2. ageLOC Science
in review

4. 18 Total Patents
3 Awards Received
8 Published Scientific Articles
AGELOC SCIENCE
IS A GLOBAL
PHENOMENON
14 Oral Presentations
26 Scientific Posters

5. “Nu Skin, with ageLOC science, stands apart from the competition because
our approach is based upon 30 years of breakthrough anti-aging research.
Our research continues to gain recognition and is validated through
presentations at global scientific conferences.”—Joe Chang, Ph.D.
Brussels, Belgium
Hangzhou,
China
Wuhan, China
Taipei,
Hong Kong, China Taiwan
Buenos Aires,
Argentina

6. “Nu Skin, with ageLOC science, stands apart from the competition because
our approach is based upon 30 years of breakthrough anti-aging research.
Our research continues to gain recognition and is validated through
presentations at global scientific conferences.”—Joe Chang, Ph.D.
Helsinki,
Finland
Berlin,
Germany
Brussels, Belgium
Corvallis,
OR USA New York,
NY USA Paris, Les Diablerets,
France Switzerland Sapporo,
Santa Barbara, Tokyo, Japan
CA Washington D.C, Hangzhou, Japan
Phoenix, USA Barcelona, Siena, China
Ventura, AZ USA Spain Italy Wuhan, China
CA Atlanta, GA, USA
Anaheim,
CA USA Taipei,
Hong Kong, China Taiwan
New Orleans,
LA USA
Bangkok,
Thailand
Singapore
Buenos Aires,
Argentina

7. ageLOC Science
2011 Timeline

8. “This research identifying
groups of genes and genetic
pathways that change in
expression as we age is
essential to building our
proprietary ageLOC science
that targets the sources of
aging.”— Joseph Chang, Ph.D., Nu
Skin Chief Scientific Officer and Executive
VP of Product Development
2011

9. 2 Presented “This research identifying
at Fifth International groups of genes and genetic
Symposium on Health andpathways that change in
expression as we age is
the Environment
essential to building our
proprietary ageLOC science
that targets the sources of
aging.”— Joseph Chang, Ph.D., Nu
Skin Chief Scientific Officer and Executive
VP of Product Development
FEBRUARY MARCH
2011
Published Presented
Article in Cosmetics and at Gordon Research
Toiletries Conference
Presented
at American Academy of
Dermatology’s 69th Annual
Meeting

10. 2011
Released
The Aging Myth, a book
by Joseph Chang, Ph.D.

11. Presented
at Society for Investigative
Dermatology
Awarded
Utah Innovation Award for
ageLOC Vitality: Natural
Products Category
APRIL MAY JUNE
2011
4 Presented Released
at Federation of American The Aging Myth, a book
Societies of Experimental by Joseph Chang, Ph.D.
Biology
Presented
Gene Expression Research
in Paris, France

12. 2011
The Aging Myth
Became a New York
Times Best Seller

13. Presented Presented
at Tenth Symposium of at Linus Pauling Institute Diet
Mycology Societies and Optimum Health
Conference
Published
2 Presented
Article in Central China
at European Society for
Agriculture University
Dermatological Research
Journal
Filed
JULY SEPTEMBER OCTOBER
2011
The Aging Myth Presented
Became a New York ageLOC R2 Research at
Times Best Seller Second International
Conference on
Environmental Stressors in
Biology and Medicine
Launched
Nutritional Product
ageLOC R2

14. Nu Skin Acquired
LifeGen Technologies
2011

15. Presented
at Fourth International
Conference and Exhibition Presented
for Nutraceuticals and at Society of Cosmetic
Functional Foods Chemists Annual Scientific
Seminar
Presented
at 2011 International
Conference on Food Nu Skin Acquired
Factors LifeGen Technologies
NOVEMBER DECEMBER
2011
Presented Published
at New TCM Product Online article in
Development and Industrial Dermatological Surgery
Development Strategy Presented
Summit at International Federation
Published of Societies of Cosmetic
Article in Zhejiang Chemists
University Journal

16. ageLOC Science
Publications and
Presentations

17. FULL LIST

18. FULL LIST
Patents Awards
Multiple Patents in the following Angela Mastaloudis,
categories: Senior Scientist, Received the DSM
Nutraceutical
Licensed Patents-Pending on Research Award
Formulation or Ingredients
Remona Gopaul, Associate Senior
Nu Skin-Developed Patents- Scientist, Named Young Scientist of
Pending on Formulation or the Year by the Society of Cosmetic
Ingredients Chemists
Licensed Patent on Method Nu Skin Awarded Utah Innovation
Award for ageLOC Vitality: Natural
Nu Skin-Developed Patent- Products category, 2011
Pending on Method

19. FULL LIST

20. FULL LIST
2011 Published Articles
February 2011 November 2011
Gopaul, R., Knaggs, H., Wickett, R. “A Li, C., Tan, N., Barger, J., Zhang, Y., Ferguson, S., Prolla,
Review of Genomic Techniques in T., Zhu, J. “Combined use of ageLOC whole-gene
Cosmetic Testing.” Cosmetics & expression profiling technology and mouse lifespan test in
Toiletries. February 2011, pp. 112-117. anti-aging herbal product study.” Proceeding of New TCM
Products Innovation and Industrial Development Summit,
July 2011 Zhejiang University Publishing, Hangzhou. 27 Nov. 2011.
Tan, N., Barger, J., Zhang, Y., Prolla, T., (in press)
Weindruch, R., Zhao, C., Bartlett, M.,
Zhu, J. “CordyMax Cs-4 restores aging- December 2011
associated changes in gene expression Chang, A., Lingala, B., Chang, T., Kern, D., Wood, S.,
and extends lifespan in normal aged Toyoda, H., Knaggs, H. “An Exploratory Study to
mice.” Proceeding of the 10th Determine the Association Between Assessed Facial Skin
Symposium of Mycology Societies Aging and Plasma Isoprostane Levels in Middle-Aged
Across Taiwan Strait, Central China Japanese Women.” Article first published online: 5 Dec.
Agriculture University Publishing. 2011, 2011 Dermatological Surgery. http://
pp 255-256. onlinelibrary.wiley.com/doi/10.1111/j.
1524-4725.2011.02235.x/abstract

21. FULL LIST

22. FULL LIST
2011 Oral Presentations
June 2011 October 2011
“Transcriptional biomarkers of calorie restriction “A unique nutritional formulation to “Whole-gene transcriptional profiling
and their modulation by dietary interventions.” promote cellular protection and purification to detect aging-associated
Invited Speaker: Free Radicals, Nutrition and via induction of the Nrf2-mediated ARE/ mitochondria dysfunction and to
Aging: From Fundamental Aspects to Clinical Phase II detoxification pathways.” Invited develop an anti-aging product.” Invited
Applications. Paris, France, June 15-17, 2011. Speaker: Second International Conference Speaker: The 2011 International
Barger, J. on Environmental Stressors in Biology and Conference on Food Factors, Taiwan,
Medicine. Centro Didattico, Policlinico Le November 20-23, 2011. Zhu, J., Dong,
Scotte Siena, Italy. October 5-7, 2011. Y., Barger, J., Lu, J., Tan, N., Prolla, T.,
July 2011
Mastaloudis, A. Weindruch, R., Bartlett, M.
“CordyMax Cs-4 restores aging-associated
changes in gene expression and extends
November 2011 “Combination of ageLOC biochip
lifespan in normal aged mice.” The 10th
“Restructuring of the ECM in Human Skin whole-gene expression profiling and
Symposium of Mycology Societies Across
by Equol: A Plant and Soy-Derived mouse lifespan test in CM anti-aging
Taiwan Strait, Wuhan, China, July 17, 2011. Tan,
Isoflavonoid.” Gene Expression and study.” Invited Speaker: Summit of
N., Barger, J., Ferguson, S., Zhang, Y., Prolla, T.,
Protein Evidence presented at the 4th New TCM product Development and
Zhu, J.
International Conference and Exhibition for Industrial Development Strategy,
Nutraceuticals and Functional Foods, Hangzhou, China, November 25-27,
September 2011 Sapporo, Japan, November 2011. Gopaul, 2011. Li, C., Tan, N., Barger, J.,
“Transcriptional biomarkers of calorie restriction R., Knaggs, H., Lephart, E. Ferguson, S., Zhang, Y., Prolla, T.,
in adipose tissue and modulation by dietary Zhu, J.
interventions.” Invited Speaker: Linus Pauling
Institute Diet and Optimum Health Conference.
Corvallis, OR, September 13-16, 2011. Barger,
J.

23. FULL LIST

24. FULL LIST
Posters 2011
February 2011 July 2011
April 2011
“Exploratory Study to Assess Association of Skin Aging with “CordyMax Cs-4 restores aging-associated changes in gene
“The lifespan-prolonging effect of Cordyceps sinensis Cs-4 in
Plasma Isoprostane Levels in Healthy Middle-Aged expression and extends lifespan in normal aged mice.”
normal mice and its molecular mechanisms.” FASEB J 2011
Japanese Women.” The American Academy of Proceeding of the 10th Symposium of Mycology Societies
25(1): 599.1. FASEB EB2011, Washington, DC, Apr. 10,
Dermatology’s 69th Annual Meeting, February 2011, New cross Taiwan Strait, Central China Agriculture University. 2011,
2011. Tan, N., Barger, J., Zhang, Y., Prolla, T., Weindruch, R.,
Orleans, LA. Chang, A., Chang, T., Lingala, B., Kern, D., pp 255-256. Oral presentation at: The 10th Symposium of
Zhao, C., Bartlett, M., Zhu, J.
Wood, S., Toyoda, H., Knaggs, H. Mycology Societies Cross Taiwan Strait, Wuhan, China, July
“ageLOC Vitality improves endurance exercise, exercise 17, 2011. Tan, N., Barger, J., Ferguson, S., Zhang, Y., Prolla,
March 2011 glucose metabolism and antioxidant capacity in an aging T., Zhu, J.
“A PCR-based screen to identify natural compounds with the model.” FASEB J 2011 25(1): 1049.2. FASEB EB2011,
ability to influence Nrf2-mediated transcriptional induction of Washington, DC, Apr. 12, 2011. Yang, J., Dong, Y., Zhao, C., September 2011
detoxification/antioxidant genes.” Gordon Research Wu, Z., Zhang, Y., Tan, N., Lu, J., Bartlett, M., Zhu, J. “A Multifactorial Approach to Addressing Body Appearance
Conference: Oxidative Stress & Disease. Emerging
Aging.” European Society for Dermatological Research
Research Areas in the Study of Oxidative Stress and “Cordyceps sinensis Cs-4 restores aging-associated (ESDR) September 2011, J. Invest Dermatol 131. S. 54 (2011).
Disease. March 13-18, 2011, Ventura, CA. Mastaloudis, A., changes in gene expression and extends lifespan in normal Knaggs, H., Kern, D., Gopaul, R., Langerveld, A.
Barger, J., Prolla, T., Weindruch, R., Ferguson, S., Wood, S. aged mice.” FASEB J 2011 25(1): 1090.13. FASEB EB2011,
Washington, DC, Apr. 13, 2011. Tan, N., Barger, J., Zhang, “A Multifactorial Gene Expression Approach to Understanding
“Cordyceps sinensis Cs-4 restores aging-associated Y., Prolla, T., Weindruch, R., Zhao, C., Bartlett, M., Zhu, J. Skin Aging.” J. Invest Dermatol 131. S. 57, September 2011.
changes in gene expression and extends lifespan in normal
Knaggs, H., Kern, D., Bartlett, M., Wood, S., Mastaloudis, A.,
aged mice.” Progress in Nutrition 2011. The 5th International “An ageLOC Vitality formula improves endurance exercise in Ferguson, S., Langerveld, A.
Symposium, “Promoting Good Health and Developing a aged mice and energy metabolism in muscle mitochondria.”
Sustainable Environment,” Hong Kong, March 10-11, 2011. FASEB J 2011 25(1): 1114.9. FASEB EB2011, Washington, “A Systematic Approach to Evaluate and Rank Natural
Zhu, J., Tan, N., Barger, J., Zhang, Y., Prolla, T., Weindruch, DC, Apr. 13, 2011. Dong, Y., Lu, J., Yang, J., Zhao, C., Tan, Ingredients Based on Their Ability to Oppose Age-Related
R., Zhao, C., Bartlett, M. N., Wu, Z., Zhang, Y., Gao, L., Bartlett, M., Zhu, J. Changes in Gene Expression.” Linus Pauling Institute Diet and
Optimum Health Conference. Corvallis, OR. September 13-16,
“ageLOC Vitality improves exercise endurance, glucose
May 2011 2011. Wood, S., Mastaloudis, A., Barger, J., Prolla, T.,
metabolism and antioxidant capacity in an aging model.”
“Association of skin aging severity with blood isoprostane Weindruch, R.
Progress in Nutrition 2011. The 5th International Symposium,
levels in healthy middle-aged Japanese women.” Society for
“Promoting Good Health and Developing a Sustainable
Investigative Dermatology (SID) May 2011, J. Invest
Environment,” Hong Kong, March 10-11, 2011. Zhu, J., Yang,
Dermatol 131. S. 85 (2011). Chang, T., Lingala, B., Kern, D.,
J., Dong, Y., Zhao, C., Wu, Z., Zhang, Y., Tan, N., Lu, J.,
Wood, S., Toyoda, H., Knaggs, H., Chang, A.
Bartlett, M.

25. FULL LIST

26. FULL LIST
Posters 2011
October 2011 “Whole-gene transcriptional profiling to detect
“A unique blend of natural compounds with the ability to aging-associated mitochondria dysfunction and to
oppose age-related changes in gene expression related develop an anti-aging product.” Proceeding of
to dysregulation of removal of cellular debris, cellular 2011 International Conference on Food Factors.
detoxification, antioxidant protection and inflammatory Zhu, J.S., Dong, Y.Z., Barger, J.L., Lu, J.H., Tan,
balance.” Second International Conference on N.Z., Prolla, T.A., Weindruch, R., Bartlett, M.
Environmental Stressors in Biology and Medicine. Invited Speaker at: The 2011 International
October 5-7, 2011, Centro Didattico, Policlinico Le Scotte Conference on Food Factors, Taiwan, November
Siena, Italy. Mastaloudis, A., Barger, J., Prolla, T., 20-23, 2011.
Weindruch, R., Bartlett, M., Wood, S.
December 2011
November 2011 “Influencing the Expression of Genes Associated
“Combination of ageLOC biochip whole-gene expression with Skin Inflammation by Combining Narcissus
profiling and mouse lifespan test in CM anti-aging study.” Tazetta Bulb Extract and Schizandra Chinensis
Proceeding of Summit of New TCM product Development Fruit Extract—an in vitro Analysis.” Society of
and Industrial Development Strategy, China J Chinese Cosmetic Chemists Annual Scientific Seminar,
Materia Medica Publishing. 2011. Li, C.L., Tan, N., New York, NY, December 2011. Gopaul, R.,
Barger, J., Ferguson, S., Zhang, Y., Prolla, T., Zhu, J. Knaggs, H., Kern, D.
Invited Speaker at: Summit of New TCM product
Development and Industrial Development Strategy, “So Why Don’t I Look Younger?” International
Hangzhou, China, November 25-27, 2011. Federation of Societies of Cosmetic Chemists,
Bangkok, Thailand, December 14-15, 2011. Kern,
D., Chang, A., Wood, S., Gopaul, R., Lephart, J.,
Knaggs, H.

27. summary
We believe Nu Skin’s ongoing research, combined with the acquisition of
LifeGen Technologies, will deepen the company’s understanding of gene
expression and its impact on reversing the effects of aging even later in life.
With our exclusive focus on identifying, targeting, and resetting Youth
Gene Clusters, we believe ageLOC science is the answer to anti-aging. It’s
a scientific breakthrough that goes beyond the signs to target the ultimate
sources of aging.
For more information about ageLOC science, please visit ageloc.com.