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PHARMA SECTOR
September, 2011                                      Domestic

•   Growth in domestic pharma
    industry to slow down to 12-13% in
    2011 due to weak macro factors
    and increase in competition from
    unlisted players and MNC pharma
    companies

•   Cut down the domestic growth
    estimates by 3-7% and earnings
    estimates by 2-9% for FY12 for
    Cipla, Cadila, Dr. Reddy, IPCA and



                                          WARNING
    Torrent .

•   Buy - Glenmark, IPCA

    Accumulate - Sun Pharma, Lupin

    Hold - Ranbaxy, Cipla, Dr. Reddy,
    Cadila, Torrent and Unichem




                                         CHALLENGES
Deepak Malik
                                           AHEAD
Senior Research Analyst
deepak.malik@emkayglobal.com
+91 22 66121257

Ashish Thavkar
Research Associate
ashish.thavkar@emkayglobal.com
+91 22 66121254

Bhavita Nagrani
Research Associate
bhavita.nagarani@emkayglobal.com
+91 22 66242486
Pharma Sector


                                                                             Contents
                                                                        Pharma Sector
Synopsis ......................................................................................................................................................................... 3
Valuation ......................................................................................................................................................................... 4
Domestic Formulations ................................................................................................................................................... 6
    Domestic Formulations: Taking a breather .................................................................................................................. 7
    Performance of Top Pharma companies ..................................................................................................................... 9
    Company specific issues - What management has to say? ..................................................................................... 10
    Pharma Industry : Recent Trends ............................................................................................................................. 11
Key Factors Driving The Slowdown ................................................................................................................................ 12
         Weakening macro factors to impact Indian Pharma growth ................................................................................. 13
         Increase in competition has led to ramp-up of sales force ................................................................................... 14
         MNCs getting aggressive .................................................................................................................................... 15
         Pricing pressure on top brands ............................................................................................................................ 18
         Anti-Infective Category – Therapy bifurcation ....................................................................................................... 20
National List of Essential Medicines .............................................................................................................................. 22
Impact of challanges ..................................................................................................................................................... 25
         Indian Pharma growth slowing down .................................................................................................................... 26
         Stress-Test on the profile of pharma companies .................................................................................................. 28
         Rivision of estimates for domestic growth ............................................................................................................ 32
         Significance of domestic business - Cash Cow ................................................................................................... 33
         Revise in earnings estimates ............................................................................................................................... 34
         Conclusion and Recommendation ....................................................................................................................... 35


                                                                             Companies
Cadila Healthcare .......................................................................................................................................................... 37
Cipla Ltd ....................................................................................................................................................................... 41
Dr. Reddy's Lab ............................................................................................................................................................. 45
Glenmark Pharma ......................................................................................................................................................... 49
GlaxoSmithKline Pharma .............................................................................................................................................. 53
Ipca Laboratories Ltd ..................................................................................................................................................... 56
Lupin Ltd. ...................................................................................................................................................................... 60
Pfizer Ltd ...................................................................................................................................................................... 64
Ranbaxy Labs ............................................................................................................................................................... 67
Sun Pharma .................................................................................................................................................................. 71
Torrent Pharma .............................................................................................................................................................. 76
Unichem Labs ............................................................................................................................................................... 80




Emkay Research                26 September, 2011                                                                                                                                   2
Pharma Sector


                                         Synopsis

                                     Last year, Indian Pharma industry grew by 16%, one of the highest growth rates in the
                                     world Pharma market. In the first two quarters Indian Pharma market growth has slowed
         Growth in domestic          down to 13% from 16% in 2010. Domestic Indian companies are the ones which are
         pharma industry to          impacted most by this slowdown in growth.
      slow down to 12-13%
        in 2011 due to weak          In our report, "Domestic Pharma market", we have diagnose the challenges faced by
         macro factors and           the Indian Pharma market, which was valued at USD 12 billion in 2010 and tried to
     increase in competition         answer the following questions.
       from unlisted players
                                           What are the reasons for decline in the growth rate of Indian Pharma industry in
             and MNCs
                                           the first half of 2011?

                                           What is the impact of these factors on different pharma companies?

                                           Find out which company will outperform the industry growth rate?

                                     Our analysis shows that there is a high degree of correlation between macro factors,
                                     economic growth and Indian pharma industry growth. When the pace of economic reforms
                                     and economic growth slows down it impacts the pharma industry growth. Other reason
                                     was, every company has increased the strength of MRs in last two years and as a result
                                     there was a spurt of growth last year which is tapering down this year. Impact of slowdown
                                     in growth is more pronounced in mid and small cap companies and the companies
                                     which have more exposure in GP therapies, which is more susceptible to competition.
                                     Competition is increasing from low cost players like Mankind & Alkem labs in the mass
                                     product therapies like anti-infective. MNCs which were focused more on acute categories
                                     till now are increasingly launching products in chronic space & that too at competitive
                                     prices.

                                     To analyse the impact of these challenges on pharma companies’ domestic portfolio, we
                                     have devised the “4 Step Stress Test “ to find out how various companies will get impacted.
                                     Even though domestic business is only 20%-50% of the overall revenues, its contribution
                                     to the base business earnings is higher at 50%- 70%. ROCE of domestic business is
                                     much higher at 40%-60% compared to other businesses which have less than 20% and
                                     as a result multiples are mainly driven by domestic business. Our analysis suggests that
       Cut down the domestic         any change in the domestic revenue has an amplified impact on the earnings and multiples
     growth estimates by 3-7%        of the companies.
      and earnings estimates
                                     Pharma Companies which are mainly focused on domestic business will be the one
        by 2-9% for FY12 for
                                     which will get impacted the most like - Cipla, Torrent, IPCA and Unichem. Other pharma
      Cipla, Cadila, Dr. Reddy,
                                     companies which have sizeable opportunities in form of Para IVs and FTF in US will able
          IPCA and Torrent
                                     to cushion the impact like Ranbaxy and Dr. Reddy. Sun and Lupin have superior portfolio
                                     in domestic business with more focus on Chronic category and good opportunities in
                                     form of Para IV and FTFs.

                                     We have cut down the domestic growth estimates for Cadila, Cipla, Dr. Reddy, IPCA,
                                     Torrent and Unichem for FY12 and FY13 by 3% to 7% and earnings growth estimates by
                                     2% to 9% & retained the growth and earnings estimates for Lupin, Ranbaxy, Sun, GSK
                                     and Pfizer.

                                           Buy - Glenmark and IPCA

                                           Accumulate – Lupin and Sun Pharma

                                           Hold - Cadila, Cipla, Dr. Reddy, Ranbaxy, Torrent and Unichem




Emkay Research      26 September, 2011                                                                                        3
Emkay Research
                     Valuations

                                                        Mcap             EPS                 PE(x)            EV/ EBITDA (x)              ROCE (%)                 ROE (%)                 P/BV




26 September, 2011
                      Company Name            Rating   (Rs bn) FY11 FY12e FY13e       FY11 FY12e FY13e      FY11 FY12e FY13e       FY11 FY12e FY13e         FY11 FY12e FY13e        FY11 FY12e FY13e

                     Cadila Healthcare        Hold        165     33     36     45     25       22    18     17     15     12       29       29       31     39       31      30      7       6     5
                     Cipla                    Hold        228     12     14     18     24       20    16     17     15     12       17       18       20     16       16      17      3       3     3
                     Dr. Reddy's Lab          Hold        252     73     69     91     20       21    16     16     14     11       24       21       25     31       25      26      6       5     4
                     Glenmark Pharma          Buy          87     17     24     24     19       13    14     18     10     10        11      20       18     21       28      22      4       3     3
                     Lupin                    Acc         212     19     22     26     25       22    19     19     15     13       24       25       25     30       27      25      6       5     4
                     Ranbaxy Labs             Hold        200     25     31     41     19       15    12     15     10         8    17       18       22     35       21      22      4       3     2
                     Panacea Biotech          Hold          8     22     15     12      6        8    11      6      7         7    14       10        9     20       13      10      1       1     1
                     Sun Pharma               Acc         482     18     22     27     26       22    17     23     18     14       22       22       23     22       23      24      5       4     4
                     Torrent Pharma           Hold         49     30     36     44     19       16    13     14     12     10       21       23       26     29       30      31      5       4     4
                     Unichem Labs             Hold         13     11      9     13     14       16    11      9     10         7    20       15       19     16       13      17      2       2     2
                     IPCA                     Buy          34     18     22     28     15       12    10      11     9         7    21       21       23     24       24      24      3       3     2
                     Pfizer                   Acc          40     58     66     79     23       20    17     13     15     12       17       18       19     16       16      17      3       3     3
                     Glaxo                    Hold        170     68     78     86     29       26    23     17     15     13       47       48       50     30       32      34      9       8     8

                     Generics                            149.2   31.0   34.2   41.1   20.3    18.0   15.0   15.0   12.7   10.5     21.8     22.2     23.8   25.2     22.9    23.0    4.6     3.9   3.3

                     Jubilant Life Sciences   Buy          32     17     18     25     12       11     8     12      9         7     7        9       11     10       13      17      1       1     1
                     Divi's Lab               Buy          96     32     38     46     22       19    16     19     15     12       27       29       30     26       25      25      5       4     4
                     Aurobindo Pharma         Buy          39     18     18     23      7        7     6      9      7         6    18       16       18     24       21      24      2       2     1
                     Dishman Pharma           Acc           5      5      8     10      11       8     6      8      7         6     5        6        7     10        7       8      1       1     1

                     CRAMS                                42.8   18.2   20.4   26.0   13.2    11.4    9.0   11.9    9.6    7.8     14.5     15.2     16.5   17.5     16.6    18.3    2.2     2.0   1.6


                     Pharmaceuticals                      96.0   28.0   31.0   37.5   18.6    16.4   13.6   14.2   11.9    9.9     20.1     20.6     22.1   23.4     21.4    21.9    4.0     3.4   2.9
                                                                                                                                                                                                         Pharma Sector




                     Source: Emkay Research




  4
Emkay Research
                     Valuations

                                               Mcap          Sales (Rs mn)              EBITDA    (Rs mn)        EBITDA Margin (%)               PAT (Rs mn)              PAT Margin (%)




26 September, 2011
                     Company Name             (Rs bn)    FY10    FY11e     FY12e      FY10    FY11e    FY12e
                                                         FY11    FY12e     FY13e      FY11    FY12e    FY13e    FY11   FY12e    FY13e    FY11       FY12e      FY13e   FY11   FY12e    FY13e

                     Cadila Healthcare           165    45,925   51,563   60,618      9,885   11,495   13,581   21.5     22.3    22.4    6,733      7,452      9,159   14.7    14.5        15.1
                     Cipla                       228    63,180   71,863   83,325     13,375   15,444   18,765   21.2     21.5    22.5    9,692     11,395   14,169     15.3    15.9        17.0
                     Dr. Reddy's Lab             252    76,558   86,552   97,044     17,121   18,008   22,407   22.4     20.8    23.1   12,314     11,695   15,374     16.1    13.5        15.8
                     Glenmark Pharma              87    29,491   36,475   39,323      5,923    9,520    9,437   20.1     26.1    24.0    4,532      6,477      6,413   15.4    17.8        16.3
                     Lupin                       212    58,320   67,682   82,022     12,000   13,322   16,680   20.6     19.7    20.3    8,625      9,825   11,435     14.8    14.5        13.9
                     Ranbaxy Labs                200    85,355   97,660   118,963    14,136   18,602   24,310   16.6     19.0    20.4   10,347     13,147   17,206     12.1    13.5        14.5
                     Panacea Biotech               8    11,702   10,802      9,777    2,765    2,419    2,233   23.6     22.4    22.8    1,327        939        741   11.3      8.7        7.6
                     Sun Pharma                  482    57,214   73,135   88,099     19,890   25,204   32,364   34.8     34.5    36.7   18,386     22,365   28,250     32.1    30.6        32.1
                     Torrent Pharma               49    21,825   24,201   28,242      3,652    4,470    5,352   16.7     18.5    19.0    2,536      3,051      3,738   11.6    12.6        13.2
                     Unichem Labs                 13     8,240    9,322   10,846      1,500    1,403    1,915   18.2     15.1    17.7     951         817      1,210   11.5      8.8       11.2
                     IPCA                         34    18,825   21,506   25,567      3,598    4,276    5,336   19.1     19.9    20.9    2,294      2,760      3,489   12.2    12.8        13.6
                     Pfizer                       40    12,446   10,642   12,345      2,589    2,299    2,728   20.8     21.6    22.1    2,294      1,974      2,349   18.4    18.6        19.0
                     Glaxo                       170    21,511   24,229   27,080      8,893    9,987   11,254   41.3     41.2    41.6    5,783      6,566      7,406   26.9    27.1        27.3
                     Generics                   149.2   39,276   45,049   52,558      8,871   10,496   12,797   22.8     23.3    24.1    6,601      7,574      9,303   16.3    16.1        16.7

                     Jubilant Life Sciences       32    34,420   38,505   46,325      5,541    7,368    8,919   16.1     19.1    19.3    2,711      2,810      3,967    7.9      7.3        8.6
                     Divi's Lab                   96    13,181   16,087   19,284      5,025    6,200    7,620   38.1     38.5    39.5    4,293      4,976      6,145   32.6    30.9        31.9
                     Aurobindo Pharma             39    41,257   47,741   57,047      7,040    8,179   10,263   17.1     17.1    18.0    5,185      5,364      6,725   12.6     11.2       11.8
                     Dishman Pharma                5     9,908   10,777    11,772     1,622    1,951    2,190   16.4     18.1    18.6     437         648        774    4.4      6.0        6.6

                     CRAMS                       42.8   24,692   28,278   33,607      4,807    5,925    7,248   21.9     23.2    23.8    3,156      3,450      4,403   14.4    13.9        14.7

                     Pharmaceuticals             96.0   35,845   41,103   48,099      7,915    9,420   11,491   22.6     23.3    24.1    5,791      6,604      8,150   15.9    15.5        16.2
                                                                                                                                                                                                  Pharma Sector




                     Source: Emkay Research




  5
Pharma Sector




                                      Domestic Formulations: Taking a breather

                                      Performance of Top Pharma companies

Domestic Formulations                 Company specific issues - What management

                                      has to say?

                                      Pharma Industry : Recent Trends




Emkay Research   26 September, 2011                                                 6
Pharma Sector


                                      Domestic Formulations: Taking a breather
                                      Indian pharma market (IPM), which had grown by 16% in 2010 has slowed down to 13.5%
                                      in the first half of 2011. This is as per AIOCD data, which is collected from secondary
                                      sources. However, if we see the performance of most of the pharma companies in the
                                      domestic space in the first half of 2011, then everybody has shown considerable decline
                                      growth. Primary data shows that the decline is much steeper.

       Most of the pharma
                                          IPM growth showing downward trend in the recent months
        companies have
      shown considerable                  20.0
     decline in growth in first                                                           16.2
                                                  14.9      14.2          15.0                      14.5
                                          16.0                                                                 13.9        13.5
           half of 2011
                                          12.0                                   10.4

                                           8.0

                                           4.0

                                           0.0
                                                 2006       2007          2008   2009     2010      MAT     Q - Mar'11 Q - Jun'11
                                                                                                   Jul'11

                                      Source: AIOCD AWACS, Emkay Research


                                      Therapy-wise growth trend
                                                                   FY10                 Q-Mar'11                      Q-Jun'11

                                      Chronic                      19.2                     16.0                          16.4
                                      Acute                        14.9                     12.9                          12.2
                                      Overall                      16.2                     13.9                          13.5
                                      Source:Company, Emkay Research


                                      Slowdown in growth is visible across the Chronic and Acute categories even though the
                                      reasons are different for both the categories.


                                      In Acute segment, the therapies which are more commoditized in nature have seen
      Acute segment - The
                                      increased competition and price pressures, whereas in Chronic segment, it has been
    therapies which are more
                                      more due to macro economic factors. In the last 2 years everybody has increased its MR
     commoditized in nature
                                      strength and as a result, there is an increase in competition which is now taking its toll.
      have seen increased
                                      MNC pharma companies are expanding very aggressively in India and have very high
      competition and price
                                      aspirations for their Indian businesses. They are rapidly expanding their field force to
      pressures, whereas in
                                      extend their geographical reach. MNCs which have strong foothold in acute therapies, are
     Chronic segment, it was
                                      now aggressively moving into chronic therapies. In some of the products which are not
       more due to macro
                                      core to their business, they are entering with extremely competitive pricing versus Indian
        economic factors
                                      companies. All these factors together with weak macro economic outlook is adding to the
                                      slowdown in growth.




Emkay Research       26 September, 2011                                                                                             7
Pharma Sector


Top 10 categories growth rate
                        Rs Cr         % Share                                        YoY Growth (%)

                      MAT' Jul'11 MAT'Jul 11       MAT'Jun 11     Jan'11    Feb'11    Mar' 11   Apr'11     May'11    Jun'11     M-Ju1'11

Anti Diabetic            3358           6%             22.0        21.6       19.3     22.4      25.2       24.2       22.1       17.4
Anti-Infectives          9681          17%             11.3        11.8        9.9      9.3       8.6        9.6        8.0         5.8
Cardiac                  6597          12%             18.2        17.1       17.2     17.4      17.6       19.3       17.5       14.6
Derma                    2813           5%             13.1        12.7       12.0     11.2      13.2       12.0       11.9         9.2
Gastro intestinal        6563          12%             13.8        12.5       11.7     11.9      12.1       12.8        7.9         5.2
Gynaecological           3538           6%             15.8        12.3       13.2     11.8       9.6       10.8        8.5       10.6
Neuro / CNS              3463           6%             14.2        14.3       13.3     12.3      13.6       14.8       12.1         9.5
Pain / Analgesics        4488           8%             14.1        19.8       11.1      6.7      10.9       13.6       12.2         7.6
Respiratory              4469           8%             11.4        14.7       10.2     12.7      12.2       13.8        7.6         6.3
Vitamins / Minerals      4678           8%             13.9        13.7       12.3     10.2      12.1       13.1       12.4        11.5

Total                  56483                           14.5        14.7       13.0     12.4      12.8       14.3       12.1         9.6
Source: AIOCD AWACS, Emkay Research


                                                If we evaluate the performance of the Indian pharma companies w.r.t different therapies,
                                                then anti-infective, pain, gynecology and gastro, show visible slowdown in growth. Anti-
                                                infective, pain and gastro which together contribute ~1/3rd of the total pharma market, are
          Anti-infective, pain,                 witnessing lot of competition from un-listed Indian companies such as Mankind. MNCs,
        gynecology and gastro                   which have strong hold in these categories, are now moving aggressively towards chronic
        show visible slowdown                   therapies, due to superior growth rate and higher entry barriers associated with this
                in growth                       category.




Emkay Research          26 September, 2011                                                                                                 8
Pharma Sector


                                  Performance of top pharma companies

                                      Performance of top pharma companies

                                       Mankind                 24%                              22%

                                         Astra                           34%                              22%

                                         Pfizer        11%                14%
                                                                                                      Grow th in Q4'11 & Q1'12
                                        Aventis        13%                12%
                                                                                                               YoY Grow th %
                                          GSK          11%                13%

                                        Torrent    9%               9%

                                           Ipca   5%          12%

                                      Dr. Reddy   5%     6%

                                          Lupin                           37%                               17%

                                      Glenmark                21%                         20%

                                           Sun          15%                    12%

                                       Ranbaxy         11%           8%

                                         Cadila               23%                    8%

                                          Cipla         15%                10%

                                                        Q4FY11             Q1FY12

                                  Source: Emkay Research


                                  From the corporate performance of Indian Pharma companies in last two quarters, mid &
                                  small cap companies, have been the most impacted.

                                  MNC pharma companies continue to grow in line with industry growth of ~13%, except
                                  Astra which has grown by more than 20%. These MNCs are aggressively investing in
                                  branded generics and moving into newer therapies like CVS, CNS and anti diabetes. In a
                                  bid to increase their presence in some of the branded generics, MNCs have aggressively
                                  priced their products below their Indian counterparts. While this has not significantly
                                  dented market share, it is a precursor to the competitive intensity in the future.

                                  In small and mid cap companies - Unichem, IPCA and Torrent are the ones which have
                                  been impacted the most. And in large cap companies - Dr. Reddys, Ranbaxy & Cipla have
                                  been impacted. For the last 3-4 years barring 2009, most of these companies were
                                  growing above or in-line with the market growth on back of strong macro environment.
                                  Now unfavorable macro enviroment coupled with intense competition from unlisted players
                                  in some therapies of acute segment has made the market even more competitive.




Emkay Research   26 September, 2011                                                                                              9
Pharma Sector


Company specific issues - What management has to say?


Cadila                                                             Pfizer
Sales in Q1FY12 were lower as the company pushed inventory         Above industry growth was led by volume increase (11% growth)
into the market in Q4FY11 (registered YoY growth of 23%) in        and price increase (3% growth). Although the anti-infective
order to achieve US$1bn revenue target.                            segment witnessed 12.5% growth on account of 3 new launches
                                                                   viz. Getex, Getex Suspension and Cefixime, management has
Cipla                                                              admitted to increased competition in the anti-infectives and
Growth was below industry rate as the Acute segment                the Vitamins/ Minerals segment.
witnessed intense competition from industry peers during the
quarter. Respiratory segment continues to do well for the          Ranbaxy
company.                                                           India business (contributed 20%) grew below industry rate at
                                                                   6% YoY, mainly led by anti-infective and gastro segment, which
Dr. Reddys                                                         witnessed lower traction due to increased competition from its
India business which contributed 15%, grew at a lower rate of      peers.
6% compared to industry rate of 14% due to ongoing issues of
DCGI on the company's top selling pain brand Nise                  Sun Pharma
(nimusulide).                                                      Domestic branded formulations grew 12% YoY due to
                                                                   discontinuation of third party sales and netting of VAT. Adjusting
Glenmark                                                           for third-party sales, domestic revenues grew by 18% YoY.
India revenues grew 20% YoY led by market share gains in key
therapies of anti-infectives, cardiac, respiratory, diabetes and   Torrent
dermatology & 2 new product launches i.e. Doriglen and Vorth       The chronic portfolio, which contributes 60% of domestic
TP in orthopedic segment. Management has guided for                portfolio reported strong growth of 17-18% during Q1FY12.
increased competitive pressures from unlisted players. As a        However, acute therapy almost remained flat due to increased
result, growth going ahead is expected to be in the range of 16-   competition mainly in anti-infective and pain segments.
17%.
                                                                   Unichem
Ipca                                                               Unichem has initiated inventory rationalization at the distributor
Lower growth was mainly due to decline in Anti bacterial (down     level in order to improve internal processes and reduce inventory
13%) and Cardiac segment (up 6%). Regrouping of sales rep          by 21-30 days. This has led to 5% YoY decline in domestic
and brands and high attrition rate also impacted growth.           formulation revenues in Q1FY12. Among the company's top 10
                                                                   brands, 6 brands reported negative YoY growth. Management
Lupin                                                              admits to increased competitive pressures from local as well
17% growth was on account of new product launches and              as MNC players.
improved performance from the company's chronic portfolio.




Emkay Research       26 September, 2011                                                                                           10
Pharma Sector


Pharma Industry : Recent trends
Key trends

      Increase in                                             Geographical                 Shifting disease            Acquisition by
                                Strategic tie-ups
      MR strength                                              expansion                        profile                   MNCs


                                Indian companies are          Expanding their
 All companies, including                                                               Increasing prosperity &    Acquisitions by MNCs to
                               entering in to strategic      presence in rural
 MNCs, have increased                                                                      changing lifestyle -     gain quick foothold in
                                tie-ups with MNCs to        markets (67% of the
  their field force in the                                                              propelling higher growth     the fastest growing
                              strengthen their product        total population)
       last one year                                                                     in the chronic segment     Indian pharma market
                                       portfolio

Source: Emkay Research




  Sun - Merck JV                                                         Lupin -Lilly

 Sun and Merck have formed a JV to develop, manufacture and             Eli Lilly India and Lupin have entered into a strategic
 commercialize new combinations and formulations of                     collaboration to promote and distribute Lilly's Huminsulin
 innovative, branded generics in the Emerging Markets. The              range of products. Lupin will promote and distribute the range
 partnership will use Sun Pharma Advanced Research                      of products in India and Nepal and will double the number of
 Company Ltd's proprietary platform technologies, and Sun               sales representatives behind the diabetes care product.
 Pharma's world-class manufacturing network. Merck will use
 its clinical development and registration expertise to
 commercialize the products. Under the JV, Sitagliptin and
 Sitagliptin + Metformin have already been commercialized in
 the Indian markets.




  Cadila - Bayer JV                                                      Biocon - Pfizer

 Cadila and Bayer have formed a JV to distribute medicine in            Biocon and Pfizer have entered into a strategic collaboration
 the Indian market. About 600 employees from both companies             to commercialize Biocon's bio-similar version of Insulin and
 will work for the venture. The venture will sell brands from           Insulin analogue products such as recombinant human
 both companies, such as Bayer's blood thinner Xarelto and              insulin, Glargine, Aspart and Lispro. Pfizer will have the
 Cadila's Euglim for diabetes                                           exclusive rights to commercialize these products globally
                                                                        including co-exclusive rights with Biocon in Germany, India
                                                                        and Malayasia.




                                     Universal Medicines- Aventis

                                     Sanofi Aventis has acquired Universal Medicines for over
                                     US$100mn. This acquisition is in-line with Sanofi-Aventis
                                     global strategy to expand its foot-print in the Emerging Markets.
                                     Universal Medicare manufactures markets and distributes
                                     branded nutraceutical formulations in India, including its
                                     popular cod liver oil capsules. This will help Sanofi to boost
                                     its over-the-counter business in India.




Emkay Research           26 September, 2011                                                                                              11
Pharma Sector




                                      Weakening macro factors

                                      Increase in competition
Key Factors driving
                                            MNC's getting aggressive
the slowdown
                                            Competition from unlisted players

                                            Pricing pressure in anti-infectives

                                      National List of Essential Medicines - Future impact

                                      analysis




Emkay Research   26 September, 2011                                                          12
Pharma Sector


                                     Weakening macro factors impacting Indian pharma growth
                                         IPM has a strong correlation with India GDP growth

                                         10.0%      9.8%          9.5%          15.0%                      16.2%
                                                                                                                                 16.0%

                                          9.0%      14.9%                                                              12.6%     14.0%
                                                                 14.2%                                         8.9%
      With rising interest rate,                                                              10.4%                              12.0%
                                                                                                                       7.6%
       the Indian economy is              8.0%
                                                                                                                                 10.0%
     slowing down, resulting in                                                  7.4%
                                          7.0%                                                 7.2%
      slower growth in Indian                                                                                                    8.0%
            pharma also                   6.0%                                                                                   6.0%
                                                    2006          2007           2008         2009         2010        2011 *
                                                                       GDP Gr % (LHS)                 IPM Gr % (RHS)

                                     * Project numbers based on historic GDP average and Emkay Economics


                                     Rise in disposable income and favorable income demographies are the major catalyst
                                     responsible for the growth of the Indian pharma industry. Within this, increase in disposable
                                     income is a larger contributor (approx. 40%). However, with rise in interest rate scenario,
                                     the Indian economy is slowing down and is expected to grow by 7.6% during 2011 as
                                     compared to 8.9% in 2010. Home loan EMIs are going up, salary growth has slowed
                                     down; as a consequence, the disposable income has also got impacted resulting in
                                     slowing the pace of the Indian pharma industry. According to Mckinsey report on Indian
                                     Pharma, rise in disposable income and upward shift in income demographies account
                                     for 40% of the Indian pharma market growth, as depicted below.


                                         IPM growth largely driven by rise in income levels



                                                                                            15%
     Rise in interest rates have
       impacted disposable                                                       40%            10%
    income, which is the largest
                                                                                               15%
     growth driver of the Indian
                                                                                        20%
          pharma industry


                                              Others                            Increase in prevalence         Insurance penetration
                                              Medical Infrastructure            Income Grow th

                                     Source: Mckinsey Report on Indian Pharma


                                     With increase in interest rate, the capital expenditure for new medical infrastructure will
                                     also slow down as it is a capital intensive segment. Growth in insurance penetration will
                                     also slow down resulting in overall slow down in the growth of Indian Pharma.




Emkay Research      26 September, 2011                                                                                                  13
Pharma Sector


                                  Increase in competition has led to ramp-up of sales force
                                      Pharma companies have ramped up their field force...

                                      7500                           4.8               Marketing Representatives Grow th                      Sales per MR
                                                                                                  Rates in %                            in numbers (at top of bar)
                                      6000                                       1
                                                                      21%        .          4          4          3
                                      4500                                      14%         .          .                     2




                                             Sales Forcce Numbers
                                                                                           13%        12%        47%                    6       8          4
                                      3000                                                                                                                           3
                                                                                                                             7%
                                                                                                                                        23%     4%         32%
                                      1500                                                                                                                           10%
                                                                      8%        38%        36%        56%        26%         24%        4%      4%          5%       11%
                                                        0
                                                                      Cipla     Ipca       Cadila Ranbaxy Lupin             Torrent     GSK     Sun        DRL       Glen
                                                                                                                 FY10                   FY11

                                      ...leading to pharma companies clocking good growth

                                                                    30000      28       Domestic Revenues in Rs bn                Grow th in domestic revenues in %
                                                                    25000                                                                         24
                                       Domestic Sales




                                                                              14%                19                                       19
                                                                    20000                                   16         16                        17%
                                                                    15000                                                                                 12
                                                                                                 20%                                    14%
                                                                                                            8%        15%         8                               8
                                                                    10000              7                                                                 15%
                                                                              10%      16%                                       15%             15%             12%
                                                                    5000                         14%                  18%               10%
                                                                                       25%                  11%                  17%                     20%     18%
                                                                       0
                                                                              Cipla    Ipca      Cadila Ranbaxy Lupin Torrent GSK                   Sun     DRL      Glen

                                                                                                                  FY10           FY11


                                  Some of the initiatives adopted by the Indian pharma companies in the domestic business –

                                       Pfizer                                                                               Ranbaxy
                                      The company has launched two new                                                      The company launched Project Viraat
                                      divisions CNS and Diabetes and has                                                    in order to ramp up its presence across
                                      added 300 people across two                                                           the country, especially in rural areas.
                                      divisions. The company plans to launch                                                This included introduction of new
                                      insulin products from Biocon’s portfolio                                              products, increasing its field force and
                                      in the next quarter. This will help the                                               targeting more than 350,000 doctors.
                                      company focus on branded generics
                                      and fill portfolio gaps.

                                  During the past 2 years, most of the Indian pharma companies have resorted to strong
                                  addition of MRs in order to give a boost to its domestic business. For e.g. Ipca Labs has
                                  added around 1,800 MRs to its force taking the total to 5,000 MRs, which is one of the
                                  highest in the industry. As a result, its domestic formulation business grew by 21% CAGR
                                  over FY09-11 to Rs7bn. Similarly, Cadila added around 1,550 MRs to its field force taking
                                  the total to 4,500 MRs by end of FY11, resulting in its domestic formulations business
                                  growing by 17% CAGR to Rs22bn. In contrast, dispite a meagre addition of just 200 MRs
                                  (taking its field force to 2,700) in last 2 years buy Sun pharma, its domestic formulation
                                  business has grown by 16% CAGR to Rs24bn.

                                  Going ahead, we believe all the domestic companies who have strengthed the field force
                                  to spurt up the growth will eventually witness a slowdown in domestic growth rates. In
                                  order to sustain higher growth rates of 15-16%, companies will have to increasingly focus
                                  on improving MR productivity by expanding to new therapies, newer markets and new
                                  launches. Companies like Sun pharma and Lupin with strong brand equity are likely to
                                  outperform.


Emkay Research   26 September, 2011                                                                                                                                         14
Pharma Sector


                                             MNCs getting aggressive
                                             MNC pharma companies continue to growing in line with industry growth of ~13% except
                                             AstraZeneca which has grown by more than 20%. Major chunk of the portfolio of these
                                             MNCs is from acute category. In acute category, they are able to withstand the competition
                                             because of their superior brand strength. Going forward, competition will hot-up even in
                                             chronic category as these MNC’s are now increasingly focussing on chronic therapies.



 Pfizer                                                                   GSK
 Pfizer's current portfolio derives strength from Respiratory, Anti-     GSK derives its strength from anti-infective, dermatology, pain
 infective and Vitamins/ Minerals segment. The acute segment             & vaccines segments. GSK is the leader in the vaccine
 (contributes 87% of the domestic sales) is growing by 20%               segment in India with an effective market share of ~20%. GSK's
 and the chronic segment (13% of domestic sales) is growing              strategy has been to create portfolio of high value products.
 by 25%. With a view to improve focus on chronic therapy, Pfizer         GSK has 4 business verticals namely, Vaccines, Specialties,
 has recently launched two new divisions - CNS and Diabetes              Mass specialties and Mass markets. Glaxo Plc, the parent
 and has added 300 people across these divisions. The                    company, has outlined one of the most aggressive growth
 company will also be launching insulin products from Biocon's           plans for emerging markets, with India being one of the key
 portfolio in FY12. This will help the company focus on branded          markets. The acute segment (contributes 95% of the domestic
 generics and fill the gaps in its portfolio. The company's six          sales) is growing by 12% and the chronic segment (5% of
 key brands are in the list of top 100 in the industry. Becosules        domestic sales) is growing by 12%. GSK has launched 2
 and Corex are ranked # 1 in their respective therapeutic                patented products from its parent's portfolio i.e. Revolade (drug
 segments.                                                               for low platelets) and Votrient (metastatic renal cell carcinoma)
                                                                         in the oncology segment. Earlier, GSK had successfully
                                                                         launched an Onco product Tykerb in India in May 2008.
                                                                         According to the management, within the first year of its launch
                                                                         it self Tykerb has clocked revenue of Rs70-80mn according to
                                                                         the management and is expected to gain.



                                             MNC Pharma - Currently focussed on acute therapy

                                                 100%

                                                  80%                                                                        44%

                                                  60%                               87%                  82%
                                                                 95%
                                                  40%
                                                                                                                             56%
                                                  20%
                                                                                    13%                  18%
                                                   0%            5%
                                                                 GSK                Pfizer             Novartis             Aventis
                                                                                        Chronic %     Acute %

                                             Source: AIOCD AWACS, Emkay Research


                                             MNC pharma companies continue to grow in line with industry growth of ~13%, except
                                             Astra which has grown by more than 20%. These MNCs are aggressively investing in
                                             branded generics and moving into newer therapies like CVS, CNS and anti diabetes. In a
                                             bid to increase their presence in some of the branded generics, MNCs have aggressively
                                             priced their products below their Indian counterparts. While this has not significantly
                                             dented market share, it is a precursor to the competitive intensity in the future.




Emkay Research         26 September, 2011                                                                                                15
Pharma Sector


Exhibit 5: MNCs are adopting aggressive pricing strategies in many of the new products
                                                                                 Indian Company Brands
MNC       Molecules            Therapy   Brand Name   Pricing       Company        Brand Name     Pricing   Pack
GSK       Atorvastatin         Cardio    Lilo         Rs43          Ranbaxy        Storvas        Rs180     10 tablets
                                                      10 tablets    Intas          Lipicor        Rs125     10 tablets
                                                                    Dr. Reddys     Atocor R       Rs110     10 tablets
                                                                    Cipla          Atorlip - 5    Rs157     10 tablets
Pfizer    Rabeprazole          Gastro    Above 5      Rs24          Intas          Raium Plus     Rs55      15 tablets
                                                      7 tablets     Cipla          Rabicip - 10   Rs64      15 tablets
                                                                    Dr. Reddys     RZ 20          Rs70      10 tablets
Sanofi    Metoprolol           Cardio    Sitelol      Rs30          Cipla          Metolar-XR     Rs39      10 tablets
                                                      10 Capsules   USV            Metzok         Rs30      10 tablets
                                                                    Sun Pharma     ProlometXR     Rs40      10 tablets
                                                                    Lupin          Topol XL       Rs40      10 tablets
Source: CIMS, Emkay Research




Emkay Research           26 September, 2011                                                                         16
Pharma Sector


                                  New products launched by MNCs during the last 1 year
                                                                          New Launches                  Sales (Rs Cr)
                                  COMPANY                   BRAND                 Therapy                MAT July 11
                                  GSK                       Rosutec               Hormones                  1.80
                                  (17 pdts)                 Calpol T              Pain                      1.53
                                                            Ansolar SPF           Onco                      1.28
                                                            Lilo                                            0.67
                                                            Modvate 3             Derma - antibiotics       0.43
                                                            Modvate AF            Derma - antibiotics       0.22
                                                            Metlead               Anti-diabetic             0.04
                                  Total                                                                     5.98
                                  PFIZER LTD                Jetex                 Hormones                  1.34
                                  (29 pdts)                 Dolonat               Derma                     1.12
                                                            My Pal                                          0.99
                                                            Debrit                                          0.36
                                                            Vicon                 Iron supplements          0.32
                                                            Cytosar               Onco                      0.23
                                                            Maxtorin              Hormones                  0.21
                                                            Prostin VR            Hormones                  0.16
                                                            Atubri                                          0.12
                                                            Tuvace                                          0.12
                                                            Levefree                                        0.11
                                                            IMEDIAB M             Anti-diebetics            0.10
                                                            Aivo                                            0.08
                                                            Imediab               Anti-diebetics            0.07
                                                            Bidiab                Anti-diebetics            0.04
                                                            Felban AL             Hormones                  0.02
                                  Total                                                                     5.42
                                  SANOFI-AVENTIS            Solian                                          1.94
                                  (18 pdts)                 Rejusite              AI                        0.59
                                                            Telsite h             CVS                       0.55
                                                            Multaq                GI                        0.52
                                                            Cardace Protect       CVS                       0.42
                                                            Amaryl P              Anti-diabetic             0.41
                                                            Sitelol                                         0.18
                                                            Sofrahext                                       0.14
                                                            Sitestat F                                      0.11
                                                            Vitahext              Vitamins                  0.07
                                                            Menomune              Onco                      0.06
                                                            Fasturtec             Onco                      0.05
                                                            Sitelol am            CVS                       0.03
                                                            Cetapin V             Anti-diebetics            0.02
                                                            Shanchol              AI                        0.02
                                  Total                                                                      5.11
                                  NOVARTIS                  Pactel                CNS                       2.05
                                  (16 pdts)                 Aclasta               Onco                      0.86
                                                            Onbrez Breezhaler                               0.85
                                                            Tacsant               AI                        0.11
                                                            Macalvit New          Vitamins                  0.09
                                                            Vingose                                         0.08
                                                            Afinitor              Onco                      0.05
                                                            Tminic Cold                                     0.03
                                                            Sacsecure                                       0.03
                                                            Calc(i)ayur                                     0.02
                                                            Certican                                        0.02
                                                            Calc(c)ayur                                     0.02
                                  Total                                                                     4.20
                                  Source: AIOCD AWACS, Emkay Research



Emkay Research   26 September, 2011                                                                                     17
Pharma Sector


Pricing pressure on top brands

Top Brands                  Company                 Year of            Therapy                    Market              MAT                 YoY
MAT Jul 2011                                        Launch                                     Share (%)             ‘Jul 11          Gr. %
Corex                       Pfizer                      1993           Respiratory                  0.5               210                 -0.2
Human Mixtard               Novo Nordisk                1994           Anti-Diabetic                0.4               196               10.4
Monocef                     Aristo Pharma               2001           Anti-Infective               0.3               187                 11.9
Voveron                     Novartis                    1986           Pain                         0.4               185                 5.5
Augmentin                   GSK                         1992           Anti-Infective               0.4               177                 6.1
Revital                     Ranbaxy                     1989           Vitamins                     0.4               151               10.5
Taxim - O                   Alkem                       1998           Anti-Infective               0.3               150               17.7
Taxim                       Alkem                       1990           Anti-Infective               0.3               149                 11.2
Dexorange                   Franco Indian               1990           Vitamins                     0.3               143                 9.0
Betadine                    Win Medicare                1990           Derma                        0.3               142               10.7
Asthalin                    Cipla                       1993           Respiratory                  0.3               142                 11.5
Storvas                     Ranbaxy-Stancare            1999           Cardiac                      0.2               138                 7.6
Calpol                      GSK                         1995           Pain                         0.2               137                 6.8
Phensydyl Cough             Piramal                     1996           Respiratory                  0.4               134              -25.8
Zifi                        FDC                         1999           Anti-Infective               0.3               134                 6.2
Liv - 52                    Himalaya                    1989           Gastro                       0.3               123               22.4
Becosules                   Pfizer                      1989           Vitamins                     0.3               119               13.4
Zinetac                     GSK                         1986           Gastro                       0.2               117                 5.3
Mox                         Ranbaxy                     1997           Anti-Infective               0.3               115                 -2.1
Source: AIOCD, Emkay Research



                                                 Growth in Anti-Infective segment has slowed down during the past 2 quarters due to
                                                 increase in competition and pricing pressure both from local peers as well as MNCs.
                                                 Competition in the top 20 brands in Indian Pharma market is also increasing with average
                                                 growth slowing down to single digit.


                                                 Most of the products, which feature in the top 20 list belong to acute therapy. Companies
                                                 like Mankind are increasingly targeting these products and launching cheaper alternatives.
                                                 Not only Mankind Pharma but even MNCs have been launching many drugs at considerably
                                                 lower prices.


 Pricing pressure in Ranbaxy's Mox (Anti-Infective) -250mg                      Pricing pressure in GSK's Augmentin (Anti-Infective) -
 15 strip capsules                                                              Amoxcillin + Clavulanic Acid combination

 90                                                                              90
 80                                                                              80
 70                                                  73% premium                 70                                    34% premium
 60          24% premium
                                                                                 60
 50                                                                                               25% premium
             86                                                                  50
 40
                       70                                                        40
 30                                     54         53                                        67
                                                                  50             30
 20                                                                                                             54                   50
 10                                                                              20
  0                                                                              10
             Mox-    Novamox-         Moxydil-   Lupimox-      Glamoxin-          0
           Ranbaxy     Cipla           Solvay      Lupin         GSK                    Augmentin-GSK      Clavam-Alkem        Moxikind-Mankind

Source: CIMS, Emkay Research




Emkay Research          26 September, 2011                                                                                                        18
Pharma Sector


Pricing pressure in NovoNordisk's Human Mixtrad                      Pricing pressure in Abbotts Phaensedyl & Pfizer's Corex
(Anti-Diabetic) - 70:30 Isophane/ Soluble Insulin                    Syrup - 100ml SYR

 250                                                                 80

 200
                                               79% premium           60
                                                                                                                  74% premium
 150                 37% premium                                               9% premium
                                                                     40
 100           218                                                             70             64
                                   159                                                                       45
                                                      122            20                                                    40
  50

   0                                                                  0
         Insuman Rapid-        Human Mixtard     Insugen-Biocon            Phensedyl-        Corex        Ascoril-       Codocuf-
             Sanofi                                                          Abbott                       Glenmark        Zydus

Source: CIMS, Emkay Research




 Doctor Visit – Key Notables
 We visited set of doctors who are providing services in big hospitals in Mumbai and also had their private practice.

 During our visit to some of the General Practitioners in Mumbai, we found that for most of the infections and general illness, they
 was prescribing Mankind medicines. E.g. most of anti-infective prescribed belonged to penicillin’s and cephalosporin’s category.
 During our interaction, we understood that Mankind gives superior incentives for each prescription written by the doctor. If the
 patients case is very serious, then higher class of anti-infectives i.e. Penem’s were prescribed by the doctors and that too only
                                                                                  MNC brands. The reason cited was – MNC
                                                                                  brands are original research molecules and so
                                                                                  doctors comfort level is usually higher when
                                                                                  prescribing these medicines.


                                                                                  The line of treatment action begins with
                                                                                  prescribing penicillin’s and cephalosporin’s
                                                                                  (Mankind is the preferred company in the anti-
                                                                                  infective space) and higher treatment uses
                                                                                  penem’s where MNC drugs are preferred.




Emkay Research          26 September, 2011                                                                                          19
Pharma Sector


Anti-infective category – therapy bifurcation

                                      Rs Cr                                    YoY Growth %                           MAT’Jun 11 Gr. Contributors
Groups                                 MAT’       %      MAT’        Sept’ 10       Dec’ 10     Mar’11    Jun’11       Vol     Price        NP
                                      Jun11    Share    Jun11                                                          GR        GR         GR

Systemic Antibacterials               8,596     91%       11.7           13.0          12.9        10.4        8.2     6.6        0.3       4.8
Cephalosporins                        4,191     44%       14.2           19.4          14.6        11.5       10.3     8.8       -0.5       5.9
Broad spectrum penicillins            1,618     17%           9.5        14.4           5.1         9.2        9.4     6.5       -0.8       3.8
Macrolides and similar types          1,092     12%       14.6           20.0           9.9        14.2       14.8    10.0        0.5       4.2
Fluoroquinolones                      1,070     11%           4.3            8.6        4.3         5.9        -2.5   -1.2        1.9       3.6
Tetracyclines and combinations          123      1%           9.7        14.0           11.8        7.4        5.1    -2.0        2.8         9
Others                                  502      5%             -       -26.3          71.1         6.8        -0.5      -          -          -

Anti - fungals                          237      3%       23.3           15.5          16.6        38.0       27.0    18.8         -2       6.4
Antimyco - bacterials                   395      4%       10.5           12.7           6.7        11.6       11.0     8.7        1.2       0.6
Anti - virals                           211      2%       19.1           13.8          15.6        25.2       21.9     8.7        0.2      10.2

Total Sales                           9,428    100%       12.0           13.0          12.8        11.3        9.1     6.7        0.5       4.8
Source: AIOCD AWACS, Emkay Research

                                               Growth in anti-infective category is mainly coming from volume growth and new product
                                               launches. Failure to launch new products will make it difficult for the companies to match
                                               the industry growth. Cephalosporins which contribute ~ 44% to the Anti-Infective category
                                               was impacted most.

                                               Reasons for the slowdown in Anti Infective category are
                                                  Weather patterns – Heat wave was not that strong in North
                                                  Decline in API prices of Cephalosporins due to dumping in China
                                                  Pricing pressure due to Increase in competition
                                                  Lower success rate of new product launches

Top Companies in the Anti-Infective Category (Rs bn)
                        Rs bn                                                                   YoY Gr. (%)
Anti-Infective     MAT’Jun 11     MAT’Jun 11        Nov’10          Dec’10         Jan’11      Feb’11     Mar’11      Apr’11   May’11    Jun’11
Ranbaxy                   8.6           13.0           11.7           13.7           25.1        16.8         19.2      25.9     21.3      14.7
Alkem                     8.4           20.2           20.4           10.6           13.2         9.9         14.8      13.0     14.9      16.2
GSK Pharma                6.6           10.0            7.0            4.9           10.0        13.9          8.5      12.7     14.9      10.4
Cipla                     6.4            8.3           15.7            0.1            3.2         2.2          5.2      -0.7      -7.6      -3.8
Mankind                   5.4           22.2           27.3           21.4           24.8        19.4         13.2      14.2     17.0       9.2
Lupin                     3.1            7.8            5.9            4.8            5.9         5.9          6.4      -0.3      3.5       -4.2
Glenmark                  1.5           10.5            6.8            4.3            9.0        15.1         -2.6      -0.8      11.8      1.1
Zydus Cadila              1.2           -6.5            1.2           -7.4          -13.7       -18.4      -15.8        -2.5      -7.0      -8.9
Dr. Reddys                1.1            6.7            7.4            8.3           21.3         9.9          6.2      -7.3      -1.6      -6.7

Total AI                96.3            12.0           11.6            9.0           11.8         9.9          9.3       8.6      9.6       8.0
Source: AIOCD AWACS, Emkay Research

                                               Most of the companies in Anti infective category barring Ranbaxy have been erratic in their
                                               growth. Ranbaxy, the largest company in category, grew in line with the industry, on the
                                               back of higher volumes (driven by increse in field force and new launches). Industry
                                               growth is mainly driven by unlisted players like Mankind and Alkem - evident from top 10
                                               brand performance in this catagory.




Emkay Research            26 September, 2011                                                                                                       20
Pharma Sector


Top brands in anti-infective                                                                                                            in Rs bn
Brand             Company Name           MAT Value         MAT Value          YoY Gr.               YTD           YTD             YoY Gr.
                                           June 11           June 10             (%)             June 11       June 10               (%)
Monocef           Aristo Pharma                  1.9                   1.6        15.5               0.5               0.4                7.6
Augmentin         GSK                            1.8                   1.7         5.4               0.4               0.4               11.4
Taxim O           Alkem Lab                      1.5                   1.2        19.2               0.4               0.3               18.1
Taxim             Alkem Lab                      1.5                   1.3        12.5               0.4               0.3                1.9
Zifi              FDC                            1.3                   1.3         6.2               0.3               0.3                4.5
Clavam            Alkem Lab                      1.2                   1.0        24.9               0.3               0.2               29.5
Mox               Ranbaxy Lab                    1.2                   1.2        -0.3               0.2               0.2               -4.7
Mikacin           Aristo Pharma                  1.1                   1.0        10.9               0.3               0.3               -7.3
Ceftum            GSK                            1.0                   1.0         9.5               0.3               0.2               12.8
Moxikind CV       Mankind Pharma                 1.0                   0.8        20.9               0.2               0.2               20.5
Total                                           96.3                85.9          12.0              22.3              20.3                9.7

Top brands of Mankind – Strategic pricing has led to intense competition
                                                                             Other Indian Company Brands
Brand             Therapy          Pricing               Company              Brand Name             Pricing                 Pack
Moxikind CV       Anti-Infective   Rs114                 Ranbaxy              Moxclav                Rs403                   10 tablets
                                   6 tablets             Aristo               Mega CV                Rs99                    6 tablets
                                                         Cipla                Novaclav               Rs240                   6 tablets
                                                         Abbott               Nuclav Duo             Rs206                   6 tablets
Bandy Plus        Anti Parasitic   Rs6                   Zydus                Biwom                  Rs11                    1 tablet
                                   1 tablet              Lupin                Lupibend               Rs12                    1 tablet
                                                         Ipca                 Nemozole               Rs12                    1 tablet
                                                         Dr. Reddy’s          Rediout                Rs35                    5 tablets
Unwanted Kit      Gynaec           Rs335                 Cipla                MT Pill                Rs331                   1 tablet
                                   1 tablet              Zydus                Mifegest               Rs370                   10 tablets
                                                         FDC                  Undo                   Rs367                   3 tablets
Nurokind Plus     Vitamins         Rs36                  Lupin                Matilda Forte          Rs103                   10 Capsules
                                   6 Capsules            Zuventus             Mecovon                Rs90                    10 Capsules
Manforce          Stimulants       Rs142                 Ranbaxy              Caverta                Rs173                   4 tablets
                                   4 tablets             Lupin                Enthusia               Rs108                   4 tablets
                                                         Zydus                Penegra                Rs124                   4 tablets
                                                         Cipla                Progra                 Rs108                   4 tablets


                                       Mankind has been pricing its products at relatively lower rates as compared to other
                                       pharma companies in India. Mankind is particularly strong in commoditized therapies
                                       such as the anti-infectives, gynaecology and gastro which together contribute more than
                                       50% of the domestic revenues.

                                       Mankind Pharma - Therapy-wise Revenue breakup
                                       Rs bn                         FY11                MAT                  MAT                        YoY
                                                                  % Contr.              Jul’11               Jul’10                       Gr.
                                       Anti-infectives              29.0%                 5.4                   4.5                 19.4%
                                       Gastro                       13.1%                 2.4                   2.0                 23.3%
                                       Gynaecology                  10.2%                 1.9                   1.4                 30.8%
                                       Vitamins                      7.8%                 1.4                   1.1                 26.9%
                                       Stimulants                    6.9%                 1.3                   1.1                 15.6%
                                       CVS                           5.8%                 1.1                   0.8                 28.4%
                                       Pain                          5.0%                 0.9                   0.8                 17.8%
                                       Anti-Diabetic                 3.3%                 0.6                   0.4                 37.5%
                                       CNS                           2.8%                 0.5                   0.4                 22.2%
                                       Others                       99.2%                18.4                  14.6                 25.7%
                                       Acute                        86.4%                16.0                  12.8                 24.7%
                                       Chronic                      13.6%                 2.5                   1.9                 32.0%
                                       Total Sales                 100.0%                18.5                  14.7                 25.7%
                                       Source: AIOCD AWACS, Emkay Research



Emkay Research       26 September, 2011                                                                                                         21
Pharma Sector


                                  National List of Essential Medicines

                                  What is NLEM?
                                  Essential medicines are those that satisfy the priority healthcare needs of majority of the
                                  population. The essential medicines list needs to be country specific addressing the
                                  disease burden of the nation and the commonly used medicines at primary, secondary
                                  and tertiary healthcare levels.

                                  The medicines in National List of Essential Medicines (NLEM) should be available at
                                  affordable costs and with assured quality. The medicines used in the various national
                                  health programs, emerging and re-emerging infections should be addressed in the list.
                                  The Government of India, Ministry of Health & Family Welfare (MOHFW) is mandated to
                                  ensure quality healthcare by assuring availability of safe and efficacious medicines for
                                  its population.

                                  In a move that could bring more than half the country’s Rs 65,000-crore medicine market
                                  under price control, the health ministry plans to enlarge the scope and size of the
                                  National List of Essential Medicines (NLEM).

                                  Following a Supreme Court directive to include all NLEM drugs under price control, the
                                  central government is working out a new policy incorporating such changes. While the
                                  current NLEM list, prepared in 2003, does not have too many drugs to be included in the
                                  price control list, the revision will bring about a significant change.

                                  According to rough estimate, the government currently controls the prices of about 20
                                  per cent of the domestic drug market. The span of price control will go up to 35 per cent
                                  once the drugs mentioned in the current NLEM gets included.


                                  Main features of NLEM 2011
                                  The medicines have been categorized according to therapeutic area. Therefore, it is
                                  possible that a medicine with more than one indication appears in more than one
                                  category.The issue of mentioning the strength of the medicine dose was deliberated. The
                                  committee took the considered view that the strength should be mentioned in the NLEM.

                                  For essentiality of requirement the medicines have been categorized as follows:

                                  - P, S and T denote essentiality at Primary, Secondary and Tertiary levels respectively
                                  while P, S, T (U in NLEM 2003) indicates essentiality at all the levels.

                                  A total of 348 medicines (excluding repetitions) are present in NLEM 2011.

                                  In the NLEM 2011, 181 medicines fall under the category of P, S and T, 106 medicines fall
                                  under the category of S, T while 61 medicines are categorized as T only.

                                  In comparison to NLEM 2003, number of medicines deleted is 47 and 43 medicines
                                  have been added




Emkay Research   26 September, 2011                                                                                       22
Pharma Sector


Recently 43 new medicines added to NLEM List

Medicines                           Cadila   Cipla   Dr. Reddy   Glenmark   Ipca   Lupin Ranbaxy   Sun Torrent Unichem GSK

Amoxicillin+Clavulinic Acid

Atorvastatin
Betamethasone

Carboplatin

Cefixime
Cetrizen

Chlorambucil

Clindamycin
Clopidogrel

Decarbazine

Daunorubicin
Diazepam

Enoxaparin

Famotidine
Fentanyl

Filgrastim

Hydroxychloroquine phosphate
Ifosfamide

Imatinib
Ipratropium bromide

Leflunomide

Lorazepam
Mefloquine

Mesna

Misoprostol
N-acetylysteine

Olanzapine

Oxaliplatin
Pantaprazole

Permethrin

Piperazine
Premix Insulin 30/70 Inj

Propofol

Stavudine+Lamivudine
Tramadol

Vecuronium

Zidovudine+Lamivudine
+Nevirapine

Total                                 15        14      6           4        2      10      5       7     6        4      6
Source: Emkay Research




Emkay Research             26 September, 2011                                                                            23
Pharma Sector


                                  NLEM Impact Analysis

                                  Category: Oncology
                                  Medicines Added: Imatinib mesylate
                                  Companies Impacted:

                                  The medicines that would be enlisted in the revised NLEM include costly blood cancer
                                  drug, imatinib mesylate, sold by Swiss multinational Novartis under the brand name
                                  Glivec. Other medicines in the list are carboplatin, daunorubicin, filgrastim, ifosfamide,
                                  mesna, oxaliplatin and clorambucil, manufactured by leading companies such as Bristol
                                  Myers Squibb, GlaxoSmithKline, Amgen, Dr Reddys, Intas and Sun Pharma. All the cancer
                                  medicines in the current NLEM list, which was prepared in 2003, have been retained

                                  Category: Anti-Infective
                                  Medicines Added: Amoxicillin + Clavulanic Acid and Cefixime
                                  Companies Impacted:

                                  Amoxicillin + Clavulanic Acid – Augmentin, Clavam and Moxikind are the top 10 brands
                                  in the anti-infective category. These brands are owned by GSK, Alkem and Mankind Pharma
                                  respectively. These 3 brands collectively contribute ~30% of the top 10 brand sales and
                                  ~4% to the anti-infective category.

                                  Cefixime – Companies impacted are Alkem (Brand – Taxim) and FDC (Brand – Zifi) which
                                  contribute ~32% to the top 10 brands and ~4% to the anti-infective category.

                                  Category: Cardiovascular
                                  Medicines Added: Atorvastatin
                                  Companies Impacted:
                                  Atorvastatin – Atorva and Strovas are the two brands owned by Cadila and Ranbaxy
                                  Labs. These 2 brands contribute 3% to the Indian pharma CVS category and 27% of the
                                  top 10 brands in the category.

                                  Category: Hormones
                                  Medicines Added: Betamethasone
                                  Companies Impacted: GSK Pharma

                                  Betnesol - N – This is a GSK Pharma product which, falls in the top 10 brands in the
                                  Hormones category. It contributes 9% to the IPM and 16% to the top 10 category.

                                  Category: CVS
                                  Medicines Added: Enoxaparin
                                  Companies Impacted: Lupin
                                  Lupenox – Among our coverage companies, Lupin is the only company having a drug in
                                  this category. Other notable companies are Sanofi Aventis and Biocon.

                                  Category: Gastrointestinal
                                  Medicines Added: Famotidine
                                  Companies Impacted:

                                  Most of the top Indian companies like Alkem, Sun Pharma, Cadila and Torrent Pharma
                                  have an established presence in the gastro segment.




Emkay Research   26 September, 2011                                                                                      24
Pharma Sector




                                      Indian Pharma growth slowing down

                                      4 Step Stress Test

Impact of challanges                  Revision of estimates for domestic growth

                                      Significance of domestic business - Cash Cow

                                      Conclusion and Recommendation




Emkay Research   26 September, 2011                                                   25
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Pharma sector analysis_reprot_-_sample

  • 1. PHARMA SECTOR September, 2011 Domestic • Growth in domestic pharma industry to slow down to 12-13% in 2011 due to weak macro factors and increase in competition from unlisted players and MNC pharma companies • Cut down the domestic growth estimates by 3-7% and earnings estimates by 2-9% for FY12 for Cipla, Cadila, Dr. Reddy, IPCA and WARNING Torrent . • Buy - Glenmark, IPCA Accumulate - Sun Pharma, Lupin Hold - Ranbaxy, Cipla, Dr. Reddy, Cadila, Torrent and Unichem CHALLENGES Deepak Malik AHEAD Senior Research Analyst deepak.malik@emkayglobal.com +91 22 66121257 Ashish Thavkar Research Associate ashish.thavkar@emkayglobal.com +91 22 66121254 Bhavita Nagrani Research Associate bhavita.nagarani@emkayglobal.com +91 22 66242486
  • 2. Pharma Sector Contents Pharma Sector Synopsis ......................................................................................................................................................................... 3 Valuation ......................................................................................................................................................................... 4 Domestic Formulations ................................................................................................................................................... 6 Domestic Formulations: Taking a breather .................................................................................................................. 7 Performance of Top Pharma companies ..................................................................................................................... 9 Company specific issues - What management has to say? ..................................................................................... 10 Pharma Industry : Recent Trends ............................................................................................................................. 11 Key Factors Driving The Slowdown ................................................................................................................................ 12 Weakening macro factors to impact Indian Pharma growth ................................................................................. 13 Increase in competition has led to ramp-up of sales force ................................................................................... 14 MNCs getting aggressive .................................................................................................................................... 15 Pricing pressure on top brands ............................................................................................................................ 18 Anti-Infective Category – Therapy bifurcation ....................................................................................................... 20 National List of Essential Medicines .............................................................................................................................. 22 Impact of challanges ..................................................................................................................................................... 25 Indian Pharma growth slowing down .................................................................................................................... 26 Stress-Test on the profile of pharma companies .................................................................................................. 28 Rivision of estimates for domestic growth ............................................................................................................ 32 Significance of domestic business - Cash Cow ................................................................................................... 33 Revise in earnings estimates ............................................................................................................................... 34 Conclusion and Recommendation ....................................................................................................................... 35 Companies Cadila Healthcare .......................................................................................................................................................... 37 Cipla Ltd ....................................................................................................................................................................... 41 Dr. Reddy's Lab ............................................................................................................................................................. 45 Glenmark Pharma ......................................................................................................................................................... 49 GlaxoSmithKline Pharma .............................................................................................................................................. 53 Ipca Laboratories Ltd ..................................................................................................................................................... 56 Lupin Ltd. ...................................................................................................................................................................... 60 Pfizer Ltd ...................................................................................................................................................................... 64 Ranbaxy Labs ............................................................................................................................................................... 67 Sun Pharma .................................................................................................................................................................. 71 Torrent Pharma .............................................................................................................................................................. 76 Unichem Labs ............................................................................................................................................................... 80 Emkay Research 26 September, 2011 2
  • 3. Pharma Sector Synopsis Last year, Indian Pharma industry grew by 16%, one of the highest growth rates in the world Pharma market. In the first two quarters Indian Pharma market growth has slowed Growth in domestic down to 13% from 16% in 2010. Domestic Indian companies are the ones which are pharma industry to impacted most by this slowdown in growth. slow down to 12-13% in 2011 due to weak In our report, "Domestic Pharma market", we have diagnose the challenges faced by macro factors and the Indian Pharma market, which was valued at USD 12 billion in 2010 and tried to increase in competition answer the following questions. from unlisted players What are the reasons for decline in the growth rate of Indian Pharma industry in and MNCs the first half of 2011? What is the impact of these factors on different pharma companies? Find out which company will outperform the industry growth rate? Our analysis shows that there is a high degree of correlation between macro factors, economic growth and Indian pharma industry growth. When the pace of economic reforms and economic growth slows down it impacts the pharma industry growth. Other reason was, every company has increased the strength of MRs in last two years and as a result there was a spurt of growth last year which is tapering down this year. Impact of slowdown in growth is more pronounced in mid and small cap companies and the companies which have more exposure in GP therapies, which is more susceptible to competition. Competition is increasing from low cost players like Mankind & Alkem labs in the mass product therapies like anti-infective. MNCs which were focused more on acute categories till now are increasingly launching products in chronic space & that too at competitive prices. To analyse the impact of these challenges on pharma companies’ domestic portfolio, we have devised the “4 Step Stress Test “ to find out how various companies will get impacted. Even though domestic business is only 20%-50% of the overall revenues, its contribution to the base business earnings is higher at 50%- 70%. ROCE of domestic business is much higher at 40%-60% compared to other businesses which have less than 20% and as a result multiples are mainly driven by domestic business. Our analysis suggests that Cut down the domestic any change in the domestic revenue has an amplified impact on the earnings and multiples growth estimates by 3-7% of the companies. and earnings estimates Pharma Companies which are mainly focused on domestic business will be the one by 2-9% for FY12 for which will get impacted the most like - Cipla, Torrent, IPCA and Unichem. Other pharma Cipla, Cadila, Dr. Reddy, companies which have sizeable opportunities in form of Para IVs and FTF in US will able IPCA and Torrent to cushion the impact like Ranbaxy and Dr. Reddy. Sun and Lupin have superior portfolio in domestic business with more focus on Chronic category and good opportunities in form of Para IV and FTFs. We have cut down the domestic growth estimates for Cadila, Cipla, Dr. Reddy, IPCA, Torrent and Unichem for FY12 and FY13 by 3% to 7% and earnings growth estimates by 2% to 9% & retained the growth and earnings estimates for Lupin, Ranbaxy, Sun, GSK and Pfizer. Buy - Glenmark and IPCA Accumulate – Lupin and Sun Pharma Hold - Cadila, Cipla, Dr. Reddy, Ranbaxy, Torrent and Unichem Emkay Research 26 September, 2011 3
  • 4. Emkay Research Valuations Mcap EPS PE(x) EV/ EBITDA (x) ROCE (%) ROE (%) P/BV 26 September, 2011 Company Name Rating (Rs bn) FY11 FY12e FY13e FY11 FY12e FY13e FY11 FY12e FY13e FY11 FY12e FY13e FY11 FY12e FY13e FY11 FY12e FY13e Cadila Healthcare Hold 165 33 36 45 25 22 18 17 15 12 29 29 31 39 31 30 7 6 5 Cipla Hold 228 12 14 18 24 20 16 17 15 12 17 18 20 16 16 17 3 3 3 Dr. Reddy's Lab Hold 252 73 69 91 20 21 16 16 14 11 24 21 25 31 25 26 6 5 4 Glenmark Pharma Buy 87 17 24 24 19 13 14 18 10 10 11 20 18 21 28 22 4 3 3 Lupin Acc 212 19 22 26 25 22 19 19 15 13 24 25 25 30 27 25 6 5 4 Ranbaxy Labs Hold 200 25 31 41 19 15 12 15 10 8 17 18 22 35 21 22 4 3 2 Panacea Biotech Hold 8 22 15 12 6 8 11 6 7 7 14 10 9 20 13 10 1 1 1 Sun Pharma Acc 482 18 22 27 26 22 17 23 18 14 22 22 23 22 23 24 5 4 4 Torrent Pharma Hold 49 30 36 44 19 16 13 14 12 10 21 23 26 29 30 31 5 4 4 Unichem Labs Hold 13 11 9 13 14 16 11 9 10 7 20 15 19 16 13 17 2 2 2 IPCA Buy 34 18 22 28 15 12 10 11 9 7 21 21 23 24 24 24 3 3 2 Pfizer Acc 40 58 66 79 23 20 17 13 15 12 17 18 19 16 16 17 3 3 3 Glaxo Hold 170 68 78 86 29 26 23 17 15 13 47 48 50 30 32 34 9 8 8 Generics 149.2 31.0 34.2 41.1 20.3 18.0 15.0 15.0 12.7 10.5 21.8 22.2 23.8 25.2 22.9 23.0 4.6 3.9 3.3 Jubilant Life Sciences Buy 32 17 18 25 12 11 8 12 9 7 7 9 11 10 13 17 1 1 1 Divi's Lab Buy 96 32 38 46 22 19 16 19 15 12 27 29 30 26 25 25 5 4 4 Aurobindo Pharma Buy 39 18 18 23 7 7 6 9 7 6 18 16 18 24 21 24 2 2 1 Dishman Pharma Acc 5 5 8 10 11 8 6 8 7 6 5 6 7 10 7 8 1 1 1 CRAMS 42.8 18.2 20.4 26.0 13.2 11.4 9.0 11.9 9.6 7.8 14.5 15.2 16.5 17.5 16.6 18.3 2.2 2.0 1.6 Pharmaceuticals 96.0 28.0 31.0 37.5 18.6 16.4 13.6 14.2 11.9 9.9 20.1 20.6 22.1 23.4 21.4 21.9 4.0 3.4 2.9 Pharma Sector Source: Emkay Research 4
  • 5. Emkay Research Valuations Mcap Sales (Rs mn) EBITDA (Rs mn) EBITDA Margin (%) PAT (Rs mn) PAT Margin (%) 26 September, 2011 Company Name (Rs bn) FY10 FY11e FY12e FY10 FY11e FY12e FY11 FY12e FY13e FY11 FY12e FY13e FY11 FY12e FY13e FY11 FY12e FY13e FY11 FY12e FY13e Cadila Healthcare 165 45,925 51,563 60,618 9,885 11,495 13,581 21.5 22.3 22.4 6,733 7,452 9,159 14.7 14.5 15.1 Cipla 228 63,180 71,863 83,325 13,375 15,444 18,765 21.2 21.5 22.5 9,692 11,395 14,169 15.3 15.9 17.0 Dr. Reddy's Lab 252 76,558 86,552 97,044 17,121 18,008 22,407 22.4 20.8 23.1 12,314 11,695 15,374 16.1 13.5 15.8 Glenmark Pharma 87 29,491 36,475 39,323 5,923 9,520 9,437 20.1 26.1 24.0 4,532 6,477 6,413 15.4 17.8 16.3 Lupin 212 58,320 67,682 82,022 12,000 13,322 16,680 20.6 19.7 20.3 8,625 9,825 11,435 14.8 14.5 13.9 Ranbaxy Labs 200 85,355 97,660 118,963 14,136 18,602 24,310 16.6 19.0 20.4 10,347 13,147 17,206 12.1 13.5 14.5 Panacea Biotech 8 11,702 10,802 9,777 2,765 2,419 2,233 23.6 22.4 22.8 1,327 939 741 11.3 8.7 7.6 Sun Pharma 482 57,214 73,135 88,099 19,890 25,204 32,364 34.8 34.5 36.7 18,386 22,365 28,250 32.1 30.6 32.1 Torrent Pharma 49 21,825 24,201 28,242 3,652 4,470 5,352 16.7 18.5 19.0 2,536 3,051 3,738 11.6 12.6 13.2 Unichem Labs 13 8,240 9,322 10,846 1,500 1,403 1,915 18.2 15.1 17.7 951 817 1,210 11.5 8.8 11.2 IPCA 34 18,825 21,506 25,567 3,598 4,276 5,336 19.1 19.9 20.9 2,294 2,760 3,489 12.2 12.8 13.6 Pfizer 40 12,446 10,642 12,345 2,589 2,299 2,728 20.8 21.6 22.1 2,294 1,974 2,349 18.4 18.6 19.0 Glaxo 170 21,511 24,229 27,080 8,893 9,987 11,254 41.3 41.2 41.6 5,783 6,566 7,406 26.9 27.1 27.3 Generics 149.2 39,276 45,049 52,558 8,871 10,496 12,797 22.8 23.3 24.1 6,601 7,574 9,303 16.3 16.1 16.7 Jubilant Life Sciences 32 34,420 38,505 46,325 5,541 7,368 8,919 16.1 19.1 19.3 2,711 2,810 3,967 7.9 7.3 8.6 Divi's Lab 96 13,181 16,087 19,284 5,025 6,200 7,620 38.1 38.5 39.5 4,293 4,976 6,145 32.6 30.9 31.9 Aurobindo Pharma 39 41,257 47,741 57,047 7,040 8,179 10,263 17.1 17.1 18.0 5,185 5,364 6,725 12.6 11.2 11.8 Dishman Pharma 5 9,908 10,777 11,772 1,622 1,951 2,190 16.4 18.1 18.6 437 648 774 4.4 6.0 6.6 CRAMS 42.8 24,692 28,278 33,607 4,807 5,925 7,248 21.9 23.2 23.8 3,156 3,450 4,403 14.4 13.9 14.7 Pharmaceuticals 96.0 35,845 41,103 48,099 7,915 9,420 11,491 22.6 23.3 24.1 5,791 6,604 8,150 15.9 15.5 16.2 Pharma Sector Source: Emkay Research 5
  • 6. Pharma Sector Domestic Formulations: Taking a breather Performance of Top Pharma companies Domestic Formulations Company specific issues - What management has to say? Pharma Industry : Recent Trends Emkay Research 26 September, 2011 6
  • 7. Pharma Sector Domestic Formulations: Taking a breather Indian pharma market (IPM), which had grown by 16% in 2010 has slowed down to 13.5% in the first half of 2011. This is as per AIOCD data, which is collected from secondary sources. However, if we see the performance of most of the pharma companies in the domestic space in the first half of 2011, then everybody has shown considerable decline growth. Primary data shows that the decline is much steeper. Most of the pharma IPM growth showing downward trend in the recent months companies have shown considerable 20.0 decline in growth in first 16.2 14.9 14.2 15.0 14.5 16.0 13.9 13.5 half of 2011 12.0 10.4 8.0 4.0 0.0 2006 2007 2008 2009 2010 MAT Q - Mar'11 Q - Jun'11 Jul'11 Source: AIOCD AWACS, Emkay Research Therapy-wise growth trend FY10 Q-Mar'11 Q-Jun'11 Chronic 19.2 16.0 16.4 Acute 14.9 12.9 12.2 Overall 16.2 13.9 13.5 Source:Company, Emkay Research Slowdown in growth is visible across the Chronic and Acute categories even though the reasons are different for both the categories. In Acute segment, the therapies which are more commoditized in nature have seen Acute segment - The increased competition and price pressures, whereas in Chronic segment, it has been therapies which are more more due to macro economic factors. In the last 2 years everybody has increased its MR commoditized in nature strength and as a result, there is an increase in competition which is now taking its toll. have seen increased MNC pharma companies are expanding very aggressively in India and have very high competition and price aspirations for their Indian businesses. They are rapidly expanding their field force to pressures, whereas in extend their geographical reach. MNCs which have strong foothold in acute therapies, are Chronic segment, it was now aggressively moving into chronic therapies. In some of the products which are not more due to macro core to their business, they are entering with extremely competitive pricing versus Indian economic factors companies. All these factors together with weak macro economic outlook is adding to the slowdown in growth. Emkay Research 26 September, 2011 7
  • 8. Pharma Sector Top 10 categories growth rate Rs Cr % Share YoY Growth (%) MAT' Jul'11 MAT'Jul 11 MAT'Jun 11 Jan'11 Feb'11 Mar' 11 Apr'11 May'11 Jun'11 M-Ju1'11 Anti Diabetic 3358 6% 22.0 21.6 19.3 22.4 25.2 24.2 22.1 17.4 Anti-Infectives 9681 17% 11.3 11.8 9.9 9.3 8.6 9.6 8.0 5.8 Cardiac 6597 12% 18.2 17.1 17.2 17.4 17.6 19.3 17.5 14.6 Derma 2813 5% 13.1 12.7 12.0 11.2 13.2 12.0 11.9 9.2 Gastro intestinal 6563 12% 13.8 12.5 11.7 11.9 12.1 12.8 7.9 5.2 Gynaecological 3538 6% 15.8 12.3 13.2 11.8 9.6 10.8 8.5 10.6 Neuro / CNS 3463 6% 14.2 14.3 13.3 12.3 13.6 14.8 12.1 9.5 Pain / Analgesics 4488 8% 14.1 19.8 11.1 6.7 10.9 13.6 12.2 7.6 Respiratory 4469 8% 11.4 14.7 10.2 12.7 12.2 13.8 7.6 6.3 Vitamins / Minerals 4678 8% 13.9 13.7 12.3 10.2 12.1 13.1 12.4 11.5 Total 56483 14.5 14.7 13.0 12.4 12.8 14.3 12.1 9.6 Source: AIOCD AWACS, Emkay Research If we evaluate the performance of the Indian pharma companies w.r.t different therapies, then anti-infective, pain, gynecology and gastro, show visible slowdown in growth. Anti- infective, pain and gastro which together contribute ~1/3rd of the total pharma market, are Anti-infective, pain, witnessing lot of competition from un-listed Indian companies such as Mankind. MNCs, gynecology and gastro which have strong hold in these categories, are now moving aggressively towards chronic show visible slowdown therapies, due to superior growth rate and higher entry barriers associated with this in growth category. Emkay Research 26 September, 2011 8
  • 9. Pharma Sector Performance of top pharma companies Performance of top pharma companies Mankind 24% 22% Astra 34% 22% Pfizer 11% 14% Grow th in Q4'11 & Q1'12 Aventis 13% 12% YoY Grow th % GSK 11% 13% Torrent 9% 9% Ipca 5% 12% Dr. Reddy 5% 6% Lupin 37% 17% Glenmark 21% 20% Sun 15% 12% Ranbaxy 11% 8% Cadila 23% 8% Cipla 15% 10% Q4FY11 Q1FY12 Source: Emkay Research From the corporate performance of Indian Pharma companies in last two quarters, mid & small cap companies, have been the most impacted. MNC pharma companies continue to grow in line with industry growth of ~13%, except Astra which has grown by more than 20%. These MNCs are aggressively investing in branded generics and moving into newer therapies like CVS, CNS and anti diabetes. In a bid to increase their presence in some of the branded generics, MNCs have aggressively priced their products below their Indian counterparts. While this has not significantly dented market share, it is a precursor to the competitive intensity in the future. In small and mid cap companies - Unichem, IPCA and Torrent are the ones which have been impacted the most. And in large cap companies - Dr. Reddys, Ranbaxy & Cipla have been impacted. For the last 3-4 years barring 2009, most of these companies were growing above or in-line with the market growth on back of strong macro environment. Now unfavorable macro enviroment coupled with intense competition from unlisted players in some therapies of acute segment has made the market even more competitive. Emkay Research 26 September, 2011 9
  • 10. Pharma Sector Company specific issues - What management has to say? Cadila Pfizer Sales in Q1FY12 were lower as the company pushed inventory Above industry growth was led by volume increase (11% growth) into the market in Q4FY11 (registered YoY growth of 23%) in and price increase (3% growth). Although the anti-infective order to achieve US$1bn revenue target. segment witnessed 12.5% growth on account of 3 new launches viz. Getex, Getex Suspension and Cefixime, management has Cipla admitted to increased competition in the anti-infectives and Growth was below industry rate as the Acute segment the Vitamins/ Minerals segment. witnessed intense competition from industry peers during the quarter. Respiratory segment continues to do well for the Ranbaxy company. India business (contributed 20%) grew below industry rate at 6% YoY, mainly led by anti-infective and gastro segment, which Dr. Reddys witnessed lower traction due to increased competition from its India business which contributed 15%, grew at a lower rate of peers. 6% compared to industry rate of 14% due to ongoing issues of DCGI on the company's top selling pain brand Nise Sun Pharma (nimusulide). Domestic branded formulations grew 12% YoY due to discontinuation of third party sales and netting of VAT. Adjusting Glenmark for third-party sales, domestic revenues grew by 18% YoY. India revenues grew 20% YoY led by market share gains in key therapies of anti-infectives, cardiac, respiratory, diabetes and Torrent dermatology & 2 new product launches i.e. Doriglen and Vorth The chronic portfolio, which contributes 60% of domestic TP in orthopedic segment. Management has guided for portfolio reported strong growth of 17-18% during Q1FY12. increased competitive pressures from unlisted players. As a However, acute therapy almost remained flat due to increased result, growth going ahead is expected to be in the range of 16- competition mainly in anti-infective and pain segments. 17%. Unichem Ipca Unichem has initiated inventory rationalization at the distributor Lower growth was mainly due to decline in Anti bacterial (down level in order to improve internal processes and reduce inventory 13%) and Cardiac segment (up 6%). Regrouping of sales rep by 21-30 days. This has led to 5% YoY decline in domestic and brands and high attrition rate also impacted growth. formulation revenues in Q1FY12. Among the company's top 10 brands, 6 brands reported negative YoY growth. Management Lupin admits to increased competitive pressures from local as well 17% growth was on account of new product launches and as MNC players. improved performance from the company's chronic portfolio. Emkay Research 26 September, 2011 10
  • 11. Pharma Sector Pharma Industry : Recent trends Key trends Increase in Geographical Shifting disease Acquisition by Strategic tie-ups MR strength expansion profile MNCs Indian companies are Expanding their All companies, including Increasing prosperity & Acquisitions by MNCs to entering in to strategic presence in rural MNCs, have increased changing lifestyle - gain quick foothold in tie-ups with MNCs to markets (67% of the their field force in the propelling higher growth the fastest growing strengthen their product total population) last one year in the chronic segment Indian pharma market portfolio Source: Emkay Research Sun - Merck JV Lupin -Lilly Sun and Merck have formed a JV to develop, manufacture and Eli Lilly India and Lupin have entered into a strategic commercialize new combinations and formulations of collaboration to promote and distribute Lilly's Huminsulin innovative, branded generics in the Emerging Markets. The range of products. Lupin will promote and distribute the range partnership will use Sun Pharma Advanced Research of products in India and Nepal and will double the number of Company Ltd's proprietary platform technologies, and Sun sales representatives behind the diabetes care product. Pharma's world-class manufacturing network. Merck will use its clinical development and registration expertise to commercialize the products. Under the JV, Sitagliptin and Sitagliptin + Metformin have already been commercialized in the Indian markets. Cadila - Bayer JV Biocon - Pfizer Cadila and Bayer have formed a JV to distribute medicine in Biocon and Pfizer have entered into a strategic collaboration the Indian market. About 600 employees from both companies to commercialize Biocon's bio-similar version of Insulin and will work for the venture. The venture will sell brands from Insulin analogue products such as recombinant human both companies, such as Bayer's blood thinner Xarelto and insulin, Glargine, Aspart and Lispro. Pfizer will have the Cadila's Euglim for diabetes exclusive rights to commercialize these products globally including co-exclusive rights with Biocon in Germany, India and Malayasia. Universal Medicines- Aventis Sanofi Aventis has acquired Universal Medicines for over US$100mn. This acquisition is in-line with Sanofi-Aventis global strategy to expand its foot-print in the Emerging Markets. Universal Medicare manufactures markets and distributes branded nutraceutical formulations in India, including its popular cod liver oil capsules. This will help Sanofi to boost its over-the-counter business in India. Emkay Research 26 September, 2011 11
  • 12. Pharma Sector Weakening macro factors Increase in competition Key Factors driving MNC's getting aggressive the slowdown Competition from unlisted players Pricing pressure in anti-infectives National List of Essential Medicines - Future impact analysis Emkay Research 26 September, 2011 12
  • 13. Pharma Sector Weakening macro factors impacting Indian pharma growth IPM has a strong correlation with India GDP growth 10.0% 9.8% 9.5% 15.0% 16.2% 16.0% 9.0% 14.9% 12.6% 14.0% 14.2% 8.9% With rising interest rate, 10.4% 12.0% 7.6% the Indian economy is 8.0% 10.0% slowing down, resulting in 7.4% 7.0% 7.2% slower growth in Indian 8.0% pharma also 6.0% 6.0% 2006 2007 2008 2009 2010 2011 * GDP Gr % (LHS) IPM Gr % (RHS) * Project numbers based on historic GDP average and Emkay Economics Rise in disposable income and favorable income demographies are the major catalyst responsible for the growth of the Indian pharma industry. Within this, increase in disposable income is a larger contributor (approx. 40%). However, with rise in interest rate scenario, the Indian economy is slowing down and is expected to grow by 7.6% during 2011 as compared to 8.9% in 2010. Home loan EMIs are going up, salary growth has slowed down; as a consequence, the disposable income has also got impacted resulting in slowing the pace of the Indian pharma industry. According to Mckinsey report on Indian Pharma, rise in disposable income and upward shift in income demographies account for 40% of the Indian pharma market growth, as depicted below. IPM growth largely driven by rise in income levels 15% Rise in interest rates have impacted disposable 40% 10% income, which is the largest 15% growth driver of the Indian 20% pharma industry Others Increase in prevalence Insurance penetration Medical Infrastructure Income Grow th Source: Mckinsey Report on Indian Pharma With increase in interest rate, the capital expenditure for new medical infrastructure will also slow down as it is a capital intensive segment. Growth in insurance penetration will also slow down resulting in overall slow down in the growth of Indian Pharma. Emkay Research 26 September, 2011 13
  • 14. Pharma Sector Increase in competition has led to ramp-up of sales force Pharma companies have ramped up their field force... 7500 4.8 Marketing Representatives Grow th Sales per MR Rates in % in numbers (at top of bar) 6000 1 21% . 4 4 3 4500 14% . . 2 Sales Forcce Numbers 13% 12% 47% 6 8 4 3000 3 7% 23% 4% 32% 1500 10% 8% 38% 36% 56% 26% 24% 4% 4% 5% 11% 0 Cipla Ipca Cadila Ranbaxy Lupin Torrent GSK Sun DRL Glen FY10 FY11 ...leading to pharma companies clocking good growth 30000 28 Domestic Revenues in Rs bn Grow th in domestic revenues in % 25000 24 Domestic Sales 14% 19 19 20000 16 16 17% 15000 12 20% 14% 8% 15% 8 8 10000 7 15% 10% 16% 15% 15% 12% 5000 14% 18% 10% 25% 11% 17% 20% 18% 0 Cipla Ipca Cadila Ranbaxy Lupin Torrent GSK Sun DRL Glen FY10 FY11 Some of the initiatives adopted by the Indian pharma companies in the domestic business – Pfizer Ranbaxy The company has launched two new The company launched Project Viraat divisions CNS and Diabetes and has in order to ramp up its presence across added 300 people across two the country, especially in rural areas. divisions. The company plans to launch This included introduction of new insulin products from Biocon’s portfolio products, increasing its field force and in the next quarter. This will help the targeting more than 350,000 doctors. company focus on branded generics and fill portfolio gaps. During the past 2 years, most of the Indian pharma companies have resorted to strong addition of MRs in order to give a boost to its domestic business. For e.g. Ipca Labs has added around 1,800 MRs to its force taking the total to 5,000 MRs, which is one of the highest in the industry. As a result, its domestic formulation business grew by 21% CAGR over FY09-11 to Rs7bn. Similarly, Cadila added around 1,550 MRs to its field force taking the total to 4,500 MRs by end of FY11, resulting in its domestic formulations business growing by 17% CAGR to Rs22bn. In contrast, dispite a meagre addition of just 200 MRs (taking its field force to 2,700) in last 2 years buy Sun pharma, its domestic formulation business has grown by 16% CAGR to Rs24bn. Going ahead, we believe all the domestic companies who have strengthed the field force to spurt up the growth will eventually witness a slowdown in domestic growth rates. In order to sustain higher growth rates of 15-16%, companies will have to increasingly focus on improving MR productivity by expanding to new therapies, newer markets and new launches. Companies like Sun pharma and Lupin with strong brand equity are likely to outperform. Emkay Research 26 September, 2011 14
  • 15. Pharma Sector MNCs getting aggressive MNC pharma companies continue to growing in line with industry growth of ~13% except AstraZeneca which has grown by more than 20%. Major chunk of the portfolio of these MNCs is from acute category. In acute category, they are able to withstand the competition because of their superior brand strength. Going forward, competition will hot-up even in chronic category as these MNC’s are now increasingly focussing on chronic therapies. Pfizer GSK Pfizer's current portfolio derives strength from Respiratory, Anti- GSK derives its strength from anti-infective, dermatology, pain infective and Vitamins/ Minerals segment. The acute segment & vaccines segments. GSK is the leader in the vaccine (contributes 87% of the domestic sales) is growing by 20% segment in India with an effective market share of ~20%. GSK's and the chronic segment (13% of domestic sales) is growing strategy has been to create portfolio of high value products. by 25%. With a view to improve focus on chronic therapy, Pfizer GSK has 4 business verticals namely, Vaccines, Specialties, has recently launched two new divisions - CNS and Diabetes Mass specialties and Mass markets. Glaxo Plc, the parent and has added 300 people across these divisions. The company, has outlined one of the most aggressive growth company will also be launching insulin products from Biocon's plans for emerging markets, with India being one of the key portfolio in FY12. This will help the company focus on branded markets. The acute segment (contributes 95% of the domestic generics and fill the gaps in its portfolio. The company's six sales) is growing by 12% and the chronic segment (5% of key brands are in the list of top 100 in the industry. Becosules domestic sales) is growing by 12%. GSK has launched 2 and Corex are ranked # 1 in their respective therapeutic patented products from its parent's portfolio i.e. Revolade (drug segments. for low platelets) and Votrient (metastatic renal cell carcinoma) in the oncology segment. Earlier, GSK had successfully launched an Onco product Tykerb in India in May 2008. According to the management, within the first year of its launch it self Tykerb has clocked revenue of Rs70-80mn according to the management and is expected to gain. MNC Pharma - Currently focussed on acute therapy 100% 80% 44% 60% 87% 82% 95% 40% 56% 20% 13% 18% 0% 5% GSK Pfizer Novartis Aventis Chronic % Acute % Source: AIOCD AWACS, Emkay Research MNC pharma companies continue to grow in line with industry growth of ~13%, except Astra which has grown by more than 20%. These MNCs are aggressively investing in branded generics and moving into newer therapies like CVS, CNS and anti diabetes. In a bid to increase their presence in some of the branded generics, MNCs have aggressively priced their products below their Indian counterparts. While this has not significantly dented market share, it is a precursor to the competitive intensity in the future. Emkay Research 26 September, 2011 15
  • 16. Pharma Sector Exhibit 5: MNCs are adopting aggressive pricing strategies in many of the new products Indian Company Brands MNC Molecules Therapy Brand Name Pricing Company Brand Name Pricing Pack GSK Atorvastatin Cardio Lilo Rs43 Ranbaxy Storvas Rs180 10 tablets 10 tablets Intas Lipicor Rs125 10 tablets Dr. Reddys Atocor R Rs110 10 tablets Cipla Atorlip - 5 Rs157 10 tablets Pfizer Rabeprazole Gastro Above 5 Rs24 Intas Raium Plus Rs55 15 tablets 7 tablets Cipla Rabicip - 10 Rs64 15 tablets Dr. Reddys RZ 20 Rs70 10 tablets Sanofi Metoprolol Cardio Sitelol Rs30 Cipla Metolar-XR Rs39 10 tablets 10 Capsules USV Metzok Rs30 10 tablets Sun Pharma ProlometXR Rs40 10 tablets Lupin Topol XL Rs40 10 tablets Source: CIMS, Emkay Research Emkay Research 26 September, 2011 16
  • 17. Pharma Sector New products launched by MNCs during the last 1 year New Launches Sales (Rs Cr) COMPANY BRAND Therapy MAT July 11 GSK Rosutec Hormones 1.80 (17 pdts) Calpol T Pain 1.53 Ansolar SPF Onco 1.28 Lilo 0.67 Modvate 3 Derma - antibiotics 0.43 Modvate AF Derma - antibiotics 0.22 Metlead Anti-diabetic 0.04 Total 5.98 PFIZER LTD Jetex Hormones 1.34 (29 pdts) Dolonat Derma 1.12 My Pal 0.99 Debrit 0.36 Vicon Iron supplements 0.32 Cytosar Onco 0.23 Maxtorin Hormones 0.21 Prostin VR Hormones 0.16 Atubri 0.12 Tuvace 0.12 Levefree 0.11 IMEDIAB M Anti-diebetics 0.10 Aivo 0.08 Imediab Anti-diebetics 0.07 Bidiab Anti-diebetics 0.04 Felban AL Hormones 0.02 Total 5.42 SANOFI-AVENTIS Solian 1.94 (18 pdts) Rejusite AI 0.59 Telsite h CVS 0.55 Multaq GI 0.52 Cardace Protect CVS 0.42 Amaryl P Anti-diabetic 0.41 Sitelol 0.18 Sofrahext 0.14 Sitestat F 0.11 Vitahext Vitamins 0.07 Menomune Onco 0.06 Fasturtec Onco 0.05 Sitelol am CVS 0.03 Cetapin V Anti-diebetics 0.02 Shanchol AI 0.02 Total 5.11 NOVARTIS Pactel CNS 2.05 (16 pdts) Aclasta Onco 0.86 Onbrez Breezhaler 0.85 Tacsant AI 0.11 Macalvit New Vitamins 0.09 Vingose 0.08 Afinitor Onco 0.05 Tminic Cold 0.03 Sacsecure 0.03 Calc(i)ayur 0.02 Certican 0.02 Calc(c)ayur 0.02 Total 4.20 Source: AIOCD AWACS, Emkay Research Emkay Research 26 September, 2011 17
  • 18. Pharma Sector Pricing pressure on top brands Top Brands Company Year of Therapy Market MAT YoY MAT Jul 2011 Launch Share (%) ‘Jul 11 Gr. % Corex Pfizer 1993 Respiratory 0.5 210 -0.2 Human Mixtard Novo Nordisk 1994 Anti-Diabetic 0.4 196 10.4 Monocef Aristo Pharma 2001 Anti-Infective 0.3 187 11.9 Voveron Novartis 1986 Pain 0.4 185 5.5 Augmentin GSK 1992 Anti-Infective 0.4 177 6.1 Revital Ranbaxy 1989 Vitamins 0.4 151 10.5 Taxim - O Alkem 1998 Anti-Infective 0.3 150 17.7 Taxim Alkem 1990 Anti-Infective 0.3 149 11.2 Dexorange Franco Indian 1990 Vitamins 0.3 143 9.0 Betadine Win Medicare 1990 Derma 0.3 142 10.7 Asthalin Cipla 1993 Respiratory 0.3 142 11.5 Storvas Ranbaxy-Stancare 1999 Cardiac 0.2 138 7.6 Calpol GSK 1995 Pain 0.2 137 6.8 Phensydyl Cough Piramal 1996 Respiratory 0.4 134 -25.8 Zifi FDC 1999 Anti-Infective 0.3 134 6.2 Liv - 52 Himalaya 1989 Gastro 0.3 123 22.4 Becosules Pfizer 1989 Vitamins 0.3 119 13.4 Zinetac GSK 1986 Gastro 0.2 117 5.3 Mox Ranbaxy 1997 Anti-Infective 0.3 115 -2.1 Source: AIOCD, Emkay Research Growth in Anti-Infective segment has slowed down during the past 2 quarters due to increase in competition and pricing pressure both from local peers as well as MNCs. Competition in the top 20 brands in Indian Pharma market is also increasing with average growth slowing down to single digit. Most of the products, which feature in the top 20 list belong to acute therapy. Companies like Mankind are increasingly targeting these products and launching cheaper alternatives. Not only Mankind Pharma but even MNCs have been launching many drugs at considerably lower prices. Pricing pressure in Ranbaxy's Mox (Anti-Infective) -250mg Pricing pressure in GSK's Augmentin (Anti-Infective) - 15 strip capsules Amoxcillin + Clavulanic Acid combination 90 90 80 80 70 73% premium 70 34% premium 60 24% premium 60 50 25% premium 86 50 40 70 40 30 54 53 67 50 30 20 54 50 10 20 0 10 Mox- Novamox- Moxydil- Lupimox- Glamoxin- 0 Ranbaxy Cipla Solvay Lupin GSK Augmentin-GSK Clavam-Alkem Moxikind-Mankind Source: CIMS, Emkay Research Emkay Research 26 September, 2011 18
  • 19. Pharma Sector Pricing pressure in NovoNordisk's Human Mixtrad Pricing pressure in Abbotts Phaensedyl & Pfizer's Corex (Anti-Diabetic) - 70:30 Isophane/ Soluble Insulin Syrup - 100ml SYR 250 80 200 79% premium 60 74% premium 150 37% premium 9% premium 40 100 218 70 64 159 45 122 20 40 50 0 0 Insuman Rapid- Human Mixtard Insugen-Biocon Phensedyl- Corex Ascoril- Codocuf- Sanofi Abbott Glenmark Zydus Source: CIMS, Emkay Research Doctor Visit – Key Notables We visited set of doctors who are providing services in big hospitals in Mumbai and also had their private practice. During our visit to some of the General Practitioners in Mumbai, we found that for most of the infections and general illness, they was prescribing Mankind medicines. E.g. most of anti-infective prescribed belonged to penicillin’s and cephalosporin’s category. During our interaction, we understood that Mankind gives superior incentives for each prescription written by the doctor. If the patients case is very serious, then higher class of anti-infectives i.e. Penem’s were prescribed by the doctors and that too only MNC brands. The reason cited was – MNC brands are original research molecules and so doctors comfort level is usually higher when prescribing these medicines. The line of treatment action begins with prescribing penicillin’s and cephalosporin’s (Mankind is the preferred company in the anti- infective space) and higher treatment uses penem’s where MNC drugs are preferred. Emkay Research 26 September, 2011 19
  • 20. Pharma Sector Anti-infective category – therapy bifurcation Rs Cr YoY Growth % MAT’Jun 11 Gr. Contributors Groups MAT’ % MAT’ Sept’ 10 Dec’ 10 Mar’11 Jun’11 Vol Price NP Jun11 Share Jun11 GR GR GR Systemic Antibacterials 8,596 91% 11.7 13.0 12.9 10.4 8.2 6.6 0.3 4.8 Cephalosporins 4,191 44% 14.2 19.4 14.6 11.5 10.3 8.8 -0.5 5.9 Broad spectrum penicillins 1,618 17% 9.5 14.4 5.1 9.2 9.4 6.5 -0.8 3.8 Macrolides and similar types 1,092 12% 14.6 20.0 9.9 14.2 14.8 10.0 0.5 4.2 Fluoroquinolones 1,070 11% 4.3 8.6 4.3 5.9 -2.5 -1.2 1.9 3.6 Tetracyclines and combinations 123 1% 9.7 14.0 11.8 7.4 5.1 -2.0 2.8 9 Others 502 5% - -26.3 71.1 6.8 -0.5 - - - Anti - fungals 237 3% 23.3 15.5 16.6 38.0 27.0 18.8 -2 6.4 Antimyco - bacterials 395 4% 10.5 12.7 6.7 11.6 11.0 8.7 1.2 0.6 Anti - virals 211 2% 19.1 13.8 15.6 25.2 21.9 8.7 0.2 10.2 Total Sales 9,428 100% 12.0 13.0 12.8 11.3 9.1 6.7 0.5 4.8 Source: AIOCD AWACS, Emkay Research Growth in anti-infective category is mainly coming from volume growth and new product launches. Failure to launch new products will make it difficult for the companies to match the industry growth. Cephalosporins which contribute ~ 44% to the Anti-Infective category was impacted most. Reasons for the slowdown in Anti Infective category are Weather patterns – Heat wave was not that strong in North Decline in API prices of Cephalosporins due to dumping in China Pricing pressure due to Increase in competition Lower success rate of new product launches Top Companies in the Anti-Infective Category (Rs bn) Rs bn YoY Gr. (%) Anti-Infective MAT’Jun 11 MAT’Jun 11 Nov’10 Dec’10 Jan’11 Feb’11 Mar’11 Apr’11 May’11 Jun’11 Ranbaxy 8.6 13.0 11.7 13.7 25.1 16.8 19.2 25.9 21.3 14.7 Alkem 8.4 20.2 20.4 10.6 13.2 9.9 14.8 13.0 14.9 16.2 GSK Pharma 6.6 10.0 7.0 4.9 10.0 13.9 8.5 12.7 14.9 10.4 Cipla 6.4 8.3 15.7 0.1 3.2 2.2 5.2 -0.7 -7.6 -3.8 Mankind 5.4 22.2 27.3 21.4 24.8 19.4 13.2 14.2 17.0 9.2 Lupin 3.1 7.8 5.9 4.8 5.9 5.9 6.4 -0.3 3.5 -4.2 Glenmark 1.5 10.5 6.8 4.3 9.0 15.1 -2.6 -0.8 11.8 1.1 Zydus Cadila 1.2 -6.5 1.2 -7.4 -13.7 -18.4 -15.8 -2.5 -7.0 -8.9 Dr. Reddys 1.1 6.7 7.4 8.3 21.3 9.9 6.2 -7.3 -1.6 -6.7 Total AI 96.3 12.0 11.6 9.0 11.8 9.9 9.3 8.6 9.6 8.0 Source: AIOCD AWACS, Emkay Research Most of the companies in Anti infective category barring Ranbaxy have been erratic in their growth. Ranbaxy, the largest company in category, grew in line with the industry, on the back of higher volumes (driven by increse in field force and new launches). Industry growth is mainly driven by unlisted players like Mankind and Alkem - evident from top 10 brand performance in this catagory. Emkay Research 26 September, 2011 20
  • 21. Pharma Sector Top brands in anti-infective in Rs bn Brand Company Name MAT Value MAT Value YoY Gr. YTD YTD YoY Gr. June 11 June 10 (%) June 11 June 10 (%) Monocef Aristo Pharma 1.9 1.6 15.5 0.5 0.4 7.6 Augmentin GSK 1.8 1.7 5.4 0.4 0.4 11.4 Taxim O Alkem Lab 1.5 1.2 19.2 0.4 0.3 18.1 Taxim Alkem Lab 1.5 1.3 12.5 0.4 0.3 1.9 Zifi FDC 1.3 1.3 6.2 0.3 0.3 4.5 Clavam Alkem Lab 1.2 1.0 24.9 0.3 0.2 29.5 Mox Ranbaxy Lab 1.2 1.2 -0.3 0.2 0.2 -4.7 Mikacin Aristo Pharma 1.1 1.0 10.9 0.3 0.3 -7.3 Ceftum GSK 1.0 1.0 9.5 0.3 0.2 12.8 Moxikind CV Mankind Pharma 1.0 0.8 20.9 0.2 0.2 20.5 Total 96.3 85.9 12.0 22.3 20.3 9.7 Top brands of Mankind – Strategic pricing has led to intense competition Other Indian Company Brands Brand Therapy Pricing Company Brand Name Pricing Pack Moxikind CV Anti-Infective Rs114 Ranbaxy Moxclav Rs403 10 tablets 6 tablets Aristo Mega CV Rs99 6 tablets Cipla Novaclav Rs240 6 tablets Abbott Nuclav Duo Rs206 6 tablets Bandy Plus Anti Parasitic Rs6 Zydus Biwom Rs11 1 tablet 1 tablet Lupin Lupibend Rs12 1 tablet Ipca Nemozole Rs12 1 tablet Dr. Reddy’s Rediout Rs35 5 tablets Unwanted Kit Gynaec Rs335 Cipla MT Pill Rs331 1 tablet 1 tablet Zydus Mifegest Rs370 10 tablets FDC Undo Rs367 3 tablets Nurokind Plus Vitamins Rs36 Lupin Matilda Forte Rs103 10 Capsules 6 Capsules Zuventus Mecovon Rs90 10 Capsules Manforce Stimulants Rs142 Ranbaxy Caverta Rs173 4 tablets 4 tablets Lupin Enthusia Rs108 4 tablets Zydus Penegra Rs124 4 tablets Cipla Progra Rs108 4 tablets Mankind has been pricing its products at relatively lower rates as compared to other pharma companies in India. Mankind is particularly strong in commoditized therapies such as the anti-infectives, gynaecology and gastro which together contribute more than 50% of the domestic revenues. Mankind Pharma - Therapy-wise Revenue breakup Rs bn FY11 MAT MAT YoY % Contr. Jul’11 Jul’10 Gr. Anti-infectives 29.0% 5.4 4.5 19.4% Gastro 13.1% 2.4 2.0 23.3% Gynaecology 10.2% 1.9 1.4 30.8% Vitamins 7.8% 1.4 1.1 26.9% Stimulants 6.9% 1.3 1.1 15.6% CVS 5.8% 1.1 0.8 28.4% Pain 5.0% 0.9 0.8 17.8% Anti-Diabetic 3.3% 0.6 0.4 37.5% CNS 2.8% 0.5 0.4 22.2% Others 99.2% 18.4 14.6 25.7% Acute 86.4% 16.0 12.8 24.7% Chronic 13.6% 2.5 1.9 32.0% Total Sales 100.0% 18.5 14.7 25.7% Source: AIOCD AWACS, Emkay Research Emkay Research 26 September, 2011 21
  • 22. Pharma Sector National List of Essential Medicines What is NLEM? Essential medicines are those that satisfy the priority healthcare needs of majority of the population. The essential medicines list needs to be country specific addressing the disease burden of the nation and the commonly used medicines at primary, secondary and tertiary healthcare levels. The medicines in National List of Essential Medicines (NLEM) should be available at affordable costs and with assured quality. The medicines used in the various national health programs, emerging and re-emerging infections should be addressed in the list. The Government of India, Ministry of Health & Family Welfare (MOHFW) is mandated to ensure quality healthcare by assuring availability of safe and efficacious medicines for its population. In a move that could bring more than half the country’s Rs 65,000-crore medicine market under price control, the health ministry plans to enlarge the scope and size of the National List of Essential Medicines (NLEM). Following a Supreme Court directive to include all NLEM drugs under price control, the central government is working out a new policy incorporating such changes. While the current NLEM list, prepared in 2003, does not have too many drugs to be included in the price control list, the revision will bring about a significant change. According to rough estimate, the government currently controls the prices of about 20 per cent of the domestic drug market. The span of price control will go up to 35 per cent once the drugs mentioned in the current NLEM gets included. Main features of NLEM 2011 The medicines have been categorized according to therapeutic area. Therefore, it is possible that a medicine with more than one indication appears in more than one category.The issue of mentioning the strength of the medicine dose was deliberated. The committee took the considered view that the strength should be mentioned in the NLEM. For essentiality of requirement the medicines have been categorized as follows: - P, S and T denote essentiality at Primary, Secondary and Tertiary levels respectively while P, S, T (U in NLEM 2003) indicates essentiality at all the levels. A total of 348 medicines (excluding repetitions) are present in NLEM 2011. In the NLEM 2011, 181 medicines fall under the category of P, S and T, 106 medicines fall under the category of S, T while 61 medicines are categorized as T only. In comparison to NLEM 2003, number of medicines deleted is 47 and 43 medicines have been added Emkay Research 26 September, 2011 22
  • 23. Pharma Sector Recently 43 new medicines added to NLEM List Medicines Cadila Cipla Dr. Reddy Glenmark Ipca Lupin Ranbaxy Sun Torrent Unichem GSK Amoxicillin+Clavulinic Acid Atorvastatin Betamethasone Carboplatin Cefixime Cetrizen Chlorambucil Clindamycin Clopidogrel Decarbazine Daunorubicin Diazepam Enoxaparin Famotidine Fentanyl Filgrastim Hydroxychloroquine phosphate Ifosfamide Imatinib Ipratropium bromide Leflunomide Lorazepam Mefloquine Mesna Misoprostol N-acetylysteine Olanzapine Oxaliplatin Pantaprazole Permethrin Piperazine Premix Insulin 30/70 Inj Propofol Stavudine+Lamivudine Tramadol Vecuronium Zidovudine+Lamivudine +Nevirapine Total 15 14 6 4 2 10 5 7 6 4 6 Source: Emkay Research Emkay Research 26 September, 2011 23
  • 24. Pharma Sector NLEM Impact Analysis Category: Oncology Medicines Added: Imatinib mesylate Companies Impacted: The medicines that would be enlisted in the revised NLEM include costly blood cancer drug, imatinib mesylate, sold by Swiss multinational Novartis under the brand name Glivec. Other medicines in the list are carboplatin, daunorubicin, filgrastim, ifosfamide, mesna, oxaliplatin and clorambucil, manufactured by leading companies such as Bristol Myers Squibb, GlaxoSmithKline, Amgen, Dr Reddys, Intas and Sun Pharma. All the cancer medicines in the current NLEM list, which was prepared in 2003, have been retained Category: Anti-Infective Medicines Added: Amoxicillin + Clavulanic Acid and Cefixime Companies Impacted: Amoxicillin + Clavulanic Acid – Augmentin, Clavam and Moxikind are the top 10 brands in the anti-infective category. These brands are owned by GSK, Alkem and Mankind Pharma respectively. These 3 brands collectively contribute ~30% of the top 10 brand sales and ~4% to the anti-infective category. Cefixime – Companies impacted are Alkem (Brand – Taxim) and FDC (Brand – Zifi) which contribute ~32% to the top 10 brands and ~4% to the anti-infective category. Category: Cardiovascular Medicines Added: Atorvastatin Companies Impacted: Atorvastatin – Atorva and Strovas are the two brands owned by Cadila and Ranbaxy Labs. These 2 brands contribute 3% to the Indian pharma CVS category and 27% of the top 10 brands in the category. Category: Hormones Medicines Added: Betamethasone Companies Impacted: GSK Pharma Betnesol - N – This is a GSK Pharma product which, falls in the top 10 brands in the Hormones category. It contributes 9% to the IPM and 16% to the top 10 category. Category: CVS Medicines Added: Enoxaparin Companies Impacted: Lupin Lupenox – Among our coverage companies, Lupin is the only company having a drug in this category. Other notable companies are Sanofi Aventis and Biocon. Category: Gastrointestinal Medicines Added: Famotidine Companies Impacted: Most of the top Indian companies like Alkem, Sun Pharma, Cadila and Torrent Pharma have an established presence in the gastro segment. Emkay Research 26 September, 2011 24
  • 25. Pharma Sector Indian Pharma growth slowing down 4 Step Stress Test Impact of challanges Revision of estimates for domestic growth Significance of domestic business - Cash Cow Conclusion and Recommendation Emkay Research 26 September, 2011 25