1. REVIEW OF
US PATENT NO. 7,912,650
Information Processing
System Using Nucleotide
Sequence-Related Information
June 12, 2013

2. China, Japan, Canada, Korea, Taiw
an, Europe
US 7,912,650; App.
10/153,691, Filed May
24, 2002.
JP 2001-156943,
Filed May 25, 2001
Divisional US App.
No 2005/0086011
Filed October 29, 2004
Status: Abandoned
Divisional US 7,945,389
Filed October 24, 2004
Status: Issued
Continuation US 8,103,368
Filed February 26, 2003
Status: Issued
Divisional US 2012/0101601
Filed January 3, 2012
Status: Pending – Likely Allowable
Non-US Applications
2Proprietary & Confidential Information
INFORMATION PROCESSING SYSTEM USING
NUCLEOTIDE SEQUENCE-RELATED INFORMATION US PATENT FAMILY MAP

3. HOW HITACHI‟S ATTORNEYS
DESCRIBED INVENTION BEING CLAIMED
Shared
Apparatus 2, 4,
17, 14 (Figs.1-3)
Personal
Computer 3
(Figs. 1, 4 and 5)
From page 10 of OA response filed
January 18, 2011 in the „368 patent which claims an apparatus – i.e., the
“remote host computer”.
Request information
(morbidity rate of large-bowel cancer?)
Positional information
(for large-bowel cancer, address = 223456)
Polymorphism information
(for address = 223456, pattern = G)
Semantic (or corresponding) information
(for address, pattern = 223456, G, morbidity rate = (i))
3Proprietary & Confidential Information

4. (a) Service request for
disease information
(f) Outputting obtained
semantic info
PATIENT APPLICATION SERVICE
Personal
Genome Information
stored
PRECISION MEDICINE – GENOME INFORMATION SERVICES
(b) & (e) databases only have to be
“remote” to user – e.g., in the cloud,
down the hall, or separate
computers in same room
Personalized
Medicine
Disease
Identified
US PATENT 7,912,650 ISSUED MAR 22, 2011
(c) Polymorphism address sent
back to patient/local computer
(d) Patient specific
polymorphism pattern at
polymorphism address
Vendor C
Vendor D
The entire personal genomic
information of the patient is never
available outside of local computer
Semantic info is stored in
constantly updating
database
(e) Obtaining semantic
info for patient specific
polymorphism pattern
(b) polymorphism
address obtained for
requested disease
Vendor N
4Proprietary & Confidential Information

5. INFORMATION PROCESSING SYSTEM USING
NUCLEOTIDE SEQUENCE-RELATED INFORMATION US PATENT NO. 7,912,650 MAP
Proprietary & Confidential Information 5
• via a communication network,
•request information of an object or service, wherein the object or
service
• for positional information
• retrieving the positional information
• wherein the first memory area is permitted to be accessed by a
firstprocessor
• via the communication network
• the positional information retrieved in step (b) above
• to a second processor
• via the communication network
• polymorphism information
• a third memory area
• for semantic information or information corresponding to the
semantic information
• for retrieving said semantic information or information responding to
semantic information and
• the semantic information or information corresponding to the
semantic information
• to a user; and
(a) receiving,
(b) searching, a first
memory area
(c) transmitting,
(d) receiving [first
processor receives from
second processor],
(e) searching
(f) outputting
(Original) 1. A
computer implemented
method for processing
information on a
nucleotide sequence
comprising the steps of:
Wherein steps (a)-(f) are
conducted under the control of
the first processor.
• is provided for an individual
• based on one or more genetic differences
between individuals and
• wherein the request information does not
include genetic information;
• corresponding to information on classification
of the object or service and
• wherein the positional information represents a
position in a nucleotide sequence.
which is permitted to access a secondary memory
area storing polymorphism information regarding
the individual
based on the positional information transmitted in
step (c) above;
retrieved in step (e) above
7,912,650
CLAIM
CHART
}
}
}
}
}

6. Proprietary & Confidential Information 6
INFORMATION PROCESSING SYSTEM USING
NUCLEOTIDE SEQUENCE-RELATED INFORMATION US PATENT NO. 7,912,650
“REWRITTEN” MAP
• a request for information based on genetic polymorphisms and
concerning a particular disease or condition for an individual
• for a polymorphism address [a position in a nucleotide sequence
where a polymorphism is present and associated with the particular
disease or condition requested]
• and retrieves the polymorphism address
• the polymorphism address retrieved in step (b) above
• to a local computer
• a polymorphism pattern [the sequence or polymorphism of the
individual at the position determined above]
• the information associated with the individual‟s polymorphism
pattern
• to a user; and
• a third database [a dynamic and ever changing database of
information]
• for information associated with the individual‟s polymorphism
pattern (i.e., responsiveness to medicaments, disease risk) and
• retrieves the information associated with the individual‟s
polymorphism pattern, and
(a) a remote computer
receives
(b) the remote computer
accesses and searches a
first database
(c) the remote computer
transmits to the local
computer
(d) the remote computer
receives from the local
computer
(e) the remote computer
searches
(f) the remote computer
outputs
(Rewritten) 1. A
computer implemented
method for processing
information on a
nucleotide sequence
compromising the steps
of:
wherein steps (a)-(f) are
conducted under the control
of the remote computer.
•wherein the request does not include genetic
information;
•corresponding to the particular disease or
condition requested
• which is permitted to access a second database
storing the individual‟s genetic information
• wherein the third memory area is permitted to
be accessed by the first processor; and
7,912,650
CLAIM
CHART
}
}
}
}

7. China, Japan, Canada, Korea, Taiw
an, Europe
US 7,912,650; App.
10/153,691, Filed May
24, 2002.
JP 2001-156943,
Filed May 25, 2001
Divisional US App.
No 2005/0086011
Filed October 29, 2004
Status: Abandoned
Divisional US 7,945,389
Filed October 24, 2004
Status: Issued
Continuation US 8,103,368
Filed February 26, 2003
Status: Issued
Method & Software
Claims
Divisional US 2012/0101601
Filed January 3, 2012
Status: Pending – Likely Allowable
Method & Software Claims
similar in scope to
„650 – “a user” issue
Non-US Applications
7Proprietary & Confidential Information
INFORMATION PROCESSING SYSTEM USING
NUCLEOTIDE SEQUENCE-RELATED INFORMATION US PATENT FAMILY MAP

8. Proprietary & Confidential Information 8
INFORMATION PROCESSING SYSTEM
USINGNUCLEOTIDE SEQUENCE-RELATED INFORMATION US PATENT NO. 7,945,389
MAP
• wherein the object or service is provided for an individual based on
one or more genetic differences between individuals, and
• wherein the request information does not include genetic information
• and wherein the positional information to information on
classification of the object or service,
• and wherein the positional information represents a position in a
nucleotide sequence, and
• retrieving the positional information,
• wherein the first memory area is permitted to be accessed by a first
processor
• to a second processor
• based on the positional information transmitted in step (c); and
• to a user
• and wherein the user includes athird processor
“A User” defined in the specification as an individual/person –
unknown how a person can have a “third processor” to do certain
functions.
(a) receiving, via a
communication
network, request information
of an object or service,
(b) searching a first memory
area for positional
information,
(c) Transmitting, via a
communication network, the
positional information
retrieved in step (b)
(d) Receiving, via a
communication
network, polymorphism
information
(e) Outputting, via a
communication network, the
polymorphism information
received in step (d)
1. A computer-
implemented method for
processing information
on a nucleotide
sequence comprising
the steps of:
Wherein steps (a)-(e) are
conducted under the control of
the first processor.
• which is permitted to access a second memory
area storing polymorphism information regarding
the individual
• which is permitted to access a third memory
area storing semantic information
• and which searches the third memory area to
retrieve, in response to said transmission of the
polymorphism information based on the
transmitted polymorphism information, and
• outputs the semantic information to a device
• that utilizes the semantic information or
information corresponding to the semantic
information,
• which is used for a provision of the object or
service substantially included in the request
information,
US
7,945,389
CLAIM
CHART
}
}

9. China, Japan, Canada, Korea, Taiw
an, Europe
US 7,912,650; App.
10/153,691, Filed May
24, 2002.
JP 2001-156943,
Filed May 25, 2001
Divisional US App.
No 2005/0086011
Filed October 29, 2004
Status: Abandoned
Divisional US 7,945,389
Filed October 24, 2004
Status: Issued
Continuation US 8,103,368
Filed February 26, 2003
Status: Issued
Method & Software
Claims
Divisional US 2012/0101601
Filed January 3, 2012
Status: Pending – Likely Allowable
Apparatus claims – “a CPU”
controlling shared computer
Method & Software Claims
similar in scope to
„650 – “a user” issue
Non-US Applications
9Proprietary & Confidential Information
INFORMATION PROCESSING SYSTEM USING
NUCLEOTIDE SEQUENCE-RELATED INFORMATION US PATENT FAMILY MAP

10. Proprietary & Confidential Information 10
INFORMATION PROCESSING SYSTEM
USINGNUCLEOTIDE SEQUENCE-RELATED INFORMATION US PATENT NO. 8,103,368
MAP
• that is configured to receive request information from a request
computer,
• search the database for positional information
• cause the transmitter/receiver to transmit, via the communication
network, the retrieved positional information, which corresponds to the
received request information, to a computer
• obtain polymorphism information based on the transmitted
positional information, received by the transmitter/receiver via
communication network;
• search the database for semantic information or search for
information that is stored in the database or another database based on
the polymorphism information
• output the semantic information or information corresponding to the
retrieved semantic information to the request computer
a transmitter/receiver
a CPU that is
configured to:
1. An apparatus for
processing information
on a nucleotide
sequence, in which the
apparatus is configured
to access a database
storing positional
information
representing a position
in the nucleotide
sequence, polymorphis
m information, and
semantic
information, comprising
:
CPU – a CPU must “totally”
control shared computer
• via a communication network, corresponding to
an object or service,
• and wherein the request information does not
include genome-related information; and
• corresponding to the received request
information, and retrieve the positional
information
• which is configured to access a recording
medium storing polymorphism information
regarding an individual;
US
8,103,368
CLAIM
CHART
}
}
}
• and retrieve the semantic information or
information corresponding to the semantic
information; and
•or a device that utilizes the semantic information
corresponding to the semantic information to
comply with a request substantially included in
the request information
}
}

11. China, Japan, Canada, Korea, Taiw
an, Europe
US 7,912,650; App.
10/153,691, Filed May
24, 2002.
JP 2001-156943,
Filed May 25, 2001
Divisional US App.
No 2005/0086011
Filed October 29, 2004
Status: Abandoned
Divisional US 7,945,389
Filed October 24, 2004
Status: Issued
Continuation US 8,103,368
Filed February 26, 2003
Status: Issued
Method & Software
Claims
Divisional US 2012/0101601
Filed January 3, 2012
Status: Pending – Likely Allowable
Apparatus claims – “a CPU”
controlling shared computer
Method & Software Claims
similar in scope to
„650 – “a user” issue
Non-US Applications
Apparatus claims similar to „368 – “a
CPU” replaced with “controller”
11Proprietary & Confidential Information
INFORMATION PROCESSING SYSTEM USING
NUCLEOTIDE SEQUENCE-RELATED INFORMATION US PATENT FAMILY MAP

12. Proprietary & Confidential Information 12
INFORMATION PROCESSING SYSTEM
USINGNUCLEOTIDE SEQUENCE-RELATED INFORMATION US PATENT APP. NO.
2012/0101601 MAP
• transmits, via a communication network, request information and
• receives, via the communication network, positional information
form the first processor
• Searches nucleotide sequence-related information regarding an
individual to retrieve nucleotide sequence-related information based on
the received positional information, and
• retrieves said nucleotide sequence-related information, wherein the
nucleotide sequence-related information that is searched
• causes the transmitter/receiver to transmit, via the communication
network, the retrieved nucleotide sequence-related information to the
processor
a transmitter/receiver
that
a controller that
103. An apparatus for
processing information
on a nucleotide
sequence comprising:
Wherein the controller and the
transmitter/receiver are under
the control of the second
processor.
• to a first processor which is permitted to access
positional information, wherein the positional
information represents a position in a nucleotide
sequence,
• wherein the received positional information is
based on the transmitted request information;
• is permitted to be accessed by a second
processor; and
• to the first processor which is permitted to
access semantic information,
• and which searches the semantic information to
retrieve, in response to said transmission of the
nucleotide sequence-related information, semantic
information based on the transmitted nucleotide
sequence-related information,
• and outputs the semantic information
• to a device that utilizes the semantic
information or information corresponding to the
semantic information to comply with a request
substantially included in the request information,
US
2012/0101601
CLAIM
CHART
(AS ALLOWABLE
PER OA DEC. 12,
2012 AND PER
TERMINAL
DISCLAIMER FILED)
}
}
}
}
“a Controller” replaced “a CPU” – arguably
broader – may provide basis for distributed
network

13. 7,912,650 Patent
Distributed infringement issue re: method
claims – functionalities being done by 2
or more parties.
Included software claims require
software to be on single “medium”
(i.e., the shared memory) – the described
functions are, however, performed in a
distributed manner among several
processors/computers.
7,945,389
Distributed infringement issue re: method
claims – functionalities being done by 2
or more parties.
Included software claims require
software to be on single “medium”
(i.e., the shared memory) – the described
functions are, however, performed in a
distributed manner among several
processors/computers.
Claim requires that “a user” have “a
processor”.
8,103,368
Apparatus claims require a single CPU
which “totally controls operation” of the
shared computer – the described
functions are, however, performed in a
distributed manner among several
processors/computers.
2012/0101601
Broadened the claims to recite “a
controller” instead of “a CPU”.
Claims are split to cover either the shared
computer (claim 101) or the user’s
computer (claim 103).
Broadest set of claims consistent with
current patent law requirements for
components of a computer system.
PORTFOLIO OVERVIEW
13Proprietary & Confidential Information

14. POTENTIAL CLAIMS TO ADD IN
CONTINUATION APPLICATION(S) TO ADDRESS NOTED ISSUES
The definition of distributed memory is:
In computer science, distributed memory refers
to a multiple-processor computer system in
which each processor has its own private
memory. Computational tasks can only operate
on local data, and if remote data is required, the
computational task must communicate with one
or more remote processors. In contrast, a shared
memory multi processor offers a single memory
space used by all processors. Processors do not
have to be aware where data resides, except that
there may be performance penalties, and that
race conditions are to be avoided.
See, Wikipedia, for example.
The ordinary definition of distributed system is:
A distributed system is a software system in
which components located on networked
computers communicate and coordinate
their actions by passing messages. The
components interact with each other in order
to achieve a common goal."
See, Wikipedia, for example.
The ordinary definition of distributed
program is "a computer program that runs in
a distributed system" See, Wikipedia, for
example.
The terms "distributed memory", "distributed
program" and "distributed system" are not found in
the specification of the patent(s) and
application, but concept is arguably implicit or
inherent in the disclosure as the system describe and
shown is a distributed system.
2. Non-transitory computer readable mediums
encoded with a distributed program for
processing information on a nucleotide
sequence which allows a distributed system
to execute processes including: ....
1. A non-transitory distributed memory encoded with
programs for processing information on a nucleotide
sequence which allows computers to execute
processes including…
14Proprietary & Confidential Information

15. FEATURES OF THE PORTFOLIO
REMOTE COMPUTER CAN BE IN THE
CLOUD, IN ANOTHER ROOM, IN ANOTHER
DATA CENTER, FOR EXAMPLE.
Not required to be in the cloud – simply must be
connected to the local computer via a communication
network.
LANGUAGE IN APPLICATIONS BROADLY
DEFINES THE FUNCTIONAL ABILITIES OF A
DISTRIBUTED COMPUTER SYSTEM:
Entirety of patient DNA not made available to “remote
location”.
THE SEMANTIC INFORMATION
ENCOMPASSES ALL TYPES OF INFORMATION
–
MORBIDITY, TREATMENTS, MEDICATIONS, ET
C.The semantic information is constantly updating.
THE PATENT ASSETS COVER MULTIPLE
ASPECTS OF THE TECHNOLOGY IN THE „650
PATENT AND CONTINUATION/DIVISIONAL
APPLICATIONS:
Apparatus claims, method claims, computer readable
mediums (software).
15Proprietary & Confidential Information

16. OPPORTUNITY TO FILE CONTINUATION/NEW
APPLICATIONS STILL EXISTS:
Apply for new claims to cover additional features.
New applications will have benefit of 2001 priority date
for purposes of prior art.
BROAD FUNCTIONAL/METHOD DISCLOSURE
WITH AN EARLY FILING DATE:
Priority re: prior art is 2001 (Japan).
US Expiration in 2022.
INVENTION IS KEY COMPONENT OF
REGULATORY FOCUS – SAFETY & SECURITY
OF PERSONAL GENOMIC INFORMATION.
Claims directed to “remote” use of only the patient’s
polymorphism pattern and not the entirety of the
genome.
ABILITY TO COVER IN ADDITIONAL
APPLICATION(S) HARDWARE/DATABASES
BEING USED OUTSIDE US TO PROVIDE
BENEFIT WITHIN US.
Such activity would be an infringement of patent(s).
BENEFITS OF THE PORTFOLIO
16Proprietary & Confidential Information

17. Proprietary & Confidential Information 17
ISSUES OF THE PORTFOLIO
APPARATUS & HARDWARE
DISCLOSURE IS MORE
LIMITED IN SCOPE AND
BREADTH.
SIGNIFICANT AMOUNT OF
BACK/FORTH BETWEEN
US ATTY AND USPTO –
MAY CREATE UNHELPFUL
ADMISSIONS RE: SCOPE
OF CLAIMS.
CURRENT ISSUED CLAIMS MAY
REQUIRE COORDINATED
EFFORT BETWEEN
PATIENT/DOCTOR/RESEAR
CHER & REMOTE DB
PROVIDER TO INFRINGE
THE CLAIMS.
2012 PUBLISHED APP.
MAY BE STRONGEST
ITEM IN FAMILY. NINE (9) YEARS LEFT ON
PATENT TERM.
• Will have to rely on common
dictionary definitions.
• What did terms mean in
2001?
• If two are not operating in
conjunction, may not be able
to assert infringement of
method claims.
• Claim focused on
“controller” rather than
“CPU”.
• Likely to be allowed Summer
2013.
• Any new apps need to be
filed quickly and prioritized
for early issuance.
• New apps must be filed
before 2012 app. Issues in
order to maintain priority
date.

18. FREEDOM TO OPERATE/LANDSCAPE REVIEW
AND OPINION OBTAINED:
Identify 3rd party patents/apps in the field.
Determine impact, if any, on ability to implement
envisioned commercial embodiment(s).
IMMEDIATE FILING OF NEW APPLICATION(S)
DIRECTED TO ADDITIONAL FEATURES OF
INVENTION.
Claims directed to current envisioned commercial
embodiment(s) or activities of potential licensees.
REVIEW OF PATENT NO. 7,337,071 AND FAMILY
WHICH APPEARS TO BE RELATED TO AND
SIMILAR IN SCOPE:
Disclosure & claims cover similar processing steps for
nucleotide sequences for semantic information.
May not be limited to polymorphism address/patterns.
DETERMINE OTHER HITACHI
OWNED/LICENSED PATENTS/APPS THAT MAY
FALL WITHIN SCOPE OF POTENTIAL
COMMERCIAL EMBODIMENTS.
Text
ITEMS FOR CONSIDERATION
18Proprietary & Confidential Information

19. Proprietary & Confidential Information 19
TEXT HERE
Statement or quote
Title

20. DUNLAP CODDING, PC
The Film Exchange District
609 W. Sheridan Avenue
Oklahoma City, OK 73102
dunlapcodding.com
405.607.8600 (p)
405.607.8686 (f)
20Proprietary & Confidential Information