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Dna and chromosome structure
1.
Cell & Molecular Biology
2.
Genes
3.
Chapter 5
4.
5.
6.
DNA Structure
7.
The Double Helix and
Base Pairing
8.
9.
10.
Figure 5-6a Essential
Cell Biology (© Garland Science 2010)
11.
Figure 5-6b Essential
Cell Biology (© Garland Science 2010)
12.
Figure 5-7 Essential
Cell Biology (© Garland Science 2010)
13.
Information in a linear
sequence
14.
Figure 5-8 Essential
Cell Biology (© Garland Science 2010)
15.
Figure 5-9 Essential
Cell Biology (© Garland Science 2010)
16.
Genes
17.
“A gene is
usually defined as a segment of DNA that contains instructions for making a particular protein.”
18.
Genome
19.
“The complete set
of information in an organism’s DNA...”
20.
Figure 5-10 Essential
Cell Biology (© Garland Science 2010)
21.
Chromosomes
22.
Figure 5-11 Essential
Cell Biology (© Garland Science 2010)
23.
Human somatic cells have
23 pairs of homologous chromosomes
24.
Figure 5-10 Essential
Cell Biology (© Garland Science 2010)
25.
We often look
at mitotic chromosomes
26.
Figure 5-17 Essential
Cell Biology (© Garland Science 2010)
27.
But interphase chromosomes are
“less compact”
28.
Figure 5-15 Essential
Cell Biology (© Garland Science 2010)
29.
Figure 5-18 Essential
Cell Biology (© Garland Science 2010)
30.
Chromatin
31.
Figure 5-19 Essential
Cell Biology (© Garland Science 2010)
32.
“The complex of DNA
and proteins...”
33.
Figure 5-21 Essential
Cell Biology (© Garland Science 2010)
34.
Chromosomal Structure
35.
Linear information, highly structured
36.
Figure 5-21 Essential
Cell Biology (© Garland Science 2010)
37.
Nucleosomes
38.
39.
40.
Histones
41.
Figure 5-23 Essential
Cell Biology (© Garland Science 2010)
42.
Chromosome Packing
43.
Figure 5-25 Essential
Cell Biology (© Garland Science 2010)
44.
http://www.mun.ca/biology/scarr/Histone_Protein_Structure.html
45.
http://www.mun.ca/biology/scarr/Histone_Protein_Structure.html
46.
http://www.mun.ca/biology/scarr/Histone_Protein_Structure.html
47.
Changing Nucleosome Structure
48.
Chromatin-Remodeling Complexes
49.
Figure 5-27a Essential
Cell Biology (© Garland Science 2010)
50.
Figure 5-27b Essential
Cell Biology (© Garland Science 2010)
51.
Chemical Modification of
Histones
52.
Acetyl, methyl and
phosphate groups can be added to or removed from histone tails.
53.
Figure 5-28a Essential
Cell Biology (© Garland Science 2010)
54.
Figure 5-28b Essential
Cell Biology (© Garland Science 2010)
55.
These modifications can
affect 30-nm chromatin fiber stability and the ability of histone tails to bind specific proteins.
56.
Heterochromatin
57.
“The most highly
condensed form of interphase chromatin...”
58.
Figure 5-29 Essential
Cell Biology (© Garland Science 2010)
59.
Figure 5-30 Essential
Cell Biology (© Garland Science 2010)
60.
Euchromatin
61.
“...chromatin that exists in
a more extended state...”
62.
Figure 5-31 Essential
Cell Biology (© Garland Science 2010)
63.
Figure 5-31 Essential
Cell Biology (© Garland Science 2010)
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