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Epidemiology 2 Digby Tantam Clinical Professor of Psychotherapy, ScHARR Honorary Consultant Psychotherapist and Psychiatrist Honorary Senior Visiting Research Fellow, University of Cambridge
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object]
 
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Stem and leaf plots are a way of presenting numerical data. The data found on the left hand side of the solid line is considered the stem, and the numbers on the right are the leaves. This particular stem and leaf plot depicts infant mortality rates in Western Africa. The rates range from 51 to 151. This stem and leaf plot was taken from http://mainland.cctt.org/mathsummer/JosephBond/StemAndPlots/images/table2.gif
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Inception rate Incidence rate Prevalence Odds
[object Object],[object Object],[object Object]
Scale Level Scale of Measurement Scale Qualities Example(s) 4 Ratio (scale for SPSS) Magnitude Equal Intervals Absolute Zero Age, Height, Weight, Percentage Geometric mean, log transform 3 Interval (scale for SPSS) Magnitude Equal Intervals Temperature 2 Ordinal Magnitude Likert Scale, Anything rank ordered 1 Nominal (categorical) None Names, Lists of words 0 Dichotomous: both nominal, and pseudo-interval None, but can be combined Yes/ No
Visual analogue scale Is this a Likert scale?
Likert scale ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
What kinds of variables are these? ,[object Object],[object Object],[object Object],[object Object],[object Object]
Continous and discontinuous variables ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Parametric and non-parametric ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Parametric and nonparametric tests ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Sampling ,[object Object],[object Object],[object Object]
Probability sampling ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Nonrandom sampling ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
 
Questionnaire design ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Internal consistency vs. redundancy ,[object Object],[object Object],[object Object],[object Object],[object Object]
Validity ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Reliability: can be measured using correlations ,[object Object],[object Object],[object Object]
[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Copyright ©1994 BMJ Publishing Group Ltd. Altman, D G et al. BMJ 1994;309:188 FIG 1 (left) – Receiver operating characteristic curve Distribution of values of an index of mixed epidermal cell lymphocyte reactions in patients who did or did not develop grafts versus host disease3 Area under the curve is the ‘diagnostic accuracy’
Which has the greater diagnostic accuracy?
 
 
[object Object],[object Object],[object Object],[object Object]
How might these studies be carried out epidemiologically? ,[object Object],[object Object],[object Object],[object Object]
Classification of the trinucleotide repeat, and resulting disease status, depends on the number of CAG repeats [13] Repeat count Classification Disease status <28 Normal Unaffected 28–35 Intermediate Unaffected 36–40 Reduced Penetrance +/- Affected >40 Full Penetrance Affected
Genomic epidemiology ,[object Object],[object Object]
Segregation ,[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object]
Odds ratios ,[object Object],[object Object],[object Object]
Association between hay fever and eczema in 11 year old children 1 From  BMJ  2000;320:1468 ( 27 May ) Eczema Hay fever Total Yes No Yes   141     420     561 No   928 13 525 14 453 Total 1069 13 945 15 522
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object]
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Cause cannot be inferred from associations/ correlation does not imply causation ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
The third factor problem ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Symptoms vs. ‘constructs’ ,[object Object],[object Object],[object Object],[object Object],[object Object]

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Epidemiology 2 dec 2010

  • 1. Epidemiology 2 Digby Tantam Clinical Professor of Psychotherapy, ScHARR Honorary Consultant Psychotherapist and Psychiatrist Honorary Senior Visiting Research Fellow, University of Cambridge
  • 2.
  • 3.
  • 4.  
  • 5.
  • 6.
  • 7.
  • 8.
  • 9.
  • 10.
  • 11. Stem and leaf plots are a way of presenting numerical data. The data found on the left hand side of the solid line is considered the stem, and the numbers on the right are the leaves. This particular stem and leaf plot depicts infant mortality rates in Western Africa. The rates range from 51 to 151. This stem and leaf plot was taken from http://mainland.cctt.org/mathsummer/JosephBond/StemAndPlots/images/table2.gif
  • 12.
  • 13.
  • 14.
  • 15.
  • 16.
  • 17. Inception rate Incidence rate Prevalence Odds
  • 18.
  • 19. Scale Level Scale of Measurement Scale Qualities Example(s) 4 Ratio (scale for SPSS) Magnitude Equal Intervals Absolute Zero Age, Height, Weight, Percentage Geometric mean, log transform 3 Interval (scale for SPSS) Magnitude Equal Intervals Temperature 2 Ordinal Magnitude Likert Scale, Anything rank ordered 1 Nominal (categorical) None Names, Lists of words 0 Dichotomous: both nominal, and pseudo-interval None, but can be combined Yes/ No
  • 20. Visual analogue scale Is this a Likert scale?
  • 21.
  • 22.
  • 23.
  • 24.
  • 25.
  • 26.
  • 27.
  • 28.
  • 29.  
  • 30.
  • 31.
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  • 33.
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  • 38.
  • 39.
  • 40. Copyright ©1994 BMJ Publishing Group Ltd. Altman, D G et al. BMJ 1994;309:188 FIG 1 (left) – Receiver operating characteristic curve Distribution of values of an index of mixed epidermal cell lymphocyte reactions in patients who did or did not develop grafts versus host disease3 Area under the curve is the ‘diagnostic accuracy’
  • 41. Which has the greater diagnostic accuracy?
  • 42.  
  • 43.  
  • 44.
  • 45.
  • 46. Classification of the trinucleotide repeat, and resulting disease status, depends on the number of CAG repeats [13] Repeat count Classification Disease status <28 Normal Unaffected 28–35 Intermediate Unaffected 36–40 Reduced Penetrance +/- Affected >40 Full Penetrance Affected
  • 47.
  • 48.
  • 49.
  • 50.
  • 51.
  • 52.
  • 53. Association between hay fever and eczema in 11 year old children 1 From BMJ  2000;320:1468 ( 27 May ) Eczema Hay fever Total Yes No Yes   141     420     561 No   928 13 525 14 453 Total 1069 13 945 15 522
  • 54.
  • 55.
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  • 58.  
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  • 60.  
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  • 64.  
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  • 66.  
  • 67.  
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  • 70.
  • 71.
  • 72.