12. Serotonin
S t i
Sex
Concentration
Hunger
Interest
Mood
Pain
Sleep
p
13. Classes of Medications
Cl f M di ti
Class: Neurotransmiter: Affects:
Antipsychotics Dopamine Psychosis
Antidepressants Serotonin Mood
Norepinephrine
Antimanic Polarization of Mood
neuron
Benzodiazepines GABA Anxiety
20. Classes of Medications
Cl f M di ti
Class: Neurotransmiter: Affects:
Antipsychotics Dopamine Psychosis
Antidepressants Serotonin Mood
Norepinephrine
Antimanic Polarization of Mood
neuron
Benzodiazepines GABA Anxiety
21. Antipsychotic therapy:
Historical perspective in the United States
Reserpine
Chlorpromazine
Fluphenazine
Quetiapine
Thioridazine
Haloperidol Olanzapine
Risperidone Aripiprazole
Clozapine Ziprasidone
1950
19 0 1960 1970
19 0 1980 1990 2000 2002
Kaplan HI et al. Kaplan and Sadock’s Synopsis of Psychiatry. 7th ed.1994.
Black DW et al. Introductory Textbook of Psychiatry. 2001.
24. Anti-psychotics
A ti h ti
Typical (e.g. Haldol)
Anticholinergic side effects (thorazine)
Extrapyramidal side effects
Atypical (e.g. Zyprexa and Respirdal)
Sedation, weight gain, dizziness,
S d ti i ht i di i
orthostatic hypotension
25. Antidepressants
A tid t
Multimechanism Serotonin
Effexor Prozac
Welbutrin
e but Paxil
a
TCA Zoloft
Remeron Luvox
Cymbalta Lexapro
Celexa
26. Selective Serotonin Reuptake Inhibitors
Prozac The most common side effects of SSRI
medications are: Nausea, diarrhea,
Paxil headache, restlessness, insomnia,
Zoloft anxiety, sexual dysfunction,
perspiration, tremor, insomnia,
Luvox sleepiness, dry mouth.
Celexa
Lexapro
27. Anxiety Di d
A i t Disorders
Serotonin Benzodiazepines
Prozac Valium
Paxil Ativan
Zoloft Xanax
Luvox Klonopin
Celexa Librium
Lexapro
36. Multi-mechanism Antidepressants
Effexor -weight loss, insomnia, nausea, sleepiness, anxiety, decreased
appetite. Other side effects include: blurry vision, dizziness, constipation,
seizures, changes in blood pressure, decreased energy, sweating, sexual
dysfunction, dry mouth, yawning.
Welbutrin -Nausea, vomiting, sweating, dry mouth, nervousness,
constipation, dizziness
constipation dizziness. Other side effects include: seizure insomnia, motor
seizure, insomnia
tics, rash.
Tricyclic Antidepressants -weight gain, weight loss, sleepiness, irritability
and aggression, dizziness sexual dysfunction changes in breast size
aggression dizziness, dysfunction, size,
nightmares, stuttering, sensitivity to the sun. Severe side effects include:
seizures, irregular heart beats, rash, hallucinations.
Remeron- b careful with weight gain
R be f l ih i h i
Serzone – be careful with liver failure
37. Child Issues
Diagnostic nosology difficult to apply to children
and adolescents.
Symptom/Syndrome treatment should be the
focus when there is diagnostic uncertainty.
Reconsider the intervention every 6-12 months.
6 12
Start low and go slow.
41. Even more Abbreviations
qD once daily
Bid twice daily
Tid three times daily
Qid f times d l
d for daily
Q6h every six hours
Qod every other day
Tsp teaspoon (5ml)Tbsp tablespoon
(15ml)