LogPad Mobile device designed to collect patient reported outcomes at home, for efficient clinical trial data management.

1. LogPad® System with SimpleSend™ Transmissions
The Voice of the Patient — Delivered
Trustworthy Patient Data
Not too long ago, it would have seemed impossible for sponsors, sites and regulatory authorities to trust
PRO data captured outside the clinic.
• How could researchers know when a patient filled out a diary?
• How could data managers reconcile illogical responses? (For example, a patient who reports
no pain, but then rates evening pain intensity as 7 out of 10.)
• How could sites know when a patient was non-compliant, perhaps for weeks at a time, or
entering worsening symptoms?
PHT’s LogPad System has forever changed the way ePRO data are captured and managed in clinical
research. Protocol-specific eDiary applications, designed with support from PHT’s PROVision™ scientific
team, use intuitive features and quality controls to transform complicated diaries into simple ones.
Features Benefits
• Restricted time response windows Timely and verified data entry with no unplanned recall
• Accurate timestamps bias or prospective responses.
• Reminder alarms High compliance and fewer subject drop-outs to reduce
• Regular communication with sites missing data.
• Missed Diary Minder
• Branching logic Logical, legible and complete data and significantly
• Edit checks eased respondent burden.
• Structured response options
• SafetyPRO™ alerts Proactive safety and compliance management enabled
• Missed Diary Minder by automatic email and phone alerts based on custom
criteria and thresholds The LogPad’s flexible architecture is deployed
on a range of convenient touchscreen devices
• TrueCompute™ calculations Real-time symptom and eligibility scores are performed from proven hardware manufacturers including
on field devices without having to connect to the server. Hewlett-Packard and Palm.
• 100% application integrity LogPads prevented from reverting to PDAs after soft/hard
resets or battery loss; timestamps are always accurate. PHT’s experienced PROVision science team
and expert project managers help sponsors
• Private access codes Confidentiality elicits honest subject answers in trials for determine the ideal device for their specific
sensitive indications. study and patient population requirements.
eSense™ Measurement Device Integration
Research shows that subjects report false measurement data by transcribing it incorrectly or by outright
inventing it. Consider the asthma sufferer who forgets his Peak Expiratory Flow (PEF) meter at work and
estimates an evening FEV1 score, or the diabetic patient who misreports her high blood sugar level.
eSense solves these problems by integrating objective physiological measurements directly with subjec-
tive self-assessments on the LogPad using Bluetooth, infrared and exclusive low-power RF. By ensuring
measurement devices are used appropriately and on time, according to the protocol, eSense enables
scientific researchers to ask new questions and provides sponsors with a more complete patient picture.
In one client study, 174 subjects were given the choice of either using eSense or transcribing data
manually into the LogPad after each blow into a PEF meter. 86% of 12,195 expected blows were
recorded by eSense, while only 13% were transcribed manually and less than 1% were missing.
Imagine the improvements in data reliability as compared to paper or other separate eSource methods!

2. PHT Corporation
LogPad System with SimpleSend Transmissions
SimpleSend — for Reliable and Consistent Global Transmissions
Capturing high-quality ePRO data is part of the solution, but it is only valuable if subjects are able to transmit — simply and conveniently — from anywhere in the world.
PHT’s robust family of user-friendly SimpleSend options enable wired and wireless data transmissions from any LogPad device. Data are encrypted and typically sent in
a matter of seconds to PHT’s central servers over a subject’s home phone line. Increasingly, however, certain global geographies (such as Asia) and patient populations
(such as students) lack a reliable landline infrastructure and rely exclusively on cellular networks. Some sites and tech-savvy subject, meanwhile, prefer to utilize high-speed
Internet connections to send data. PHT provides sponsors with the freedom of choice by supporting wired, wireless and Internet auto-send telecommunications options.
Palm Devices Hewlett-Packard Devices
Wired SimpleSend TeleCradle SimpleSend Landline Modem
The TeleCradle is the recognized HP’s devices are easily equipped
industry standard for sending with compact cards that fit into the
data reliably over a landline. The top of the LogPad and enable data
TeleCradle charges the LogPad, transmission. Subjects simply attach
sends data automatically, and does one end of a home phone line into
not interfere with the subject’s home the top of the card to transmit data.
telephone when set up.
Wireless SimpleSend Wireless Pack SimpleSend Mobile Card
This PHT exclusive sled is the only The Mobile Card is similar to the
mobile device that enables cellular Landline Modem in that it is inserted
data transmission from a Palm. It into the top of the HP devices. Its
attaches to the eDiary to allow data built-in antenna, however, enables
entry and sending from a single strong cellular telecommunications
convenient device. The Wireless Pak over leading global GPRS networks.
also charges the LogPad.
Internet SimpleSend Internet — Palm SimpleSend Internet — HP
Users connect the LogPad to their a This compact card connects the
high-speed cable and transmit data LogPad directly to a high-speed cable
seamlessly over the Internet. for Internet transmissions.
The Telecomm Team
PHT employs a dedicated team of experienced telecommunications experts whose sole focus is to improve the convenience and con-
sistency of data transmissions from every country we support. PHT closely monitors transmission success rates of ongoing sutdies and
makes adjustments as necessary. By partnerning with leading provider AT&T Worldwide, PHT’s Telecomm Team is able to deliver the
highest level of service worldwide.
Site Telecomm Assessments
PHT has deployed its eDiary solutions to more countries than any other ePRO provider, accumulating unsurpassed experience to recommend the ideal LogPad device type and
SimpleSend communication option depending on particular study and geographical requirements. For additional peace of mind, PHT’s thorough Site Telecomm Assessment
service consists of a continuous battery of data transmission tests designed to reduce risk and provide an extra layer of confidence in new countries or areas where there have
been recent changes in the underlying telecommuncations infrastructure.
Don’t Take Our Word For It...
PHT’s LogPad System with SimpleSend telecommunications is the premier solution for capturing and managing high-quality ePRO data in clinical trials around the world.
By reducing respondent burden, removing numerous opportunities for error and fraud, and enabling convenient and consistent data transmissions, sponsors and sites
benefit from reliable data that they — and regulatory authorities — can trust. To see for yourself, build and use an interactive LogPad at the award-winning phtcorp.com.
PHT Corporation www.phtcorp.com
500 Rutherford Avenue
Boston, MA 02129, USA
Toll-Free: 877-360-2901 Copyright © 2008 PHT Corporation V1.0