This document summarizes different types of new drug applications and reviews processes in the United States, including NDAs, ANDAs, and OTC monographs. It discusses the requirements for NDAs including chemistry, manufacturing, clinical trials, and safety data. ANDAs allow for generic drug approval by referencing an already approved drug. OTC monographs provide standards for active ingredients, doses, and labeling of non-prescription drugs. The review processes for these application types and OTC monographs are also briefly outlined.