Handling instructions for laser cartridges include removing the cartridge from its protective bag horizontally to prevent toner from shifting, gently removing any packaging seals, printing at least three test pages after installation, returning used cartridges in the box with the new/used card flipped, and calling for technical support with any problems. The document also encourages cartridge recycling to be environmentally responsible and notes statistics on waste reduction from remanufacturing cartridges.