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What Psychotherapists Should
 Know About Psychotropic
        Medication

    Daniel B. Martinez, M.D.
            Medical Director
      Pilsen Wellness Center, Inc.
The Medical Model
Biological
Psychological
P h l i l
 Sociological
   Cultural
  Spiritual
Single Ph
Si l Photon Emission Tomography
            E i i T          h




                         Images (c) Dr. Amen
Normal
N    l




         Images (c) Dr. Amen
Images (c) Dr. Amen
ENCOURAGE COMPLIANCE!!!




                   suntimes, 05
washington.edu
source
Dopamine
D    i

           Rewards
           Attention
           Motivation
           Drive
           Pleasure

                        Strahl,
                        Strahl 2000
Norepinephrine
N    i   hi

          Mood
          Interest
          I t    t
          Motivation
          Energy
Serotonin
S t i
            Sex
            Concentration
            Hunger
            Interest
            Mood
            Pain
            Sleep
                p
Classes of Medications
  Cl       f M di ti
  Class:          Neurotransmiter:   Affects:

Antipsychotics    Dopamine           Psychosis

Antidepressants   Serotonin       Mood
                  Norepinephrine
Antimanic         Polarization of Mood
                  neuron
Benzodiazepines   GABA               Anxiety
Have you decided for yourself?
Classes of Medications
  Cl       f M di ti
  Class:          Neurotransmiter:   Affects:

Antipsychotics    Dopamine           Psychosis

Antidepressants   Serotonin       Mood
                  Norepinephrine
Antimanic         Polarization of Mood
                  neuron
Benzodiazepines   GABA               Anxiety
Antipsychotic therapy:
          Historical perspective in the United States


  Reserpine
       Chlorpromazine
           Fluphenazine
                                                                                           Quetiapine
              Thioridazine
                        Haloperidol                                               Olanzapine
                                                                               Risperidone                   Aripiprazole
                                                                            Clozapine          Ziprasidone




 1950
 19 0              1960                  1970
                                         19 0                 1980               1990           2000           2002




Kaplan HI et al. Kaplan and Sadock’s Synopsis of Psychiatry. 7th ed.1994.
Black DW et al. Introductory Textbook of Psychiatry. 2001.
AAntipsychotics
-Major Tranquilizers
-Block Dopamine
-Decrease Psychosis
-Induce Parkinsonism
   d       k
Atypicals and Reported Dangers
 Clozaril    -Agranulocytosis, Seizures
 Respirdal   -EPS,
             -EPS Hyperprolactinemia
 Zyprexa     -Weight, Diabetes
 Geodon
      d      -EKG problems
                      bl
 Seroquel    -Cataracts
 Abilify     -Deaths
Anti-psychotics
         A ti     h ti

Typical (e.g. Haldol)
  Anticholinergic side effects (thorazine)
  Extrapyramidal side effects


Atypical (e.g. Zyprexa and Respirdal)
  Sedation, weight gain, dizziness,
  S d ti       i ht i di i
  orthostatic hypotension
Antidepressants
            A tid        t
Multimechanism      Serotonin

Effexor             Prozac
Welbutrin
  e but             Paxil
                     a
TCA                 Zoloft
Remeron             Luvox
Cymbalta            Lexapro
                    Celexa
Selective Serotonin Reuptake Inhibitors

Prozac     The most common side effects of SSRI
           medications are: Nausea, diarrhea,
Paxil      headache, restlessness, insomnia,
Zoloft     anxiety, sexual dysfunction,
           perspiration, tremor, insomnia,
Luvox      sleepiness, dry mouth.
Celexa
Lexapro
Anxiety Di d
A i t Disorders
 Serotonin        Benzodiazepines

 Prozac           Valium
 Paxil            Ativan
 Zoloft           Xanax
 Luvox            Klonopin
 Celexa           Librium
 Lexapro
Bipolar Disorder Medications
Lithium    .6-1.2 mEq/L   tremor, N/V, kidney,
                          thyroid, acne,
                            y    ,     ,
                          sedation

Depakote   50-120ug/ml    N/V, wt,sedation,
                          hair loss

Tegretol   6-12 ug/ml     sedation, N/V, rash
Look t for:
L k out f

Coma, kidney, Heart                   -Lithium

Liver, Pancreas, Skin, Ovary, Blood-Depakote

Blood, Skin, Liver                    -Tegretol
Benzodiazepines’
          p
5 Dangerous Ds

 Dependence
 Disinhibition
 Dizziness
 Depression
 Deficits in Memory
ADHD Treatments

                      Dopamine          Norepinepherine
                       Ritaline          And Dopamine
                      Concerta                Adderall
                       Focalin                Vyvanse




                              Norepinephrine
                                  Strattera




a2-agonist Intunive
Attention Deficit Hyperactivity
                    yp         y
 Disorder
Stimulants (Ritalin, Dexedrine, Adderall, Concerta,
Cylert)
Blood Pressure Medication            (clonidine and
Tenex)
     )
Wellbutrin
Tricyclic Anti-Depressants          (Imipramine,
                                    (Imipramine
Desipramine)
Strattera (atomoxetine)
HHOW ABOUT NATURAL MEDS?
  Omega-3
  DHEA
  St. John's Wort
  Melatonin
     l
Sun-Times 6/04
Multi-mechanism Antidepressants
Effexor -weight loss, insomnia, nausea, sleepiness, anxiety, decreased
appetite. Other side effects include: blurry vision, dizziness, constipation,
seizures, changes in blood pressure, decreased energy, sweating, sexual
dysfunction, dry mouth, yawning.
Welbutrin -Nausea, vomiting, sweating, dry mouth, nervousness,
constipation, dizziness
constipation dizziness. Other side effects include: seizure insomnia, motor
                                                    seizure, insomnia
tics, rash.
Tricyclic Antidepressants -weight gain, weight loss, sleepiness, irritability
and aggression, dizziness sexual dysfunction changes in breast size
     aggression dizziness,         dysfunction,                     size,
nightmares, stuttering, sensitivity to the sun. Severe side effects include:
seizures, irregular heart beats, rash, hallucinations.
Remeron- b careful with weight gain
R        be    f l ih i h        i
Serzone – be careful with liver failure
Child Issues

Diagnostic nosology difficult to apply to children
and adolescents.
Symptom/Syndrome treatment should be the
focus when there is diagnostic uncertainty.
Reconsider the intervention every 6-12 months.
                                   6 12
Start low and go slow.
Figiuring out Prescriptions
Pharmacy Abbreviations
p.o.   By mouth
i.m.
im     Intramuscularly
Tab    tablet
Cap    Capsulel
Liq    Liquid
Elix   Elixer
More Pharmacy Abbreviations
Am    morning
Pm    evening (afternoon)
Hs    at bedtime
Q     every
Prn   as needed
Even more Abbreviations
qD once daily
Bid twice daily
Tid three times daily
Qid f times d l
  d for       daily
Q6h every six hours
Qod every other day
Tsp teaspoon (5ml)Tbsp tablespoon
  (15ml)
Medication
Sig.       (Directions)

#
Number

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What psychotherapists should know about psychiatric medication

  • 1. What Psychotherapists Should Know About Psychotropic Medication Daniel B. Martinez, M.D. Medical Director Pilsen Wellness Center, Inc.
  • 3. Biological Psychological P h l i l Sociological Cultural Spiritual
  • 4. Single Ph Si l Photon Emission Tomography E i i T h Images (c) Dr. Amen
  • 5. Normal N l Images (c) Dr. Amen
  • 7. ENCOURAGE COMPLIANCE!!! suntimes, 05
  • 10. Dopamine D i Rewards Attention Motivation Drive Pleasure Strahl, Strahl 2000
  • 11. Norepinephrine N i hi Mood Interest I t t Motivation Energy
  • 12. Serotonin S t i Sex Concentration Hunger Interest Mood Pain Sleep p
  • 13. Classes of Medications Cl f M di ti Class: Neurotransmiter: Affects: Antipsychotics Dopamine Psychosis Antidepressants Serotonin Mood Norepinephrine Antimanic Polarization of Mood neuron Benzodiazepines GABA Anxiety
  • 14. Have you decided for yourself?
  • 15.
  • 16.
  • 17.
  • 18.
  • 19.
  • 20. Classes of Medications Cl f M di ti Class: Neurotransmiter: Affects: Antipsychotics Dopamine Psychosis Antidepressants Serotonin Mood Norepinephrine Antimanic Polarization of Mood neuron Benzodiazepines GABA Anxiety
  • 21. Antipsychotic therapy: Historical perspective in the United States Reserpine Chlorpromazine Fluphenazine Quetiapine Thioridazine Haloperidol Olanzapine Risperidone Aripiprazole Clozapine Ziprasidone 1950 19 0 1960 1970 19 0 1980 1990 2000 2002 Kaplan HI et al. Kaplan and Sadock’s Synopsis of Psychiatry. 7th ed.1994. Black DW et al. Introductory Textbook of Psychiatry. 2001.
  • 23. Atypicals and Reported Dangers Clozaril -Agranulocytosis, Seizures Respirdal -EPS, -EPS Hyperprolactinemia Zyprexa -Weight, Diabetes Geodon d -EKG problems bl Seroquel -Cataracts Abilify -Deaths
  • 24. Anti-psychotics A ti h ti Typical (e.g. Haldol) Anticholinergic side effects (thorazine) Extrapyramidal side effects Atypical (e.g. Zyprexa and Respirdal) Sedation, weight gain, dizziness, S d ti i ht i di i orthostatic hypotension
  • 25. Antidepressants A tid t Multimechanism Serotonin Effexor Prozac Welbutrin e but Paxil a TCA Zoloft Remeron Luvox Cymbalta Lexapro Celexa
  • 26. Selective Serotonin Reuptake Inhibitors Prozac The most common side effects of SSRI medications are: Nausea, diarrhea, Paxil headache, restlessness, insomnia, Zoloft anxiety, sexual dysfunction, perspiration, tremor, insomnia, Luvox sleepiness, dry mouth. Celexa Lexapro
  • 27. Anxiety Di d A i t Disorders Serotonin Benzodiazepines Prozac Valium Paxil Ativan Zoloft Xanax Luvox Klonopin Celexa Librium Lexapro
  • 28. Bipolar Disorder Medications Lithium .6-1.2 mEq/L tremor, N/V, kidney, thyroid, acne, y , , sedation Depakote 50-120ug/ml N/V, wt,sedation, hair loss Tegretol 6-12 ug/ml sedation, N/V, rash
  • 29. Look t for: L k out f Coma, kidney, Heart -Lithium Liver, Pancreas, Skin, Ovary, Blood-Depakote Blood, Skin, Liver -Tegretol
  • 30. Benzodiazepines’ p 5 Dangerous Ds Dependence Disinhibition Dizziness Depression Deficits in Memory
  • 31. ADHD Treatments Dopamine Norepinepherine Ritaline And Dopamine Concerta Adderall Focalin Vyvanse Norepinephrine Strattera a2-agonist Intunive
  • 32. Attention Deficit Hyperactivity yp y Disorder Stimulants (Ritalin, Dexedrine, Adderall, Concerta, Cylert) Blood Pressure Medication (clonidine and Tenex) ) Wellbutrin Tricyclic Anti-Depressants (Imipramine, (Imipramine Desipramine) Strattera (atomoxetine)
  • 33. HHOW ABOUT NATURAL MEDS? Omega-3 DHEA St. John's Wort Melatonin l
  • 34.
  • 36. Multi-mechanism Antidepressants Effexor -weight loss, insomnia, nausea, sleepiness, anxiety, decreased appetite. Other side effects include: blurry vision, dizziness, constipation, seizures, changes in blood pressure, decreased energy, sweating, sexual dysfunction, dry mouth, yawning. Welbutrin -Nausea, vomiting, sweating, dry mouth, nervousness, constipation, dizziness constipation dizziness. Other side effects include: seizure insomnia, motor seizure, insomnia tics, rash. Tricyclic Antidepressants -weight gain, weight loss, sleepiness, irritability and aggression, dizziness sexual dysfunction changes in breast size aggression dizziness, dysfunction, size, nightmares, stuttering, sensitivity to the sun. Severe side effects include: seizures, irregular heart beats, rash, hallucinations. Remeron- b careful with weight gain R be f l ih i h i Serzone – be careful with liver failure
  • 37. Child Issues Diagnostic nosology difficult to apply to children and adolescents. Symptom/Syndrome treatment should be the focus when there is diagnostic uncertainty. Reconsider the intervention every 6-12 months. 6 12 Start low and go slow.
  • 39. Pharmacy Abbreviations p.o. By mouth i.m. im Intramuscularly Tab tablet Cap Capsulel Liq Liquid Elix Elixer
  • 40. More Pharmacy Abbreviations Am morning Pm evening (afternoon) Hs at bedtime Q every Prn as needed
  • 41. Even more Abbreviations qD once daily Bid twice daily Tid three times daily Qid f times d l d for daily Q6h every six hours Qod every other day Tsp teaspoon (5ml)Tbsp tablespoon (15ml)
  • 42. Medication Sig. (Directions) # Number