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Drugs Affecting Urinary
System
Diuretics
Outlines:
1- Diuretics
A-Loop Diuretics → Furesmide (Lasix®)
B- Thiazides → Chlorothiazide (Diuril®)
C- Potassium Sparing Diuretics → Spironolactone (Aldactone®)
D- Osmotic Diuretics → Mannitol (Osmitrol®)
C- Carbonic Anhydrase Inhibitors → Acetazolamide (Diamox®)

2- Urinary antiseptics
- Ciprofluxacine HCl (Cipro®)

- Nitrofurantoin (Macrodantin®)

3- Urinary analgesic
Phenazopyredine
References:
•

Catherine Paradiso.1998 , Pharmacology. Lippincott’s. USA.

•

Bruce D. Clayton., Yvonne N. Stock.1997, Basic pharmacology for
nurses. 11th Ed, Mosby.USA.

•

Ben Greenstein., 2004 , Trounce’s Clinical Pharmacology for Nurses.
17th Ed, Churchill Livingstone.USA.

•

Brunner & Suddarth., 2004 , Medical-Surgical Nursing. 10th Ed,
Lippincott’s. USA.

•

http://en.wikipedia.org/wiki/Adenosine

•

Amy M. Karch., 2003 , Nursing Drug Guide. Lippincott’s. USA.
Diuretics
Cortex

Medulla
Loop of Henle

Thiazides
Inhibit active exchange of
Cl-Na
in the cortical diluting
segment of the
ascending loop of Henle
K-sparing
Inhibit reabsorption of
Na in the distal convoluted
and collecting tubule
Loop diuretics
Inhibit exchange of Cl-Na-K in
the thick segment of
the ascending loop of Henle

Collecting tubule
Study Questions

1. Which of the following Diuretics is the first line used
to Glaucoma?
a. Lasix®

b. Aldactone ®
c. Diuril®
d. Diamox®
2. Which of the following Diuretics is the first line used
to Hypertension with Hyperkalemia ?
a. Lasix®

b. Osmitrol®
c. Aldactone®
d. Diamox®
3. Which of the following Diuretics is the first line used
in cases of Hyperaldosteronism ?
a. Lasix®

b. Aldactone ®
c. Diuril®
d. Diamox®
4. Which of the following Diuretics is the first line used
to Hypertention?
a. Lasix®

b. Aldactone®
c. Diuril®
d. Diamox®
5. Which of the following Diuretics is the first line used
in cases of edema ?
a. Lasix®

b. Aldactone®
c. Diuril®
d. Diamox®
6. Which of the following Diuretics is the Second line
used to Hypertension?
a. Lasix®

b. Aldactone®
c. Diuril®
d. Diamox®
2. Complete the following Table with an appropriate
diuretics below
-Loop Diuretic

-Osmotic Diuretics

-Potassium Sparing diuretics

-Thiazides

-Carbonic Anhydrase Inhibitors
Diuretic

Site of Action

Loop of Henle
Distal Convoluted Tubule
Collecting Tubule
Proximal Convoluted tubule

Entire Tubule

Abdulqadir Nashwan

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Diuretics

  • 2. Outlines: 1- Diuretics A-Loop Diuretics → Furesmide (Lasix®) B- Thiazides → Chlorothiazide (Diuril®) C- Potassium Sparing Diuretics → Spironolactone (Aldactone®) D- Osmotic Diuretics → Mannitol (Osmitrol®) C- Carbonic Anhydrase Inhibitors → Acetazolamide (Diamox®) 2- Urinary antiseptics - Ciprofluxacine HCl (Cipro®) - Nitrofurantoin (Macrodantin®) 3- Urinary analgesic Phenazopyredine
  • 3. References: • Catherine Paradiso.1998 , Pharmacology. Lippincott’s. USA. • Bruce D. Clayton., Yvonne N. Stock.1997, Basic pharmacology for nurses. 11th Ed, Mosby.USA. • Ben Greenstein., 2004 , Trounce’s Clinical Pharmacology for Nurses. 17th Ed, Churchill Livingstone.USA. • Brunner & Suddarth., 2004 , Medical-Surgical Nursing. 10th Ed, Lippincott’s. USA. • http://en.wikipedia.org/wiki/Adenosine • Amy M. Karch., 2003 , Nursing Drug Guide. Lippincott’s. USA.
  • 4. Diuretics Cortex Medulla Loop of Henle Thiazides Inhibit active exchange of Cl-Na in the cortical diluting segment of the ascending loop of Henle K-sparing Inhibit reabsorption of Na in the distal convoluted and collecting tubule Loop diuretics Inhibit exchange of Cl-Na-K in the thick segment of the ascending loop of Henle Collecting tubule
  • 5. Study Questions 1. Which of the following Diuretics is the first line used to Glaucoma? a. Lasix® b. Aldactone ® c. Diuril® d. Diamox®
  • 6. 2. Which of the following Diuretics is the first line used to Hypertension with Hyperkalemia ? a. Lasix® b. Osmitrol® c. Aldactone® d. Diamox®
  • 7. 3. Which of the following Diuretics is the first line used in cases of Hyperaldosteronism ? a. Lasix® b. Aldactone ® c. Diuril® d. Diamox®
  • 8. 4. Which of the following Diuretics is the first line used to Hypertention? a. Lasix® b. Aldactone® c. Diuril® d. Diamox®
  • 9. 5. Which of the following Diuretics is the first line used in cases of edema ? a. Lasix® b. Aldactone® c. Diuril® d. Diamox®
  • 10. 6. Which of the following Diuretics is the Second line used to Hypertension? a. Lasix® b. Aldactone® c. Diuril® d. Diamox®
  • 11. 2. Complete the following Table with an appropriate diuretics below -Loop Diuretic -Osmotic Diuretics -Potassium Sparing diuretics -Thiazides -Carbonic Anhydrase Inhibitors Diuretic Site of Action Loop of Henle Distal Convoluted Tubule Collecting Tubule Proximal Convoluted tubule Entire Tubule Abdulqadir Nashwan