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Markeri tumorali in bolile digestive
Dr Ditoiu M Alecse Valerian
Spitalul Fundeni Clinica medicala
Bucuresti
Markerii tumorali sunt substante
secretate de tesuturile canceroase.
Mentionez ca exista situatii numeroase
de cancere digestive cu markeri
tumorali in limite normale, si
numeroase cazuri de markeri tumorali
crescuti fara a fi vorba de cancer.
De aceea, markerii tumorali nu sunt folositi pentru diagnosticul de cancer decat cu rol
orientativ.
In tabelul de mai jos sunt mentionati cei mai utilizati markeri tumorali din
gastroenterologie, valorile lor si nivelul de la care au semnificatie in evaluarea unui caz
medical oncologic.
Markerul
tumoral
Valori
normale
Tumora
in care
creste
markerul
Alte cancere in
care creste
markerul
Situatii
necanceroase
de crestere a
markerului
Valoarea
semnificativa
pentru
cancer
Sensibilitatea
analizei
CA 27.29 < 38
unit/mL
Cancer de
san
Cancer de colon,
gastric, hepatic,
plaman,
pancreatic,
ovarian, prostata
Boli de san,,
ficat, rinich,
chist de ovar
> 100 unit/mL Creste in 33%
din stadiile
initiale de
cancer de san
si in 67% din
fazele
avansate de
cancer de san.
CEA < 2.5 ng/ml
la
nefumatori
si < 5
ng /mL
lafumatori
Cancer de
colon
Cancere de
san,stromac,
pancreas, vezica
urinara,
tiroida,ficat,
limfom,
melanom,faringe
Fumat., ulcer
gastric, boala
inflamatorie
intestinala,
pancreatita,
ciroza,
hipotiroidie,
icter mecanic
>10 ng /mL Creste in 35%
din stadiile
initiale de
cancer de
colon si in
75% din fazele
avansate de
cancer de
colon
CA 19-95 < 37
unit/mL
Cancer de
pancreas
Cancer de colon,
esofag si ficat
Ciroza,
pancreatita,
> 1,000
unit/mL
Creste in 80-
90% din
Markerul
tumoral
Valori
normale
Tumora
in care
creste
markerul
Alte cancere in
care creste
markerul
Situatii
necanceroase
de crestere a
markerului
Valoarea
semnificativa
pentru
cancer
Sensibilitatea
analizei
si cai
biliare
boli biliare cancerele de
pancreas si 60-
70% din
cancerele
cailor biliare
AFP < 5.4 ng /
mL
Cancer de
ficat si
genital
Cancer gastric,
biliar si
pancreatic
Ciroza,
hepatita virala,
sarcina
> 500 ng /mLCreste in 80%
din cancerele hepatice
CA = cancer antigen; CEA = carcinoembryonic antigen; AFP = alpha-fetoprotein; β
Cea mai mare sensibilitate a unei metode de determinare a markerilor tumorali este de
95%.

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Markeri tumorali in bolile digestive

  • 1. Markeri tumorali in bolile digestive Dr Ditoiu M Alecse Valerian Spitalul Fundeni Clinica medicala Bucuresti Markerii tumorali sunt substante secretate de tesuturile canceroase. Mentionez ca exista situatii numeroase de cancere digestive cu markeri tumorali in limite normale, si numeroase cazuri de markeri tumorali crescuti fara a fi vorba de cancer. De aceea, markerii tumorali nu sunt folositi pentru diagnosticul de cancer decat cu rol orientativ. In tabelul de mai jos sunt mentionati cei mai utilizati markeri tumorali din gastroenterologie, valorile lor si nivelul de la care au semnificatie in evaluarea unui caz medical oncologic. Markerul tumoral Valori normale Tumora in care creste markerul Alte cancere in care creste markerul Situatii necanceroase de crestere a markerului Valoarea semnificativa pentru cancer Sensibilitatea analizei CA 27.29 < 38 unit/mL Cancer de san Cancer de colon, gastric, hepatic, plaman, pancreatic, ovarian, prostata Boli de san,, ficat, rinich, chist de ovar > 100 unit/mL Creste in 33% din stadiile initiale de cancer de san si in 67% din fazele avansate de cancer de san. CEA < 2.5 ng/ml la nefumatori si < 5 ng /mL lafumatori Cancer de colon Cancere de san,stromac, pancreas, vezica urinara, tiroida,ficat, limfom, melanom,faringe Fumat., ulcer gastric, boala inflamatorie intestinala, pancreatita, ciroza, hipotiroidie, icter mecanic >10 ng /mL Creste in 35% din stadiile initiale de cancer de colon si in 75% din fazele avansate de cancer de colon CA 19-95 < 37 unit/mL Cancer de pancreas Cancer de colon, esofag si ficat Ciroza, pancreatita, > 1,000 unit/mL Creste in 80- 90% din
  • 2. Markerul tumoral Valori normale Tumora in care creste markerul Alte cancere in care creste markerul Situatii necanceroase de crestere a markerului Valoarea semnificativa pentru cancer Sensibilitatea analizei si cai biliare boli biliare cancerele de pancreas si 60- 70% din cancerele cailor biliare AFP < 5.4 ng / mL Cancer de ficat si genital Cancer gastric, biliar si pancreatic Ciroza, hepatita virala, sarcina > 500 ng /mLCreste in 80% din cancerele hepatice CA = cancer antigen; CEA = carcinoembryonic antigen; AFP = alpha-fetoprotein; β Cea mai mare sensibilitate a unei metode de determinare a markerilor tumorali este de 95%.