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Autoclave
Steam Sterilizer
R
OSWORLD
Experiment With The Truth
CONTENTS
Osworld Timeline
What Is An Autoclave?
Autoclave Sterilization Graph
Autoclave Steam Sterilizer
Osworld Portable Autoclave: Model No OAT-P
Osworld Standard Model Autoclave: Model OAT S Wingnut Type
Osworld Fully Automatic Or Gmp Model Autoclave – Model OAT E/S
Osworld Premium Model Autoclave –
Single Handle – Internal/external Reservoir – Model OAT – SHI/SHE
Osworld Horizontal Autoclave – Model OAT – H
Osworld Range of Products
Clientele
03
04
05
06
07
08
09
10
11
06
06
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Experiment With The Truth
At Osworld,
“Perseverance is the hard work
we do after we get tired of doing the
hard work we already did”
PROFILEPROFILE
OSWORLDTIMELINE
1972:
1988:
1990:
1994:
1997:
2000:
2003:
2004:
2007:
2008:
2010
…………………Characterin Osworldisnot automatic,
ithasbeenworkedat.Thebenefithoweveriswellworth the time andeffort invested.
Joseph D’Souza founded the business, and started by manufacturing and
selling Oven, Incubator, Heating Mantle, Water Bath, and Hot Plate during the first
years. The key factors behind company growth and continuance is his persistence and
a strong sense of determination. As the organizations founder he values high morals
andinjectedthemstrategicallyintothegroundwork.
Osbert D’Souza his son joins the business; the product range is further
increased with additional products such as Autoclaves, Stability Chamber, BOD
Incubator,CoolingIncubatorandVacuumOven.
Osworldexecutesitsfirstexportorderof50Waterbathsand30Autoclaves.
Oswin D’Souza his youngest son joins business. In the following year Osworld
for the first time participates in a trade exhibition and displays its products at the
ChemtechexhibitionheldatNehruCentre,Mumbai.
With the enforcement of GMP regulatory compliance in the pharmaceutical
sector. Osworld takes proactive steps in implementing the guidelines to comply to the
provisions of the new ruling 21 CFR Part 11 from the Food & Drug Administration
(FDA).
Company moves its registered office and assembly area to a new location in
viewofincreasedadminstaffandmarketingexecutives.
A new manufacturing facility with increased production capabilities is built. The
additional space with sophisticated machinery provides for increased production to
copewiththesalesdemand.
ISO 9000: 2000 quality assurance system is adopted, with Bureau Veritas,
(formerlyBVQI),worldsleadingcertifyingbodyastheauditing agency.
CE certification for Stability Chamber and BOD Incubator was effectively
completed. This involves compliance to safety electrical requirements which were
testedandassessedbyaregulatorygoverninginstitute.
The essential stringent compliance to the provisions of ruling 21 CFR Part 11
and its firm enforcement by the FDA led to Osworld outsourcing the development of
new data storage software. Godrej & Boyce Mfg. Co. Ltd, one of India’s most trusted,
reputed brands, having entered in to an agreement with Osworld, took over the task of
developing the 21 CFR Part 11 software. A reliable well equipped software team at
Godrejensuredthesoftwarewasdevelopedinacompliant way.
Osworld filed its first Patent (Patent Pending Application No. 2075/MUM/2010) for
Oslog Data Storage Device, a device used to interface varous Osworld equipments to a
PCusingOslog21CFRPart11compliantsoftware.
OsworldalsolauncheditsPremiumModelAutoclaveSteam Sterilizer.
ISO9001:2000certificationwasenhancedtoISO9001:2008certification.”
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OSWORLD
Experiment With The Truth
ISO 9001: 2008
Certified Organization
Recognition in the form of “Lifetime
Achievement Award” received by
Founder of Osworld group, Mr. Joseph
D’Souza from his Excellency, Governor
of Maharashtra at the Pharmaceutical
Leadership Summit 2010 held on 26th
June2010atMumbai,India.
An autoclave is a device to sterilize equipment and supplies by subjecting them to high pressure saturated steam at 121 °C or
more,typicallyfor15-20minutes.
In its most basic form the autoclave is a pressure cooker. Water is heated in a pressurized environment to create steam. Using
pressure makes it possible to heat to higher temperatures with less energy. Autoclaves are usually made of steel and have
various configurations for removing air prior to pressurization. Downward displacement autoclaves use gravity to remove air.
Steam pulsing autoclaves use pulses of steam along with pressurizing and depressurizing to reach optimum pressure. Vacuum
pump autoclaves suck air out for pressurization. Superatmospheric autoclaves are a combination of steam pulsing and vacuum
pumptechniques.
Autoclaves are widely used in microbiology, medicine, tattooing, body piercing, veterinary science, mycology, dentistry,
chiropodyandprostheticfabrication.
Typical loads include laboratory glassware, surgical instruments, medical waste, patient care utensils, animal cage bedding,
andLysogenybroth.
A notable growing application of autoclaves is in the pre-disposal treatment and sterilization of waste material, such as
pathogenic hospital waste. Machines in this category largely operate under the same principles as the original autoclave in that
theyareabletoneutralizepotentiallyinfectiousagentsbyutilizing pressurizedsteamandsuperheatedwater.
HowDoesanAutoclaveWork?
WhatDoesanAutoclaveKill?
AirRemoval
An autoclave sterilizes items by heating them with steam to a very high temperature. Some common temperatures at which
autoclaves operate are: 115 degrees C/10 p.s.i., 121 degrees C/15 p.s.i., and 134 degrees C/30 p.s.i. (p.s.i.=pounds per
squareinch).Thetemperature,pressureandtimeofoperationdependonthedegreeofsterilizationneeded.
An autoclave using standard settings can kill most bacteria, spores, viruses and fungi (all models of Osworld Autoclaves). Most
doctor's offices, tattoo parlors, dentist offices and other places where instruments might come in contact with contaminants
have a small autoclave on site for disinfection (Osworld Portable Autoclave). Hospitals use larger autoclaves that look similar to
industrial dishwashers to sterilize many items at once (Osworld Rectangular/Cylindrical Horizontal Autoclave).
Heat kills microorganisms by causing vital proteins to coagulate. The proteins stick together causing fatal damage to the
microorganism. An autoclave cooks microorganisms in the same way a pressure cooker cooks food, but at a higher
temperature. Autoclaves use steam instead of dry heat because steam can more effectively transmit heat to the
microorganisms.
It is very important to ensure that all of the trapped air is removed, as hot air is very poor at achieving sterility. Steam at 134 °C
can achieve in 3 minutes the same sterility that hot air at 160 °C takes two hours to achieve. Methods of achieving air removal
include:
Downward displacement (or gravity type) - As steam enters the chamber, it fills the upper areas as it is less dense than air. This
compresses the air to the bottom, forcing it out through a drain. Often a temperature sensing device is placed in the drain. Only
when air evacuation is complete should the discharge stop. Flow is usually controlled through the use of a steam trap or a
solenoid valve, but bleed holes are sometimes used, often in conjunction with a solenoid valve. As the steam and air mix it is also
possibletoforceoutthemixturefromlocationsinthechamberotherthanthebottom.
Steam pulsing - Air dilution by using a series of steam pulses, in which the chamber is alternately pressurized and then
depressurizedtonearatmosphericpressure.
Vacuumpumps-Vacuumpumpstosuckairorair/steammixturesfromthechamber.
What is an Autoclave?
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Autoclave Quality Assurance
physical, chemical biological indicators temperature
time
Chemical indicators medical packaging autoclave tape color
sterilization
TypesofSterilizers
a)ClinicalSterilizer:
b) Laboratory Sterilizers:
Sterilants:
Sterilization bags/pads often have a "sterilization indicator mark" that typically darkens when the bag/pad has been processed.
Comparingthemarkonanunprocessedbagtoabagthathasbeenproperlycycledwillshowanobviousvisualdifference.
There are , and that can be used to ensure an autoclave reaches the correct for the
correctamountof .
can be found on and , and these change once the correct conditions have
beenmet.Thiscolorchangeindicatesthattheobjectinsidethepackage,orunderthetape,hasbeenprocessed.
Some computer-controlled autoclaves use an F0 (F-nought) value to control the cycle. F0 values are set as the number of
minutes of equivalent sterilization at 121 °C (250 °F) at 15 psi (100 kPa) above atmospheric pressure for 15 minutes . Since exact
temperaturecontrolisdifficult,thetemperatureismonitored,andthesterilizationtimeadjustedaccordingly.
Designedtoprocessmedicaldevicesormedicinalproducts.
are designed to process laboratory goods and materials that are neither medical devices nor
medicinalproductsandarenotintendedforuseintheclinicalcareofpatients.
Sterilizerscanalsobeclassifiedaccordingtothesterilantusedtoeffectsterilization.Thecommonlyusedsterilantsare:
a)high-temperature steam.
b)dryheat(hotair).
c)low-temperaturesteamandformaldehyde(LTSF).
d)ethyleneoxide(EO).
The High-Temperature Steam is the sterilant ofchoice because ofits superior sterilizing qualities. The various High Temperature Steam
SterilizersthatOsworldmanufacturesisshownherein.
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Autoclave Sterilization Graph
•Chamber-vePressure(mbar)•+veChamberPressure(mbar)
x
Sterilization Exhaust Post
Vac
Drying
Cycle
Auto Exhaust
& cycle complete
End Cycle Buzer ON
& Cooling Cycles ON
+ve Pressure
Pulsing
-ve Pressure
Pulsing
Pre
vac
Drying
Cycle
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Osworld offers various types of Autoclaves (High Temperature Steam Sterilizers):
Vertical Top Loading Autoclaves
•
• StandardmodelAutoclave–Wingnuttype
• FullyAutomaticAutoclave–Wingnuttype(availableonlyinGMPModel)
• PremiumModel–SingleHandleAutoclavewithInternalReservoir(AvailableinStandardaswellasGMPmodel)
• PremiumModel–SingleHandleAutoclavewithExternalReservoir(AvailableinStandardaswellasGMPmodel)
HorizontalFrontLoadingAutoclaves
•HorizontalAutoclave–CylindricalorRectangularAutoclaves(AvailableinStandardaswellasGMPmodel)
PortableAutoclave–smalldesktopautoclave
Autoclave Steam Sterilizer
Vertical Top Loading Autoclaves
Osworld Portable Autoclave: Model No OAT-P
• Desktop Autoclave, available in small capacities of 21 litres.
• Single Drum with heater and stand inside.
• Entirely made of Stainless Steel 304 grade, mirror finish.
• Standard size available: 300mm dia x 300 mm height.
Osworld Standard Model Autoclave: Model OAT S Wingnut Type
Application: For use in Microbiology, QC & Research laboratories - Pharma Industry.
• Vertical type, Double wall design has single chamber for steam and water.
• Inner chamber/Outer cover made of SS 304 grade.
• Lid, flange & bottom sheet also made of stainless steel. All joints argon welded.
• Pressure range: 15 PSI. Temperature Range: 121°C to 125°C.
• Lid fitted pressure gauge, safety spring loaded pressure valve, and steam release valve.
• Electrical: 230V / 15A / 50 Hz.
• Temperature Control: controls pressure and temperature with digital temperature indication,
factory set at 121°C (15 PSI), along with built in adjustable digital timer for maintaining
sterilization cycle time with auto cut off.
Optional Accessories
offered by Standard model:
Basket, Printer Interface, High Temp Safety Controller
Size of Useable
Chamber
in cms
Dia x Ht
30 x 50
35 x 55
45 x 60
45 x 75
55 x 75
Rating
KW
2.0
3.0
4.0
4.0
3.0x2
Model No
Standard
Model
OAT S – 35
OAT S – 52
OAT S – 95
OAT S 125
OAT S 175
–
–
Foot Lifting
Arrangement
To Lift Lid
No
No
Yes
Yes
Yes
Overall
Dimension
in cms
L x W x H
45 x 66 x 106
51 x 71 x 117
72 x 78 x 122
72 x 78 x 137
82 x 92 x 135
Capacity
Litres
35
52
95
125
175
Optional Accessories
offered by Fully Automatic model:
Basket
Printer Interface (1 Temp + 1 Pressure
printing or 3 Temp + 1 Pressure
Printing)
High Temp Safety Controller
Fo printing
PC software 21CFR Part 11 compliant
Basket
PC SoftwarePrinter Interface
PLC Based System
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Application: For use in Microbiology, QC & Research laboratory – Pharma Industry.?
• Double wall design has single chamber for steam and water.
• Fully Automatic operation; cycle begins by press of the START button.
• Initial air purging cycle; at the beginning air is automatically removed from the chamber.
• Microprocessor based Digital Temperature Indicator Controller.
Controls temperature / pressure precisely at set value.
• In built adjusted digital timer; programmable as per sterilization load requirement.
• Automatic steam exhaust at the end of cycle.
• Electrical Low water level heater safeguard.
• All parts of stainless steel 304 grade. All joints argon welded.
• Jointless silicon gasket. Heavy duty industrial flange heater.
• Pressure range: 15 PSI. Temperature Range: 121°C to 125°C.
• Lid fitting pressure gauge, safety spring loaded pressure valve, steam release valve.
• Hydraulically tested at 60PSI.
• Foot lifting arrangement included for capacity 95ltrs and above.
• Electrical: 230V / 15A / 50 Hz.
• Calibration certificate by ERTL – Mumbai with traceability to NPL – New Delhi.
Provided with DQ, IQ, OQ, documentation.
Vertical Top Loading Autoclaves
Osworld Fully Automatic or GMP Model Autoclave – Model OAT E/S
Size of Useable
Chamber
in cms
Dia x Ht
30 x 50
35 x 55
45 x 60
45 x 75
55 x 75
Capacity
Litres
35
52
95
125
175
Rating
KW
2.0
3.0
4.0
4.0
3.0x2
Model No
GMP
OAT G - 35
OAT G - 52
OAT G - 95
OAT G – 125
OAT G – 175
Foot Lifting
Arrangement
To Lift Lid
No
No
Yes
Yes
Yes
Overall
Dimension
in cms
L x W x H
45 x 64 x 92
51 x 69 x 102
62 x 73 x 110
62 x 73 x 125
82 x 92 x 125
• Double wall type design however has inner chamber for steam, outer as cover.
• Choose from 2 models Internal Reservoir or External Reservoir.
• Fully Automatic operation; cycle begins by press of the START button.
• Initial air purging cycle; at the beginning air is automatically removed from the chamber.
• Microprocessor based Digital Temperature Indicator Controller Controls temperature / pressure precisely at set value.
• Temperature Sensor: PT – 100.
• In built digital timer; timer can be adjusted as per sterilization load requirement, 1 to 99minutes.
• Automatic steam exhaust at the end of cycle.
• Low water level heater safeguard.
• Safety high pressure release valve.
• Safety high temperature cut off.
• Working chamber made of stainless steel LM 304 grade.
• Outer cover made of Mild Steel for Standard model duly powder coated and stainless steel 1mm thick for GMP model, however,
inner frame structure of solid chrome plated finish.
• Lid, flange & bottom sheet also made of stainless steel SS 304. All joints argon welded.
• Silicon gasket. Heavy duty industrial flange heater.
• Pressure range: 15 to 30 PSI, factory set at 15 PSI, 15 minutes ster. Cycle time.
• Temperature Range: 121°C to 134°C.
• Temperature Resolution: 0.1°C / Temperature Accuracy: ±0.5°C.
• Pressure gauge 0-50 PSI, safety spring loaded pressure valve, steam release valve.
• Hydraulically tested at 75PSI.
• Additional Safety:
i) Pressure Switch made in Europe, CE certified for additional safety. Factory set at 30PSI.
ii) Vacuum breaker cum lid locking arrangement for locking lid above 80degC.
iii) Multiple micro-switches to sense lid closure, lid proper latching such that heating won't start if parameters not satisfied.
• Electrical: 230V / 15A / 50 Hz.
• Calibration certificate by ERTL – Mumbai with traceability to NPL – New Delhi.
• Provided with DQ, IQ, OQ, documentation.
Application: For use in Microbiology, QC & Research laboratory – Pharma Industry
* I/E for Internal or External Reservoir model
Optional Accessories offered by Premium Model:
•
•
•
•
•
•
• PLC based system with 5.7” HMI Touch Screen display:
• Basket
Printer Interface (1 Temp + 1 Pressure printing or 3 Temp + 1 Pressure
Printing).
High Temp Safety Controller.
Fo printing.
PC software 21CFR Part 11 compliant.
Electrical actuator to ensure lid doesn't open under pressure.
Electromagnetic door lock for locking lid under pressure. Imported from
Europe, patented design, CE marked. Can keep door locked upto 300
Newton pressure.
Osworld Premium Model Autoclave –
Single Handle – Internal / External Reservoir – Model OAT – SHI / SHE
Vertical Top Loading Autoclaves
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Size of Useable
Chamber
in cms
Dia x Ht
35 x 55
35 x 66
35 x 75
45 x 60
45 x 75
55 x 75
Capacity
Litres
52
65
75
95
125
175
Rating
KW
3.0
3.0
4.0
4.0
3.0x2
4.0
Complete Unit of
SS 304 Grade
Model No
For GMP Model
OAT – SHI/E*-/G 52
OAT – SHI/E*-/G 65
OAT – SHI/E*-/G 75
OAT – SHI/E*-/G 125
OAT – SHI/E*-/G 175
OAT – SHI/E*-/G 95
Model No
For Standard Model
Outer Mild Steel
and Inner S.S.
OAT – SHI/E*-S 52
OAT – SHI/E*-S 65
OAT – SHI/E*-S 75
OAT – SHI/E*-S 125
OAT – SHI/E*-S 175
OAT – SHI/E*-S 95
Overall
Dimension
in cms
L x W x H
45 x 64 x 92
51 x 69 x 102
62 x 73 x 110
62 x 73 x 125
82 x 92 x 125
62 x 73 x 115
- Pressure Pulsing: both +ve and –ve pressure pulsing is programmable.
- Assisted Air Cooling: for quick cooling of chamber.
- Vacuum Pump system for automatic pre/post vacuuming with pulsing.
- Drying cycle.
- Automatic Water Fill – automatic water filling in reservoir.
Osworld Horizontal Autoclave –
Front Loading– Cylindrical / Rectangular Model
Model OAT-H
Opening: Front opening
2
Working pressure: 1.2 to 1.7 kgf / cm g
Working temperature: 121°C to 134°C
Material of Construction: Inner and outer
Inner working chamber: Stainless steel 316 grade of 6mm thickness
Chamber flange: Stainless steel 304 grade of 10mm thickness
Steam jacket: MS Boiler / SS 304 of 10 mm thickness
Door :Thick Stainless Steel door of 15mm thick
For Double Door Option: two thick SS doors of 15mm thickness, one opening in
sterile area and the other opening in non sterile area
Outer cabinet: Stainless steel 304 grade of 1mm thick - mirror finish
Other fittings:
Piping: Stainless steel 316 grade good quality seamless
Fittings: Stainless steel 316 grade with B.S.P thread
Radial locking assembly: MS chrome plated or SS with CI lock with radial arm or
Sliding Door arrangement.
Stand: MS / SS round pipe
Insulation: Rock wool slabs 50mm thick
Gasket: Silicon jointless
Optional Accessories :
• S.S. Loading carriage (1 no.) & S.S. Transfer trolley (2 Nos).
• Vacuum Pump water immersion type.
• Semi-Automatic model with Printing facility (date, time, temperature and pressure)
on EPSON 80 column dot matrix printer (printer not supplied).
• Datalogger: 8 channel with Printer Interface/PC software.
• Thermograph Circular type, single channel.
• Interlocking system for Double Door models: When one door opened the other
cannot be opened.
• Flush mounting system: Increases the aesthetics of the equipment by having a
Stainless Steel Sheet on the Sterile side of the equipment flushed with the wall.
• Fully automatic cycle through PLC (PLC with computer based system with Printer).
Technical Details: The system is equipped with a PC based Controlled Process Management System. The process is
programmable for selecting:
- Number of pulses, vacuum strength for pulse, sterilization time, operating temperature & pressure, drying time & post
vacuum strength- all these parameters selectable & programmable as per requirement.
- Fully Automatic operation.
- Self diagnostic system is incorporated in microprocessor programming & fault / error message with indication & alarm on
system failure.
- Manual operating arrangement is also provided in case of auto system failure for emergency use.
- Equipped with a printer for printing key process parameters like name of organization, batch no., date, time, no. of pulsing
time of pulsing, temperature sterilization holding period, pressure, post vacuum & cycle over for every sterilization process
and periodically at an interval of one minutes (variable) using a dot-matrix printer.
Osworld Horizontal Autoclave
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Experiment With The Truth
Horizontal cylindrical
sterilizer with an electric
steam generator resting on a
robust stand
Stainless steel carriage being
half way in the rectangular
sterilizer with easily
maneuverable trolley
Osworld Range of Products
i bWalk- n-Sta ility
Sta itybil Chamber
OD ubatorB Inc
Oven Gravity Convection
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Experiment With The Truth
Autoclave Steam Sterilizer
Bacteriological Incubator
BOD Incubator
Cooling Incubator
Deep Freezer
Muffle Furnace
Oven
Photostability Chamber
Stability Chamber
Vacuum Oven
Walk in Stability Chamber ISO 9001: 2008
Certified Organization
• Access Industrial Systems Pvt. Ltd., Sri Lanka
• Al Bayan Technical Equipment Est., U.A.E
• Al Razi ChemicalInd’s Trading LLC, U.A.E
• Alco Pharmaceuticals Ltd., Bangladesh
• Alive Pharmaceuticals Pvt. Ltd., Nepal
• Amulet Pharmaceuticals Ltd., Bangladesh
• Apex Pharmaceuticals Pvt. Ltd., Nepal
• Asian Pharmaceuticals Pvt. Ltd., Nepal
• Bio Pharm Industries, Algerie
• Chemi Drug Industries Pvt. Ltd., Nepal
• Consolidated Pharma Industries, Sudan
• Crystal Pharmaceuticals, Bangladesh
• CTL Pharmaceuticals , Nepal
• Curex Pharmaceuticals Pvt. Ltd., Nepal
• Deurali Janta Pharmaceuticals Pvt. Ltd., Nepal
• Delta Pharmaceuticals Ltd., Bangladesh
• Elder Universal Pharmaceuticals (Nepal) Pvt. Ltd., Nepal
• Eskay Therapeutics Ltd., Ghana
• Everest Pharmaceuticals Pvt. Ltd., Nepal
• G D Pharmaceuticals Pvt. Ltd., Nepal
Domestic Clients
• Alkem Laboratories Ltd., Mumbai
• Aurobindo Pharma Ltd., Hyderabad
• Bhabha Automic Research Centre, Mumbai
• Cadila Healthcare Ltd., Ahmedabad, Sikkim
• Central Drug Testing Laboratory, Mumbai
• Cipla Ltd., Mumbai
• Concept Pharmaceuticals Ltd., Aurangabad
• Defence Research & Development Estt, Gwalior
• Dr. D.Y. Patil Institute, Mumbai
• Dr. Reddy's Laboratories Ltd., Hyderabad
• Dr. Sabharwal's Wound Care, Baddi
• E.I. Dupont Ltd., Hyderabad
• Fritolay India Ltd., Pune
• Glaxo Smithkline Ltd., Hyderabad
• Glenmark Pharmaceutical Ltd., Mumbai, Pune, Nashik, Goa
• Godfrey Philips India Ltd., Mumbai
• Glochem Industries Ltd., Hyderabad/Vishakapatnam
• Haffkine Pharmaceuticals, Pune, Mumbai
• Hindustan Unilever Ltd., Mumbai
• Incozen Therapeutics Pvt. Ltd., Hyderabad
• Indian Drugs & Pharmaceuticals Ltd., Rishikesh
• Indian Institute of Technology, Mumbai
• Indoco Remedies Ltd., New Mumbai
• Ipca Laboratories Ltd., Silvassa, Ratlam, Indore
• Lilavati Hospital, Mumbai
• Lupin Ltd., Tarapur, Mumbai
• Macleod Pharma Ltd., Mumbai
• Maneesh Pharmaceuticals Ltd, Baddi
• Mark Formulations Pvt. Ltd., Nepal
• Maks Pharmaceuticals Ltd., Bangladesh
• Medivet Pharmaceuticals Pvt. Ltd., Nepal
• National Healthcare Pvt. Ltd., Nepal
• Nepal Pharmaceuticals Laboratory Pvt. Ltd., Nepal
• Product Proforma, Czech Republic
• Premier Pharmaceuticals Ltd., Bangladesh
• Quest Pharmaceuticals Pvt. Ltd., Nepal
• Red River Pharma, U.S.A
• S N Pharmaceuticals Ltd., Bangladesh
• S R Drugs Pvt. Ltd. , Nepal
• Shiba Pharmaceuticals, Yemen
• Syarikat Bumi Sains, West Malaysia
• Time Pharmaceuticals Pvt. Ltd., Nepal
• Unimed Pharmaceuticals Ltd., Bangladesh
• Unique Pharmaceuticals (P) Ltd., Nepal
• Universal Pharmaceuticals Pvt. Ltd., Nepal
• Vijayadeep Laboratories Ltd., Nepal
• Yemen Egyptian Pharma, Yemen
• IBN Sina Pharmaceuticals Ltd., Bangladesh
• Manipal Accadimy of Higher Education, Mangalore
• Merck Specialties Pvt. Ltd., Mumbai
• MSN Laboratories Ltd., Hyderabad
• Nicholas Piramal Ltd., Mumbai
• Orchid Chemicals & Pharmaceuticals Ltd., Chennai
• Orient Fans Ltd., Kolkata
• Parle Agro Pvt. Ltd., Mumbai
• Pfizer Ltd., New Mumbai
• Pharmasolve Specialities India Pvt. Ltd., Mumbai
• Pidilite Industries Ltd., Mumbai, Vapi
• Piramal Healthcare Ltd., Mumbai
• Ranbaxy Laboratories Ltd., Mumbai
• Raptakos Brett & Company Ltd., Mumbai
• Reliance Life Sciences Pvt. Ltd., New Mumbai
• Richer Themis Ltd., Vapi
• S. Kant Healthcare Ltd., Vapi
• Sandoz Private Ltd., Thane
• Sarvotherm Healthcare Pvt. Ltd., Baddi
• Sun Pharmaceuticals Industries Ltd., Baroda
• Themis Medicare Ltd., Vapi
• Unichem Laboratories Ltd., Goa
• Unimark Remedies Ltd., Ahmedabad
• US Vitamin Ltd., Mumbai
• Vet India Pharmaceuticals, Hyderabad
• Wallace Pharmaceuticals Ltd., Goa, Baddi
• Wockhardt Ltd., Aurangabad, Baddi
• Zydus Cadila Ltd., Ahmedabad, Goa
• Zenotech Laboratories Ltd., Hyderabad
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Clients
International Clients
Ane Many More...
Olympus Industrial Estate, Off Layoff Road,
Mahakali Caves Road, Andheri - (East),
Mumbai - 400 093, India.
Factory:
Admin Office:
B-44, New Empire Industrial Premises, Kondivita Road, J.B. Nagar, Andheri (E), Mumbai - 400 059, India.
Phone : +91-22-28320880 / 28390487, Fax : +91-22-66916595
Email : info@osworldindia.com
Website : www.osworldindia.com
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Experiment With The Truth
ISO 9001: 2008
Certified Organization

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Autoclave Steam Sterilizer - Pharmaceutical

  • 2. CONTENTS Osworld Timeline What Is An Autoclave? Autoclave Sterilization Graph Autoclave Steam Sterilizer Osworld Portable Autoclave: Model No OAT-P Osworld Standard Model Autoclave: Model OAT S Wingnut Type Osworld Fully Automatic Or Gmp Model Autoclave – Model OAT E/S Osworld Premium Model Autoclave – Single Handle – Internal/external Reservoir – Model OAT – SHI/SHE Osworld Horizontal Autoclave – Model OAT – H Osworld Range of Products Clientele 03 04 05 06 07 08 09 10 11 06 06 R OSWORLD Experiment With The Truth
  • 3. At Osworld, “Perseverance is the hard work we do after we get tired of doing the hard work we already did” PROFILEPROFILE OSWORLDTIMELINE 1972: 1988: 1990: 1994: 1997: 2000: 2003: 2004: 2007: 2008: 2010 …………………Characterin Osworldisnot automatic, ithasbeenworkedat.Thebenefithoweveriswellworth the time andeffort invested. Joseph D’Souza founded the business, and started by manufacturing and selling Oven, Incubator, Heating Mantle, Water Bath, and Hot Plate during the first years. The key factors behind company growth and continuance is his persistence and a strong sense of determination. As the organizations founder he values high morals andinjectedthemstrategicallyintothegroundwork. Osbert D’Souza his son joins the business; the product range is further increased with additional products such as Autoclaves, Stability Chamber, BOD Incubator,CoolingIncubatorandVacuumOven. Osworldexecutesitsfirstexportorderof50Waterbathsand30Autoclaves. Oswin D’Souza his youngest son joins business. In the following year Osworld for the first time participates in a trade exhibition and displays its products at the ChemtechexhibitionheldatNehruCentre,Mumbai. With the enforcement of GMP regulatory compliance in the pharmaceutical sector. Osworld takes proactive steps in implementing the guidelines to comply to the provisions of the new ruling 21 CFR Part 11 from the Food & Drug Administration (FDA). Company moves its registered office and assembly area to a new location in viewofincreasedadminstaffandmarketingexecutives. A new manufacturing facility with increased production capabilities is built. The additional space with sophisticated machinery provides for increased production to copewiththesalesdemand. ISO 9000: 2000 quality assurance system is adopted, with Bureau Veritas, (formerlyBVQI),worldsleadingcertifyingbodyastheauditing agency. CE certification for Stability Chamber and BOD Incubator was effectively completed. This involves compliance to safety electrical requirements which were testedandassessedbyaregulatorygoverninginstitute. The essential stringent compliance to the provisions of ruling 21 CFR Part 11 and its firm enforcement by the FDA led to Osworld outsourcing the development of new data storage software. Godrej & Boyce Mfg. Co. Ltd, one of India’s most trusted, reputed brands, having entered in to an agreement with Osworld, took over the task of developing the 21 CFR Part 11 software. A reliable well equipped software team at Godrejensuredthesoftwarewasdevelopedinacompliant way. Osworld filed its first Patent (Patent Pending Application No. 2075/MUM/2010) for Oslog Data Storage Device, a device used to interface varous Osworld equipments to a PCusingOslog21CFRPart11compliantsoftware. OsworldalsolauncheditsPremiumModelAutoclaveSteam Sterilizer. ISO9001:2000certificationwasenhancedtoISO9001:2008certification.” R OSWORLD Experiment With The Truth ISO 9001: 2008 Certified Organization Recognition in the form of “Lifetime Achievement Award” received by Founder of Osworld group, Mr. Joseph D’Souza from his Excellency, Governor of Maharashtra at the Pharmaceutical Leadership Summit 2010 held on 26th June2010atMumbai,India.
  • 4. An autoclave is a device to sterilize equipment and supplies by subjecting them to high pressure saturated steam at 121 °C or more,typicallyfor15-20minutes. In its most basic form the autoclave is a pressure cooker. Water is heated in a pressurized environment to create steam. Using pressure makes it possible to heat to higher temperatures with less energy. Autoclaves are usually made of steel and have various configurations for removing air prior to pressurization. Downward displacement autoclaves use gravity to remove air. Steam pulsing autoclaves use pulses of steam along with pressurizing and depressurizing to reach optimum pressure. Vacuum pump autoclaves suck air out for pressurization. Superatmospheric autoclaves are a combination of steam pulsing and vacuum pumptechniques. Autoclaves are widely used in microbiology, medicine, tattooing, body piercing, veterinary science, mycology, dentistry, chiropodyandprostheticfabrication. Typical loads include laboratory glassware, surgical instruments, medical waste, patient care utensils, animal cage bedding, andLysogenybroth. A notable growing application of autoclaves is in the pre-disposal treatment and sterilization of waste material, such as pathogenic hospital waste. Machines in this category largely operate under the same principles as the original autoclave in that theyareabletoneutralizepotentiallyinfectiousagentsbyutilizing pressurizedsteamandsuperheatedwater. HowDoesanAutoclaveWork? WhatDoesanAutoclaveKill? AirRemoval An autoclave sterilizes items by heating them with steam to a very high temperature. Some common temperatures at which autoclaves operate are: 115 degrees C/10 p.s.i., 121 degrees C/15 p.s.i., and 134 degrees C/30 p.s.i. (p.s.i.=pounds per squareinch).Thetemperature,pressureandtimeofoperationdependonthedegreeofsterilizationneeded. An autoclave using standard settings can kill most bacteria, spores, viruses and fungi (all models of Osworld Autoclaves). Most doctor's offices, tattoo parlors, dentist offices and other places where instruments might come in contact with contaminants have a small autoclave on site for disinfection (Osworld Portable Autoclave). Hospitals use larger autoclaves that look similar to industrial dishwashers to sterilize many items at once (Osworld Rectangular/Cylindrical Horizontal Autoclave). Heat kills microorganisms by causing vital proteins to coagulate. The proteins stick together causing fatal damage to the microorganism. An autoclave cooks microorganisms in the same way a pressure cooker cooks food, but at a higher temperature. Autoclaves use steam instead of dry heat because steam can more effectively transmit heat to the microorganisms. It is very important to ensure that all of the trapped air is removed, as hot air is very poor at achieving sterility. Steam at 134 °C can achieve in 3 minutes the same sterility that hot air at 160 °C takes two hours to achieve. Methods of achieving air removal include: Downward displacement (or gravity type) - As steam enters the chamber, it fills the upper areas as it is less dense than air. This compresses the air to the bottom, forcing it out through a drain. Often a temperature sensing device is placed in the drain. Only when air evacuation is complete should the discharge stop. Flow is usually controlled through the use of a steam trap or a solenoid valve, but bleed holes are sometimes used, often in conjunction with a solenoid valve. As the steam and air mix it is also possibletoforceoutthemixturefromlocationsinthechamberotherthanthebottom. Steam pulsing - Air dilution by using a series of steam pulses, in which the chamber is alternately pressurized and then depressurizedtonearatmosphericpressure. Vacuumpumps-Vacuumpumpstosuckairorair/steammixturesfromthechamber. What is an Autoclave? R OSWORLD Experiment With The Truth
  • 5. Autoclave Quality Assurance physical, chemical biological indicators temperature time Chemical indicators medical packaging autoclave tape color sterilization TypesofSterilizers a)ClinicalSterilizer: b) Laboratory Sterilizers: Sterilants: Sterilization bags/pads often have a "sterilization indicator mark" that typically darkens when the bag/pad has been processed. Comparingthemarkonanunprocessedbagtoabagthathasbeenproperlycycledwillshowanobviousvisualdifference. There are , and that can be used to ensure an autoclave reaches the correct for the correctamountof . can be found on and , and these change once the correct conditions have beenmet.Thiscolorchangeindicatesthattheobjectinsidethepackage,orunderthetape,hasbeenprocessed. Some computer-controlled autoclaves use an F0 (F-nought) value to control the cycle. F0 values are set as the number of minutes of equivalent sterilization at 121 °C (250 °F) at 15 psi (100 kPa) above atmospheric pressure for 15 minutes . Since exact temperaturecontrolisdifficult,thetemperatureismonitored,andthesterilizationtimeadjustedaccordingly. Designedtoprocessmedicaldevicesormedicinalproducts. are designed to process laboratory goods and materials that are neither medical devices nor medicinalproductsandarenotintendedforuseintheclinicalcareofpatients. Sterilizerscanalsobeclassifiedaccordingtothesterilantusedtoeffectsterilization.Thecommonlyusedsterilantsare: a)high-temperature steam. b)dryheat(hotair). c)low-temperaturesteamandformaldehyde(LTSF). d)ethyleneoxide(EO). The High-Temperature Steam is the sterilant ofchoice because ofits superior sterilizing qualities. The various High Temperature Steam SterilizersthatOsworldmanufacturesisshownherein. R OSWORLD Experiment With The Truth Autoclave Sterilization Graph •Chamber-vePressure(mbar)•+veChamberPressure(mbar) x Sterilization Exhaust Post Vac Drying Cycle Auto Exhaust & cycle complete End Cycle Buzer ON & Cooling Cycles ON +ve Pressure Pulsing -ve Pressure Pulsing Pre vac Drying Cycle
  • 6. R OSWORLD Experiment With The Truth Osworld offers various types of Autoclaves (High Temperature Steam Sterilizers): Vertical Top Loading Autoclaves • • StandardmodelAutoclave–Wingnuttype • FullyAutomaticAutoclave–Wingnuttype(availableonlyinGMPModel) • PremiumModel–SingleHandleAutoclavewithInternalReservoir(AvailableinStandardaswellasGMPmodel) • PremiumModel–SingleHandleAutoclavewithExternalReservoir(AvailableinStandardaswellasGMPmodel) HorizontalFrontLoadingAutoclaves •HorizontalAutoclave–CylindricalorRectangularAutoclaves(AvailableinStandardaswellasGMPmodel) PortableAutoclave–smalldesktopautoclave Autoclave Steam Sterilizer Vertical Top Loading Autoclaves Osworld Portable Autoclave: Model No OAT-P • Desktop Autoclave, available in small capacities of 21 litres. • Single Drum with heater and stand inside. • Entirely made of Stainless Steel 304 grade, mirror finish. • Standard size available: 300mm dia x 300 mm height. Osworld Standard Model Autoclave: Model OAT S Wingnut Type Application: For use in Microbiology, QC & Research laboratories - Pharma Industry. • Vertical type, Double wall design has single chamber for steam and water. • Inner chamber/Outer cover made of SS 304 grade. • Lid, flange & bottom sheet also made of stainless steel. All joints argon welded. • Pressure range: 15 PSI. Temperature Range: 121°C to 125°C. • Lid fitted pressure gauge, safety spring loaded pressure valve, and steam release valve. • Electrical: 230V / 15A / 50 Hz. • Temperature Control: controls pressure and temperature with digital temperature indication, factory set at 121°C (15 PSI), along with built in adjustable digital timer for maintaining sterilization cycle time with auto cut off. Optional Accessories offered by Standard model: Basket, Printer Interface, High Temp Safety Controller Size of Useable Chamber in cms Dia x Ht 30 x 50 35 x 55 45 x 60 45 x 75 55 x 75 Rating KW 2.0 3.0 4.0 4.0 3.0x2 Model No Standard Model OAT S – 35 OAT S – 52 OAT S – 95 OAT S 125 OAT S 175 – – Foot Lifting Arrangement To Lift Lid No No Yes Yes Yes Overall Dimension in cms L x W x H 45 x 66 x 106 51 x 71 x 117 72 x 78 x 122 72 x 78 x 137 82 x 92 x 135 Capacity Litres 35 52 95 125 175
  • 7. Optional Accessories offered by Fully Automatic model: Basket Printer Interface (1 Temp + 1 Pressure printing or 3 Temp + 1 Pressure Printing) High Temp Safety Controller Fo printing PC software 21CFR Part 11 compliant Basket PC SoftwarePrinter Interface PLC Based System R OSWORLD Experiment With The Truth Application: For use in Microbiology, QC & Research laboratory – Pharma Industry.? • Double wall design has single chamber for steam and water. • Fully Automatic operation; cycle begins by press of the START button. • Initial air purging cycle; at the beginning air is automatically removed from the chamber. • Microprocessor based Digital Temperature Indicator Controller. Controls temperature / pressure precisely at set value. • In built adjusted digital timer; programmable as per sterilization load requirement. • Automatic steam exhaust at the end of cycle. • Electrical Low water level heater safeguard. • All parts of stainless steel 304 grade. All joints argon welded. • Jointless silicon gasket. Heavy duty industrial flange heater. • Pressure range: 15 PSI. Temperature Range: 121°C to 125°C. • Lid fitting pressure gauge, safety spring loaded pressure valve, steam release valve. • Hydraulically tested at 60PSI. • Foot lifting arrangement included for capacity 95ltrs and above. • Electrical: 230V / 15A / 50 Hz. • Calibration certificate by ERTL – Mumbai with traceability to NPL – New Delhi. Provided with DQ, IQ, OQ, documentation. Vertical Top Loading Autoclaves Osworld Fully Automatic or GMP Model Autoclave – Model OAT E/S Size of Useable Chamber in cms Dia x Ht 30 x 50 35 x 55 45 x 60 45 x 75 55 x 75 Capacity Litres 35 52 95 125 175 Rating KW 2.0 3.0 4.0 4.0 3.0x2 Model No GMP OAT G - 35 OAT G - 52 OAT G - 95 OAT G – 125 OAT G – 175 Foot Lifting Arrangement To Lift Lid No No Yes Yes Yes Overall Dimension in cms L x W x H 45 x 64 x 92 51 x 69 x 102 62 x 73 x 110 62 x 73 x 125 82 x 92 x 125
  • 8. • Double wall type design however has inner chamber for steam, outer as cover. • Choose from 2 models Internal Reservoir or External Reservoir. • Fully Automatic operation; cycle begins by press of the START button. • Initial air purging cycle; at the beginning air is automatically removed from the chamber. • Microprocessor based Digital Temperature Indicator Controller Controls temperature / pressure precisely at set value. • Temperature Sensor: PT – 100. • In built digital timer; timer can be adjusted as per sterilization load requirement, 1 to 99minutes. • Automatic steam exhaust at the end of cycle. • Low water level heater safeguard. • Safety high pressure release valve. • Safety high temperature cut off. • Working chamber made of stainless steel LM 304 grade. • Outer cover made of Mild Steel for Standard model duly powder coated and stainless steel 1mm thick for GMP model, however, inner frame structure of solid chrome plated finish. • Lid, flange & bottom sheet also made of stainless steel SS 304. All joints argon welded. • Silicon gasket. Heavy duty industrial flange heater. • Pressure range: 15 to 30 PSI, factory set at 15 PSI, 15 minutes ster. Cycle time. • Temperature Range: 121°C to 134°C. • Temperature Resolution: 0.1°C / Temperature Accuracy: ±0.5°C. • Pressure gauge 0-50 PSI, safety spring loaded pressure valve, steam release valve. • Hydraulically tested at 75PSI. • Additional Safety: i) Pressure Switch made in Europe, CE certified for additional safety. Factory set at 30PSI. ii) Vacuum breaker cum lid locking arrangement for locking lid above 80degC. iii) Multiple micro-switches to sense lid closure, lid proper latching such that heating won't start if parameters not satisfied. • Electrical: 230V / 15A / 50 Hz. • Calibration certificate by ERTL – Mumbai with traceability to NPL – New Delhi. • Provided with DQ, IQ, OQ, documentation. Application: For use in Microbiology, QC & Research laboratory – Pharma Industry * I/E for Internal or External Reservoir model Optional Accessories offered by Premium Model: • • • • • • • PLC based system with 5.7” HMI Touch Screen display: • Basket Printer Interface (1 Temp + 1 Pressure printing or 3 Temp + 1 Pressure Printing). High Temp Safety Controller. Fo printing. PC software 21CFR Part 11 compliant. Electrical actuator to ensure lid doesn't open under pressure. Electromagnetic door lock for locking lid under pressure. Imported from Europe, patented design, CE marked. Can keep door locked upto 300 Newton pressure. Osworld Premium Model Autoclave – Single Handle – Internal / External Reservoir – Model OAT – SHI / SHE Vertical Top Loading Autoclaves R OSWORLD Experiment With The Truth Size of Useable Chamber in cms Dia x Ht 35 x 55 35 x 66 35 x 75 45 x 60 45 x 75 55 x 75 Capacity Litres 52 65 75 95 125 175 Rating KW 3.0 3.0 4.0 4.0 3.0x2 4.0 Complete Unit of SS 304 Grade Model No For GMP Model OAT – SHI/E*-/G 52 OAT – SHI/E*-/G 65 OAT – SHI/E*-/G 75 OAT – SHI/E*-/G 125 OAT – SHI/E*-/G 175 OAT – SHI/E*-/G 95 Model No For Standard Model Outer Mild Steel and Inner S.S. OAT – SHI/E*-S 52 OAT – SHI/E*-S 65 OAT – SHI/E*-S 75 OAT – SHI/E*-S 125 OAT – SHI/E*-S 175 OAT – SHI/E*-S 95 Overall Dimension in cms L x W x H 45 x 64 x 92 51 x 69 x 102 62 x 73 x 110 62 x 73 x 125 82 x 92 x 125 62 x 73 x 115 - Pressure Pulsing: both +ve and –ve pressure pulsing is programmable. - Assisted Air Cooling: for quick cooling of chamber. - Vacuum Pump system for automatic pre/post vacuuming with pulsing. - Drying cycle. - Automatic Water Fill – automatic water filling in reservoir.
  • 9. Osworld Horizontal Autoclave – Front Loading– Cylindrical / Rectangular Model Model OAT-H Opening: Front opening 2 Working pressure: 1.2 to 1.7 kgf / cm g Working temperature: 121°C to 134°C Material of Construction: Inner and outer Inner working chamber: Stainless steel 316 grade of 6mm thickness Chamber flange: Stainless steel 304 grade of 10mm thickness Steam jacket: MS Boiler / SS 304 of 10 mm thickness Door :Thick Stainless Steel door of 15mm thick For Double Door Option: two thick SS doors of 15mm thickness, one opening in sterile area and the other opening in non sterile area Outer cabinet: Stainless steel 304 grade of 1mm thick - mirror finish Other fittings: Piping: Stainless steel 316 grade good quality seamless Fittings: Stainless steel 316 grade with B.S.P thread Radial locking assembly: MS chrome plated or SS with CI lock with radial arm or Sliding Door arrangement. Stand: MS / SS round pipe Insulation: Rock wool slabs 50mm thick Gasket: Silicon jointless Optional Accessories : • S.S. Loading carriage (1 no.) & S.S. Transfer trolley (2 Nos). • Vacuum Pump water immersion type. • Semi-Automatic model with Printing facility (date, time, temperature and pressure) on EPSON 80 column dot matrix printer (printer not supplied). • Datalogger: 8 channel with Printer Interface/PC software. • Thermograph Circular type, single channel. • Interlocking system for Double Door models: When one door opened the other cannot be opened. • Flush mounting system: Increases the aesthetics of the equipment by having a Stainless Steel Sheet on the Sterile side of the equipment flushed with the wall. • Fully automatic cycle through PLC (PLC with computer based system with Printer). Technical Details: The system is equipped with a PC based Controlled Process Management System. The process is programmable for selecting: - Number of pulses, vacuum strength for pulse, sterilization time, operating temperature & pressure, drying time & post vacuum strength- all these parameters selectable & programmable as per requirement. - Fully Automatic operation. - Self diagnostic system is incorporated in microprocessor programming & fault / error message with indication & alarm on system failure. - Manual operating arrangement is also provided in case of auto system failure for emergency use. - Equipped with a printer for printing key process parameters like name of organization, batch no., date, time, no. of pulsing time of pulsing, temperature sterilization holding period, pressure, post vacuum & cycle over for every sterilization process and periodically at an interval of one minutes (variable) using a dot-matrix printer. Osworld Horizontal Autoclave R OSWORLD Experiment With The Truth Horizontal cylindrical sterilizer with an electric steam generator resting on a robust stand Stainless steel carriage being half way in the rectangular sterilizer with easily maneuverable trolley
  • 10. Osworld Range of Products i bWalk- n-Sta ility Sta itybil Chamber OD ubatorB Inc Oven Gravity Convection R OSWORLD Experiment With The Truth Autoclave Steam Sterilizer Bacteriological Incubator BOD Incubator Cooling Incubator Deep Freezer Muffle Furnace Oven Photostability Chamber Stability Chamber Vacuum Oven Walk in Stability Chamber ISO 9001: 2008 Certified Organization
  • 11. • Access Industrial Systems Pvt. Ltd., Sri Lanka • Al Bayan Technical Equipment Est., U.A.E • Al Razi ChemicalInd’s Trading LLC, U.A.E • Alco Pharmaceuticals Ltd., Bangladesh • Alive Pharmaceuticals Pvt. Ltd., Nepal • Amulet Pharmaceuticals Ltd., Bangladesh • Apex Pharmaceuticals Pvt. Ltd., Nepal • Asian Pharmaceuticals Pvt. Ltd., Nepal • Bio Pharm Industries, Algerie • Chemi Drug Industries Pvt. Ltd., Nepal • Consolidated Pharma Industries, Sudan • Crystal Pharmaceuticals, Bangladesh • CTL Pharmaceuticals , Nepal • Curex Pharmaceuticals Pvt. Ltd., Nepal • Deurali Janta Pharmaceuticals Pvt. Ltd., Nepal • Delta Pharmaceuticals Ltd., Bangladesh • Elder Universal Pharmaceuticals (Nepal) Pvt. Ltd., Nepal • Eskay Therapeutics Ltd., Ghana • Everest Pharmaceuticals Pvt. Ltd., Nepal • G D Pharmaceuticals Pvt. Ltd., Nepal Domestic Clients • Alkem Laboratories Ltd., Mumbai • Aurobindo Pharma Ltd., Hyderabad • Bhabha Automic Research Centre, Mumbai • Cadila Healthcare Ltd., Ahmedabad, Sikkim • Central Drug Testing Laboratory, Mumbai • Cipla Ltd., Mumbai • Concept Pharmaceuticals Ltd., Aurangabad • Defence Research & Development Estt, Gwalior • Dr. D.Y. Patil Institute, Mumbai • Dr. Reddy's Laboratories Ltd., Hyderabad • Dr. Sabharwal's Wound Care, Baddi • E.I. Dupont Ltd., Hyderabad • Fritolay India Ltd., Pune • Glaxo Smithkline Ltd., Hyderabad • Glenmark Pharmaceutical Ltd., Mumbai, Pune, Nashik, Goa • Godfrey Philips India Ltd., Mumbai • Glochem Industries Ltd., Hyderabad/Vishakapatnam • Haffkine Pharmaceuticals, Pune, Mumbai • Hindustan Unilever Ltd., Mumbai • Incozen Therapeutics Pvt. Ltd., Hyderabad • Indian Drugs & Pharmaceuticals Ltd., Rishikesh • Indian Institute of Technology, Mumbai • Indoco Remedies Ltd., New Mumbai • Ipca Laboratories Ltd., Silvassa, Ratlam, Indore • Lilavati Hospital, Mumbai • Lupin Ltd., Tarapur, Mumbai • Macleod Pharma Ltd., Mumbai • Maneesh Pharmaceuticals Ltd, Baddi • Mark Formulations Pvt. Ltd., Nepal • Maks Pharmaceuticals Ltd., Bangladesh • Medivet Pharmaceuticals Pvt. Ltd., Nepal • National Healthcare Pvt. Ltd., Nepal • Nepal Pharmaceuticals Laboratory Pvt. Ltd., Nepal • Product Proforma, Czech Republic • Premier Pharmaceuticals Ltd., Bangladesh • Quest Pharmaceuticals Pvt. Ltd., Nepal • Red River Pharma, U.S.A • S N Pharmaceuticals Ltd., Bangladesh • S R Drugs Pvt. Ltd. , Nepal • Shiba Pharmaceuticals, Yemen • Syarikat Bumi Sains, West Malaysia • Time Pharmaceuticals Pvt. Ltd., Nepal • Unimed Pharmaceuticals Ltd., Bangladesh • Unique Pharmaceuticals (P) Ltd., Nepal • Universal Pharmaceuticals Pvt. Ltd., Nepal • Vijayadeep Laboratories Ltd., Nepal • Yemen Egyptian Pharma, Yemen • IBN Sina Pharmaceuticals Ltd., Bangladesh • Manipal Accadimy of Higher Education, Mangalore • Merck Specialties Pvt. Ltd., Mumbai • MSN Laboratories Ltd., Hyderabad • Nicholas Piramal Ltd., Mumbai • Orchid Chemicals & Pharmaceuticals Ltd., Chennai • Orient Fans Ltd., Kolkata • Parle Agro Pvt. Ltd., Mumbai • Pfizer Ltd., New Mumbai • Pharmasolve Specialities India Pvt. Ltd., Mumbai • Pidilite Industries Ltd., Mumbai, Vapi • Piramal Healthcare Ltd., Mumbai • Ranbaxy Laboratories Ltd., Mumbai • Raptakos Brett & Company Ltd., Mumbai • Reliance Life Sciences Pvt. Ltd., New Mumbai • Richer Themis Ltd., Vapi • S. Kant Healthcare Ltd., Vapi • Sandoz Private Ltd., Thane • Sarvotherm Healthcare Pvt. Ltd., Baddi • Sun Pharmaceuticals Industries Ltd., Baroda • Themis Medicare Ltd., Vapi • Unichem Laboratories Ltd., Goa • Unimark Remedies Ltd., Ahmedabad • US Vitamin Ltd., Mumbai • Vet India Pharmaceuticals, Hyderabad • Wallace Pharmaceuticals Ltd., Goa, Baddi • Wockhardt Ltd., Aurangabad, Baddi • Zydus Cadila Ltd., Ahmedabad, Goa • Zenotech Laboratories Ltd., Hyderabad R OSWORLD Experiment With The Truth Clients International Clients Ane Many More...
  • 12. Olympus Industrial Estate, Off Layoff Road, Mahakali Caves Road, Andheri - (East), Mumbai - 400 093, India. Factory: Admin Office: B-44, New Empire Industrial Premises, Kondivita Road, J.B. Nagar, Andheri (E), Mumbai - 400 059, India. Phone : +91-22-28320880 / 28390487, Fax : +91-22-66916595 Email : info@osworldindia.com Website : www.osworldindia.com R OSWORLD Experiment With The Truth ISO 9001: 2008 Certified Organization