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TONOMETRY




            BY

      Dr.Arun Kumar Reddy
Tonometry
• Tonometry is the procedure performed to
  determine the intraocular pressure (IOP)
history
•   1826:  William Bowman used digital tonometry as a routine examination
    test.

•   1863: Albrecht von Grafe designed the first instrument to attempt to
    measure intraocular pressure.

•   Further instruments followed, notably by Donders in 1865 and Preistly-
    Smith in 1880.
    These instruments were all of the indentation type and rested on the sclera (no
    anaesthetic was used until 1884).

•   1885: Maklakov designed an applanation tonometer. This was refined in
    1892. Used for a number of years in Russia and Eastern Europe. This was
    used till 1959.
•
    1905: Hjalmar Schiotz produced his indentation tonometer. This made
    tonometry a simple and routine clinical test.
Albrecht von Grafe tonometer
Donders tonometer
Ideal tonometer
• Should give accurate and reasonable IOP
  measurement
• Convenient to use
• Simple to calibrate
• Stable from day to day
• Easier to standardise
• Free of maintenance problems
Types of tonometry
• Tonometry (IOP)
   • Direct – manometry
   • Indirect –
   • A) Static tonometry – a)contact, b)noncontact
   • a) contact tonometers
   • 1)Indentation
   • Schiotz ,Mercurial ,Electronic ,Scleral tonometry

    • 2)Applanation
        • Variable force
            • GAT, Perkins, MMT, Tonopen, Pneum.Tonometer
        • Constant force
            • Maklakov, Glucotest, Applanometer


    • b)Non Contact tonometer – Pulsair
B) Dynamic instruments
           • Ballistic tonometers
               • Impact acceleration
                  Impact duration
                  Rebound velocity
               • Vibration tonometers (Krakau)


• Vogelsang 1927 – Ballistic Tonometer .The rebound of a
  small metal ball from the eye is measured and this depends
  to a large extent on the physical properties of the coats of
  the eye.
• Roth & Blake 1963- Vibration tonometer cause minimal
  deformation by oscillating force by a probe, which also
  functions as a sensor and measures the resonant frequency
  of the eye.
Types of tonometers
• In a normal eye IOP becomes more during Schiøtz
  tonometry.
• low-displacement tonometers.
• Tonometers in which the IOP is negligibly raised during
  tonometry (less than 5%) are termed as low-displacement
  tonometers.
• Eg. Goldmann Applanation Tonometer.Mackay-Marg
  tonometer.
• The Goldmann tonometer displaces only 0.5 μl of aqueous
  humor and raises IOP by only 3%.
• high-displacement tonometers
• Tonometers that displace a large volume of fluid and
  consequently raise IOP significantly are termed as high-
  displacement tonometers.
High displacement tonometers are mostly less
accurate than low-displacement tonometers.
Direct method
    • Manometry
          • Canula inserted into eye.
          • Not practical clinically.
• Intraocular pressure is higher than atmospheric pressure; therefore, if
    a small hollow needle is inserted into the anterior chamber, aqueous
    humor flows out through the needle.
• If the needle is attached to a
reservoir of fluid that is raised just
 high enough to prevent any loss of
 aqueous, the height of the column
of fluid, usually calibrated in cm of

water or mm of mercury, reflects
the intraocular pressure
Indirect method
• Palpation Method/ digital tonometry
• Intraocular pressure (IOP) is estimated by
  response of eye to pressure applied by
  finger pulp.
• indents easily – low IOP
• Firm to touch – normal IOP
• Hard to touch – high IOP
Schiotz tonometry
• Schiotz (1905, Modified 1924/1926)
Parts of schiotz tonometer
           Tonometer weight = 11g
               scale




               needle

     Additional weights
     7.5,10,15g
                  lever
       Weight 5.5g
3mm diameter plunger
               holder


ROC 15mm     Foot plate
Schiotz tonometry - characteristics
• The extent to which cornea is indented by plunger
  is measured as the distance from the foot plate
  curve to the plunger base and a lever system
  moves a needle on calibrated scale.
• The indicated scale reading and the plunger
  weight are converted to an IOP measurement.
• More the plunger indents the cornea, higher 
  the scale reading and lower the IOP
• Each scale unit represents 0.05 mm protrusion 
  of the plunger.
PRINCIPLE
• The weight of tonometer on the eye increases the actual
  IOP (Po) to a higher level (Pt). 
• The change in pressure from Po to Pt is an expression of
  the resistance of the eye (scleral rigidity) to the
  displacement of fluid.
•  P(t) = P(o) + E

• IOP with Tonometer in  position Pt = 

     Actual IOP Po + Scleral Rigidity E


• Determination of Po from a scale reading Pt requires
  conversion which is done according to Friedenwald 
  conversion tables.
Friedenwald formula

• Friedenwald generated formula for linear relationship
  between the log function of IOP and the ocular distension.
• Pt = log Po + C ΔV
• This formula has ‘C’ a numerical constant, the coefficient 
  of ocular rigidity which is an expression of distensibility
  of eye. Its average value is 0.025
• ΔV is the change in volume
Friedenwald conversion table
                                Plunger Load
•
Scale Reading   5.5 g   7.5 g         10 g     15 g
3.0             24.4    35.8          50.6     81.8
3.5             22.4    33.0          46.9     76.2
4.0             20.6    30.4          43.4     71.0
4.5             18.9    28.0          40.2     66.2
5.0             17.3    25.8          37.2     61.8
5.5             15.9    23.8          34.4     57.6
6.0             14.6    21.9          31.8     53.6
6.5             13.4    20.1          29.4     49.9
7.0             12.2    18.5          27.2     46.5
7.5             11.2    17.0          25.1     43.2
8.0             10.2    15.6          23.1     40.2
8.5             9.4     14.3          21.3     38.1
9.0             8.5     13.1          19.6     34.6
9.5             7.8     12.0          18.0     32.0
10.0            7.1     10.9          16.5     29.6
TECHNIQUE
• Patient should be anasthetised with 4%lignocaine or 0.5%
  proparacaine
• With the patient in supine position, looking up at a
  fixation target while examiner separates the lids and
  lowers the tonometer plate to rest on the anesthetized
  cornea so that plunger is free to move vertically .
• Scale reading is measured.
• The 5.5 gm weight is initially used.
• If scale reading is 4 or less, additional weight is added to
  plunger.
• Conversion table is used to derive IOP in mm Hg from
  scale reading and plunger weight.
SOURCES OF ERROR
• Accuracy is limited as ocular rigidity varies from eye to
  eye.
• As conversion tables are based on an average coefficient
  of ocular rigidity; eye that varies significantly from this
  value gives erroneous IOP.
• Repeated measurements lower IOP.
• steeper or a thicker cornea causes greater displacement of
  fluid during tonometry and gives a falsely high IOP
  measurement.
• Schiøtz reads lower than GAT
Factors Affecting Scleral Rigidity


• High Scleral Rigidity
     •   hyperopia
     •   long standing glaucoma
     •   ARMD
     •   vasoconstrictors
Factors Affecting Scleral Rigidity
•Low Scleral Rigidity
     •increasing age
     • high myopia
     •miotics
     •vasodilators
     •Postoperative after RD surgery (vitrectomy,
     cryopexy, scleral band)
     •intravitreal injection of compressible gas.
     •keratoconus (?).

     •Low ocular rigidity ----- falsely high scale reading
     ----- falsely low IOP.
LIMITATIONS
  • Instrumental errors
     • Standardisation - testing labs for certification
     • Mechanical obstruction to plunger etc.
  • Muscular contractions
     • Of extra ocular muscles increase IOP
     • Accomodation decreases IOP
• Variations in volume of globe
  • Microphthalmos
  • High Myopia
  • Buphthalmos
  • It can be recorded in supine position only
Advantages of schiotz tonometer
• Simple technique
• Elegant design
• Portable
• No need for SlitLamp or power supply
• Reasonably priced
• Anodized scale mount which is highly
  resistant to sterilizing water.
• Schiotz tonometer is still most widely
  tonometer.
calibration
• The instrument should be calibrated before
  each use by placing it on a polished metal
  sphere and checking to be sure that the
  scale reading is zero.
• If the reading is not zero, the instrument
  must be repaired.
sterilization
• The tonometer is disassembled between each use
  and the barrel is cleaned with 2 pipe cleaners, the
  first soaked in isopropyl alcohol 70 % or 
  methylated spirit and the second dry.
• The foot plate is cleaned with alcohol swab.
• All surfaces must be dried before reassembling.
• The instrument can be sterilized with ultraviolet
  radiation, steam, ethylene oxide.
• As with other tonometer tips, the Schiotz can be
  damaged by some disinfecting solutions such as
  hydrogen peroxide and bleach.
Differential tonometry
• It is done to get rid from ocular rigidity.
• A reading is taken with one weight on the Plunger and then a second
  reading' in taken with a different weight.
• Making a diagnosis of glaucoma in a pt. with myopia presents
  unusual difficulties. The low ocular rigidity in these eyes result in
  Schiotz readings within normal limits.
5.5g              10g               Ocular             IOP
                                    rigidity
18 mm Hg          15 mm Hg          lower              >18

18 mm Hg          21 mm Hg          higher             <18

18 mm Hg          18 mm Hg          equal              18
APPLANATION TONOMETER


              Connects to the slit
              lamp
              Biprism
              (measuring prism)

              Feeder arm

              Control weight insert
              Housing
              Adjusting knob
PRINCIPLE

• Applanation tonometry is based on the
  Imbert-Fick principle, which states that
  the pressure (p) inside an ideal dry, thin-
  walled sphere equals the force (F)
  necessary to flatten its surface divided by
  the area of the flattening (A).
           F
• P=
           A
• Cornea being aspherical, wet, and slightly inflexible fails
  to follow the law.
• Moisture creates surface tension (S) or capillary
  attraction of tear film for tonometry head.
• Lack of flexibility requires force to bend the cornea (B)
  which is independent of internal pressure.
• The central thickness of cornea is about 0.55 mm and the
  outer area of corneal flattening differs from the inner area
  of flattening (A1). It is this inner area which is of
  importance.
IMBERT FICKS LAW & MODIFIED
IMBERT FICKS LAW

    W=PA             W+S=PA1+B
• Modified Imbert-Fick Law is
• W + S = PA1 + B
• When A1 = 7.35 mm2, S balances B and W =P.
• This internal area of applanation is achieved when
  the diameter of the external area of corneal
  applanation is around 3.06 mm.
• Grams of force applied to flatten 3.06 diameter of
  the cornea multiplied by 10 is directly converted
  to mmHg.
cont…..




The two beam-splitting prism within the
applanating unit optically convert the circular
area of corneal contact in to semicircles
cont….
The instrument is mounted
on a standard slit lamp in such
a way that the examiners view
is directed through the centre
of a plastic Biprism.
 Biprism is attached by a rod
to a housing which contains a
coil spring and series of levers
that are used to adjust the
force of the biprism against
the cornea.
Two beam splitting prisms
within applanating unit
optically convert circular area
of corneal contact in 2
semicircles.
procedure
• The patient is asked not to drink alcoholic beverages as it
  will lower IOP and not to take large amounts of fluid (e.g.,
  500 ml or more) for 2 hours before the test, as it may raise
  the IOP.
• The angle between the illumination and the microscope
  should be approximately 60°.
• The room illumination is reduced.
• A fixation light may be placed in front of the fellow eye.
• The tension knob is set at 1 g. If the knob is set at 0, the
  prism head may vibrate when it touches the eye and
  damage the corneal epithelium.
• The 1 g position is used before each measurement.
Procedure cont..
• The palpebral fissure is a little wider if the patient looks
   up. However, the gaze should be no more than 15° above
   the horizontal to prevent an elevation of IOP.
• After instilling topical anaestheia, Edge of corneal contact
   is made apparent by instilling fluorescein while viewing
   in cobalt blue light.
• The biprism should not touch the lids or lashes because
   this stimulates blinking and squeezing.
• The patient should blink the eyes once or twice to spread
   the fluorescein-stained tear film over the cornea, and then
   should keep the eyes open wide.
Do not to place any pressure on the globe because this raises
 IOP.
Procedure cont..
• In some patients, it is necessary for the examiner to hold
   the eyelids open with
 the thumb and forefinger
 of one hand against the
orbital rim.
• By manually rotating a dial calibrated in grams, the force
   is adjusted by changing the length of a spring within the
   device.
• The prisms are calibrated in such a fashion that inner 
   margin of semicircles touch when 3.06 mm of the cornea
   is applanated.
• The Intra ocular pressure is then read directly from a scale
   on the tonometry housing.
cont….




The fluorescein rings should be      The fluorescent semicircles are viewed
approximately 0.25–0.3 mm in         through the biprism and the force against
thickness – or about one-tenth the   the cornea is adjusted until the inner
diameter of the flattened area.      edges overlap.
Potential Sources of Error – During Measurement
Effect of central corneal thickness (CCT):
• A thinner cornea may require less force to applanate it,
   leading to underestimation of true IOP while a thicker 
   cornea would need more force to applanate it, giving an
   artificially higher IOP.
• The Goldmann applanation tonometer was designed to
   give accurate readings when the CCT was 520 μm.
• The deviation of CCT from 520 μm yields a change in
   applanation readings of 0.7 mm Hg per 10 μm.
• IOP measurements are
also modified after PRK and
 LASIK.
• Thinning of the central
cornea is gives lower readings
 on applanation.
•    Wider meniscus or improper vertical alignment gives
    higher IOP readings
•   If the two semicircles are not equal in size, IOP is
    overestimated.
•   For every 3D increase in corneal curvature, IOP raises
    about 1 mm Hg as more fluid is displaced under steeper
    corneas causing increase in ocular rigidity
•   More than 6 D astigmatism produces an elliptical area
    on applanation that gives erroneous IOP. 4D with-the-rule
    astigmatism underestimate IOP and 4D against-the-rule
    astigmatism overestimate IOP.
•   Mires may be distorted on applanating on irregular 
    corneas .
• Elevating the eyes more than 15° above the horizontal
  causes an overestimation of IOP.
• Widening the lid fissure excessively causes an
  overestimation of IOP
• Repeated tonometry reduces IOP, causing an
  underestimation of the true level.This effect is greatest
  between the first and second readings, but the trend
  continues through a number of repetitions.
• A natural bias for even numbers may cause slight errors in
  readings.
Applanation - Possible Errors
• Falsely low IOP                • Falsely high IOP

   • too little flouroscein         •   too much flouroscein
   • thin cornea                    •   thick cornea
                                    •   steep cornea
   • corneal edema                  •   against the rule
   • with the rule astigmatism          astigmatism
                                    1mm Hg per 3D
       • 1mm Hg per 4 D             •    wider meniscus
                                    • Widening the lid fissure
   • prolonged contact                excessively
   • Repeated tonometry             • Elevating the eyes more
                                      than 15°
Potential Sources of Error – During Measurement
    If the fluorescein rings are too wide, the patient’s eyelids should be blotted
    carefully with a tissue, and the front surface of the prism should be dried with
    lint-free material.
     An excessively wide fluorescein ring can cause IOP to be overestimated
Potential Sources of Error – During Measurement

      If the rings are too narrow, the patient should blink two or three times to
      replenish the fluorescein; additional fluorescein may be added if necessary.
       If the fluorescein rings are too narrow,IOP is underestimated.
Potential Sources of Error – During Measurement
Potential Sources of Error – During Measurement
Potential Sources of Error – During Measurement
Potential Sources of Error – During Measurement
Potential Sources of Error – During Measurement
Potential Sources of Error – During Measurement
Potential Sources of Error – During Measurement
Potential Sources of Error – During Measurement
CALIBRATION
• GAT should be calibrated periodically, at least monthly. If
  the GAT is not within 0.1 g (1 mmHg) of the correct
  calibration, the instrument should be repaired; however,
  calibration errors of up to 2.5 mmHg may still be tolerated
  clinically.
• Following checks are necessary:
• • Check position 0: Turn the zero calibration on the
  measuring drum downwards by the width of one
  calibration marking, against the index marker.
• When the feeler arm is in the free movement zone, it
  should then move itself against the stop piece in the
  direction of the examiner.
• • Check position 0.05: Turn the zero calibration on the
  measuring drum upwards by the width of one calibration
  marking, against the index marker.
• When the feeler arm is in the free movement zone, it
  should then move itself against the stop piece in the
  direction of the patient.
• • Check position at drum setting 2: For checking this
  position, check weight is used.
• Five circles are engraved on the weight bar.
• The middle one corresponds to drum position 0, the two
  immediately to the left and right to position 2 and the
  outer ones to position 6.
• One of the marks on the weight corresponding to drum
  position 2 is set precisely on the index mark of the weight
  holder.
• Holder and weight are then fitted over the axis of the
  tonometer so that the longer part of the weight points
  towards the examiner.
• Check position 1.95: The feeler arm should move towards
   the examiner.
• Check position 2.05.The feeler arm should move in the
   direction of the patient.
• • Check at measuring drum setting 6: Turn the weight
   bar to scale calibration 6, the longer part shows in the
   direction of the examiner.
• • Check position 5.9/6.1 as performed for drum setting 2.
sterilization
• Applanation tip should be soaked for 5-15 min in
  diluted sodium hypochlorite, 3% H2O2 or 70%
  isopropyl alcohol or by wiping with alcohol, H2O2,
  povidone iodine or 1: 1000 merthiolate.
• Other methods of sterilization include: 10 min of
  rinsing in running tap water, wash with soap and
  water, cover the tip with a disposable film, and
  exposure to UV light.
• Disposable tonometer tips may also be used
When using disposable tips, they have a smooth
applanating surface.
 The acrylic disposable tips seem to be somewhat more
accurate than the silicone ones.
 While disposable shields or tips may be safer than
disinfection solutions, they are not 100% protective against
prion disease.
• It is possible to transfer bacteria, viruses, and other
  infectious agents with the tonometer head, including such
  potentially serious infections as epidemic
  keratoconjunctivitis, hepatitis B, Jacob-Kreutzfeld and,
  theoretically, acquired immunodeficiency syndrome.
• Care must be taken to be sure any sterilizing solution has
  been completely rinsed off the tonometer tip, as some of
  these solutions may be toxic to the corneal epithelium,
  especially after LASIK or other corneal procedures.
• If the tonometer tip is not mechanically wiped after each
  use, epithelial cells may stick to the tip with the small but
  serious risk of transmitting Jacob-Kreutzfeld virus.
SAFETY REGULATIONS
• No examination should be undertaken in case of eye
  infections (or) injured corneas.
• Only clean and disinfected measuring prism should be
  used.
• No damaged prisms should be used.
   • If the measuring prism come in to contact with the
     cornea without the drum having previously been
     correctly set, vibration can occur in the feeler arm,
     which will produce unpleasant feeling for the patient.
   • The tonometer tips should be examined periodically
     under magnification as the antiseptic solutions and
     mechanical wiping may cause irregularities in the
     surface of the tip that can, in turn, injure the cornea.
Perkins tonometer
• It uses same prisms as Goldmann
• It is counterbalanced so that tonometry is
  performed in any position
• The prism is illuminated by battery
  powered bulbs.
• Being portable it is practical when
  measuring IOP in infants / children, bed
  ridden patients and for use in operating
  rooms.
Draeger Tonometer
• Draeger tonometer is similar to Perkins
• It has a different set of prisms
• It operates with a motor.
Mackay marg tonometer
Mackay-Marg Tonometer
• 1.5 mm diameter plunger
• rigid spring
• rubber sleeve.
• Movement of plunger is electronically monitored by a
  transducer and recorded on a moving paper strip.
• This instrument is useful for measuring IOP in eyes with
  scarred, irregular, or edematous corneas because the end
  point does not depend on the evaluation of a light reflex
  sensitive to optical irregularity, as does the Goldmann
  tonometer.
• It is accurate when used over therapeutic soft contact
  lenses.
At 1.5 mm of corneal area applanation, tracing reaches a
peak and the force applied = IOP + force required to deform
the cornea.
At 3 mm flattening, force required to deform cornea is
transferred from plunger to surrounding sleeve, creating a
dip in tracing corresponding to IOP.
Flattening of >3 mm of area gives artificial elevation of
IOP.
Tonopen
Tono pen
• Portable
• battery operated .
• same principle as that of Mackay-Marg tonometer.
• It is particularly useful in community health fairs, on
  ward rounds ,children, irregular surfaces, measuring
  through an amniotic membrance patch graft, to read from
  the sclera .
• Tono-Pen tends to overestimate the IOP in infants so its
  usefulness in congenital glaucoma screening and
  monitoring is somewhat limited.
• In band keratopathy where the surface of the pathology is
  harder than normal cornea, the Tono-Pen tends to
  overestimate the IOP
• A disposable latex cover which is discarded after each use
  provides infection control.
Pneumatonometer or pneumatic tonometer 

• It is like Mackay-Marg tonometer.
• The sensor is a air pressure like electronically controlled
  plunger in Mackay-Marg tonometer.
• It can also be used for continuous monitoring of IOP.
• It gives significantly higher IOP estimates.
• It has a sensing device that consists of a gas chamber
  covered by a polymeric silicone diaphragm.
• A transducer converts the gas pressure in the chamber into
  an electrical signal that is recorded on a paper strip.
• The gas in the chamber escapes through an exhaust vent
  between the diaphragm and the tip of the support nozzle.
• As the diaphragm touches the cornea, the gas vent is
  reduced in size, and the pressure in the chamber rises.
Maklakov tonometer
                     •Indentation
                     •Pt supine
                     •wire holder
                      Dumb-bell-shaped
                     metal cylinders with
                     flat end plates of
                     polished glass
                      Diameter of 10 mm
                     The surface of the
                     weight is painted
                     with a dye, such as
                     mild silver protein 
                     (Argyrol) mixed 
                     with glycerin.
                     1 sec contact
                     imprint on end plate
• IOP = W / π (d/2) 2
• weight (W) diameter of the area of applanation (d)
• Intraocular pressure is measured in grams per square
  centimeter and is converted to millimeters of mercury by
  dividing by 1.36.
• widely in Russia and China
• This instrument displaces a greater volume of aqueous
  humor and thus IOP readings are more influenced by
  ocular rigidity.
• It does not correct for corneal bending, capillary
  attraction, or tear encroachment on the layer of dye.
• Many instruments similar to the Maklakow device have
  been described,like the Applanometer, Tonomat, Halberg
  tonometer, and GlaucoTest.
The Ocuton tonometer
•   The Ocuton™ tonometer
•   hand-held tonometer
•    works on the applanation principle
•   probe is so light that it is barely felt
•   needs no anesthetic in most patients.
•   It has been marketed in Europe for home tonometry 
•   useful to get some idea of the relative diurnal variation in IOP if the patient
    or spouse (etc.) can learn to use it.
Rebound tonometer
• It is a new and updated version of an indentation tonometer
• Portable
• can be used without anesthetizing the eye.
• A very light, disposable, sterile probe is propelled forward
  into the cornea .
• The time taken for the probe to return to its resting position
  and the characteristics of the rebound motion are indicative
  of the IOP.
• The time taken for the probe to return to its resting position
  is longer in eyes with lower IOP and faster in eyes with
  higher IOP.
• It is comparable to the GAT.
• It correlates with central corneal thickness like the
  Goldmann, .
• used in screening situations, when patients are unable to
  be seated or measured at the slit lamp, or when topical
  anesthetics are not feasible or usable.
• Not useful in scarred corneas (as does the Goldmann).
Trans palpebral tonometry




 used in situations where other, more accurate, devices are not practical,
such as in young children, demented patients and severely
developmentally-challenged patients.
In addition to all the problems facing indentation tonometry, such as
scleral rigidity, transpalpebral tonometry adds variables such as the
thickness of the eyelids, orbicularis muscle tone and potential Intra 
palpebral scarring.
• Portable. patients can measure their own IOP at home,
  DVT
• pressure on the eyelid in most eyes produces retinal
  phosphenes.
• The pressure on the eyelid required to induce these
  phosphenes is proportional to the intraocular pressure.
• It is not accurate always. inter observer and intra observer
  variability was large.subsequent studies failed to confirm
  the accuracy of this device.
Non contact tonometer
•  Noncontact tonometer (NCT) was introduced by Grolman. 
•  Original NCT has 3 subsystems:
•  1. Alignment system: It aligns patient’s eye in 3 dimensions.
•  2. Optoelectronic applanation monitoring system:
•  It comprises transmitter, receiver and detector, and timer.
•  a. Transmitter directs a collimated beam of light at corneal apex.
•  b. Receiver and detector accept only parallel coaxial rays of light
   reflected from cornea.
• c. Timer measures from an internal reference to the point of peak light
   intensity.
• 3. Pneumatic system: It generates a
 puff of room air directed against cornea
PRINCIPLE
• A puff of room air creates a constant force that
  momentarily flattens the cornea. The corneal apex is
  deformed by a jet of air
• The force of air jet which is generated by a solenoid
  activated piston increases linearly over time.
• When the reflected light is at peak intensity, the cornea is
  presumed to be flattened.
• The time elapsed is directly related to the force of jet
  necessary to flatten the cornea and correspondingly to
  IOP.
• The time from an internal reference point to the moment
  of flattening is measured and converted to IOP.
• A puff of air of known area is generated against cornea (B).
• At the moment of corneal applanation,a light (T), which is
  usually reflected from the normal cornea into space,
  suddenly is reflected (R) into an optical sensor (A).
• When the sensor is activated by the reflected light, the air
  generator is switched off. The level of force at which the
  generator stops is recorded, and a computer calculates and
  displays the intraocular pressure.
• NCT is accurate if IOP is nearly normal, accuracy
  decreases with increase in IOP and in eyes with abnormal
  cornea or poor fixation.
• It is useful for screening programs because it can be
  operated by non-medical personnel
• It does not absolutely require topical anesthesia .
• There is no direct contact between instrument and the eye.
• The patient should be warned that the air puff can be
  startling.
• The non-contact tonometer measures IOP over very short
  intervals, so it is important to average a series of readings.
• New NCT, Pulsair is a portable hand held tonometer.
Ocular Response Analyzer
• It is an adaptation of the non-contact tonometer.
• It directs the air jet against the cornea and measures not one but two 
  pressures at which applanation occurs




• 1) when the air jet flattens the cornea as the cornea is bent inward and
  2) as the air jet lessens in force and the cornea recovers.
Ocular response analyser
• The first is the resting intraocular pressure.
• The difference between the first and the second
  applanation pressure is called corneal hysteresis 
• corneal hysteresis is a measure of the viscous 
  dampening and, hence, the biomechanical properties of 
  the cornea.
• The biomechanical properties of the cornea are related to
  corneal thickness and include elastic and viscous
  dampening attributes.
• IOP correlate well with Goldmann tonometry but, on
  average, measure a few millimeters higher.
• Further , while IOP varies over the 24-hour day,
  hysteresis seems to be stable.
• Congdon et al found that a ‘low’ hysteresis reading with 
  the ORA correlates with progression of glaucoma,
  whereas thin central corneal thickness correlates with 
  glaucoma damage.
• It has practical value in the management of glaucoma.
Dynamic contour tonometer
• Introduced by Kanngiesser 
• It is based on a totally different concept other than
  indentation or applanation tonometry.
• Principle :  By surrounding and matching the contour of a
  sphere (or a portion thereof ), the pressure on the outside 
  equals the pressure on the inside.
• The tip of the probe matches the contour of the cornea.
• A pressure transducer built into the center of the probe
  measures the outside pressure, which should equal the
  inside pressure, and the IOP is recorded digitally on the
  liquid crystal display (LCD).
• The concept developed from a previous contact lens
  tonometer called the ‘Smart Lens”.
• It superior in accuracy to Goldmann tonometry and
  pneumotonometry .
• IOP is not affected by corneal thickness.
• IOP is not altered by corneal refractive surgery that thins
  the cornea.
• Because the DCT measures IOP in real time, the actual
  measurement, like the IOP, is pulsed. The internal
  electronics ‘call’ the IOP as the bottom of the pulsed 
  curve and indicate it digitally on the LCD ..
• IOP readings with the DCT are generally lower than GAT
  because, when properly done, indicates the average
  difference between the maximum and minimum pressures
  whereas the DCT reads the minimum.
Ocular pulse amplitude
• The DCT indicates the magnitude of the difference
   between maximum and minimum IOP as the ocular 
   pulse amplitude.
• OPA may be indicative of the status of ocular blood flow
   and be differentially affected in different types of
   glaucoma.
• ocular pulse amplitude is
 increased over normals in
 most forms of glaucoma and
 may be related to the level
of IOP.
Continuous monitoring of intraocular
pressure
• Applanation instruments inside contact lenses or suction
  cups or strain gauges in encircling bands that resemble
  scleral buckling elements.
• None of these instruments has achieved widespread use.
• resonance applanation tonometry measuring the sonic
  resonance of the eye when a continuous force over a fixed
  area is applied.
• use of infrared spectroscopy to measure IOP.
• To build a miniature pressure sensor that can reside 
  inside the eye; one such device is part of an intraocular
  lens.
Tonometry for Special Clinical Circumstances
• Tonometry on Irregular Corneas
• The accuracy of Goldmann and Tono-Pen tonometers and
  the noncontact tonometers is limited in eyes with irregular
  corneas.
• The pneumatic tonometer has been shown to be useful in
  eyes with diseased or irregular corneas .
• Tonometry over Soft Contact Lenses
• Pneumo tonometry and the Tono-Pen can measure with
  reasonable accuracy the IOP through bandage contact
  lenses .
• pneumotonometer correlates well with manometrically
  determined IOP, whereas the Tono-Pen consistently
  underestimates the pressure.
• Tonometry with Gas-Filled Eyes
• Intraocular gas affects scleral rigidity, rendering
  indentation tonometry unsatisfactory.
• pneumatic tonometer and Tono-Pen used.
• A pneumatic tonometer underestimates Goldmann IOP
  measurements in eyes with intravitreal gas
• Tono-Pen compares favorably with Goldmann readings.
• Both instruments significantly underestimated the IOP at
  pressures greater than 30 mm Hg .
• Tonometry with Flat Anterior Chamber
• IOP readings from the Goldmann applanation tonometer,
  pneumotonometer, and Tono-Pen do not correlate well
  with manometrically determined pressures.
• Tonometry in Eyes with Keratoprostheses
• In patients at high risk for corneal transplant rejection,
  implantation of a keratoprosthesis is now a viable option
  for vision rehabilitation .
• Most keratoprostheses have a rigid, clear surface, it is
  impossible to measure IOP by using applanation or
  indentation instruments.
• In such eyes, tactile assessment appears to be the most
  widely used method to estimate IOP.
nk y ou
Tha
references
• 1)anatomy & physiology of eye
  A.K.Khurana
• 2) Shields glaucoma
• 3)Becker-Shaffers glaucoma
• 4) Diagnostic Procedures in ophthalmology
  Nema
• 5) Duane's Clinical Ophthalmology
• 6) kerala journal of ophthalmology Vol.
  XXII, No.4, Dec. 2010
• 7) Internet

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Tonometry by arun

  • 1. TONOMETRY BY Dr.Arun Kumar Reddy
  • 2. Tonometry • Tonometry is the procedure performed to determine the intraocular pressure (IOP)
  • 3. history • 1826:  William Bowman used digital tonometry as a routine examination test. • 1863: Albrecht von Grafe designed the first instrument to attempt to measure intraocular pressure. • Further instruments followed, notably by Donders in 1865 and Preistly- Smith in 1880. These instruments were all of the indentation type and rested on the sclera (no anaesthetic was used until 1884). • 1885: Maklakov designed an applanation tonometer. This was refined in 1892. Used for a number of years in Russia and Eastern Europe. This was used till 1959. • 1905: Hjalmar Schiotz produced his indentation tonometer. This made tonometry a simple and routine clinical test.
  • 4. Albrecht von Grafe tonometer
  • 6. Ideal tonometer • Should give accurate and reasonable IOP measurement • Convenient to use • Simple to calibrate • Stable from day to day • Easier to standardise • Free of maintenance problems
  • 7. Types of tonometry • Tonometry (IOP) • Direct – manometry • Indirect – • A) Static tonometry – a)contact, b)noncontact • a) contact tonometers • 1)Indentation • Schiotz ,Mercurial ,Electronic ,Scleral tonometry • 2)Applanation • Variable force • GAT, Perkins, MMT, Tonopen, Pneum.Tonometer • Constant force • Maklakov, Glucotest, Applanometer • b)Non Contact tonometer – Pulsair
  • 8. B) Dynamic instruments • Ballistic tonometers • Impact acceleration Impact duration Rebound velocity • Vibration tonometers (Krakau) • Vogelsang 1927 – Ballistic Tonometer .The rebound of a small metal ball from the eye is measured and this depends to a large extent on the physical properties of the coats of the eye. • Roth & Blake 1963- Vibration tonometer cause minimal deformation by oscillating force by a probe, which also functions as a sensor and measures the resonant frequency of the eye.
  • 9. Types of tonometers • In a normal eye IOP becomes more during Schiøtz tonometry. • low-displacement tonometers. • Tonometers in which the IOP is negligibly raised during tonometry (less than 5%) are termed as low-displacement tonometers. • Eg. Goldmann Applanation Tonometer.Mackay-Marg tonometer. • The Goldmann tonometer displaces only 0.5 μl of aqueous humor and raises IOP by only 3%. • high-displacement tonometers • Tonometers that displace a large volume of fluid and consequently raise IOP significantly are termed as high- displacement tonometers.
  • 10. High displacement tonometers are mostly less accurate than low-displacement tonometers.
  • 11. Direct method • Manometry • Canula inserted into eye. • Not practical clinically. • Intraocular pressure is higher than atmospheric pressure; therefore, if a small hollow needle is inserted into the anterior chamber, aqueous humor flows out through the needle. • If the needle is attached to a reservoir of fluid that is raised just high enough to prevent any loss of aqueous, the height of the column of fluid, usually calibrated in cm of water or mm of mercury, reflects the intraocular pressure
  • 12. Indirect method • Palpation Method/ digital tonometry • Intraocular pressure (IOP) is estimated by response of eye to pressure applied by finger pulp. • indents easily – low IOP • Firm to touch – normal IOP • Hard to touch – high IOP
  • 13. Schiotz tonometry • Schiotz (1905, Modified 1924/1926)
  • 14. Parts of schiotz tonometer Tonometer weight = 11g scale needle Additional weights 7.5,10,15g lever Weight 5.5g 3mm diameter plunger holder ROC 15mm Foot plate
  • 15. Schiotz tonometry - characteristics • The extent to which cornea is indented by plunger is measured as the distance from the foot plate curve to the plunger base and a lever system moves a needle on calibrated scale. • The indicated scale reading and the plunger weight are converted to an IOP measurement. • More the plunger indents the cornea, higher  the scale reading and lower the IOP • Each scale unit represents 0.05 mm protrusion  of the plunger.
  • 16. PRINCIPLE • The weight of tonometer on the eye increases the actual IOP (Po) to a higher level (Pt).  • The change in pressure from Po to Pt is an expression of the resistance of the eye (scleral rigidity) to the displacement of fluid. •  P(t) = P(o) + E • IOP with Tonometer in  position Pt =       Actual IOP Po + Scleral Rigidity E • Determination of Po from a scale reading Pt requires conversion which is done according to Friedenwald  conversion tables.
  • 17. Friedenwald formula • Friedenwald generated formula for linear relationship between the log function of IOP and the ocular distension. • Pt = log Po + C ΔV • This formula has ‘C’ a numerical constant, the coefficient  of ocular rigidity which is an expression of distensibility of eye. Its average value is 0.025 • ΔV is the change in volume
  • 18. Friedenwald conversion table   Plunger Load • Scale Reading 5.5 g 7.5 g 10 g 15 g 3.0 24.4 35.8 50.6 81.8 3.5 22.4 33.0 46.9 76.2 4.0 20.6 30.4 43.4 71.0 4.5 18.9 28.0 40.2 66.2 5.0 17.3 25.8 37.2 61.8 5.5 15.9 23.8 34.4 57.6 6.0 14.6 21.9 31.8 53.6 6.5 13.4 20.1 29.4 49.9 7.0 12.2 18.5 27.2 46.5 7.5 11.2 17.0 25.1 43.2 8.0 10.2 15.6 23.1 40.2 8.5 9.4 14.3 21.3 38.1 9.0 8.5 13.1 19.6 34.6 9.5 7.8 12.0 18.0 32.0 10.0 7.1 10.9 16.5 29.6
  • 19. TECHNIQUE • Patient should be anasthetised with 4%lignocaine or 0.5% proparacaine • With the patient in supine position, looking up at a fixation target while examiner separates the lids and lowers the tonometer plate to rest on the anesthetized cornea so that plunger is free to move vertically . • Scale reading is measured. • The 5.5 gm weight is initially used. • If scale reading is 4 or less, additional weight is added to plunger. • Conversion table is used to derive IOP in mm Hg from scale reading and plunger weight.
  • 20. SOURCES OF ERROR • Accuracy is limited as ocular rigidity varies from eye to eye. • As conversion tables are based on an average coefficient of ocular rigidity; eye that varies significantly from this value gives erroneous IOP. • Repeated measurements lower IOP. • steeper or a thicker cornea causes greater displacement of fluid during tonometry and gives a falsely high IOP measurement. • Schiøtz reads lower than GAT
  • 21. Factors Affecting Scleral Rigidity • High Scleral Rigidity • hyperopia • long standing glaucoma • ARMD • vasoconstrictors
  • 22. Factors Affecting Scleral Rigidity •Low Scleral Rigidity •increasing age • high myopia •miotics •vasodilators •Postoperative after RD surgery (vitrectomy, cryopexy, scleral band) •intravitreal injection of compressible gas. •keratoconus (?). •Low ocular rigidity ----- falsely high scale reading ----- falsely low IOP.
  • 23. LIMITATIONS • Instrumental errors • Standardisation - testing labs for certification • Mechanical obstruction to plunger etc. • Muscular contractions • Of extra ocular muscles increase IOP • Accomodation decreases IOP • Variations in volume of globe • Microphthalmos • High Myopia • Buphthalmos • It can be recorded in supine position only
  • 24. Advantages of schiotz tonometer • Simple technique • Elegant design • Portable • No need for SlitLamp or power supply • Reasonably priced • Anodized scale mount which is highly resistant to sterilizing water. • Schiotz tonometer is still most widely tonometer.
  • 25. calibration • The instrument should be calibrated before each use by placing it on a polished metal sphere and checking to be sure that the scale reading is zero. • If the reading is not zero, the instrument must be repaired.
  • 26. sterilization • The tonometer is disassembled between each use and the barrel is cleaned with 2 pipe cleaners, the first soaked in isopropyl alcohol 70 % or  methylated spirit and the second dry. • The foot plate is cleaned with alcohol swab. • All surfaces must be dried before reassembling. • The instrument can be sterilized with ultraviolet radiation, steam, ethylene oxide. • As with other tonometer tips, the Schiotz can be damaged by some disinfecting solutions such as hydrogen peroxide and bleach.
  • 27. Differential tonometry • It is done to get rid from ocular rigidity. • A reading is taken with one weight on the Plunger and then a second reading' in taken with a different weight. • Making a diagnosis of glaucoma in a pt. with myopia presents unusual difficulties. The low ocular rigidity in these eyes result in Schiotz readings within normal limits. 5.5g 10g Ocular  IOP rigidity 18 mm Hg 15 mm Hg lower >18 18 mm Hg 21 mm Hg higher <18 18 mm Hg 18 mm Hg equal 18
  • 28. APPLANATION TONOMETER Connects to the slit lamp Biprism (measuring prism) Feeder arm Control weight insert Housing Adjusting knob
  • 29. PRINCIPLE • Applanation tonometry is based on the Imbert-Fick principle, which states that the pressure (p) inside an ideal dry, thin- walled sphere equals the force (F) necessary to flatten its surface divided by the area of the flattening (A). F • P= A
  • 30. • Cornea being aspherical, wet, and slightly inflexible fails to follow the law. • Moisture creates surface tension (S) or capillary attraction of tear film for tonometry head. • Lack of flexibility requires force to bend the cornea (B) which is independent of internal pressure. • The central thickness of cornea is about 0.55 mm and the outer area of corneal flattening differs from the inner area of flattening (A1). It is this inner area which is of importance.
  • 31. IMBERT FICKS LAW & MODIFIED IMBERT FICKS LAW W=PA W+S=PA1+B
  • 32. • Modified Imbert-Fick Law is • W + S = PA1 + B • When A1 = 7.35 mm2, S balances B and W =P. • This internal area of applanation is achieved when the diameter of the external area of corneal applanation is around 3.06 mm. • Grams of force applied to flatten 3.06 diameter of the cornea multiplied by 10 is directly converted to mmHg.
  • 33. cont….. The two beam-splitting prism within the applanating unit optically convert the circular area of corneal contact in to semicircles
  • 34. cont…. The instrument is mounted on a standard slit lamp in such a way that the examiners view is directed through the centre of a plastic Biprism.  Biprism is attached by a rod to a housing which contains a coil spring and series of levers that are used to adjust the force of the biprism against the cornea. Two beam splitting prisms within applanating unit optically convert circular area of corneal contact in 2 semicircles.
  • 35. procedure • The patient is asked not to drink alcoholic beverages as it will lower IOP and not to take large amounts of fluid (e.g., 500 ml or more) for 2 hours before the test, as it may raise the IOP. • The angle between the illumination and the microscope should be approximately 60°. • The room illumination is reduced. • A fixation light may be placed in front of the fellow eye. • The tension knob is set at 1 g. If the knob is set at 0, the prism head may vibrate when it touches the eye and damage the corneal epithelium. • The 1 g position is used before each measurement.
  • 36. Procedure cont.. • The palpebral fissure is a little wider if the patient looks up. However, the gaze should be no more than 15° above the horizontal to prevent an elevation of IOP. • After instilling topical anaestheia, Edge of corneal contact is made apparent by instilling fluorescein while viewing in cobalt blue light. • The biprism should not touch the lids or lashes because this stimulates blinking and squeezing. • The patient should blink the eyes once or twice to spread the fluorescein-stained tear film over the cornea, and then should keep the eyes open wide. Do not to place any pressure on the globe because this raises IOP.
  • 37. Procedure cont.. • In some patients, it is necessary for the examiner to hold the eyelids open with the thumb and forefinger of one hand against the orbital rim. • By manually rotating a dial calibrated in grams, the force is adjusted by changing the length of a spring within the device. • The prisms are calibrated in such a fashion that inner  margin of semicircles touch when 3.06 mm of the cornea is applanated. • The Intra ocular pressure is then read directly from a scale on the tonometry housing.
  • 38. cont…. The fluorescein rings should be The fluorescent semicircles are viewed approximately 0.25–0.3 mm in through the biprism and the force against thickness – or about one-tenth the the cornea is adjusted until the inner diameter of the flattened area. edges overlap.
  • 39. Potential Sources of Error – During Measurement
  • 40. Effect of central corneal thickness (CCT): • A thinner cornea may require less force to applanate it, leading to underestimation of true IOP while a thicker  cornea would need more force to applanate it, giving an artificially higher IOP. • The Goldmann applanation tonometer was designed to give accurate readings when the CCT was 520 μm. • The deviation of CCT from 520 μm yields a change in applanation readings of 0.7 mm Hg per 10 μm. • IOP measurements are also modified after PRK and LASIK. • Thinning of the central cornea is gives lower readings on applanation.
  • 41. Wider meniscus or improper vertical alignment gives higher IOP readings • If the two semicircles are not equal in size, IOP is overestimated. • For every 3D increase in corneal curvature, IOP raises about 1 mm Hg as more fluid is displaced under steeper corneas causing increase in ocular rigidity • More than 6 D astigmatism produces an elliptical area on applanation that gives erroneous IOP. 4D with-the-rule astigmatism underestimate IOP and 4D against-the-rule astigmatism overestimate IOP. • Mires may be distorted on applanating on irregular  corneas .
  • 42. • Elevating the eyes more than 15° above the horizontal causes an overestimation of IOP. • Widening the lid fissure excessively causes an overestimation of IOP • Repeated tonometry reduces IOP, causing an underestimation of the true level.This effect is greatest between the first and second readings, but the trend continues through a number of repetitions. • A natural bias for even numbers may cause slight errors in readings.
  • 43. Applanation - Possible Errors • Falsely low IOP • Falsely high IOP • too little flouroscein • too much flouroscein • thin cornea • thick cornea • steep cornea • corneal edema • against the rule • with the rule astigmatism astigmatism 1mm Hg per 3D • 1mm Hg per 4 D • wider meniscus • Widening the lid fissure • prolonged contact excessively • Repeated tonometry • Elevating the eyes more than 15°
  • 44. Potential Sources of Error – During Measurement If the fluorescein rings are too wide, the patient’s eyelids should be blotted carefully with a tissue, and the front surface of the prism should be dried with lint-free material. An excessively wide fluorescein ring can cause IOP to be overestimated
  • 45. Potential Sources of Error – During Measurement If the rings are too narrow, the patient should blink two or three times to replenish the fluorescein; additional fluorescein may be added if necessary. If the fluorescein rings are too narrow,IOP is underestimated.
  • 54. CALIBRATION • GAT should be calibrated periodically, at least monthly. If the GAT is not within 0.1 g (1 mmHg) of the correct calibration, the instrument should be repaired; however, calibration errors of up to 2.5 mmHg may still be tolerated clinically.
  • 55. • Following checks are necessary: • • Check position 0: Turn the zero calibration on the measuring drum downwards by the width of one calibration marking, against the index marker. • When the feeler arm is in the free movement zone, it should then move itself against the stop piece in the direction of the examiner. • • Check position 0.05: Turn the zero calibration on the measuring drum upwards by the width of one calibration marking, against the index marker. • When the feeler arm is in the free movement zone, it should then move itself against the stop piece in the direction of the patient.
  • 56. • • Check position at drum setting 2: For checking this position, check weight is used. • Five circles are engraved on the weight bar. • The middle one corresponds to drum position 0, the two immediately to the left and right to position 2 and the outer ones to position 6. • One of the marks on the weight corresponding to drum position 2 is set precisely on the index mark of the weight holder. • Holder and weight are then fitted over the axis of the tonometer so that the longer part of the weight points towards the examiner.
  • 57. • Check position 1.95: The feeler arm should move towards the examiner. • Check position 2.05.The feeler arm should move in the direction of the patient. • • Check at measuring drum setting 6: Turn the weight bar to scale calibration 6, the longer part shows in the direction of the examiner. • • Check position 5.9/6.1 as performed for drum setting 2.
  • 58. sterilization • Applanation tip should be soaked for 5-15 min in diluted sodium hypochlorite, 3% H2O2 or 70% isopropyl alcohol or by wiping with alcohol, H2O2, povidone iodine or 1: 1000 merthiolate. • Other methods of sterilization include: 10 min of rinsing in running tap water, wash with soap and water, cover the tip with a disposable film, and exposure to UV light. • Disposable tonometer tips may also be used
  • 59. When using disposable tips, they have a smooth applanating surface.  The acrylic disposable tips seem to be somewhat more accurate than the silicone ones.  While disposable shields or tips may be safer than disinfection solutions, they are not 100% protective against prion disease.
  • 60. • It is possible to transfer bacteria, viruses, and other infectious agents with the tonometer head, including such potentially serious infections as epidemic keratoconjunctivitis, hepatitis B, Jacob-Kreutzfeld and, theoretically, acquired immunodeficiency syndrome. • Care must be taken to be sure any sterilizing solution has been completely rinsed off the tonometer tip, as some of these solutions may be toxic to the corneal epithelium, especially after LASIK or other corneal procedures. • If the tonometer tip is not mechanically wiped after each use, epithelial cells may stick to the tip with the small but serious risk of transmitting Jacob-Kreutzfeld virus.
  • 61. SAFETY REGULATIONS • No examination should be undertaken in case of eye infections (or) injured corneas. • Only clean and disinfected measuring prism should be used. • No damaged prisms should be used. • If the measuring prism come in to contact with the cornea without the drum having previously been correctly set, vibration can occur in the feeler arm, which will produce unpleasant feeling for the patient. • The tonometer tips should be examined periodically under magnification as the antiseptic solutions and mechanical wiping may cause irregularities in the surface of the tip that can, in turn, injure the cornea.
  • 62. Perkins tonometer • It uses same prisms as Goldmann • It is counterbalanced so that tonometry is performed in any position • The prism is illuminated by battery powered bulbs. • Being portable it is practical when measuring IOP in infants / children, bed ridden patients and for use in operating rooms.
  • 63.
  • 64. Draeger Tonometer • Draeger tonometer is similar to Perkins • It has a different set of prisms • It operates with a motor.
  • 66. Mackay-Marg Tonometer • 1.5 mm diameter plunger • rigid spring • rubber sleeve. • Movement of plunger is electronically monitored by a transducer and recorded on a moving paper strip. • This instrument is useful for measuring IOP in eyes with scarred, irregular, or edematous corneas because the end point does not depend on the evaluation of a light reflex sensitive to optical irregularity, as does the Goldmann tonometer. • It is accurate when used over therapeutic soft contact lenses.
  • 67. At 1.5 mm of corneal area applanation, tracing reaches a peak and the force applied = IOP + force required to deform the cornea. At 3 mm flattening, force required to deform cornea is transferred from plunger to surrounding sleeve, creating a dip in tracing corresponding to IOP. Flattening of >3 mm of area gives artificial elevation of IOP.
  • 69. Tono pen • Portable • battery operated . • same principle as that of Mackay-Marg tonometer. • It is particularly useful in community health fairs, on ward rounds ,children, irregular surfaces, measuring through an amniotic membrance patch graft, to read from the sclera . • Tono-Pen tends to overestimate the IOP in infants so its usefulness in congenital glaucoma screening and monitoring is somewhat limited. • In band keratopathy where the surface of the pathology is harder than normal cornea, the Tono-Pen tends to overestimate the IOP • A disposable latex cover which is discarded after each use provides infection control.
  • 70. Pneumatonometer or pneumatic tonometer  • It is like Mackay-Marg tonometer. • The sensor is a air pressure like electronically controlled plunger in Mackay-Marg tonometer. • It can also be used for continuous monitoring of IOP.
  • 71. • It gives significantly higher IOP estimates. • It has a sensing device that consists of a gas chamber covered by a polymeric silicone diaphragm. • A transducer converts the gas pressure in the chamber into an electrical signal that is recorded on a paper strip. • The gas in the chamber escapes through an exhaust vent between the diaphragm and the tip of the support nozzle. • As the diaphragm touches the cornea, the gas vent is reduced in size, and the pressure in the chamber rises.
  • 72. Maklakov tonometer •Indentation •Pt supine •wire holder  Dumb-bell-shaped metal cylinders with flat end plates of polished glass  Diameter of 10 mm The surface of the weight is painted with a dye, such as mild silver protein  (Argyrol) mixed  with glycerin. 1 sec contact imprint on end plate
  • 73. • IOP = W / π (d/2) 2 • weight (W) diameter of the area of applanation (d) • Intraocular pressure is measured in grams per square centimeter and is converted to millimeters of mercury by dividing by 1.36. • widely in Russia and China • This instrument displaces a greater volume of aqueous humor and thus IOP readings are more influenced by ocular rigidity. • It does not correct for corneal bending, capillary attraction, or tear encroachment on the layer of dye. • Many instruments similar to the Maklakow device have been described,like the Applanometer, Tonomat, Halberg tonometer, and GlaucoTest.
  • 74. The Ocuton tonometer • The Ocuton™ tonometer • hand-held tonometer • works on the applanation principle • probe is so light that it is barely felt • needs no anesthetic in most patients. • It has been marketed in Europe for home tonometry  • useful to get some idea of the relative diurnal variation in IOP if the patient or spouse (etc.) can learn to use it.
  • 76. • It is a new and updated version of an indentation tonometer • Portable • can be used without anesthetizing the eye. • A very light, disposable, sterile probe is propelled forward into the cornea . • The time taken for the probe to return to its resting position and the characteristics of the rebound motion are indicative of the IOP. • The time taken for the probe to return to its resting position is longer in eyes with lower IOP and faster in eyes with higher IOP.
  • 77. • It is comparable to the GAT. • It correlates with central corneal thickness like the Goldmann, . • used in screening situations, when patients are unable to be seated or measured at the slit lamp, or when topical anesthetics are not feasible or usable. • Not useful in scarred corneas (as does the Goldmann).
  • 78. Trans palpebral tonometry  used in situations where other, more accurate, devices are not practical, such as in young children, demented patients and severely developmentally-challenged patients. In addition to all the problems facing indentation tonometry, such as scleral rigidity, transpalpebral tonometry adds variables such as the thickness of the eyelids, orbicularis muscle tone and potential Intra  palpebral scarring.
  • 79. • Portable. patients can measure their own IOP at home, DVT • pressure on the eyelid in most eyes produces retinal phosphenes. • The pressure on the eyelid required to induce these phosphenes is proportional to the intraocular pressure. • It is not accurate always. inter observer and intra observer variability was large.subsequent studies failed to confirm the accuracy of this device.
  • 80. Non contact tonometer • Noncontact tonometer (NCT) was introduced by Grolman.  • Original NCT has 3 subsystems: • 1. Alignment system: It aligns patient’s eye in 3 dimensions. • 2. Optoelectronic applanation monitoring system: • It comprises transmitter, receiver and detector, and timer. • a. Transmitter directs a collimated beam of light at corneal apex. • b. Receiver and detector accept only parallel coaxial rays of light reflected from cornea. • c. Timer measures from an internal reference to the point of peak light intensity. • 3. Pneumatic system: It generates a puff of room air directed against cornea
  • 81. PRINCIPLE • A puff of room air creates a constant force that momentarily flattens the cornea. The corneal apex is deformed by a jet of air • The force of air jet which is generated by a solenoid activated piston increases linearly over time. • When the reflected light is at peak intensity, the cornea is presumed to be flattened. • The time elapsed is directly related to the force of jet necessary to flatten the cornea and correspondingly to IOP. • The time from an internal reference point to the moment of flattening is measured and converted to IOP.
  • 82. • A puff of air of known area is generated against cornea (B). • At the moment of corneal applanation,a light (T), which is usually reflected from the normal cornea into space, suddenly is reflected (R) into an optical sensor (A). • When the sensor is activated by the reflected light, the air generator is switched off. The level of force at which the generator stops is recorded, and a computer calculates and displays the intraocular pressure.
  • 83. • NCT is accurate if IOP is nearly normal, accuracy decreases with increase in IOP and in eyes with abnormal cornea or poor fixation. • It is useful for screening programs because it can be operated by non-medical personnel • It does not absolutely require topical anesthesia . • There is no direct contact between instrument and the eye. • The patient should be warned that the air puff can be startling. • The non-contact tonometer measures IOP over very short intervals, so it is important to average a series of readings. • New NCT, Pulsair is a portable hand held tonometer.
  • 84.
  • 85. Ocular Response Analyzer • It is an adaptation of the non-contact tonometer. • It directs the air jet against the cornea and measures not one but two  pressures at which applanation occurs • 1) when the air jet flattens the cornea as the cornea is bent inward and 2) as the air jet lessens in force and the cornea recovers.
  • 86. Ocular response analyser • The first is the resting intraocular pressure. • The difference between the first and the second applanation pressure is called corneal hysteresis  • corneal hysteresis is a measure of the viscous  dampening and, hence, the biomechanical properties of  the cornea. • The biomechanical properties of the cornea are related to corneal thickness and include elastic and viscous dampening attributes.
  • 87. • IOP correlate well with Goldmann tonometry but, on average, measure a few millimeters higher. • Further , while IOP varies over the 24-hour day, hysteresis seems to be stable. • Congdon et al found that a ‘low’ hysteresis reading with  the ORA correlates with progression of glaucoma, whereas thin central corneal thickness correlates with  glaucoma damage. • It has practical value in the management of glaucoma.
  • 89. • Introduced by Kanngiesser  • It is based on a totally different concept other than indentation or applanation tonometry. • Principle :  By surrounding and matching the contour of a sphere (or a portion thereof ), the pressure on the outside  equals the pressure on the inside. • The tip of the probe matches the contour of the cornea. • A pressure transducer built into the center of the probe measures the outside pressure, which should equal the inside pressure, and the IOP is recorded digitally on the liquid crystal display (LCD).
  • 90. • The concept developed from a previous contact lens tonometer called the ‘Smart Lens”. • It superior in accuracy to Goldmann tonometry and pneumotonometry . • IOP is not affected by corneal thickness. • IOP is not altered by corneal refractive surgery that thins the cornea.
  • 91. • Because the DCT measures IOP in real time, the actual measurement, like the IOP, is pulsed. The internal electronics ‘call’ the IOP as the bottom of the pulsed  curve and indicate it digitally on the LCD .. • IOP readings with the DCT are generally lower than GAT because, when properly done, indicates the average difference between the maximum and minimum pressures whereas the DCT reads the minimum.
  • 92. Ocular pulse amplitude • The DCT indicates the magnitude of the difference between maximum and minimum IOP as the ocular  pulse amplitude. • OPA may be indicative of the status of ocular blood flow and be differentially affected in different types of glaucoma. • ocular pulse amplitude is increased over normals in most forms of glaucoma and may be related to the level of IOP.
  • 93. Continuous monitoring of intraocular pressure • Applanation instruments inside contact lenses or suction cups or strain gauges in encircling bands that resemble scleral buckling elements. • None of these instruments has achieved widespread use. • resonance applanation tonometry measuring the sonic resonance of the eye when a continuous force over a fixed area is applied. • use of infrared spectroscopy to measure IOP. • To build a miniature pressure sensor that can reside  inside the eye; one such device is part of an intraocular lens.
  • 94. Tonometry for Special Clinical Circumstances • Tonometry on Irregular Corneas • The accuracy of Goldmann and Tono-Pen tonometers and the noncontact tonometers is limited in eyes with irregular corneas. • The pneumatic tonometer has been shown to be useful in eyes with diseased or irregular corneas . • Tonometry over Soft Contact Lenses • Pneumo tonometry and the Tono-Pen can measure with reasonable accuracy the IOP through bandage contact lenses . • pneumotonometer correlates well with manometrically determined IOP, whereas the Tono-Pen consistently underestimates the pressure.
  • 95. • Tonometry with Gas-Filled Eyes • Intraocular gas affects scleral rigidity, rendering indentation tonometry unsatisfactory. • pneumatic tonometer and Tono-Pen used. • A pneumatic tonometer underestimates Goldmann IOP measurements in eyes with intravitreal gas • Tono-Pen compares favorably with Goldmann readings. • Both instruments significantly underestimated the IOP at pressures greater than 30 mm Hg .
  • 96. • Tonometry with Flat Anterior Chamber • IOP readings from the Goldmann applanation tonometer, pneumotonometer, and Tono-Pen do not correlate well with manometrically determined pressures. • Tonometry in Eyes with Keratoprostheses • In patients at high risk for corneal transplant rejection, implantation of a keratoprosthesis is now a viable option for vision rehabilitation . • Most keratoprostheses have a rigid, clear surface, it is impossible to measure IOP by using applanation or indentation instruments. • In such eyes, tactile assessment appears to be the most widely used method to estimate IOP.
  • 98. references • 1)anatomy & physiology of eye A.K.Khurana • 2) Shields glaucoma • 3)Becker-Shaffers glaucoma • 4) Diagnostic Procedures in ophthalmology Nema • 5) Duane's Clinical Ophthalmology • 6) kerala journal of ophthalmology Vol. XXII, No.4, Dec. 2010 • 7) Internet