Dermo epidermal junction

D ermo – E pidermal J unction Presented by Adel A. Al-Ghamdi Dermatology Department King Fahd Hospital of university

[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

[object Object],[object Object],[object Object],[object Object]

[object Object],[object Object],[object Object]

Origin of Basement Membrane ,[object Object],[object Object],[object Object],[object Object]

Functions of basement membrane ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Ultrastructure of DEJ ,[object Object],[object Object],DEJ 1 ST ZONE 2 ND ZONE 3 RD ZONE Sub basal lamina Lamina densa Tonofilement, Hemidesmosomes Anchoring filement complexs

First zone ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Second zone ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

[object Object],[object Object]

Third zone ( the sub basal lamina) ,[object Object],[object Object],[object Object],[object Object]

Ubiquitous Components of Basement Membrane Type IV collage Laminin Nidogen/Entactin Heparan sulfate proteoglycan

Type IV Collagen ,[object Object],[object Object],[object Object],[object Object]

[object Object],[object Object],[object Object],[object Object],[object Object]

Laminin ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Nidogen / Entactin ,[object Object],[object Object],[object Object],[object Object]

Heparan sulfate proteoglycan ,[object Object],[object Object],[object Object],[object Object]

Epithelial-Specific Basement membrane Components Hemidesmosome Anchoring filaments Epithelial lamina densa Anchoring fibrils & anchoring plaques

Hemidesmosome (HD) ,[object Object],[object Object],[object Object]

Major Hemidesmosomal Antigens 240-kDa protein BPAG1 180-kDA protein BPAG2 Plectin Integrin alpha6 beta4

BPAG1 ,[object Object],[object Object],[object Object]

BPAG2 ,[object Object],[object Object],[object Object],[object Object]

Plectin ,[object Object],[object Object],[object Object],[object Object],[object Object]

Integrin alpha6 beta4 ,[object Object],[object Object],[object Object],[object Object]

Anchoring filaments ,[object Object],[object Object]

Major Anchoring filament Antigens Laminin 5 125-kDa 19-DEJ-1 105-kDa Ladinin LAD-1

Laminin 5 (alpha3 beta3 gamma 2) ,[object Object],[object Object],[object Object],[object Object],[object Object]

125-kDa protein ,[object Object]

19-DEJ-1 antigen ,[object Object],[object Object],[object Object]

105-kDa Antigen ,[object Object],[object Object],[object Object]

Ladinin & LAD-1 ,[object Object],[object Object]

Epithelial Lamina Densa ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Anchoring fibrils & Anchoring plaques ,[object Object],[object Object],[object Object],[object Object],[object Object]

EBS EBS MD EBS GABEB JEB Herlitz JEB Dystrophic EB WWW.SMSO.NET

Dermo epidermal junction

Recomendados

Recomendados

Más contenido relacionado

La actualidad más candente

La actualidad más candente (20)

Destacado

Destacado (20)

Similar a Dermo epidermal junction

Similar a Dermo epidermal junction (20)

Último

Último (20)

Dermo epidermal junction