1. Cristina M. Cruz Irizarry RISE program
Annotation # 3:
Laurence Simmat-Durand a,*, Claude Lejeune b, Laurent Gourarier c. 2008. Pregnancy under
the high-dose of Buprenorphine. La Terrasse, Hoˆpital Maison Blanche, 222 bis, rue Marcadet,
75018 Paris, France.
This research was conducted to examine the cost of methadone overdose in pregnant women in
comparison with Buprenorphine. They also included the genetics of the women under a high
dose of Buprenorphine. The effects of the pregnancy and delivery of the new-born babies were
examined. This data was collected from 251 women addicted to methadone or Buprenorphine.
These women were placed in different hospitals. One hundred and fifty-nine (159) of the women
had been taking Buprenorphine during their pregnancy. T hat group of women had delivered 160
live children. The condition of the women was alarming because most of them smoked every
day, used heroin, and injected themselves with Buprenorphine. Half of the newborns were
treated for neonatal abstinence syndrome. This disordered occurs because the mother is addicted
to certain drugs causing the newborn to become addicted as well. All this substance abuse is
always going to result in the neonatal abstinence syndrome. This is very useful information
because many of the women that are in substance abuse end up pregnant. This is a very alarming
reality.