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E-Cigarettes a disruptive public health
phenomenon:
Ethics, risk and the precautionary principle
Antoine Flahault, MD, PhD, Professor of Biostatistics, Descartes School of Medicine
Conflicts of Interest:
- direct = none
- indirect = institutional research grant from Sanofi ; a member of my family works at the French Association of Pharma
Manufacturers
Many definitions of the PP exist
• “Caution in advance“, “Caution practised in the
context of uncertainty“, or “Informed prudence”
• Principle #15 of the Rio Declaration
"In order to protect the environment, the precautionary
approach shall be widely applied by States according to
their capabilities. Where there are threats of serious or
irreversible damage, lack of full scientific certainty shall
not be used as a reason for postponing cost-effective
measures to prevent environmental degradation"
“…threats of serious or irreversible
damage…”
“…threats of serious or
irreversible damage…”
E-cigarettes a disruptive public health phenomenon: Ethics, risk and the precautionary principle London 2013
“…lack of full scientific certainty…”
Uncertainties or wrong messages?
Swedish males and the cultural use
of oral tobacco
Sweden
13% smokers (WHO target < 20%) (1)
19% use of snus (% of male pop.) (2)
Lung cancers (37/100,000 in males) lowest
rate in Europe (63 in Germany, UK 73 in
France /100,000) (1)
Oral cancers (0.6/100,000) lowest rate in
Europe (4/100 000)

(1) OECD statistics, 2011, 2012
(2) Furberg H. Addiction, 2006
Oral tobacco in Sweden is not a
gateway for smoking tobacco!

WHO statistics, 2009
“…cost-effective measure…”
“There were 172,000 lung cancer
deaths among men in the EU in 2002. If
all EU countries had the LCMR of men in
Sweden, there would have been 92,000
(54%) fewer deaths.”

Rodu B, Scand J Public Health, 2009
“…Caution practised in the context of
uncertainty” - “Informed prudence…”
Electronic cigarettes
• How harmful are E-cigs?
• What about secondhand
vapor?
• Will they lead to smoking
cessation?
• Will they reinforce the
tobacco smoking habit?

•
•
•

•

Cigarettes
Cigs kill half of their users
Secondhand smoke does kill
too (600,000 deaths/yr)
A plateau in smoking
prevalence seems to be
reached everywhere
Preliminary stats show
decrease in cigarettes sales
when E-cig increases its share

=> More science is needed and will come in the near future
Conclusions
• Ethics
– Recording 6 Mn deaths/yr: a failure to assist persons in
danger?

• Risks
– Cigarette is a well known major killer facing a competitor (Ecig) which may dramatically reduce the risk, although at an
unknown level

• Precautionary Principle
– There are known and certain threats of serious and
irreversible damage with smoking tobacco
– The lack of full scientific certainty (on E-cigs) shall not be used
as a reason for postponing recommending the use of
electronic cigarettes in addition to other tobacco control
measures to prevent further smoking tobacco devastation

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E-cigarettes a disruptive public health phenomenon: Ethics, risk and the precautionary principle London 2013

  • 1. E-Cigarettes a disruptive public health phenomenon: Ethics, risk and the precautionary principle Antoine Flahault, MD, PhD, Professor of Biostatistics, Descartes School of Medicine Conflicts of Interest: - direct = none - indirect = institutional research grant from Sanofi ; a member of my family works at the French Association of Pharma Manufacturers
  • 2. Many definitions of the PP exist • “Caution in advance“, “Caution practised in the context of uncertainty“, or “Informed prudence” • Principle #15 of the Rio Declaration "In order to protect the environment, the precautionary approach shall be widely applied by States according to their capabilities. Where there are threats of serious or irreversible damage, lack of full scientific certainty shall not be used as a reason for postponing cost-effective measures to prevent environmental degradation"
  • 3. “…threats of serious or irreversible damage…”
  • 4. “…threats of serious or irreversible damage…”
  • 6. “…lack of full scientific certainty…”
  • 8. Swedish males and the cultural use of oral tobacco Sweden 13% smokers (WHO target < 20%) (1) 19% use of snus (% of male pop.) (2) Lung cancers (37/100,000 in males) lowest rate in Europe (63 in Germany, UK 73 in France /100,000) (1) Oral cancers (0.6/100,000) lowest rate in Europe (4/100 000) (1) OECD statistics, 2011, 2012 (2) Furberg H. Addiction, 2006
  • 9. Oral tobacco in Sweden is not a gateway for smoking tobacco! WHO statistics, 2009
  • 10. “…cost-effective measure…” “There were 172,000 lung cancer deaths among men in the EU in 2002. If all EU countries had the LCMR of men in Sweden, there would have been 92,000 (54%) fewer deaths.” Rodu B, Scand J Public Health, 2009
  • 11. “…Caution practised in the context of uncertainty” - “Informed prudence…” Electronic cigarettes • How harmful are E-cigs? • What about secondhand vapor? • Will they lead to smoking cessation? • Will they reinforce the tobacco smoking habit? • • • • Cigarettes Cigs kill half of their users Secondhand smoke does kill too (600,000 deaths/yr) A plateau in smoking prevalence seems to be reached everywhere Preliminary stats show decrease in cigarettes sales when E-cig increases its share => More science is needed and will come in the near future
  • 12. Conclusions • Ethics – Recording 6 Mn deaths/yr: a failure to assist persons in danger? • Risks – Cigarette is a well known major killer facing a competitor (Ecig) which may dramatically reduce the risk, although at an unknown level • Precautionary Principle – There are known and certain threats of serious and irreversible damage with smoking tobacco – The lack of full scientific certainty (on E-cigs) shall not be used as a reason for postponing recommending the use of electronic cigarettes in addition to other tobacco control measures to prevent further smoking tobacco devastation