The controversial protein only hypothesis of prion propagation
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The controversial protein-only hypothesis of prion propagation. Nat Med. 2004 Jul;10 Suppl:S63-7. Soto C, Castilla J. Department of Neurology, University of Texas Medical Branch, Galveston, Texas, USA.
![Prion diseases(TSE) ,[object Object],Proc Natl Acad Sci U S A. 1998 Nov 10;95(23):13363-83.](data:image/gif;base64,R0lGODlhAQABAIAAAAAAAP///yH5BAEAAAAALAAAAAABAAEAAAIBRAA7)
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The controversial protein only hypothesis of prion propagation
- 1. The controversial protein-only hypothesis of prion propagation Nat Med. 2004 Jul;10 Suppl:S63-7. Soto C, Castilla J. Department of Neurology, University of Texas Medical Branch, Galveston, Texas, USA. Design by ChanLao 2010.04
- 12. 利用抗 PrP 抗體 (6H4,PIPLC) 防止細胞受到感染及累積 PrP res Proc Natl Acad Sci U S A. 2001 July 31; 98(16): 9295–9299.
- 16. 遺傳性 TSEs 中之 PrP 突變 Annu. Rev. Neurosci. 2001. 24:519–50
- 17. PrP 過度表現老鼠之病變 Science. 1990 Dec 14;250(4987):1587-90.
- 20. Protein-only 假說的支持與反對 Science. 1998 Jan 2;279(5347):42-3.
- 21. Science. 1998 Jan 2;279(5347):42-3.
- 22. Science. 1998 Jan 2;279(5347):42-3. 阿茲海默症、柏金森症等，均未找到 transmissible agent
- 24. 研究方法的提升可進一步了解 prion 特性… 利用 PMCA 可在 in vitro 環境產生較多量 PrP res ，較容易偵測，是 prion 研究的有效增殖方法 http://labs.ansci.illinois.edu/novakofski/BSE/