of
                              Scien/fic	
  Discourse	
  Annota/on:
      Five	
  levels	
  of	
  markup:	
  
         1.Sec/on:	
  “Discussion”,	
  ~	
  several	
  paragraphs	
  (+HCLS)




                                                                                    2

Thursday, October 20, 2011
One	
  way	
  of	
  subdividing	
  the	
  field	
  of
                              Scien/fic	
  Discourse	
  Annota/on:
      Five	
  levels	
  of	
  markup:	
  
         1.Sec/on:	
  “Discussion”,	
  ~	
  several	
  paragraphs	
  (+HCLS)
         2.Module:	
  “Research	
  Ques/on”,	
  ~	
  paragraph




                                                                                    2

Thursday, October 20, 2011
One	
  way	
  of	
  subdividing	
  the	
  field	
  of
                              Scien/fic	
  Discourse	
  Annota/on:
      Five	
  levels	
  of	
  markup:	
  
         1.Sec/on:	
  “Discussion”,	
  ~	
  several	
  paragraphs	
  (+HCLS)
         2.Module:	
  “Research	
  Ques/on”,	
  ~	
  paragraph
         3.Statement:	
  “Hypothesis”,	
  ~	
  sentence/clause	
  (+UU)




                                                                                    2

Thursday, October 20, 2011
One	
  way	
  of	
  subdividing	
  the	
  field	
  of
                              Scien/fic	
  Discourse	
  Annota/on:
      Five	
  levels	
  of	
  markup:	
  
         1.Sec/on:	
  “Discussion”,	
  ~	
  several	
  paragraphs	
  (+HCLS)
         2.Module:	
  “Research	
  Ques/on”,	
  ~	
  paragraph
         3.Statement:	
  “Hypothesis”,	
  ~	
  sentence/clause	
  (+UU)
         4.Rela/on:	
  “Supports”,	
  ~	
  hyperlink
           (En/ty:	
  “Gene	
  Name”,	
  ~	
  NP)




                                                                                    2

Thursday, October 20, 2011
One	
  way	
  of	
  subdividing	
  the	
  field	
  of
                              Scien/fic	
  Discourse	
  Annota/on:
      Five	
  levels	
  of	
  markup:	
  
         1.Sec/on:	
  “Discussion”,	
  ~	
  several	
  paragraphs	
  (+HCLS)
         2.Module:	
  “Research	
  Ques/on”,	
  ~	
  paragraph
         3.Statement:	
  “Hypothesis”,	
  ~	
  sentence/clause	
  (+UU)
         4.Rela/on:	
  “Supports”,	
  ~	
  hyperlink
           (En/ty:	
  “Gene	
  Name”,	
  ~	
  NP)
         5.Special	
  case	
  of	
  3&4:	
  Claim/Evidence	
  network	
  (+D2S)




                                                                                    2

Thursday, October 20, 2011
One	
  way	
  of	
  subdividing	
  the	
  field	
  of
                              Scien/fic	
  Discourse	
  Annota/on:
      Five	
  levels	
  of	
  markup:	
  
         1.Sec/on:	
  “Discussion”,	
  ~	
  several	
  paragraphs	
  (+HCLS)
         2.Module:	
  “Research	
  Ques/on”,	
  ~	
  paragraph
         3.Statement:	
  “Hypothesis”,	
  ~	
  sentence/clause	
  (+UU)
         4.Rela/on:	
  “Supports”,	
  ~	
  hyperlink
           (En/ty:	
  “Gene	
  Name”,	
  ~	
  NP)
         5.Special	
  case	
  of	
  3&4:	
  Claim/Evidence	
  network	
  (+D2S)
      For	
  each	
  level:	
  


                                                                                    2

Thursday, October 20, 2011
One	
  way	
  of	
  subdividing	
  the	
  field	
  of
                              Scien/fic	
  Discourse	
  Annota/on:
      Five	
  levels	
  of	
  markup:	
  
         1.Sec/on:	
  “Discussion”,	
  ~	
  several	
  paragraphs	
  (+HCLS)
         2.Module:	
  “Research	
  Ques/on”,	
  ~	
  paragraph
         3.Statement:	
  “Hypothesis”,	
  ~	
  sentence/clause	
  (+UU)
         4.Rela/on:	
  “Supports”,	
  ~	
  hyperlink
           (En/ty:	
  “Gene	
  Name”,	
  ~	
  NP)
         5.Special	
  case	
  of	
  3&4:	
  Claim/Evidence	
  network	
  (+D2S)
      For	
  each	
  level:	
  
         a) Why?	
  Use	
  cases	
  

                                                                                    2

Thursday, October 20, 2011
One	
  way	
  of	
  subdividing	
  the	
  field	
  of
                              Scien/fic	
  Discourse	
  Annota/on:
      Five	
  levels	
  of	
  markup:	
  
         1.Sec/on:	
  “Discussion”,	
  ~	
  several	
  paragraphs	
  (+HCLS)
         2.Module:	
  “Research	
  Ques/on”,	
  ~	
  paragraph
         3.Statement:	
  “Hypothesis”,	
  ~	
  sentence/clause	
  (+UU)
         4.Rela/on:	
  “Supports”,	
  ~	
  hyperlink
           (En/ty:	
  “Gene	
  Name”,	
  ~	
  NP)
         5.Special	
  case	
  of	
  3&4:	
  Claim/Evidence	
  network	
  (+D2S)
      For	
  each	
  level:	
  
         a) Why?	
  Use	
  cases	
  
         b) What,	
  by	
  whom?	
  Concepts,	
  ontology,	
  authors?
                                                                                    2

Thursday, October 20, 2011
One	
  way	
  of	
  subdividing	
  the	
  field	
  of
                              Scien/fic	
  Discourse	
  Annota/on:
      Five	
  levels	
  of	
  markup:	
  
         1.Sec/on:	
  “Discussion”,	
  ~	
  several	
  paragraphs	
  (+HCLS)
         2.Module:	
  “Research	
  Ques/on”,	
  ~	
  paragraph
         3.Statement:	
  “Hypothesis”,	
  ~	
  sentence/clause	
  (+UU)
         4.Rela/on:	
  “Supports”,	
  ~	
  hyperlink
           (En/ty:	
  “Gene	
  Name”,	
  ~	
  NP)
         5.Special	
  case	
  of	
  3&4:	
  Claim/Evidence	
  network	
  (+D2S)
      For	
  each	
  level:	
  
         a) Why?	
  Use	
  cases	
  
         b) What,	
  by	
  whom?	
  Concepts,	
  ontology,	
  authors?
         c) How?	
  Manual,	
  automated?	
                                         2

Thursday, October 20, 2011
1.	
  Sec/on-­‐level	
  markup




                                                              3

Thursday, October 20, 2011
1.	
  Sec/on-­‐level	
  markup




                                                INTRODUCTION




                                                               3

Thursday, October 20, 2011
1.	
  Sec/on-­‐level	
  markup
a.Why	
  mark	
  up	
  sec/ons?
   -­‐ Search:	
  e.g.	
  search	
  for	
  en//es	
  
         in	
  Methods
   -­‐   Visualisa/on:	
  e.g.	
  structured	
  
         browse	
  at	
  sec/on	
  level



                                                        INTRODUCTION




                                                                       3

Thursday, October 20, 2011
1.	
  Sec/on-­‐level	
  markup
a.Why	
  mark	
  up	
  sec/ons?
   -­‐ Search:	
  e.g.	
  search	
  for	
  en//es	
  
         in	
  Methods
   -­‐   Visualisa/on:	
  e.g.	
  structured	
  
         browse	
  at	
  sec/on	
  level
b.What,	
  by	
  whom?
   -­‐ Background/Contribu/on/
         Discussion	
  model	
  for	
  CS               INTRODUCTION

   -­‐   HCLS:	
  Ontology	
  of	
  Rhetorical	
  
         Blocks	
  (ORB)=	
  IMRaD	
  in	
  OWL


                                                                       3

Thursday, October 20, 2011
1.	
  Sec/on-­‐level	
  markup
a.Why	
  mark	
  up	
  sec/ons?
   -­‐ Search:	
  e.g.	
  search	
  for	
  en//es	
     Annotation

         in	
  Methods
   -­‐   Visualisa/on:	
  e.g.	
  structured	
  
         browse	
  at	
  sec/on	
  level
b.What,	
  by	
  whom?
   -­‐ Background/Contribu/on/
         Discussion	
  model	
  for	
  CS                    INTRODUCTION

   -­‐   HCLS:	
  Ontology	
  of	
  Rhetorical	
  
         Blocks	
  (ORB)=	
  IMRaD	
  in	
  OWL


                                                                            3

Thursday, October 20, 2011
1.	
  Sec/on-­‐level	
  markup
a.Why	
  mark	
  up	
  sec/ons?
   -­‐ Search:	
  e.g.	
  search	
  for	
  en//es	
     Annotation

         in	
  Methods
   -­‐   Visualisa/on:	
  e.g.	
  structured	
  
         browse	
  at	
  sec/on	
  level
b.What,	
  by	
  whom?
   -­‐ Background/Contribu/on/
         Discussion	
  model	
  for	
  CS                    INTRODUCTION

   -­‐   HCLS:	
  Ontology	
  of	
  Rhetorical	
  
         Blocks	
  (ORB)=	
  IMRaD	
  in	
  OWL
c. Automate?	
  
   -­‐ Yes	
  -­‐[Hovy/Ramakrishnan]                                        3

Thursday, October 20, 2011
HCLS	
  SciDis:	
  develop	
  standards	
  for	
  this	
  markup




                                                                       4

Thursday, October 20, 2011
2.a.	
  Module-­‐level	
  markup:	
  why?
     -­‐ BeEer	
  search:	
  e.g.	
  query	
  inside	
  ‘Research	
  ques/on’
     -­‐ Ini/al	
  idea:	
  content	
  reuse,	
  e.g.
         -­‐ Write	
  Methods	
  sec/ons	
  once,	
  import/link	
  many
         -­‐ Different	
  way	
  of	
  crea/ng	
  a	
  collec/on	
  of	
  scholarly	
  
                 content:	
  not	
  standalone	
  narra/ve,	
  but	
  connected	
  
                 set	
  of	
  modules	
  




                                                                                   5

Thursday, October 20, 2011
2.b.	
  Module-­‐level	
  markup:	
  What,	
  by	
  whom?	
  




                                                                             6

Thursday, October 20, 2011
2.b.	
  Module-­‐level	
  markup:	
  What,	
  by	
  whom?	
  
      -­‐ Kircz,	
  ’98:	
  “a	
  much	
  more	
  radical	
  
          approach	
  would	
  be	
  to	
  [break]	
  apart	
  the	
  
          linear	
  text	
  into	
  independent	
  modules,	
  
          each	
  with	
  its	
  own	
  unique	
  cogni/ve	
  
          character.”




                                                                             6

Thursday, October 20, 2011
2.b.	
  Module-­‐level	
  markup:	
  What,	
  by	
  whom?	
  
      -­‐ Kircz,	
  ’98:	
  “a	
  much	
  more	
  radical	
  
          approach	
  would	
  be	
  to	
  [break]	
  apart	
  the	
  
          linear	
  text	
  into	
  independent	
  modules,	
  
          each	
  with	
  its	
  own	
  unique	
  cogni/ve	
  
          character.”




                                                                             6

Thursday, October 20, 2011
2.b.	
  Module-­‐level	
  markup:	
  What,	
  by	
  whom?	
  
      -­‐ Kircz,	
  ’98:	
  “a	
  much	
  more	
  radical	
  
          approach	
  would	
  be	
  to	
  [break]	
  apart	
  the	
  
          linear	
  text	
  into	
  independent	
  modules,	
  
          each	
  with	
  its	
  own	
  unique	
  cogni/ve	
  
          character.”
      -­‐ Harmsze,	
  ‘00:	
  modular	
  model	
  for	
  
          physics	
  papers




                                                                             6

Thursday, October 20, 2011
2.b.	
  Module-­‐level	
  markup:	
  What,	
  by	
  whom?	
  
      -­‐ Kircz,	
  ’98:	
  “a	
  much	
  more	
  radical	
  
          approach	
  would	
  be	
  to	
  [break]	
  apart	
  the	
  
          linear	
  text	
  into	
  independent	
  modules,	
  
          each	
  with	
  its	
  own	
  unique	
  cogni/ve	
  
          character.”
      -­‐ Harmsze,	
  ‘00:	
  modular	
  model	
  for	
  
          physics	
  papers




                                                                             6

Thursday, October 20, 2011
2.b.	
  Module-­‐level	
  markup:	
  What,	
  by	
  whom?	
  
      -­‐ Kircz,	
  ’98:	
  “a	
  much	
  more	
  radical	
  
          approach	
  would	
  be	
  to	
  [break]	
  apart	
  the	
  
          linear	
  text	
  into	
  independent	
  modules,	
  
          each	
  with	
  its	
  own	
  unique	
  cogni/ve	
  
          character.”
      -­‐ Harmsze,	
  ‘00:	
  modular	
  model	
  for	
  
          physics	
  papers
      -­‐ LiquidPub,	
  2010:	
  Structured	
  Knowledge	
  
          Objects	
  




                                                                             6

Thursday, October 20, 2011
2.b.	
  Module-­‐level	
  markup:	
  What,	
  by	
  whom?	
  
      -­‐ Kircz,	
  ’98:	
  “a	
  much	
  more	
  radical	
  
          approach	
  would	
  be	
  to	
  [break]	
  apart	
  the	
  
          linear	
  text	
  into	
  independent	
  modules,	
  
          each	
  with	
  its	
  own	
  unique	
  cogni/ve	
  
          character.”
      -­‐ Harmsze,	
  ‘00:	
  modular	
  model	
  for	
  
          physics	
  papers
      -­‐ LiquidPub,	
  2010:	
  Structured	
  Knowledge	
  
          Objects	
  




                                                                             6

Thursday, October 20, 2011
2.b.	
  Module-­‐level	
  markup:	
  What,	
  by	
  whom?	
  
      -­‐ Kircz,	
  ’98:	
  “a	
  much	
  more	
  radical	
  
          approach	
  would	
  be	
  to	
  [break]	
  apart	
  the	
  
          linear	
  text	
  into	
  independent	
  modules,	
  
          each	
  with	
  its	
  own	
  unique	
  cogni/ve	
  
          character.”
      -­‐ Harmsze,	
  ‘00:	
  modular	
  model	
  for	
  
          physics	
  papers
      -­‐ LiquidPub,	
  2010:	
  Structured	
  Knowledge	
  
          Objects	
  




      -­‐ HCLS:	
  Medium-­‐grained	
  structure:	
  
          core	
  narra/ve	
  components                                     6

Thursday, October 20, 2011
2.b.	
  Module-­‐level	
  markup:	
  What,	
  by	
  whom?	
  
      -­‐ Kircz,	
  ’98:	
  “a	
  much	
  more	
  radical	
  
          approach	
  would	
  be	
  to	
  [break]	
  apart	
  the	
  
          linear	
  text	
  into	
  independent	
  modules,	
  
          each	
  with	
  its	
  own	
  unique	
  cogni/ve	
  
          character.”
      -­‐ Harmsze,	
  ‘00:	
  modular	
  model	
  for	
  
          physics	
  papers
      -­‐ LiquidPub,	
  2010:	
  Structured	
  Knowledge	
  
          Objects	
  




      -­‐ HCLS:	
  Medium-­‐grained	
  structure:	
  
          core	
  narra/ve	
  components                                     6

Thursday, October 20, 2011
Story	
  grammar	
  model	
  for	
  science
The Story of Goldilocks and          Story        Grammar     Paper              The AXH Domain of Ataxin-1 Mediates
the Three Bears                                                                  Neurodegeneration through Its Interaction with Gfi-1/
                                                                                 Senseless Proteins
Once upon a time                     Time         Setting     Background         The mechanisms mediating SCA1 pathogenesis are still not fully
                                                                                 understood, but some general principles have emerged.
a little girl named Goldilocks       Characters               Objects of study   the Drosophila Atx-1 homolog (dAtx-1) which lacks a polyQ tract,

She went for a walk in the forest.   Location                 Experimental       studied and compared in vivo effects and interactions to those of
Pretty soon, she came upon a                                  setup              the human protein
house.
She knocked and, when no one         Goal         Theme       Research           Gain insight into how Atx-1's function contributes to SCA1
answered,                                                     goal               pathogenesis. How these interactions might contribute to the
                                                                                 disease process and how they might cause toxicity in only a
she walked right in.                                                             subset of neurons in SCA1 is not fully understood.
                                                                                 Atx-1 may play a role in the regulation of gene expression
                                     Attempt                  Hypothesis

At the table in the kitchen, there   Name         Episode 1   Name               dAtX-1 and hAtx-1 Induce Similar Phenotypes When
were three bowls of porridge.                                                    Overexpressed in Files
Goldilocks was hungry.               Subgoal                  Subgoal            test the function of the AXH domain
She tasted the porridge from the     Attempt                  Method             overexpressed dAtx-1 in flies using the GAL4/UAS system
first bowl.                                                                      (Brand and Perrimon, 1993) and compared its effects to those of
This porridge is too hot! she        Outcome                  Results            hAtx-1.
                                                                                 Overexpression of dAtx-1 by Rhodopsin1(Rh1)-GAL4, which
exclaimed.                                                                       drives expression in the differentiated R1-R6 photoreceptor cells
                                                                                 (Mollereau et al., 2000 and O'Tousa et al., 1985), results in
                                                                                 neurodegeneration in the eye, as does overexpression of hAtx-1
                                                                                 [82Q]. Although at 2 days after eclosion, overexpression of either
So, she tasted the porridge from     Activity                 Data               (data not shown),
                                                                                 Atx-1 does not show obvious morphological changes in the
the second bowl.
                                                                                 photoreceptor cells
This porridge is too cold, she said Outcome                   Results            both genotypes show many large holes and loss of cell integrity
                                                                                 at 28 days
So, she tasted the last bowl of       Activity                Data               (Figures 1B-1D).
porridge.
Ahhh, this porridge is just right,   Outcome                  Results            Overexpression of dAtx-1 using the GMR-GAL4 driver also
she said happily and                                                             induces eye abnormalities. The external structures of the eyes
                        7                                                        that overexpress dAtx-1 show disorganized ommatidia and loss
she ate it all up.                                            Data               (Figure 1F),
                                                                                 of interommatidial bristles

Thursday, October 20, 2011
2.c.	
  Module-­‐level	
  markup:	
  how?




                                                                         8

Thursday, October 20, 2011
2.c.	
  Module-­‐level	
  markup:	
  how?
   -­‐ Automated	
  recogni/on:	
  very	
  difficult:




                                                                         8

Thursday, October 20, 2011
2.c.	
  Module-­‐level	
  markup:	
  how?
   -­‐ Automated	
  recogni/on:	
  very	
  difficult:
         -­‐ How	
  do	
  you	
  know	
  where	
  the	
  boundaries	
  are?	
  




                                                                                  8

Thursday, October 20, 2011
2.c.	
  Module-­‐level	
  markup:	
  how?
   -­‐ Automated	
  recogni/on:	
  very	
  difficult:
         -­‐ How	
  do	
  you	
  know	
  where	
  the	
  boundaries	
  are?	
  
         -­‐ Even	
  difficult	
  for	
  author	
  to	
  iden/fy!	
  




                                                                                  8

Thursday, October 20, 2011
2.c.	
  Module-­‐level	
  markup:	
  how?
   -­‐ Automated	
  recogni/on:	
  very	
  difficult:
         -­‐ How	
  do	
  you	
  know	
  where	
  the	
  boundaries	
  are?	
  
         -­‐ Even	
  difficult	
  for	
  author	
  to	
  iden/fy!	
  
   -­‐ Author	
  creates:	
  templates.




                                                                                  8

Thursday, October 20, 2011
2.c.	
  Module-­‐level	
  markup:	
  how?
   -­‐ Automated	
  recogni/on:	
  very	
  difficult:
         -­‐ How	
  do	
  you	
  know	
  where	
  the	
  boundaries	
  are?	
  
         -­‐ Even	
  difficult	
  for	
  author	
  to	
  iden/fy!	
  
   -­‐ Author	
  creates:	
  templates.
         -­‐ XPharm,	
  2001:	
  modular	
  text	
  book	
  in	
  pharmacology:




                                                                                  8

Thursday, October 20, 2011
2.c.	
  Module-­‐level	
  markup:	
  how?
   -­‐ Automated	
  recogni/on:	
  very	
  difficult:
         -­‐ How	
  do	
  you	
  know	
  where	
  the	
  boundaries	
  are?	
  
         -­‐ Even	
  difficult	
  for	
  author	
  to	
  iden/fy!	
  
   -­‐ Author	
  creates:	
  templates.
         -­‐ XPharm,	
  2001:	
  modular	
  text	
  book	
  in	
  pharmacology:




                                                                                  8

Thursday, October 20, 2011
2.c.	
  Module-­‐level	
  markup:	
  how?
   -­‐ Automated	
  recogni/on:	
  very	
  difficult:
         -­‐ How	
  do	
  you	
  know	
  where	
  the	
  boundaries	
  are?	
  
         -­‐ Even	
  difficult	
  for	
  author	
  to	
  iden/fy!	
  
   -­‐ Author	
  creates:	
  templates.
         -­‐ XPharm,	
  2001:	
  modular	
  text	
  book	
  in	
  pharmacology:
         -­‐ Only	
  works	
  if	
  you	
  
               pay	
  authors!




                                                                                  8

Thursday, October 20, 2011
2.c.	
  Module-­‐level	
  markup:	
  how?
   -­‐ Automated	
  recogni/on:	
  very	
  difficult:
         -­‐ How	
  do	
  you	
  know	
  where	
  the	
  boundaries	
  are?	
  
         -­‐ Even	
  difficult	
  for	
  author	
  to	
  iden/fy!	
  
   -­‐ Author	
  creates:	
  templates.
         -­‐ XPharm,	
  2001:	
  modular	
  text	
  book	
  in	
  pharmacology:
         -­‐ Only	
  works	
  if	
  you	
  
               pay	
  authors!
         -­‐   Mo/f	
  detec/on	
  work
               might	
  offer	
  help?	
  



                                                                                  8

Thursday, October 20, 2011
3.	
  Statement-­‐level	
  markup




                                                                 9

Thursday, October 20, 2011
3.	
  Statement-­‐level	
  markup
     a.Why?
           -­‐ Automated	
  summarisa/on?
           -­‐ Towards	
  claim-­‐evidence	
  networks




                                                                 9

Thursday, October 20, 2011
3.	
  Statement-­‐level	
  markup
     a.Why?
           -­‐ Automated	
  summarisa/on?
           -­‐ Towards	
  claim-­‐evidence	
  networks
     b.How,	
  by	
  whom?	
  
           -­‐ Comparison	
  of	
  three	
  groups:	
  
                 1.Liakata	
  et	
  al.:	
  CoreSC
                 2.Ananiadou	
  et	
  al.:	
  Metaknowledge	
  annota/on
                 3.De	
  Waard/Pander	
  Maat:	
  Discourse	
  Segment	
  Types
           -­‐   Annotated	
  three	
  texts:	
  compare	
  schemes,	
  levels,	
  
                 annota/on	
  overlap
                                                                                9

Thursday, October 20, 2011
3.1	
  Liakata	
  et	
  al.:	
  Core-­‐Scien/fic	
  Concepts	
  
                                       (CoreSC)	
  Annota/on	
  Scheme




                                                                                               s




Thursday, October 20, 2011
3.1	
  Liakata	
  et	
  al.:	
  Core-­‐Scien/fic	
  Concepts	
  
                                       (CoreSC)	
  Annota/on	
  Scheme
   Three-­‐layer,	
  ontology-­‐mo/vated	
  annota/on	
  scheme	
  for	
  sentence	
  
   annota/on,	
  which	
  views	
  a	
  paper	
  as	
  the	
  humanly	
  readable	
  
   representa0on	
  of	
  a	
  scien0fic	
  inves0ga0on:	
  [45-­‐page	
  guideline:	
  
   Liakata	
  &	
  Soldatova	
  2008]	
  
   -­‐ 1st	
  layer:	
  Core	
  Scien4fic	
  Concepts	
  (CoreSCs):	
  
       Hypothesis,	
  Mo/va/on,	
  Goal,	
  Object,	
  Background,	
  Method,	
  
       Experiment,	
  Model,	
  Observa/on,	
  Result,	
  Conclusion	
  
   -­‐ 2nd	
  layer:	
  Proper4es	
  of	
  CoreSCs.	
                                                  s

       Novelty	
  (New/Old)	
  and	
  Advantage	
  (advantage/disadvantage)
   -­‐ 3rd	
  layer:	
  Concept	
  Iden4fiers:	
  
       linking	
  sentences	
  together	
  which	
  refer	
  to	
  the	
  same	
  instance	
  of	
  
       a	
  CoreSC


Thursday, October 20, 2011
3.1	
  CoreSC	
  Annota/on	
  tool:




Thursday, October 20, 2011
3.1	
  CoreSC	
  Annota/on	
  tool:




• Automated	
  annota/on	
  with	
  CoreSC	
  system	
  well	
  underway!




Thursday, October 20, 2011
3.2.	
  Ananiadou	
  et	
  al:	
  Metaknowledge	
  annota/on:

                               Knowledge	
  Type                                        Certainty	
  Level
                 •	
  Inves4ga4on
                                                                       •L3
                 •	
  Observa4on
                                                                       •L2
                 •	
  Analysis
                                                                       •L1
                 •	
  General


                       Par4cipants                    Bio-­‐Event                               Class	
  /	
  Type
                 •	
  Theme(s)                      (Centred	
  on	
  an	
  Event	
         (Grounded	
  to	
  an	
  event	
  
                 •	
  Actor(s)                            Trigger)                                ontology)


                             Source                        Manner                                     Polarity
                                                   •	
  High
                •	
  Other                                                                    •	
  Nega4ve
                                                   •	
  Low
                •	
  Current                                                                  •	
  Posi4ve
                                                   •	
  Neutral




Thursday, October 20, 2011
3.2	
  Example	
  of	
  Metaknowledge	
  annota/on:

         S3 = These results suggest that Y has no effect on
              expression of X

                             Knowledge   Certainty   Lexical	
  
            Event                                                  Manner    Source
                               Type        Level     Polarity


               E1             General       L3       Posi4ve       Neutral   Current



               E2             Analysis      L2       Nega4ve       Neutral   Current




Thursday, October 20, 2011
3.2	
  Example	
  of	
  Metaknowledge	
  annota/on:

         S3 = These results suggest that Y has no effect on
              expression of X

                             Knowledge   Certainty   Lexical	
  
            Event                                                  Manner    Source
                               Type        Level     Polarity


               E1             General       L3       Posi4ve       Neutral   Current



               E2             Analysis      L2       Nega4ve       Neutral   Current




Thursday, October 20, 2011
3.2	
  Example	
  of	
  Metaknowledge	
  annota/on:

         S3 = These results suggest that Y has no effect on
              expression of X

                             Knowledge   Certainty   Lexical	
  
            Event                                                  Manner    Source
                               Type        Level     Polarity


               E1             General       L3       Posi4ve       Neutral   Current



               E2             Analysis      L2       Nega4ve       Neutral   Current




Thursday, October 20, 2011
3.2	
  Example	
  of	
  Metaknowledge	
  annota/on:

         S3 = These results suggest that Y has no effect on
              expression of X

                             Knowledge     Certainty         Lexical	
  
            Event                                                            Manner           Source
                               Type          Level           Polarity


               E1             General          L3            Posi4ve         Neutral         Current



               E2             Analysis         L2           Nega4ve          Neutral         Current


• Manual	
  annota/on	
  underway	
  of	
  the	
  GENIA	
  event	
  corpus	
  (1000	
  MEDLINE	
  abstracts)
Thursday, October 20, 2011
3.3	
  de	
  Waard/Pander	
  Maat:	
  Discourse	
  Segment	
  Types


      Both seminomas and the EC component of
      nonseminomas share features with ES cells. To
      exclude that the detection of miR-371-3 merely
      reflects its expression pattern in ES cells, we tested
      by RPA miR-302a-d, another ES cells-specific
      miRNA cluster (Suh et al, 2004). In many of the
      miR-371-3 expressing seminomas and
      nonseminomas, miR-302a-d was undetectable (Figs
      S7 and S8), suggesting that miR-371-3 expression
      is a selective event during tumorigenesis.




Thursday, October 20, 2011
3.3	
  de	
  Waard/Pander	
  Maat:	
  Discourse	
  Segment	
  Types


      Both seminomas and the EC component of
       Both seminomas and the EC component of
      nonseminomas share features with ES cells.
       nonseminomas share features with ES cells. To
      exclude thatthat detection of miR-371-3 merely
       To exclude the
      reflects its expression pattern in ES cells,reflects its
       the detection of miR-371-3 merely we tested
      by RPA miR-302a-d, another ES cells-specific
       expression pattern in ES cells,
      miRNA cluster RPA miR-302a-d, another ES cells-
       we tested by (Suh et al, 2004). In many of the
      m i R - 3 7 miRNAx p r e s s(Suh et e m2004). a s a n d
       specific 1 - 3 e cluster i n g s al, i n o m
      nonseminomas, miR-302a-d was undetectable (Figs
       In many of the miR-371-3 expressing seminomas
      S7 and S8), suggesting that miR-371-3undetectable
       and nonseminomas, miR-302a-d was expression
      is a selective event during tumorigenesis.
       (Figs S7 and S8),
       suggesting that
       miR-371-3 expression is a selective event during
       tumorigenesis.




Thursday, October 20, 2011
3.3	
  de	
  Waard/Pander	
  Maat:	
  Discourse	
  Segment	
  Types


      Both seminomas and the EC component of
       Both seminomas and the EC component of                    Fact
      nonseminomas share features with ES cells.
       nonseminomas share features with ES cells. To
      exclude thatthat detection of miR-371-3 merely
       To exclude the
      reflects its expression pattern in ES cells,reflects its
       the detection of miR-371-3 merely we tested
      by RPA miR-302a-d, another ES cells-specific
       expression pattern in ES cells,
      miRNA cluster RPA miR-302a-d, another ES cells-
       we tested by (Suh et al, 2004). In many of the
      m i R - 3 7 miRNAx p r e s s(Suh et e m2004). a s a n d
       specific 1 - 3 e cluster i n g s al, i n o m
      nonseminomas, miR-302a-d was undetectable (Figs
       In many of the miR-371-3 expressing seminomas
      S7 and S8), suggesting that miR-371-3undetectable
       and nonseminomas, miR-302a-d was expression
      is a selective event during tumorigenesis.
       (Figs S7 and S8),
       suggesting that
       miR-371-3 expression is a selective event during
       tumorigenesis.




Thursday, October 20, 2011
3.3	
  de	
  Waard/Pander	
  Maat:	
  Discourse	
  Segment	
  Types


      Both seminomas and the EC component of
       Both seminomas and the EC component of                    Fact
      nonseminomas share features with ES cells.
       nonseminomas share features with ES cells. To
      exclude thatthat detection of miR-371-3 merely
       To exclude the
      reflects its expression pattern in ES cells,reflects its
       the detection of miR-371-3 merely we tested               Hypothesis
      by RPA miR-302a-d, another ES cells-specific
       expression pattern in ES cells,
      miRNA cluster RPA miR-302a-d, another ES cells-
       we tested by (Suh et al, 2004). In many of the
      m i R - 3 7 miRNAx p r e s s(Suh et e m2004). a s a n d
       specific 1 - 3 e cluster i n g s al, i n o m
      nonseminomas, miR-302a-d was undetectable (Figs
       In many of the miR-371-3 expressing seminomas
      S7 and S8), suggesting that miR-371-3undetectable
       and nonseminomas, miR-302a-d was expression
      is a selective event during tumorigenesis.
       (Figs S7 and S8),
       suggesting that
       miR-371-3 expression is a selective event during
       tumorigenesis.




Thursday, October 20, 2011
3.3	
  de	
  Waard/Pander	
  Maat:	
  Discourse	
  Segment	
  Types


      Both seminomas and the EC component of
       Both seminomas and the EC component of                    Fact
      nonseminomas share features with ES cells.
       nonseminomas share features with ES cells. To
      exclude thatthat detection of miR-371-3 merely
       To exclude the
      reflects its expression pattern in ES cells,reflects its
       the detection of miR-371-3 merely we tested               Hypothesis
      by RPA miR-302a-d, another ES cells-specific
       expression pattern in ES cells,
      miRNA cluster RPA miR-302a-d, another ES cells-
       we tested by (Suh et al, 2004). In many of the
      m i R - 3 7 miRNAx p r e s s(Suh et e m2004). a s a n d
       specific 1 - 3 e cluster i n g s al, i n o m              Method
      nonseminomas, miR-302a-d was undetectable (Figs
       In many of the miR-371-3 expressing seminomas
      S7 and S8), suggesting that miR-371-3undetectable
       and nonseminomas, miR-302a-d was expression
      is a selective event during tumorigenesis.
       (Figs S7 and S8),
       suggesting that
       miR-371-3 expression is a selective event during
       tumorigenesis.




Thursday, October 20, 2011
3.3	
  de	
  Waard/Pander	
  Maat:	
  Discourse	
  Segment	
  Types


      Both seminomas and the EC component of
       Both seminomas and the EC component of                    Fact
      nonseminomas share features with ES cells.
       nonseminomas share features with ES cells. To
      exclude thatthat detection of miR-371-3 merely
       To exclude the
      reflects its expression pattern in ES cells,reflects its
       the detection of miR-371-3 merely we tested               Hypothesis
      by RPA miR-302a-d, another ES cells-specific
       expression pattern in ES cells,
      miRNA cluster RPA miR-302a-d, another ES cells-
       we tested by (Suh et al, 2004). In many of the
      m i R - 3 7 miRNAx p r e s s(Suh et e m2004). a s a n d
       specific 1 - 3 e cluster i n g s al, i n o m              Method
      nonseminomas, miR-302a-d was undetectable (Figs
       In many of the miR-371-3 expressing seminomas
      S7 and S8), suggesting that miR-371-3undetectable
       and nonseminomas, miR-302a-d was expression               Result
      is a selective event during tumorigenesis.
       (Figs S7 and S8),
       suggesting that
       miR-371-3 expression is a selective event during
       tumorigenesis.




Thursday, October 20, 2011
3.3	
  de	
  Waard/Pander	
  Maat:	
  Discourse	
  Segment	
  Types


      Both seminomas and the EC component of
       Both seminomas and the EC component of                    Fact
      nonseminomas share features with ES cells.
       nonseminomas share features with ES cells. To
      exclude thatthat detection of miR-371-3 merely
       To exclude the
      reflects its expression pattern in ES cells,reflects its
       the detection of miR-371-3 merely we tested               Hypothesis
      by RPA miR-302a-d, another ES cells-specific
       expression pattern in ES cells,
      miRNA cluster RPA miR-302a-d, another ES cells-
       we tested by (Suh et al, 2004). In many of the
      m i R - 3 7 miRNAx p r e s s(Suh et e m2004). a s a n d
       specific 1 - 3 e cluster i n g s al, i n o m              Method
      nonseminomas, miR-302a-d was undetectable (Figs
       In many of the miR-371-3 expressing seminomas
      S7 and S8), suggesting that miR-371-3undetectable
       and nonseminomas, miR-302a-d was expression               Result
      is a selective event during tumorigenesis.
       (Figs S7 and S8),
       suggesting that
       miR-371-3 expression is a selective event during
                                                                 Implication
       tumorigenesis.




Thursday, October 20, 2011
3.3	
  de	
  Waard/Pander	
  Maat:	
  Discourse	
  Segment	
  Types


      Both seminomas and the EC component of
       Both seminomas and the EC component of                    Fact
      nonseminomas share features with ES cells.
       nonseminomas share features with ES cells. To
      exclude thatthat detection of miR-371-3 merely
       To exclude the                                            Goal
      reflects its expression pattern in ES cells,reflects its
       the detection of miR-371-3 merely we tested               Hypothesis
      by RPA miR-302a-d, another ES cells-specific
       expression pattern in ES cells,
      miRNA cluster RPA miR-302a-d, another ES cells-
       we tested by (Suh et al, 2004). In many of the
      m i R - 3 7 miRNAx p r e s s(Suh et e m2004). a s a n d
       specific 1 - 3 e cluster i n g s al, i n o m              Method
      nonseminomas, miR-302a-d was undetectable (Figs
       In many of the miR-371-3 expressing seminomas
      S7 and S8), suggesting that miR-371-3undetectable
       and nonseminomas, miR-302a-d was expression               Result
      is a selective event during tumorigenesis.
       (Figs S7 and S8),
       suggesting that
       miR-371-3 expression is a selective event during
                                                                 Implication
       tumorigenesis.




Thursday, October 20, 2011
3.3	
  de	
  Waard/Pander	
  Maat:	
  Discourse	
  Segment	
  Types


      Both seminomas and the EC component of
       Both seminomas and the EC component of                    Fact
      nonseminomas share features with ES cells.
       nonseminomas share features with ES cells. To
      exclude thatthat detection of miR-371-3 merely
       To exclude the                                            Goal
      reflects its expression pattern in ES cells,reflects its
       the detection of miR-371-3 merely we tested               Hypothesis
      by RPA miR-302a-d, another ES cells-specific
       expression pattern in ES cells,
      miRNA cluster RPA miR-302a-d, another ES cells-
       we tested by (Suh et al, 2004). In many of the
      m i R - 3 7 miRNAx p r e s s(Suh et e m2004). a s a n d
       specific 1 - 3 e cluster i n g s al, i n o m              Method
      nonseminomas, miR-302a-d was undetectable (Figs
       In many of the miR-371-3 expressing seminomas
      S7 and S8), suggesting that miR-371-3undetectable
       and nonseminomas, miR-302a-d was expression               Result
      is a selective event during tumorigenesis.
       (Figs S7 and S8),
       suggesting that                                           Reg-Implication
       miR-371-3 expression is a selective event during
                                                                 Implication
       tumorigenesis.




Thursday, October 20, 2011
3.3	
  de	
  Waard/Pander	
  Maat:	
  Discourse	
  Segment	
  Types

                                                                           Conceptual
      Both seminomas and the EC component of
       Both seminomas and the EC component of                              knowledge
                                                                 Fact
      nonseminomas share features with ES cells.
       nonseminomas share features with ES cells. To
      exclude thatthat detection of miR-371-3 merely
       To exclude the                                            Goal
      reflects its expression pattern in ES cells,reflects its
       the detection of miR-371-3 merely we tested               Hypothesis
      by RPA miR-302a-d, another ES cells-specific
       expression pattern in ES cells,
      miRNA cluster RPA miR-302a-d, another ES cells-
       we tested by (Suh et al, 2004). In many of the
      m i R - 3 7 miRNAx p r e s s(Suh et e m2004). a s a n d
       specific 1 - 3 e cluster i n g s al, i n o m              Method
      nonseminomas, miR-302a-d was undetectable (Figs
       In many of the miR-371-3 expressing seminomas
      S7 and S8), suggesting that miR-371-3undetectable
       and nonseminomas, miR-302a-d was expression               Result
      is a selective event during tumorigenesis.
       (Figs S7 and S8),
       suggesting that                                           Reg-Implication
       miR-371-3 expression is a selective event during
                                                                 Implication
       tumorigenesis.




Thursday, October 20, 2011
3.3	
  de	
  Waard/Pander	
  Maat:	
  Discourse	
  Segment	
  Types

                                                                           Conceptual
      Both seminomas and the EC component of
       Both seminomas and the EC component of                              knowledge
                                                                 Fact
      nonseminomas share features with ES cells.
       nonseminomas share features with ES cells. To
      exclude thatthat detection of miR-371-3 merely
       To exclude the                                            Goal
      reflects its expression pattern in ES cells,reflects its
       the detection of miR-371-3 merely we tested               Hypothesis
      by RPA miR-302a-d, another ES cells-specific
       expression pattern in ES cells,
      miRNA cluster RPA miR-302a-d, another ES cells-
       we tested by (Suh et al, 2004). In many of the
      m i R - 3 7 miRNAx p r e s s(Suh et e m2004). a s a n d
       specific 1 - 3 e cluster i n g s al, i n o m              Method
                                                                     Experimental
      nonseminomas, miR-302a-d was undetectable (Figs
       In many of the miR-371-3 expressing seminomas
                                                                         Evidence
      S7 and S8), suggesting that miR-371-3undetectable
       and nonseminomas, miR-302a-d was expression               Result
      is a selective event during tumorigenesis.
       (Figs S7 and S8),
       suggesting that                                           Reg-Implication
       miR-371-3 expression is a selective event during
                                                                 Implication
       tumorigenesis.




Thursday, October 20, 2011
3.3	
  Iden/fica/on	
  of	
  DSTs:




                                                                 15

Thursday, October 20, 2011
3.3	
  Iden/fica/on	
  of	
  DSTs:
  -­‐ Verb	
  form:	
  tense,	
  e.g.	
  
      -­‐ Concepts	
  in	
  ‘state’	
  (gnomic)	
  present:
          ‘Dopaminergic	
  innerva/on	
  plays	
  a	
  major	
  role	
  in	
  the	
  control	
  of	
  
          mood	
  and	
  its	
  perturba/on’	
  
      -­‐ Experiments	
  in	
  ‘event’	
  past:	
  
          ‘Four	
  out	
  of	
  seven	
  cell	
  lines	
  expressed	
  this	
  cluster’




                                                                                                  15

Thursday, October 20, 2011
3.3	
  Iden/fica/on	
  of	
  DSTs:
  -­‐ Verb	
  form:	
  tense,	
  e.g.	
  
       -­‐ Concepts	
  in	
  ‘state’	
  (gnomic)	
  present:
           ‘Dopaminergic	
  innerva/on	
  plays	
  a	
  major	
  role	
  in	
  the	
  control	
  of	
  
           mood	
  and	
  its	
  perturba/on’	
  
       -­‐ Experiments	
  in	
  ‘event’	
  past:	
  
           ‘Four	
  out	
  of	
  seven	
  cell	
  lines	
  expressed	
  this	
  cluster’
  -­‐ Seman4c	
  verb	
  class:	
  
       -­‐ Research	
  verbs	
  (Inves/ga/on,	
  Predic/on,	
  Procedure,	
  
           Observa/on,	
  Interpreta/on)
       -­‐ Discourse	
  verbs	
  
       -­‐ Proper/es	
  and	
  rela/onships	
  -­‐	
  between	
  things	
  and	
  concepts




                                                                                                   15

Thursday, October 20, 2011
3.3	
  Iden/fica/on	
  of	
  DSTs:
  -­‐ Verb	
  form:	
  tense,	
  e.g.	
  
       -­‐ Concepts	
  in	
  ‘state’	
  (gnomic)	
  present:
           ‘Dopaminergic	
  innerva/on	
  plays	
  a	
  major	
  role	
  in	
  the	
  control	
  of	
  
           mood	
  and	
  its	
  perturba/on’	
  
       -­‐ Experiments	
  in	
  ‘event’	
  past:	
  
           ‘Four	
  out	
  of	
  seven	
  cell	
  lines	
  expressed	
  this	
  cluster’
  -­‐ Seman4c	
  verb	
  class:	
  
       -­‐ Research	
  verbs	
  (Inves/ga/on,	
  Predic/on,	
  Procedure,	
  
           Observa/on,	
  Interpreta/on)
       -­‐ Discourse	
  verbs	
  
       -­‐ Proper/es	
  and	
  rela/onships	
  -­‐	
  between	
  things	
  and	
  concepts
  -­‐ Modality	
  
       -­‐ Types:	
  Source	
  {Author,	
  others,	
  unknown},	
  Basis	
  {Data,	
  
           Reasoning,	
  0},	
  Value	
  {Certain,	
  probable,	
  possible,	
  unknown}
       -­‐ Markers:	
  Modal	
  aux,	
  verb	
  class	
  Interpreta/on,	
  epistemic	
  adverbs
                                                                                               15

Thursday, October 20, 2011
3.	
  Same	
  Statement	
  annotated	
  three	
  ways:




Thursday, October 20, 2011
3.	
  Same	
  Statement	
  annotated	
  three	
  ways:
  CoreSC:
  <annotationART atype="GSC" type="Res" conceptID="Res24" novelty="None" advantage="None">
  Here we show that BOB.1/OBF.1 regulates Btk gene expression.
  </annotationART>

  BioEvent/MetaKnowledge:
  <sentence id="S6">Here we show that
  <term id="T13" sem="Protein_family_or_group">
      <gene-or-gene-product id="G9">BOB.1</gene-or-gene-product>/
      <gene-or-gene-product id="G10">OBF.1</gene-or-gene-product>
  </term> regulates
      <term id="T14" sem="Biological_process">
          <term id="T15" sem="DNA_domain_or_region">
              <gene-or-gene-product id="G11">Btk
              </gene-or-gene-product> gene
          </term> expression
      </term>.
  </sentence>

  Discourse Segments:
  <segment segID ="286" section = "D" segtype = "RegImplication">
  Here we show that
  </segment>
  <segment segID ="287" section = "D" segtype = "Implication">


Thursday, October 20, 2011
3.	
  Same	
  Statement	
  annotated	
  three	
  ways:
  CoreSC:
  <annotationART atype="GSC" type="Res" conceptID="Res24" novelty="None" advantage="None">
  Here we show that BOB.1/OBF.1 regulates Btk gene expression.
  </annotationART>

  BioEvent/MetaKnowledge:
  <sentence id="S6">Here we show that
  <term id="T13" sem="Protein_family_or_group">
      <gene-or-gene-product id="G9">BOB.1</gene-or-gene-product>/
      <gene-or-gene-product id="G10">OBF.1</gene-or-gene-product>
  </term> regulates
      <term id="T14" sem="Biological_process">
          <term id="T15" sem="DNA_domain_or_region">
              <gene-or-gene-product id="G11">Btk
              </gene-or-gene-product> gene
          </term> expression
      </term>.
  </sentence>

  Discourse Segments:
  <segment segID ="286" section = "D" segtype = "RegImplication">
  Here we show that
  </segment>
  <segment segID ="287" section = "D" segtype = "Implication">
  BOB.1/OBF.1 regulates Btk gene expression.
  </segment>
Thursday, October 20, 2011
3.	
  Same	
  Statement	
  annotated	
  three	
  ways:
  CoreSC:
  <annotationART atype="GSC" type="Res" conceptID="Res24" novelty="None" advantage="None">
  Here we show that BOB.1/OBF.1 regulates Btk gene expression.
  </annotationART>

  BioEvent/MetaKnowledge:
  <sentence id="S6">Here we show that
  <term id="T13" sem="Protein_family_or_group">
      <gene-or-gene-product id="G9">BOB.1</gene-or-gene-product>/
      <gene-or-gene-product id="G10">OBF.1</gene-or-gene-product>
  </term> regulates
      <term id="T14" sem="Biological_process">
          <term id="T15" sem="DNA_domain_or_region">
              <gene-or-gene-product id="G11">Btk
              </gene-or-gene-product> gene
          </term> expression
      </term>.
  </sentence>

  Discourse Segments:
  <segment segID ="286" section = "D" segtype = "RegImplication">
  Here we show that
  </segment>
  <segment segID ="287" section = "D" segtype = "Implication">
  BOB.1/OBF.1 regulates Btk gene expression.
  </segment>
Thursday, October 20, 2011
3.	
  Comparing	
  statement-­‐level	
  annota/on	
  models
 Who                         Why                             What                      How
 Liakata:	
  CoreSC          Iden/fy	
  main	
           Sentence                      Manual	
  corpus,	
  
                             components	
  of	
                                        automated	
  
                             scien/fic	
  inves/ga/on	
                                 annota/on	
  tools	
  -­‐	
  
                             for	
  machine	
  learning                                working	
  on	
  
                                                                                       automated	
  detec/on

 Ananiadou:	
                Enhance	
  informa/on	
         Events	
  (intra-­‐              Manual	
  corpus,	
  
 MetaKnowledge/              extrac/on	
  for	
              senten/al):	
  can	
  be	
   working	
  on	
  
 BioEvents                   biomedical	
  texts	
  to	
     several	
  per	
                 automated	
  detec/on
                             enable	
  metadiscourse	
       sentence,	
  or	
  one	
  in	
  
                             annota/on                       more	
  sentences
 de	
  Waard:             Iden/fy	
  mechanisms	
   Clause                             Manual,	
  ideas	
  (but	
  no	
  
 Discourse	
  Segment	
   of	
  conveying	
                                            real	
  plans!)	
  for	
  
 Types                    (epistemic)	
  knowledge	
                                   automated	
  
                          in	
  scien/fic	
  	
  discourse                              iden/fica/on



Thursday, October 20, 2011
4.	
  Rela.ons
  a.Why?
     -­‐ Argumenta/on	
  visualisa/on
  b.What,	
  by	
  whom?	
  
     -­‐ Harmsze	
  (1999):	
  Ontology	
  of	
  
           content	
  rela/onships
     -­‐   IBIS,	
  ClaiMaker	
  (2001)
     -­‐   Diligent	
  argumenta/on	
  
           ontology	
  (2005)	
  
     -­‐   SALT:	
  RST	
  (2007)
     -­‐   SWAN	
  (2010)
  c. How?	
  
     -­‐ So	
  far:	
  Manually                      18

Thursday, October 20, 2011
4.	
  Rela.ons
  a.Why?
     -­‐ Argumenta/on	
  visualisa/on
  b.What,	
  by	
  whom?	
  
     -­‐ Harmsze	
  (1999):	
  Ontology	
  of	
  
           content	
  rela/onships
     -­‐   IBIS,	
  ClaiMaker	
  (2001)
     -­‐   Diligent	
  argumenta/on	
  
           ontology	
  (2005)	
  
     -­‐   SALT:	
  RST	
  (2007)
     -­‐   SWAN	
  (2010)
  c. How?	
  
     -­‐ So	
  far:	
  Manually                      18

Thursday, October 20, 2011
4.	
  Rela.ons
  a.Why?
     -­‐ Argumenta/on	
  visualisa/on
  b.What,	
  by	
  whom?	
  
     -­‐ Harmsze	
  (1999):	
  Ontology	
  of	
  
           content	
  rela/onships
     -­‐   IBIS,	
  ClaiMaker	
  (2001)
     -­‐   Diligent	
  argumenta/on	
  
           ontology	
  (2005)	
  
     -­‐   SALT:	
  RST	
  (2007)
     -­‐   SWAN	
  (2010)
  c. How?	
  
     -­‐ So	
  far:	
  Manually                      18

Thursday, October 20, 2011
4.	
  Rela.ons
  a.Why?
     -­‐ Argumenta/on	
  visualisa/on
  b.What,	
  by	
  whom?	
  
     -­‐ Harmsze	
  (1999):	
  Ontology	
  of	
  
           content	
  rela/onships
     -­‐   IBIS,	
  ClaiMaker	
  (2001)
     -­‐   Diligent	
  argumenta/on	
  
           ontology	
  (2005)	
  
     -­‐   SALT:	
  RST	
  (2007)
     -­‐   SWAN	
  (2010)
  c. How?	
  
     -­‐ So	
  far:	
  Manually                      18

Thursday, October 20, 2011
4.	
  Rela.ons
  a.Why?
     -­‐ Argumenta/on	
  visualisa/on
  b.What,	
  by	
  whom?	
  
     -­‐ Harmsze	
  (1999):	
  Ontology	
  of	
  
           content	
  rela/onships
     -­‐   IBIS,	
  ClaiMaker	
  (2001)
     -­‐   Diligent	
  argumenta/on	
  
           ontology	
  (2005)	
  
     -­‐   SALT:	
  RST	
  (2007)
     -­‐   SWAN	
  (2010)
  c. How?	
  
     -­‐ So	
  far:	
  Manually                      18

Thursday, October 20, 2011
5.Claim-­‐Evidence	
  Networks	
  (statement	
  +	
  rela/ons)




                                                           19

Thursday, October 20, 2011
5.Claim-­‐Evidence	
  Networks	
  (statement	
  +	
  rela/ons)
 a.Why?




                                                           19

Thursday, October 20, 2011
5.Claim-­‐Evidence	
  Networks	
  (statement	
  +	
  rela/ons)
 a.Why?
       Show	
  argumenta/on	
  
       across	
  body	
  of	
  work




                                                           19

Thursday, October 20, 2011
5.Claim-­‐Evidence	
  Networks	
  (statement	
  +	
  rela/ons)
 a.Why?
       Show	
  argumenta/on	
  
       across	
  body	
  of	
  work
 b.What,	
  by	
  whom?




                                                           19

Thursday, October 20, 2011
5.Claim-­‐Evidence	
  Networks	
  (statement	
  +	
  rela/ons)
 a.Why?
       Show	
  argumenta/on	
  
       across	
  body	
  of	
  work
 b.What,	
  by	
  whom?
       -­‐ Buckingham	
  Shum,	
  1999




                                                           19

Thursday, October 20, 2011
5.Claim-­‐Evidence	
  Networks	
  (statement	
  +	
  rela/ons)
 a.Why?
       Show	
  argumenta/on	
  
       across	
  body	
  of	
  work
 b.What,	
  by	
  whom?
       -­‐ Buckingham	
  Shum,	
  1999




                                                           19

Thursday, October 20, 2011
5.Claim-­‐Evidence	
  Networks	
  (statement	
  +	
  rela/ons)
 a.Why?
       Show	
  argumenta/on	
  
       across	
  body	
  of	
  work
 b.What,	
  by	
  whom?
       -­‐ Buckingham	
  Shum,	
  1999
       -­‐ SWAN:	
  Clark,	
  Ciccarese	
  
           et	
  al.,	
  2005




                                                           19

Thursday, October 20, 2011
5.Claim-­‐Evidence	
  Networks	
  (statement	
  +	
  rela/ons)
 a.Why?
       Show	
  argumenta/on	
  
       across	
  body	
  of	
  work
 b.What,	
  by	
  whom?
       -­‐ Buckingham	
  Shum,	
  1999
       -­‐ SWAN:	
  Clark,	
  Ciccarese	
  
           et	
  al.,	
  2005




                                                           19

Thursday, October 20, 2011
5.Claim-­‐Evidence	
  Networks	
  (statement	
  +	
  rela/ons)
 a.Why?
       Show	
  argumenta/on	
  
       across	
  body	
  of	
  work
 b.What,	
  by	
  whom?
       -­‐ Buckingham	
  Shum,	
  1999
       -­‐ SWAN:	
  Clark,	
  Ciccarese	
  
           et	
  al.,	
  2005
       -­‐ Nanopublica/ons:	
  
           Mons,	
  2010




                                                           19

Thursday, October 20, 2011
5.Claim-­‐Evidence	
  Networks	
  (statement	
  +	
  rela/ons)
 a.Why?
       Show	
  argumenta/on	
  
       across	
  body	
  of	
  work
 b.What,	
  by	
  whom?
       -­‐ Buckingham	
  Shum,	
  1999
       -­‐ SWAN:	
  Clark,	
  Ciccarese	
  
           et	
  al.,	
  2005
       -­‐ Nanopublica/ons:	
  
           Mons,	
  2010




                                                           19

Thursday, October 20, 2011
5.Claim-­‐Evidence	
  Networks	
  (statement	
  +	
  rela/ons)
 a.Why?
       Show	
  argumenta/on	
  
       across	
  body	
  of	
  work
 b.What,	
  by	
  whom?
       -­‐ Buckingham	
  Shum,	
  1999
       -­‐ SWAN:	
  Clark,	
  Ciccarese	
  
           et	
  al.,	
  2005
       -­‐ Nanopublica/ons:	
  
           Mons,	
  2010
       -­‐ Nanopublica/ons	
  +	
  
           SWAN,	
  2011


                                                           19

Thursday, October 20, 2011
5.Claim-­‐Evidence	
  Networks	
  (statement	
  +	
  rela/ons)
 a.Why?
       Show	
  argumenta/on	
  
       across	
  body	
  of	
  work
 b.What,	
  by	
  whom?
       -­‐ Buckingham	
  Shum,	
  1999
       -­‐ SWAN:	
  Clark,	
  Ciccarese	
  
           et	
  al.,	
  2005
       -­‐ Nanopublica/ons:	
  
           Mons,	
  2010
       -­‐ Nanopublica/ons	
  +	
  
           SWAN,	
  2011
 c.How?	
  
                                                           19

Thursday, October 20, 2011
5.Claim-­‐Evidence	
  Networks	
  (statement	
  +	
  rela/ons)
 a.Why?
       Show	
  argumenta/on	
  
       across	
  body	
  of	
  work
 b.What,	
  by	
  whom?
       -­‐ Buckingham	
  Shum,	
  1999
       -­‐ SWAN:	
  Clark,	
  Ciccarese	
  
           et	
  al.,	
  2005
       -­‐ Nanopublica/ons:	
  
           Mons,	
  2010
       -­‐ Nanopublica/ons	
  +	
  
           SWAN,	
  2011
 c.How?	
  
       -­‐ So	
  far:	
  manually                          19

Thursday, October 20, 2011
5.Claim-­‐Evidence	
  Networks	
  (statement	
  +	
  rela/ons)
 a.Why?
       Show	
  argumenta/on	
  
       across	
  body	
  of	
  work
 b.What,	
  by	
  whom?
       -­‐ Buckingham	
  Shum,	
  1999
       -­‐ SWAN:	
  Clark,	
  Ciccarese	
  
           et	
  al.,	
  2005
       -­‐ Nanopublica/ons:	
  
           Mons,	
  2010
       -­‐ Nanopublica/ons	
  +	
  
           SWAN,	
  2011
 c.How?	
  
       -­‐ So	
  far:	
  manually                          19

Thursday, October 20, 2011
D2S	
  Use	
  case:	
  Claim-­‐Evidence	
  Network	
  in	
  Medicine




                                                                  B. Elsevier-published
A. Philips’ Electronic Patient Records                            Clinical Guideline




                             C. Elsevier (or other publisher’s)
                             Research Report or Data


                                                                                          20
Thursday, October 20, 2011
D2S	
  Use	
  case:	
  Claim-­‐Evidence	
  Network	
  in	
  Medicine
                                                Step 1: Patient data +
                                                diagnosis link to Guideline
                                                recommendation




                                                                              B. Elsevier-published
A. Philips’ Electronic Patient Records                                        Clinical Guideline




                             C. Elsevier (or other publisher’s)
                             Research Report or Data


                                                                                                      20
Thursday, October 20, 2011
D2S	
  Use	
  case:	
  Claim-­‐Evidence	
  Network	
  in	
  Medicine
                                                Step 1: Patient data +
                                                diagnosis link to Guideline
                                                recommendation




                                                                              B. Elsevier-published
A. Philips’ Electronic Patient Records                                        Clinical Guideline

                                                                     Step 2: Guideline recommendation
                                                                     links to evidence in report or data




                             C. Elsevier (or other publisher’s)
                             Research Report or Data


                                                                                                      20
Thursday, October 20, 2011
D2S	
  Use	
  case:	
  Claim-­‐Evidence	
  Network	
  in	
  Medicine
                                                Step 1: Patient data +
                                                diagnosis link to Guideline
                                                recommendation




                                                                              B. Elsevier-published
A. Philips’ Electronic Patient Records                                        Clinical Guideline

                                                                     Step 2: Guideline recommendation
                                                                     links to evidence in report or data




                             C. Elsevier (or other publisher’s)
                             Research Report or Data

  Related	
  HCLS	
  Use	
  Case:	
  Accelerate	
  uptake	
  of	
  medical	
  research	
  
  on	
  drug-­‐drug	
  interac/on	
  in	
  product	
  inserts                                         20
Thursday, October 20, 2011
Five	
  levels	
  of	
  scien/fic	
  discourse	
  annota/on




                                                                          21

Thursday, October 20, 2011
Five	
  levels	
  of	
  scien/fic	
  discourse	
  annota/on
                                   Why                    What/Who                                How

                                                                                             Automated!	
  
        Sec/on                   Search,	
  UI         ABCDE,	
  ORB/HCLS
                                                                                           Publisher	
  helps?	
  

                                                   Harmsze/Kircz,	
  LiquidPub,	
  
        Module                 Content	
  reuse
                                                            HCLS
                                                                                         Manual:	
  templates

                                                       Teufel,	
  Ananiadou,	
  
                                Summaries;	
                                              Working	
  towards	
  
    Statement                towards	
  networks
                                                            Liakata,	
  
                                                                                        automated	
  detec/on
                                                                  UU

                                                   SALT,	
  ScholOnto,	
  Diligent,	
   Manual:	
  some	
  tools,	
  
      Rela/ons                   Networks
                                                               SWAN                      never	
  took	
  off...

       Claim/                 Argumenta/on	
         	
  ScholOnto,	
  SWAN,	
            Manual-­‐	
  towards	
  
      Evidence                   networks           Nanopublica/ons,	
  D2S                automa/on?	
  
                                                                                                               21

Thursday, October 20, 2011
Five	
  levels	
  of	
  scien/fic	
  discourse	
  annota/on
                                   Why                    What/Who                                How

                                                                                             Automated!	
  
        Sec/on                   Search,	
  UI         ABCDE,	
  ORB/HCLS
                                                                                           Publisher	
  helps?	
  

                                                   Harmsze/Kircz,	
  LiquidPub,	
  
        Module                 Content	
  reuse
                                                            HCLS
                                                                                         Manual:	
  templates

                                                       Teufel,	
  Ananiadou,	
  
                                Summaries;	
                                              Working	
  towards	
  
    Statement                towards	
  networks
                                                            Liakata,	
  
                                                                                        automated	
  detec/on
                                                                  UU

                                                   SALT,	
  ScholOnto,	
  Diligent,	
   Manual:	
  some	
  tools,	
  
      Rela/ons                   Networks
                                                               SWAN                      never	
  took	
  off...

       Claim/                 Argumenta/on	
         	
  ScholOnto,	
  SWAN,	
            Manual-­‐	
  towards	
  
      Evidence                   networks           Nanopublica/ons,	
  D2S                automa/on?	
  
                                                                                                               21

Thursday, October 20, 2011
Five	
  levels	
  of	
  scien/fic	
  discourse	
  annota/on
                                   Why                    What/Who                                How

                                                                                             Automated!	
  
        Sec/on                   Search,	
  UI         ABCDE,	
  ORB/HCLS
                                                                                           Publisher	
  helps?	
  

                                                   Harmsze/Kircz,	
  LiquidPub,	
  
        Module                 Content	
  reuse
                                                            HCLS
                                                                                         Manual:	
  templates

                                                       Teufel,	
  Ananiadou,	
  
                                Summaries;	
                                              Working	
  towards	
  
    Statement                towards	
  networks
                                                            Liakata,	
  
                                                                                        automated	
  detec/on
                                                                  UU

                                                   SALT,	
  ScholOnto,	
  Diligent,	
   Manual:	
  some	
  tools,	
  
      Rela/ons                   Networks
                                                               SWAN                      never	
  took	
  off...

       Claim/                 Argumenta/on	
         	
  ScholOnto,	
  SWAN,	
            Manual-­‐	
  towards	
  
      Evidence                   networks           Nanopublica/ons,	
  D2S                automa/on?	
  
                                                                                                               21

Thursday, October 20, 2011
Five	
  levels	
  of	
  scien/fic	
  discourse	
  annota/on
                                   Why                    What/Who                                How

                                                                                             Automated!	
  
        Sec/on                   Search,	
  UI         ABCDE,	
  ORB/HCLS
                                                                                           Publisher	
  helps?	
  

                                                   Harmsze/Kircz,	
  LiquidPub,	
  
        Module                 Content	
  reuse
                                                            HCLS
                                                                                         Manual:	
  templates

                                                       Teufel,	
  Ananiadou,	
  
                                Summaries;	
                                              Working	
  towards	
  
    Statement                towards	
  networks
                                                            Liakata,	
  
                                                                                        automated	
  detec/on
                                                                  UU

                                                   SALT,	
  ScholOnto,	
  Diligent,	
   Manual:	
  some	
  tools,	
  
      Rela/ons                   Networks
                                                               SWAN                      never	
  took	
  off...

       Claim/                 Argumenta/on	
         	
  ScholOnto,	
  SWAN,	
            Manual-­‐	
  towards	
  
      Evidence                   networks           Nanopublica/ons,	
  D2S                automa/on?	
  
                                                                                                               21

Thursday, October 20, 2011
Five	
  levels	
  of	
  scien/fic	
  discourse	
  annota/on
                                   Why                    What/Who                                How

                                                                                             Automated!	
  
        Sec/on                   Search,	
  UI         ABCDE,	
  ORB/HCLS
                                                                                           Publisher	
  helps?	
  

                                                   Harmsze/Kircz,	
  LiquidPub,	
  
        Module                 Content	
  reuse
                                                            HCLS
                                                                                         Manual:	
  templates

                                                       Teufel,	
  Ananiadou,	
  
                                Summaries;	
                                              Working	
  towards	
  
    Statement                towards	
  networks
                                                            Liakata,	
  
                                                                                        automated	
  detec/on
                                                                  UU

                                                   SALT,	
  ScholOnto,	
  Diligent,	
   Manual:	
  some	
  tools,	
  
      Rela/ons                   Networks
                                                               SWAN                      never	
  took	
  off...

       Claim/                 Argumenta/on	
         	
  ScholOnto,	
  SWAN,	
            Manual-­‐	
  towards	
  
      Evidence                   networks           Nanopublica/ons,	
  D2S                automa/on?	
  
                                                                                                               21

Thursday, October 20, 2011
Five	
  levels	
  of	
  scien/fic	
  discourse	
  annota/on
                                   Why                    What/Who                                How

                                                                                             Automated!	
  
        Sec/on                   Search,	
  UI         ABCDE,	
  ORB/HCLS
                                                                                           Publisher	
  helps?	
  

                                                   Harmsze/Kircz,	
  LiquidPub,	
  
        Module                 Content	
  reuse
                                                            HCLS
                                                                                         Manual:	
  templates

                                                       Teufel,	
  Ananiadou,	
  
                                Summaries;	
                                              Working	
  towards	
  
    Statement                towards	
  networks
                                                            Liakata,	
  
                                                                                        automated	
  detec/on
                                                                  UU

                                                   SALT,	
  ScholOnto,	
  Diligent,	
   Manual:	
  some	
  tools,	
  
      Rela/ons                   Networks
                                                               SWAN                      never	
  took	
  off...

       Claim/                 Argumenta/on	
         	
  ScholOnto,	
  SWAN,	
            Manual-­‐	
  towards	
  
      Evidence                   networks           Nanopublica/ons,	
  D2S                automa/on?	
  
                                                                                                               21

Thursday, October 20, 2011
Five	
  levels	
  of	
  scien/fic	
  discourse	
  annota/on
                                   Why                     What/Who                                How

                                                                                              Automated!	
  
        Sec/on                   Search,	
  UI          ABCDE,	
  ORB/HCLS
                                                                                            Publisher	
  helps?	
  

                                                   Harmsze/Kircz,	
  LiquidPub,	
  
        Module                 Content	
  reuse
                                                            HCLS
                                                                                          Manual:	
  templates
                                                  MoFfs?                	
  
                                                   Teufel,	
  Ananiadou,	
  
                                Summaries;	
                                               Working	
  towards	
  
    Statement                towards	
  networks
                                                               Liakata,	
  
                                                                                         automated	
  detec/on
                                                                  UU

                                                    SALT,	
  ScholOnto,	
  Diligent,	
   Manual:	
  some	
  tools,	
  
      Rela/ons                   Networks
                                                                SWAN                      never	
  took	
  off...

       Claim/                 Argumenta/on	
          	
  ScholOnto,	
  SWAN,	
            Manual-­‐	
  towards	
  
      Evidence                   networks            Nanopublica/ons,	
  D2S                automa/on?	
  
                                                                                                                21

Thursday, October 20, 2011
Ques.ons:




                                         22

Thursday, October 20, 2011
Ques.ons:
 Scien/fic	
  discourse	
  -­‐>	
  fairy	
  tales:	
  how	
  can	
  we	
  transfer	
  knowledge	
  
    here	
  to	
  scien/fic	
  discourse	
  community?	
  




                                                                                                22

Thursday, October 20, 2011
Ques.ons:
 Scien/fic	
  discourse	
  -­‐>	
  fairy	
  tales:	
  how	
  can	
  we	
  transfer	
  knowledge	
  
    here	
  to	
  scien/fic	
  discourse	
  community?	
  
 Issue:	
  Scien/sts	
  do	
  not	
  like	
  being	
  told	
  that	
  they	
  write	
  fairy	
  tales!




                                                                                                         22

Thursday, October 20, 2011
Ques.ons:
 Scien/fic	
  discourse	
  -­‐>	
  fairy	
  tales:	
  how	
  can	
  we	
  transfer	
  knowledge	
  
    here	
  to	
  scien/fic	
  discourse	
  community?	
  
 Issue:	
  Scien/sts	
  do	
  not	
  like	
  being	
  told	
  that	
  they	
  write	
  fairy	
  tales!
 Fairy	
  tales	
  -­‐>	
  scien/fic	
  discourse:	
  is	
  anyone	
  here/in	
  this	
  community	
  
    interested	
  in	
  working	
  on	
  inter-­‐domain	
  transfer	
  of	
  tools,	
  
    technologies	
  and	
  theories?




                                                                                                         22

Thursday, October 20, 2011
Ques.ons:
 Scien/fic	
  discourse	
  -­‐>	
  fairy	
  tales:	
  how	
  can	
  we	
  transfer	
  knowledge	
  
    here	
  to	
  scien/fic	
  discourse	
  community?	
  
 Issue:	
  Scien/sts	
  do	
  not	
  like	
  being	
  told	
  that	
  they	
  write	
  fairy	
  tales!
 Fairy	
  tales	
  -­‐>	
  scien/fic	
  discourse:	
  is	
  anyone	
  here/in	
  this	
  community	
  
    interested	
  in	
  working	
  on	
  inter-­‐domain	
  transfer	
  of	
  tools,	
  
    technologies	
  and	
  theories?


 Anita	
  de	
  Waard,	
  a.dewaard@elsevier.com	
  
 -­‐HCLS:	
  hEp://www.w3.org/wiki/HCLSIG/SWANSIOC
 -­‐UU:	
  hEp://elsatglabs.com/labs/anita	
  
 -­‐D2S:	
  hEp://www.data2seman/cs.org
                                                                                                         22

Thursday, October 20, 2011

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Overview of scientific discourse annotatoin

  • 1. A  brief  introduc.on  to   current  efforts  in scien.fic  discourse  annota.on   Anita  de  Waard Disrup/ve  Technology  Director,  Elsevier  Labs -­‐  also  on  behalf  of  HCLS/UU/D2S... hEp://elsatglabs.com/labs/anita   Thursday, October 20, 2011
  • 2. One  way  of  subdividing  the  field  of Scien/fic  Discourse  Annota/on: 2 Thursday, October 20, 2011
  • 3. One  way  of  subdividing  the  field  of Scien/fic  Discourse  Annota/on: Five  levels  of  markup:   2 Thursday, October 20, 2011
  • 4. One  way  of  subdividing  the  field  of Scien/fic  Discourse  Annota/on: Five  levels  of  markup:   1.Sec/on:  “Discussion”,  ~  several  paragraphs  (+HCLS) 2 Thursday, October 20, 2011
  • 5. One  way  of  subdividing  the  field  of Scien/fic  Discourse  Annota/on: Five  levels  of  markup:   1.Sec/on:  “Discussion”,  ~  several  paragraphs  (+HCLS) 2.Module:  “Research  Ques/on”,  ~  paragraph 2 Thursday, October 20, 2011
  • 6. One  way  of  subdividing  the  field  of Scien/fic  Discourse  Annota/on: Five  levels  of  markup:   1.Sec/on:  “Discussion”,  ~  several  paragraphs  (+HCLS) 2.Module:  “Research  Ques/on”,  ~  paragraph 3.Statement:  “Hypothesis”,  ~  sentence/clause  (+UU) 2 Thursday, October 20, 2011
  • 7. One  way  of  subdividing  the  field  of Scien/fic  Discourse  Annota/on: Five  levels  of  markup:   1.Sec/on:  “Discussion”,  ~  several  paragraphs  (+HCLS) 2.Module:  “Research  Ques/on”,  ~  paragraph 3.Statement:  “Hypothesis”,  ~  sentence/clause  (+UU) 4.Rela/on:  “Supports”,  ~  hyperlink (En/ty:  “Gene  Name”,  ~  NP) 2 Thursday, October 20, 2011
  • 8. One  way  of  subdividing  the  field  of Scien/fic  Discourse  Annota/on: Five  levels  of  markup:   1.Sec/on:  “Discussion”,  ~  several  paragraphs  (+HCLS) 2.Module:  “Research  Ques/on”,  ~  paragraph 3.Statement:  “Hypothesis”,  ~  sentence/clause  (+UU) 4.Rela/on:  “Supports”,  ~  hyperlink (En/ty:  “Gene  Name”,  ~  NP) 5.Special  case  of  3&4:  Claim/Evidence  network  (+D2S) 2 Thursday, October 20, 2011
  • 9. One  way  of  subdividing  the  field  of Scien/fic  Discourse  Annota/on: Five  levels  of  markup:   1.Sec/on:  “Discussion”,  ~  several  paragraphs  (+HCLS) 2.Module:  “Research  Ques/on”,  ~  paragraph 3.Statement:  “Hypothesis”,  ~  sentence/clause  (+UU) 4.Rela/on:  “Supports”,  ~  hyperlink (En/ty:  “Gene  Name”,  ~  NP) 5.Special  case  of  3&4:  Claim/Evidence  network  (+D2S) For  each  level:   2 Thursday, October 20, 2011
  • 10. One  way  of  subdividing  the  field  of Scien/fic  Discourse  Annota/on: Five  levels  of  markup:   1.Sec/on:  “Discussion”,  ~  several  paragraphs  (+HCLS) 2.Module:  “Research  Ques/on”,  ~  paragraph 3.Statement:  “Hypothesis”,  ~  sentence/clause  (+UU) 4.Rela/on:  “Supports”,  ~  hyperlink (En/ty:  “Gene  Name”,  ~  NP) 5.Special  case  of  3&4:  Claim/Evidence  network  (+D2S) For  each  level:   a) Why?  Use  cases   2 Thursday, October 20, 2011
  • 11. One  way  of  subdividing  the  field  of Scien/fic  Discourse  Annota/on: Five  levels  of  markup:   1.Sec/on:  “Discussion”,  ~  several  paragraphs  (+HCLS) 2.Module:  “Research  Ques/on”,  ~  paragraph 3.Statement:  “Hypothesis”,  ~  sentence/clause  (+UU) 4.Rela/on:  “Supports”,  ~  hyperlink (En/ty:  “Gene  Name”,  ~  NP) 5.Special  case  of  3&4:  Claim/Evidence  network  (+D2S) For  each  level:   a) Why?  Use  cases   b) What,  by  whom?  Concepts,  ontology,  authors? 2 Thursday, October 20, 2011
  • 12. One  way  of  subdividing  the  field  of Scien/fic  Discourse  Annota/on: Five  levels  of  markup:   1.Sec/on:  “Discussion”,  ~  several  paragraphs  (+HCLS) 2.Module:  “Research  Ques/on”,  ~  paragraph 3.Statement:  “Hypothesis”,  ~  sentence/clause  (+UU) 4.Rela/on:  “Supports”,  ~  hyperlink (En/ty:  “Gene  Name”,  ~  NP) 5.Special  case  of  3&4:  Claim/Evidence  network  (+D2S) For  each  level:   a) Why?  Use  cases   b) What,  by  whom?  Concepts,  ontology,  authors? c) How?  Manual,  automated?   2 Thursday, October 20, 2011
  • 13. 1.  Sec/on-­‐level  markup 3 Thursday, October 20, 2011
  • 14. 1.  Sec/on-­‐level  markup INTRODUCTION 3 Thursday, October 20, 2011
  • 15. 1.  Sec/on-­‐level  markup a.Why  mark  up  sec/ons? -­‐ Search:  e.g.  search  for  en//es   in  Methods -­‐ Visualisa/on:  e.g.  structured   browse  at  sec/on  level INTRODUCTION 3 Thursday, October 20, 2011
  • 16. 1.  Sec/on-­‐level  markup a.Why  mark  up  sec/ons? -­‐ Search:  e.g.  search  for  en//es   in  Methods -­‐ Visualisa/on:  e.g.  structured   browse  at  sec/on  level b.What,  by  whom? -­‐ Background/Contribu/on/ Discussion  model  for  CS INTRODUCTION -­‐ HCLS:  Ontology  of  Rhetorical   Blocks  (ORB)=  IMRaD  in  OWL 3 Thursday, October 20, 2011
  • 17. 1.  Sec/on-­‐level  markup a.Why  mark  up  sec/ons? -­‐ Search:  e.g.  search  for  en//es   Annotation in  Methods -­‐ Visualisa/on:  e.g.  structured   browse  at  sec/on  level b.What,  by  whom? -­‐ Background/Contribu/on/ Discussion  model  for  CS INTRODUCTION -­‐ HCLS:  Ontology  of  Rhetorical   Blocks  (ORB)=  IMRaD  in  OWL 3 Thursday, October 20, 2011
  • 18. 1.  Sec/on-­‐level  markup a.Why  mark  up  sec/ons? -­‐ Search:  e.g.  search  for  en//es   Annotation in  Methods -­‐ Visualisa/on:  e.g.  structured   browse  at  sec/on  level b.What,  by  whom? -­‐ Background/Contribu/on/ Discussion  model  for  CS INTRODUCTION -­‐ HCLS:  Ontology  of  Rhetorical   Blocks  (ORB)=  IMRaD  in  OWL c. Automate?   -­‐ Yes  -­‐[Hovy/Ramakrishnan] 3 Thursday, October 20, 2011
  • 19. HCLS  SciDis:  develop  standards  for  this  markup 4 Thursday, October 20, 2011
  • 20. 2.a.  Module-­‐level  markup:  why? -­‐ BeEer  search:  e.g.  query  inside  ‘Research  ques/on’ -­‐ Ini/al  idea:  content  reuse,  e.g. -­‐ Write  Methods  sec/ons  once,  import/link  many -­‐ Different  way  of  crea/ng  a  collec/on  of  scholarly   content:  not  standalone  narra/ve,  but  connected   set  of  modules   5 Thursday, October 20, 2011
  • 21. 2.b.  Module-­‐level  markup:  What,  by  whom?   6 Thursday, October 20, 2011
  • 22. 2.b.  Module-­‐level  markup:  What,  by  whom?   -­‐ Kircz,  ’98:  “a  much  more  radical   approach  would  be  to  [break]  apart  the   linear  text  into  independent  modules,   each  with  its  own  unique  cogni/ve   character.” 6 Thursday, October 20, 2011
  • 23. 2.b.  Module-­‐level  markup:  What,  by  whom?   -­‐ Kircz,  ’98:  “a  much  more  radical   approach  would  be  to  [break]  apart  the   linear  text  into  independent  modules,   each  with  its  own  unique  cogni/ve   character.” 6 Thursday, October 20, 2011
  • 24. 2.b.  Module-­‐level  markup:  What,  by  whom?   -­‐ Kircz,  ’98:  “a  much  more  radical   approach  would  be  to  [break]  apart  the   linear  text  into  independent  modules,   each  with  its  own  unique  cogni/ve   character.” -­‐ Harmsze,  ‘00:  modular  model  for   physics  papers 6 Thursday, October 20, 2011
  • 25. 2.b.  Module-­‐level  markup:  What,  by  whom?   -­‐ Kircz,  ’98:  “a  much  more  radical   approach  would  be  to  [break]  apart  the   linear  text  into  independent  modules,   each  with  its  own  unique  cogni/ve   character.” -­‐ Harmsze,  ‘00:  modular  model  for   physics  papers 6 Thursday, October 20, 2011
  • 26. 2.b.  Module-­‐level  markup:  What,  by  whom?   -­‐ Kircz,  ’98:  “a  much  more  radical   approach  would  be  to  [break]  apart  the   linear  text  into  independent  modules,   each  with  its  own  unique  cogni/ve   character.” -­‐ Harmsze,  ‘00:  modular  model  for   physics  papers -­‐ LiquidPub,  2010:  Structured  Knowledge   Objects   6 Thursday, October 20, 2011
  • 27. 2.b.  Module-­‐level  markup:  What,  by  whom?   -­‐ Kircz,  ’98:  “a  much  more  radical   approach  would  be  to  [break]  apart  the   linear  text  into  independent  modules,   each  with  its  own  unique  cogni/ve   character.” -­‐ Harmsze,  ‘00:  modular  model  for   physics  papers -­‐ LiquidPub,  2010:  Structured  Knowledge   Objects   6 Thursday, October 20, 2011
  • 28. 2.b.  Module-­‐level  markup:  What,  by  whom?   -­‐ Kircz,  ’98:  “a  much  more  radical   approach  would  be  to  [break]  apart  the   linear  text  into  independent  modules,   each  with  its  own  unique  cogni/ve   character.” -­‐ Harmsze,  ‘00:  modular  model  for   physics  papers -­‐ LiquidPub,  2010:  Structured  Knowledge   Objects   -­‐ HCLS:  Medium-­‐grained  structure:   core  narra/ve  components 6 Thursday, October 20, 2011
  • 29. 2.b.  Module-­‐level  markup:  What,  by  whom?   -­‐ Kircz,  ’98:  “a  much  more  radical   approach  would  be  to  [break]  apart  the   linear  text  into  independent  modules,   each  with  its  own  unique  cogni/ve   character.” -­‐ Harmsze,  ‘00:  modular  model  for   physics  papers -­‐ LiquidPub,  2010:  Structured  Knowledge   Objects   -­‐ HCLS:  Medium-­‐grained  structure:   core  narra/ve  components 6 Thursday, October 20, 2011
  • 30. Story  grammar  model  for  science The Story of Goldilocks and Story Grammar Paper The AXH Domain of Ataxin-1 Mediates the Three Bears Neurodegeneration through Its Interaction with Gfi-1/ Senseless Proteins Once upon a time Time Setting Background The mechanisms mediating SCA1 pathogenesis are still not fully understood, but some general principles have emerged. a little girl named Goldilocks Characters Objects of study the Drosophila Atx-1 homolog (dAtx-1) which lacks a polyQ tract, She went for a walk in the forest. Location Experimental studied and compared in vivo effects and interactions to those of Pretty soon, she came upon a setup the human protein house. She knocked and, when no one Goal Theme Research Gain insight into how Atx-1's function contributes to SCA1 answered, goal pathogenesis. How these interactions might contribute to the disease process and how they might cause toxicity in only a she walked right in. subset of neurons in SCA1 is not fully understood. Atx-1 may play a role in the regulation of gene expression Attempt Hypothesis At the table in the kitchen, there Name Episode 1 Name dAtX-1 and hAtx-1 Induce Similar Phenotypes When were three bowls of porridge. Overexpressed in Files Goldilocks was hungry. Subgoal Subgoal test the function of the AXH domain She tasted the porridge from the Attempt Method overexpressed dAtx-1 in flies using the GAL4/UAS system first bowl. (Brand and Perrimon, 1993) and compared its effects to those of This porridge is too hot! she Outcome Results hAtx-1. Overexpression of dAtx-1 by Rhodopsin1(Rh1)-GAL4, which exclaimed. drives expression in the differentiated R1-R6 photoreceptor cells (Mollereau et al., 2000 and O'Tousa et al., 1985), results in neurodegeneration in the eye, as does overexpression of hAtx-1 [82Q]. Although at 2 days after eclosion, overexpression of either So, she tasted the porridge from Activity Data (data not shown), Atx-1 does not show obvious morphological changes in the the second bowl. photoreceptor cells This porridge is too cold, she said Outcome Results both genotypes show many large holes and loss of cell integrity at 28 days So, she tasted the last bowl of  Activity Data (Figures 1B-1D). porridge. Ahhh, this porridge is just right, Outcome Results Overexpression of dAtx-1 using the GMR-GAL4 driver also she said happily and induces eye abnormalities. The external structures of the eyes 7 that overexpress dAtx-1 show disorganized ommatidia and loss she ate it all up.   Data (Figure 1F), of interommatidial bristles Thursday, October 20, 2011
  • 31. 2.c.  Module-­‐level  markup:  how? 8 Thursday, October 20, 2011
  • 32. 2.c.  Module-­‐level  markup:  how? -­‐ Automated  recogni/on:  very  difficult: 8 Thursday, October 20, 2011
  • 33. 2.c.  Module-­‐level  markup:  how? -­‐ Automated  recogni/on:  very  difficult: -­‐ How  do  you  know  where  the  boundaries  are?   8 Thursday, October 20, 2011
  • 34. 2.c.  Module-­‐level  markup:  how? -­‐ Automated  recogni/on:  very  difficult: -­‐ How  do  you  know  where  the  boundaries  are?   -­‐ Even  difficult  for  author  to  iden/fy!   8 Thursday, October 20, 2011
  • 35. 2.c.  Module-­‐level  markup:  how? -­‐ Automated  recogni/on:  very  difficult: -­‐ How  do  you  know  where  the  boundaries  are?   -­‐ Even  difficult  for  author  to  iden/fy!   -­‐ Author  creates:  templates. 8 Thursday, October 20, 2011
  • 36. 2.c.  Module-­‐level  markup:  how? -­‐ Automated  recogni/on:  very  difficult: -­‐ How  do  you  know  where  the  boundaries  are?   -­‐ Even  difficult  for  author  to  iden/fy!   -­‐ Author  creates:  templates. -­‐ XPharm,  2001:  modular  text  book  in  pharmacology: 8 Thursday, October 20, 2011
  • 37. 2.c.  Module-­‐level  markup:  how? -­‐ Automated  recogni/on:  very  difficult: -­‐ How  do  you  know  where  the  boundaries  are?   -­‐ Even  difficult  for  author  to  iden/fy!   -­‐ Author  creates:  templates. -­‐ XPharm,  2001:  modular  text  book  in  pharmacology: 8 Thursday, October 20, 2011
  • 38. 2.c.  Module-­‐level  markup:  how? -­‐ Automated  recogni/on:  very  difficult: -­‐ How  do  you  know  where  the  boundaries  are?   -­‐ Even  difficult  for  author  to  iden/fy!   -­‐ Author  creates:  templates. -­‐ XPharm,  2001:  modular  text  book  in  pharmacology: -­‐ Only  works  if  you   pay  authors! 8 Thursday, October 20, 2011
  • 39. 2.c.  Module-­‐level  markup:  how? -­‐ Automated  recogni/on:  very  difficult: -­‐ How  do  you  know  where  the  boundaries  are?   -­‐ Even  difficult  for  author  to  iden/fy!   -­‐ Author  creates:  templates. -­‐ XPharm,  2001:  modular  text  book  in  pharmacology: -­‐ Only  works  if  you   pay  authors! -­‐ Mo/f  detec/on  work might  offer  help?   8 Thursday, October 20, 2011
  • 40. 3.  Statement-­‐level  markup 9 Thursday, October 20, 2011
  • 41. 3.  Statement-­‐level  markup a.Why? -­‐ Automated  summarisa/on? -­‐ Towards  claim-­‐evidence  networks 9 Thursday, October 20, 2011
  • 42. 3.  Statement-­‐level  markup a.Why? -­‐ Automated  summarisa/on? -­‐ Towards  claim-­‐evidence  networks b.How,  by  whom?   -­‐ Comparison  of  three  groups:   1.Liakata  et  al.:  CoreSC 2.Ananiadou  et  al.:  Metaknowledge  annota/on 3.De  Waard/Pander  Maat:  Discourse  Segment  Types -­‐ Annotated  three  texts:  compare  schemes,  levels,   annota/on  overlap 9 Thursday, October 20, 2011
  • 43. 3.1  Liakata  et  al.:  Core-­‐Scien/fic  Concepts   (CoreSC)  Annota/on  Scheme s Thursday, October 20, 2011
  • 44. 3.1  Liakata  et  al.:  Core-­‐Scien/fic  Concepts   (CoreSC)  Annota/on  Scheme Three-­‐layer,  ontology-­‐mo/vated  annota/on  scheme  for  sentence   annota/on,  which  views  a  paper  as  the  humanly  readable   representa0on  of  a  scien0fic  inves0ga0on:  [45-­‐page  guideline:   Liakata  &  Soldatova  2008]   -­‐ 1st  layer:  Core  Scien4fic  Concepts  (CoreSCs):   Hypothesis,  Mo/va/on,  Goal,  Object,  Background,  Method,   Experiment,  Model,  Observa/on,  Result,  Conclusion   -­‐ 2nd  layer:  Proper4es  of  CoreSCs.   s Novelty  (New/Old)  and  Advantage  (advantage/disadvantage) -­‐ 3rd  layer:  Concept  Iden4fiers:   linking  sentences  together  which  refer  to  the  same  instance  of   a  CoreSC Thursday, October 20, 2011
  • 45. 3.1  CoreSC  Annota/on  tool: Thursday, October 20, 2011
  • 46. 3.1  CoreSC  Annota/on  tool: • Automated  annota/on  with  CoreSC  system  well  underway! Thursday, October 20, 2011
  • 47. 3.2.  Ananiadou  et  al:  Metaknowledge  annota/on: Knowledge  Type Certainty  Level •  Inves4ga4on •L3 •  Observa4on •L2 •  Analysis •L1 •  General Par4cipants Bio-­‐Event Class  /  Type •  Theme(s) (Centred  on  an  Event   (Grounded  to  an  event   •  Actor(s) Trigger) ontology) Source Manner Polarity •  High •  Other •  Nega4ve •  Low •  Current •  Posi4ve •  Neutral Thursday, October 20, 2011
  • 48. 3.2  Example  of  Metaknowledge  annota/on: S3 = These results suggest that Y has no effect on expression of X Knowledge Certainty Lexical   Event Manner Source Type Level Polarity E1 General L3 Posi4ve Neutral Current E2 Analysis L2 Nega4ve Neutral Current Thursday, October 20, 2011
  • 49. 3.2  Example  of  Metaknowledge  annota/on: S3 = These results suggest that Y has no effect on expression of X Knowledge Certainty Lexical   Event Manner Source Type Level Polarity E1 General L3 Posi4ve Neutral Current E2 Analysis L2 Nega4ve Neutral Current Thursday, October 20, 2011
  • 50. 3.2  Example  of  Metaknowledge  annota/on: S3 = These results suggest that Y has no effect on expression of X Knowledge Certainty Lexical   Event Manner Source Type Level Polarity E1 General L3 Posi4ve Neutral Current E2 Analysis L2 Nega4ve Neutral Current Thursday, October 20, 2011
  • 51. 3.2  Example  of  Metaknowledge  annota/on: S3 = These results suggest that Y has no effect on expression of X Knowledge Certainty Lexical   Event Manner Source Type Level Polarity E1 General L3 Posi4ve Neutral Current E2 Analysis L2 Nega4ve Neutral Current • Manual  annota/on  underway  of  the  GENIA  event  corpus  (1000  MEDLINE  abstracts) Thursday, October 20, 2011
  • 52. 3.3  de  Waard/Pander  Maat:  Discourse  Segment  Types Both seminomas and the EC component of nonseminomas share features with ES cells. To exclude that the detection of miR-371-3 merely reflects its expression pattern in ES cells, we tested by RPA miR-302a-d, another ES cells-specific miRNA cluster (Suh et al, 2004). In many of the miR-371-3 expressing seminomas and nonseminomas, miR-302a-d was undetectable (Figs S7 and S8), suggesting that miR-371-3 expression is a selective event during tumorigenesis. Thursday, October 20, 2011
  • 53. 3.3  de  Waard/Pander  Maat:  Discourse  Segment  Types Both seminomas and the EC component of Both seminomas and the EC component of nonseminomas share features with ES cells. nonseminomas share features with ES cells. To exclude thatthat detection of miR-371-3 merely To exclude the reflects its expression pattern in ES cells,reflects its the detection of miR-371-3 merely we tested by RPA miR-302a-d, another ES cells-specific expression pattern in ES cells, miRNA cluster RPA miR-302a-d, another ES cells- we tested by (Suh et al, 2004). In many of the m i R - 3 7 miRNAx p r e s s(Suh et e m2004). a s a n d specific 1 - 3 e cluster i n g s al, i n o m nonseminomas, miR-302a-d was undetectable (Figs In many of the miR-371-3 expressing seminomas S7 and S8), suggesting that miR-371-3undetectable and nonseminomas, miR-302a-d was expression is a selective event during tumorigenesis. (Figs S7 and S8), suggesting that miR-371-3 expression is a selective event during tumorigenesis. Thursday, October 20, 2011
  • 54. 3.3  de  Waard/Pander  Maat:  Discourse  Segment  Types Both seminomas and the EC component of Both seminomas and the EC component of Fact nonseminomas share features with ES cells. nonseminomas share features with ES cells. To exclude thatthat detection of miR-371-3 merely To exclude the reflects its expression pattern in ES cells,reflects its the detection of miR-371-3 merely we tested by RPA miR-302a-d, another ES cells-specific expression pattern in ES cells, miRNA cluster RPA miR-302a-d, another ES cells- we tested by (Suh et al, 2004). In many of the m i R - 3 7 miRNAx p r e s s(Suh et e m2004). a s a n d specific 1 - 3 e cluster i n g s al, i n o m nonseminomas, miR-302a-d was undetectable (Figs In many of the miR-371-3 expressing seminomas S7 and S8), suggesting that miR-371-3undetectable and nonseminomas, miR-302a-d was expression is a selective event during tumorigenesis. (Figs S7 and S8), suggesting that miR-371-3 expression is a selective event during tumorigenesis. Thursday, October 20, 2011
  • 55. 3.3  de  Waard/Pander  Maat:  Discourse  Segment  Types Both seminomas and the EC component of Both seminomas and the EC component of Fact nonseminomas share features with ES cells. nonseminomas share features with ES cells. To exclude thatthat detection of miR-371-3 merely To exclude the reflects its expression pattern in ES cells,reflects its the detection of miR-371-3 merely we tested Hypothesis by RPA miR-302a-d, another ES cells-specific expression pattern in ES cells, miRNA cluster RPA miR-302a-d, another ES cells- we tested by (Suh et al, 2004). In many of the m i R - 3 7 miRNAx p r e s s(Suh et e m2004). a s a n d specific 1 - 3 e cluster i n g s al, i n o m nonseminomas, miR-302a-d was undetectable (Figs In many of the miR-371-3 expressing seminomas S7 and S8), suggesting that miR-371-3undetectable and nonseminomas, miR-302a-d was expression is a selective event during tumorigenesis. (Figs S7 and S8), suggesting that miR-371-3 expression is a selective event during tumorigenesis. Thursday, October 20, 2011
  • 56. 3.3  de  Waard/Pander  Maat:  Discourse  Segment  Types Both seminomas and the EC component of Both seminomas and the EC component of Fact nonseminomas share features with ES cells. nonseminomas share features with ES cells. To exclude thatthat detection of miR-371-3 merely To exclude the reflects its expression pattern in ES cells,reflects its the detection of miR-371-3 merely we tested Hypothesis by RPA miR-302a-d, another ES cells-specific expression pattern in ES cells, miRNA cluster RPA miR-302a-d, another ES cells- we tested by (Suh et al, 2004). In many of the m i R - 3 7 miRNAx p r e s s(Suh et e m2004). a s a n d specific 1 - 3 e cluster i n g s al, i n o m Method nonseminomas, miR-302a-d was undetectable (Figs In many of the miR-371-3 expressing seminomas S7 and S8), suggesting that miR-371-3undetectable and nonseminomas, miR-302a-d was expression is a selective event during tumorigenesis. (Figs S7 and S8), suggesting that miR-371-3 expression is a selective event during tumorigenesis. Thursday, October 20, 2011
  • 57. 3.3  de  Waard/Pander  Maat:  Discourse  Segment  Types Both seminomas and the EC component of Both seminomas and the EC component of Fact nonseminomas share features with ES cells. nonseminomas share features with ES cells. To exclude thatthat detection of miR-371-3 merely To exclude the reflects its expression pattern in ES cells,reflects its the detection of miR-371-3 merely we tested Hypothesis by RPA miR-302a-d, another ES cells-specific expression pattern in ES cells, miRNA cluster RPA miR-302a-d, another ES cells- we tested by (Suh et al, 2004). In many of the m i R - 3 7 miRNAx p r e s s(Suh et e m2004). a s a n d specific 1 - 3 e cluster i n g s al, i n o m Method nonseminomas, miR-302a-d was undetectable (Figs In many of the miR-371-3 expressing seminomas S7 and S8), suggesting that miR-371-3undetectable and nonseminomas, miR-302a-d was expression Result is a selective event during tumorigenesis. (Figs S7 and S8), suggesting that miR-371-3 expression is a selective event during tumorigenesis. Thursday, October 20, 2011
  • 58. 3.3  de  Waard/Pander  Maat:  Discourse  Segment  Types Both seminomas and the EC component of Both seminomas and the EC component of Fact nonseminomas share features with ES cells. nonseminomas share features with ES cells. To exclude thatthat detection of miR-371-3 merely To exclude the reflects its expression pattern in ES cells,reflects its the detection of miR-371-3 merely we tested Hypothesis by RPA miR-302a-d, another ES cells-specific expression pattern in ES cells, miRNA cluster RPA miR-302a-d, another ES cells- we tested by (Suh et al, 2004). In many of the m i R - 3 7 miRNAx p r e s s(Suh et e m2004). a s a n d specific 1 - 3 e cluster i n g s al, i n o m Method nonseminomas, miR-302a-d was undetectable (Figs In many of the miR-371-3 expressing seminomas S7 and S8), suggesting that miR-371-3undetectable and nonseminomas, miR-302a-d was expression Result is a selective event during tumorigenesis. (Figs S7 and S8), suggesting that miR-371-3 expression is a selective event during Implication tumorigenesis. Thursday, October 20, 2011
  • 59. 3.3  de  Waard/Pander  Maat:  Discourse  Segment  Types Both seminomas and the EC component of Both seminomas and the EC component of Fact nonseminomas share features with ES cells. nonseminomas share features with ES cells. To exclude thatthat detection of miR-371-3 merely To exclude the Goal reflects its expression pattern in ES cells,reflects its the detection of miR-371-3 merely we tested Hypothesis by RPA miR-302a-d, another ES cells-specific expression pattern in ES cells, miRNA cluster RPA miR-302a-d, another ES cells- we tested by (Suh et al, 2004). In many of the m i R - 3 7 miRNAx p r e s s(Suh et e m2004). a s a n d specific 1 - 3 e cluster i n g s al, i n o m Method nonseminomas, miR-302a-d was undetectable (Figs In many of the miR-371-3 expressing seminomas S7 and S8), suggesting that miR-371-3undetectable and nonseminomas, miR-302a-d was expression Result is a selective event during tumorigenesis. (Figs S7 and S8), suggesting that miR-371-3 expression is a selective event during Implication tumorigenesis. Thursday, October 20, 2011
  • 60. 3.3  de  Waard/Pander  Maat:  Discourse  Segment  Types Both seminomas and the EC component of Both seminomas and the EC component of Fact nonseminomas share features with ES cells. nonseminomas share features with ES cells. To exclude thatthat detection of miR-371-3 merely To exclude the Goal reflects its expression pattern in ES cells,reflects its the detection of miR-371-3 merely we tested Hypothesis by RPA miR-302a-d, another ES cells-specific expression pattern in ES cells, miRNA cluster RPA miR-302a-d, another ES cells- we tested by (Suh et al, 2004). In many of the m i R - 3 7 miRNAx p r e s s(Suh et e m2004). a s a n d specific 1 - 3 e cluster i n g s al, i n o m Method nonseminomas, miR-302a-d was undetectable (Figs In many of the miR-371-3 expressing seminomas S7 and S8), suggesting that miR-371-3undetectable and nonseminomas, miR-302a-d was expression Result is a selective event during tumorigenesis. (Figs S7 and S8), suggesting that Reg-Implication miR-371-3 expression is a selective event during Implication tumorigenesis. Thursday, October 20, 2011
  • 61. 3.3  de  Waard/Pander  Maat:  Discourse  Segment  Types Conceptual Both seminomas and the EC component of Both seminomas and the EC component of knowledge Fact nonseminomas share features with ES cells. nonseminomas share features with ES cells. To exclude thatthat detection of miR-371-3 merely To exclude the Goal reflects its expression pattern in ES cells,reflects its the detection of miR-371-3 merely we tested Hypothesis by RPA miR-302a-d, another ES cells-specific expression pattern in ES cells, miRNA cluster RPA miR-302a-d, another ES cells- we tested by (Suh et al, 2004). In many of the m i R - 3 7 miRNAx p r e s s(Suh et e m2004). a s a n d specific 1 - 3 e cluster i n g s al, i n o m Method nonseminomas, miR-302a-d was undetectable (Figs In many of the miR-371-3 expressing seminomas S7 and S8), suggesting that miR-371-3undetectable and nonseminomas, miR-302a-d was expression Result is a selective event during tumorigenesis. (Figs S7 and S8), suggesting that Reg-Implication miR-371-3 expression is a selective event during Implication tumorigenesis. Thursday, October 20, 2011
  • 62. 3.3  de  Waard/Pander  Maat:  Discourse  Segment  Types Conceptual Both seminomas and the EC component of Both seminomas and the EC component of knowledge Fact nonseminomas share features with ES cells. nonseminomas share features with ES cells. To exclude thatthat detection of miR-371-3 merely To exclude the Goal reflects its expression pattern in ES cells,reflects its the detection of miR-371-3 merely we tested Hypothesis by RPA miR-302a-d, another ES cells-specific expression pattern in ES cells, miRNA cluster RPA miR-302a-d, another ES cells- we tested by (Suh et al, 2004). In many of the m i R - 3 7 miRNAx p r e s s(Suh et e m2004). a s a n d specific 1 - 3 e cluster i n g s al, i n o m Method Experimental nonseminomas, miR-302a-d was undetectable (Figs In many of the miR-371-3 expressing seminomas Evidence S7 and S8), suggesting that miR-371-3undetectable and nonseminomas, miR-302a-d was expression Result is a selective event during tumorigenesis. (Figs S7 and S8), suggesting that Reg-Implication miR-371-3 expression is a selective event during Implication tumorigenesis. Thursday, October 20, 2011
  • 63. 3.3  Iden/fica/on  of  DSTs: 15 Thursday, October 20, 2011
  • 64. 3.3  Iden/fica/on  of  DSTs: -­‐ Verb  form:  tense,  e.g.   -­‐ Concepts  in  ‘state’  (gnomic)  present: ‘Dopaminergic  innerva/on  plays  a  major  role  in  the  control  of   mood  and  its  perturba/on’   -­‐ Experiments  in  ‘event’  past:   ‘Four  out  of  seven  cell  lines  expressed  this  cluster’ 15 Thursday, October 20, 2011
  • 65. 3.3  Iden/fica/on  of  DSTs: -­‐ Verb  form:  tense,  e.g.   -­‐ Concepts  in  ‘state’  (gnomic)  present: ‘Dopaminergic  innerva/on  plays  a  major  role  in  the  control  of   mood  and  its  perturba/on’   -­‐ Experiments  in  ‘event’  past:   ‘Four  out  of  seven  cell  lines  expressed  this  cluster’ -­‐ Seman4c  verb  class:   -­‐ Research  verbs  (Inves/ga/on,  Predic/on,  Procedure,   Observa/on,  Interpreta/on) -­‐ Discourse  verbs   -­‐ Proper/es  and  rela/onships  -­‐  between  things  and  concepts 15 Thursday, October 20, 2011
  • 66. 3.3  Iden/fica/on  of  DSTs: -­‐ Verb  form:  tense,  e.g.   -­‐ Concepts  in  ‘state’  (gnomic)  present: ‘Dopaminergic  innerva/on  plays  a  major  role  in  the  control  of   mood  and  its  perturba/on’   -­‐ Experiments  in  ‘event’  past:   ‘Four  out  of  seven  cell  lines  expressed  this  cluster’ -­‐ Seman4c  verb  class:   -­‐ Research  verbs  (Inves/ga/on,  Predic/on,  Procedure,   Observa/on,  Interpreta/on) -­‐ Discourse  verbs   -­‐ Proper/es  and  rela/onships  -­‐  between  things  and  concepts -­‐ Modality   -­‐ Types:  Source  {Author,  others,  unknown},  Basis  {Data,   Reasoning,  0},  Value  {Certain,  probable,  possible,  unknown} -­‐ Markers:  Modal  aux,  verb  class  Interpreta/on,  epistemic  adverbs 15 Thursday, October 20, 2011
  • 67. 3.  Same  Statement  annotated  three  ways: Thursday, October 20, 2011
  • 68. 3.  Same  Statement  annotated  three  ways: CoreSC: <annotationART atype="GSC" type="Res" conceptID="Res24" novelty="None" advantage="None"> Here we show that BOB.1/OBF.1 regulates Btk gene expression. </annotationART> BioEvent/MetaKnowledge: <sentence id="S6">Here we show that <term id="T13" sem="Protein_family_or_group"> <gene-or-gene-product id="G9">BOB.1</gene-or-gene-product>/ <gene-or-gene-product id="G10">OBF.1</gene-or-gene-product> </term> regulates <term id="T14" sem="Biological_process"> <term id="T15" sem="DNA_domain_or_region"> <gene-or-gene-product id="G11">Btk </gene-or-gene-product> gene </term> expression </term>. </sentence> Discourse Segments: <segment segID ="286" section = "D" segtype = "RegImplication"> Here we show that </segment> <segment segID ="287" section = "D" segtype = "Implication"> Thursday, October 20, 2011
  • 69. 3.  Same  Statement  annotated  three  ways: CoreSC: <annotationART atype="GSC" type="Res" conceptID="Res24" novelty="None" advantage="None"> Here we show that BOB.1/OBF.1 regulates Btk gene expression. </annotationART> BioEvent/MetaKnowledge: <sentence id="S6">Here we show that <term id="T13" sem="Protein_family_or_group"> <gene-or-gene-product id="G9">BOB.1</gene-or-gene-product>/ <gene-or-gene-product id="G10">OBF.1</gene-or-gene-product> </term> regulates <term id="T14" sem="Biological_process"> <term id="T15" sem="DNA_domain_or_region"> <gene-or-gene-product id="G11">Btk </gene-or-gene-product> gene </term> expression </term>. </sentence> Discourse Segments: <segment segID ="286" section = "D" segtype = "RegImplication"> Here we show that </segment> <segment segID ="287" section = "D" segtype = "Implication"> BOB.1/OBF.1 regulates Btk gene expression. </segment> Thursday, October 20, 2011
  • 70. 3.  Same  Statement  annotated  three  ways: CoreSC: <annotationART atype="GSC" type="Res" conceptID="Res24" novelty="None" advantage="None"> Here we show that BOB.1/OBF.1 regulates Btk gene expression. </annotationART> BioEvent/MetaKnowledge: <sentence id="S6">Here we show that <term id="T13" sem="Protein_family_or_group"> <gene-or-gene-product id="G9">BOB.1</gene-or-gene-product>/ <gene-or-gene-product id="G10">OBF.1</gene-or-gene-product> </term> regulates <term id="T14" sem="Biological_process"> <term id="T15" sem="DNA_domain_or_region"> <gene-or-gene-product id="G11">Btk </gene-or-gene-product> gene </term> expression </term>. </sentence> Discourse Segments: <segment segID ="286" section = "D" segtype = "RegImplication"> Here we show that </segment> <segment segID ="287" section = "D" segtype = "Implication"> BOB.1/OBF.1 regulates Btk gene expression. </segment> Thursday, October 20, 2011
  • 71. 3.  Comparing  statement-­‐level  annota/on  models Who Why What How Liakata:  CoreSC Iden/fy  main   Sentence Manual  corpus,   components  of   automated   scien/fic  inves/ga/on   annota/on  tools  -­‐   for  machine  learning working  on   automated  detec/on Ananiadou:   Enhance  informa/on   Events  (intra-­‐ Manual  corpus,   MetaKnowledge/ extrac/on  for   senten/al):  can  be   working  on   BioEvents biomedical  texts  to   several  per   automated  detec/on enable  metadiscourse   sentence,  or  one  in   annota/on more  sentences de  Waard: Iden/fy  mechanisms   Clause Manual,  ideas  (but  no   Discourse  Segment   of  conveying   real  plans!)  for   Types (epistemic)  knowledge   automated   in  scien/fic    discourse iden/fica/on Thursday, October 20, 2011
  • 72. 4.  Rela.ons a.Why? -­‐ Argumenta/on  visualisa/on b.What,  by  whom?   -­‐ Harmsze  (1999):  Ontology  of   content  rela/onships -­‐ IBIS,  ClaiMaker  (2001) -­‐ Diligent  argumenta/on   ontology  (2005)   -­‐ SALT:  RST  (2007) -­‐ SWAN  (2010) c. How?   -­‐ So  far:  Manually 18 Thursday, October 20, 2011
  • 73. 4.  Rela.ons a.Why? -­‐ Argumenta/on  visualisa/on b.What,  by  whom?   -­‐ Harmsze  (1999):  Ontology  of   content  rela/onships -­‐ IBIS,  ClaiMaker  (2001) -­‐ Diligent  argumenta/on   ontology  (2005)   -­‐ SALT:  RST  (2007) -­‐ SWAN  (2010) c. How?   -­‐ So  far:  Manually 18 Thursday, October 20, 2011
  • 74. 4.  Rela.ons a.Why? -­‐ Argumenta/on  visualisa/on b.What,  by  whom?   -­‐ Harmsze  (1999):  Ontology  of   content  rela/onships -­‐ IBIS,  ClaiMaker  (2001) -­‐ Diligent  argumenta/on   ontology  (2005)   -­‐ SALT:  RST  (2007) -­‐ SWAN  (2010) c. How?   -­‐ So  far:  Manually 18 Thursday, October 20, 2011
  • 75. 4.  Rela.ons a.Why? -­‐ Argumenta/on  visualisa/on b.What,  by  whom?   -­‐ Harmsze  (1999):  Ontology  of   content  rela/onships -­‐ IBIS,  ClaiMaker  (2001) -­‐ Diligent  argumenta/on   ontology  (2005)   -­‐ SALT:  RST  (2007) -­‐ SWAN  (2010) c. How?   -­‐ So  far:  Manually 18 Thursday, October 20, 2011
  • 76. 4.  Rela.ons a.Why? -­‐ Argumenta/on  visualisa/on b.What,  by  whom?   -­‐ Harmsze  (1999):  Ontology  of   content  rela/onships -­‐ IBIS,  ClaiMaker  (2001) -­‐ Diligent  argumenta/on   ontology  (2005)   -­‐ SALT:  RST  (2007) -­‐ SWAN  (2010) c. How?   -­‐ So  far:  Manually 18 Thursday, October 20, 2011
  • 77. 5.Claim-­‐Evidence  Networks  (statement  +  rela/ons) 19 Thursday, October 20, 2011
  • 78. 5.Claim-­‐Evidence  Networks  (statement  +  rela/ons) a.Why? 19 Thursday, October 20, 2011
  • 79. 5.Claim-­‐Evidence  Networks  (statement  +  rela/ons) a.Why? Show  argumenta/on   across  body  of  work 19 Thursday, October 20, 2011
  • 80. 5.Claim-­‐Evidence  Networks  (statement  +  rela/ons) a.Why? Show  argumenta/on   across  body  of  work b.What,  by  whom? 19 Thursday, October 20, 2011
  • 81. 5.Claim-­‐Evidence  Networks  (statement  +  rela/ons) a.Why? Show  argumenta/on   across  body  of  work b.What,  by  whom? -­‐ Buckingham  Shum,  1999 19 Thursday, October 20, 2011
  • 82. 5.Claim-­‐Evidence  Networks  (statement  +  rela/ons) a.Why? Show  argumenta/on   across  body  of  work b.What,  by  whom? -­‐ Buckingham  Shum,  1999 19 Thursday, October 20, 2011
  • 83. 5.Claim-­‐Evidence  Networks  (statement  +  rela/ons) a.Why? Show  argumenta/on   across  body  of  work b.What,  by  whom? -­‐ Buckingham  Shum,  1999 -­‐ SWAN:  Clark,  Ciccarese   et  al.,  2005 19 Thursday, October 20, 2011
  • 84. 5.Claim-­‐Evidence  Networks  (statement  +  rela/ons) a.Why? Show  argumenta/on   across  body  of  work b.What,  by  whom? -­‐ Buckingham  Shum,  1999 -­‐ SWAN:  Clark,  Ciccarese   et  al.,  2005 19 Thursday, October 20, 2011
  • 85. 5.Claim-­‐Evidence  Networks  (statement  +  rela/ons) a.Why? Show  argumenta/on   across  body  of  work b.What,  by  whom? -­‐ Buckingham  Shum,  1999 -­‐ SWAN:  Clark,  Ciccarese   et  al.,  2005 -­‐ Nanopublica/ons:   Mons,  2010 19 Thursday, October 20, 2011
  • 86. 5.Claim-­‐Evidence  Networks  (statement  +  rela/ons) a.Why? Show  argumenta/on   across  body  of  work b.What,  by  whom? -­‐ Buckingham  Shum,  1999 -­‐ SWAN:  Clark,  Ciccarese   et  al.,  2005 -­‐ Nanopublica/ons:   Mons,  2010 19 Thursday, October 20, 2011
  • 87. 5.Claim-­‐Evidence  Networks  (statement  +  rela/ons) a.Why? Show  argumenta/on   across  body  of  work b.What,  by  whom? -­‐ Buckingham  Shum,  1999 -­‐ SWAN:  Clark,  Ciccarese   et  al.,  2005 -­‐ Nanopublica/ons:   Mons,  2010 -­‐ Nanopublica/ons  +   SWAN,  2011 19 Thursday, October 20, 2011
  • 88. 5.Claim-­‐Evidence  Networks  (statement  +  rela/ons) a.Why? Show  argumenta/on   across  body  of  work b.What,  by  whom? -­‐ Buckingham  Shum,  1999 -­‐ SWAN:  Clark,  Ciccarese   et  al.,  2005 -­‐ Nanopublica/ons:   Mons,  2010 -­‐ Nanopublica/ons  +   SWAN,  2011 c.How?   19 Thursday, October 20, 2011
  • 89. 5.Claim-­‐Evidence  Networks  (statement  +  rela/ons) a.Why? Show  argumenta/on   across  body  of  work b.What,  by  whom? -­‐ Buckingham  Shum,  1999 -­‐ SWAN:  Clark,  Ciccarese   et  al.,  2005 -­‐ Nanopublica/ons:   Mons,  2010 -­‐ Nanopublica/ons  +   SWAN,  2011 c.How?   -­‐ So  far:  manually 19 Thursday, October 20, 2011
  • 90. 5.Claim-­‐Evidence  Networks  (statement  +  rela/ons) a.Why? Show  argumenta/on   across  body  of  work b.What,  by  whom? -­‐ Buckingham  Shum,  1999 -­‐ SWAN:  Clark,  Ciccarese   et  al.,  2005 -­‐ Nanopublica/ons:   Mons,  2010 -­‐ Nanopublica/ons  +   SWAN,  2011 c.How?   -­‐ So  far:  manually 19 Thursday, October 20, 2011
  • 91. D2S  Use  case:  Claim-­‐Evidence  Network  in  Medicine B. Elsevier-published A. Philips’ Electronic Patient Records Clinical Guideline C. Elsevier (or other publisher’s) Research Report or Data 20 Thursday, October 20, 2011
  • 92. D2S  Use  case:  Claim-­‐Evidence  Network  in  Medicine Step 1: Patient data + diagnosis link to Guideline recommendation B. Elsevier-published A. Philips’ Electronic Patient Records Clinical Guideline C. Elsevier (or other publisher’s) Research Report or Data 20 Thursday, October 20, 2011
  • 93. D2S  Use  case:  Claim-­‐Evidence  Network  in  Medicine Step 1: Patient data + diagnosis link to Guideline recommendation B. Elsevier-published A. Philips’ Electronic Patient Records Clinical Guideline Step 2: Guideline recommendation links to evidence in report or data C. Elsevier (or other publisher’s) Research Report or Data 20 Thursday, October 20, 2011
  • 94. D2S  Use  case:  Claim-­‐Evidence  Network  in  Medicine Step 1: Patient data + diagnosis link to Guideline recommendation B. Elsevier-published A. Philips’ Electronic Patient Records Clinical Guideline Step 2: Guideline recommendation links to evidence in report or data C. Elsevier (or other publisher’s) Research Report or Data Related  HCLS  Use  Case:  Accelerate  uptake  of  medical  research   on  drug-­‐drug  interac/on  in  product  inserts 20 Thursday, October 20, 2011
  • 95. Five  levels  of  scien/fic  discourse  annota/on 21 Thursday, October 20, 2011
  • 96. Five  levels  of  scien/fic  discourse  annota/on Why What/Who How Automated!   Sec/on Search,  UI ABCDE,  ORB/HCLS Publisher  helps?   Harmsze/Kircz,  LiquidPub,   Module Content  reuse HCLS Manual:  templates Teufel,  Ananiadou,   Summaries;   Working  towards   Statement towards  networks Liakata,   automated  detec/on UU SALT,  ScholOnto,  Diligent,   Manual:  some  tools,   Rela/ons Networks SWAN never  took  off... Claim/ Argumenta/on    ScholOnto,  SWAN,   Manual-­‐  towards   Evidence networks Nanopublica/ons,  D2S automa/on?   21 Thursday, October 20, 2011
  • 97. Five  levels  of  scien/fic  discourse  annota/on Why What/Who How Automated!   Sec/on Search,  UI ABCDE,  ORB/HCLS Publisher  helps?   Harmsze/Kircz,  LiquidPub,   Module Content  reuse HCLS Manual:  templates Teufel,  Ananiadou,   Summaries;   Working  towards   Statement towards  networks Liakata,   automated  detec/on UU SALT,  ScholOnto,  Diligent,   Manual:  some  tools,   Rela/ons Networks SWAN never  took  off... Claim/ Argumenta/on    ScholOnto,  SWAN,   Manual-­‐  towards   Evidence networks Nanopublica/ons,  D2S automa/on?   21 Thursday, October 20, 2011
  • 98. Five  levels  of  scien/fic  discourse  annota/on Why What/Who How Automated!   Sec/on Search,  UI ABCDE,  ORB/HCLS Publisher  helps?   Harmsze/Kircz,  LiquidPub,   Module Content  reuse HCLS Manual:  templates Teufel,  Ananiadou,   Summaries;   Working  towards   Statement towards  networks Liakata,   automated  detec/on UU SALT,  ScholOnto,  Diligent,   Manual:  some  tools,   Rela/ons Networks SWAN never  took  off... Claim/ Argumenta/on    ScholOnto,  SWAN,   Manual-­‐  towards   Evidence networks Nanopublica/ons,  D2S automa/on?   21 Thursday, October 20, 2011
  • 99. Five  levels  of  scien/fic  discourse  annota/on Why What/Who How Automated!   Sec/on Search,  UI ABCDE,  ORB/HCLS Publisher  helps?   Harmsze/Kircz,  LiquidPub,   Module Content  reuse HCLS Manual:  templates Teufel,  Ananiadou,   Summaries;   Working  towards   Statement towards  networks Liakata,   automated  detec/on UU SALT,  ScholOnto,  Diligent,   Manual:  some  tools,   Rela/ons Networks SWAN never  took  off... Claim/ Argumenta/on    ScholOnto,  SWAN,   Manual-­‐  towards   Evidence networks Nanopublica/ons,  D2S automa/on?   21 Thursday, October 20, 2011
  • 100. Five  levels  of  scien/fic  discourse  annota/on Why What/Who How Automated!   Sec/on Search,  UI ABCDE,  ORB/HCLS Publisher  helps?   Harmsze/Kircz,  LiquidPub,   Module Content  reuse HCLS Manual:  templates Teufel,  Ananiadou,   Summaries;   Working  towards   Statement towards  networks Liakata,   automated  detec/on UU SALT,  ScholOnto,  Diligent,   Manual:  some  tools,   Rela/ons Networks SWAN never  took  off... Claim/ Argumenta/on    ScholOnto,  SWAN,   Manual-­‐  towards   Evidence networks Nanopublica/ons,  D2S automa/on?   21 Thursday, October 20, 2011
  • 101. Five  levels  of  scien/fic  discourse  annota/on Why What/Who How Automated!   Sec/on Search,  UI ABCDE,  ORB/HCLS Publisher  helps?   Harmsze/Kircz,  LiquidPub,   Module Content  reuse HCLS Manual:  templates Teufel,  Ananiadou,   Summaries;   Working  towards   Statement towards  networks Liakata,   automated  detec/on UU SALT,  ScholOnto,  Diligent,   Manual:  some  tools,   Rela/ons Networks SWAN never  took  off... Claim/ Argumenta/on    ScholOnto,  SWAN,   Manual-­‐  towards   Evidence networks Nanopublica/ons,  D2S automa/on?   21 Thursday, October 20, 2011
  • 102. Five  levels  of  scien/fic  discourse  annota/on Why What/Who How Automated!   Sec/on Search,  UI ABCDE,  ORB/HCLS Publisher  helps?   Harmsze/Kircz,  LiquidPub,   Module Content  reuse HCLS Manual:  templates MoFfs?   Teufel,  Ananiadou,   Summaries;   Working  towards   Statement towards  networks Liakata,   automated  detec/on UU SALT,  ScholOnto,  Diligent,   Manual:  some  tools,   Rela/ons Networks SWAN never  took  off... Claim/ Argumenta/on    ScholOnto,  SWAN,   Manual-­‐  towards   Evidence networks Nanopublica/ons,  D2S automa/on?   21 Thursday, October 20, 2011
  • 103. Ques.ons: 22 Thursday, October 20, 2011
  • 104. Ques.ons: Scien/fic  discourse  -­‐>  fairy  tales:  how  can  we  transfer  knowledge   here  to  scien/fic  discourse  community?   22 Thursday, October 20, 2011
  • 105. Ques.ons: Scien/fic  discourse  -­‐>  fairy  tales:  how  can  we  transfer  knowledge   here  to  scien/fic  discourse  community?   Issue:  Scien/sts  do  not  like  being  told  that  they  write  fairy  tales! 22 Thursday, October 20, 2011
  • 106. Ques.ons: Scien/fic  discourse  -­‐>  fairy  tales:  how  can  we  transfer  knowledge   here  to  scien/fic  discourse  community?   Issue:  Scien/sts  do  not  like  being  told  that  they  write  fairy  tales! Fairy  tales  -­‐>  scien/fic  discourse:  is  anyone  here/in  this  community   interested  in  working  on  inter-­‐domain  transfer  of  tools,   technologies  and  theories? 22 Thursday, October 20, 2011
  • 107. Ques.ons: Scien/fic  discourse  -­‐>  fairy  tales:  how  can  we  transfer  knowledge   here  to  scien/fic  discourse  community?   Issue:  Scien/sts  do  not  like  being  told  that  they  write  fairy  tales! Fairy  tales  -­‐>  scien/fic  discourse:  is  anyone  here/in  this  community   interested  in  working  on  inter-­‐domain  transfer  of  tools,   technologies  and  theories? Anita  de  Waard,  a.dewaard@elsevier.com   -­‐HCLS:  hEp://www.w3.org/wiki/HCLSIG/SWANSIOC -­‐UU:  hEp://elsatglabs.com/labs/anita   -­‐D2S:  hEp://www.data2seman/cs.org 22 Thursday, October 20, 2011