Pharmacokinetics (updated 2011) - drdhriiti
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An updated PowerPoint presentation on Pharmacokinetics suitable for UG MBBS Medical students
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Pharmacokinetics (updated 2011) - drdhriiti
- 1. Pharmacokinetics Dr. D. K. Brahma Department of Pharmacology NEIGRIHMS, Shillong
- 3. Relationship – Dynamics and Kinetics Dosage Regimen Concentration in Plasma Concentration at the site of action Absorption Distribution Metabolism Excretion Pharmacokinetics Pharmacodynamics Effect
- 4. The Pharmacokinetic Process Blood
- 6. Biological Membrane - image
- 13. pH Vs ionization
- 17. Filtration
- 23. Images from Text book
- 30. 1 st pass Elimination – Metabolism in liver Buccal cavity Stomach Intestine Rectum Portal vein Vena cava
- 31. Buccal and Rectal – bypasses liver Vena cava
- 35. Biovailability - AUC Plasma concentration (mcg/ml) Time (h) 0 5 10 15 AUC p.o. F = ------------ x 100% AUC i.v. AUC – area under the curve F – bioavailability
- 36. Biovailability – contd. MTC MEC
- 39. Volume of Distribution (V) Total Body Fluid = 42 L (approx.)
- 41. Volume of Distribution (V) Vd = IV dose/C
- 51. 3. Biotransformation Metabolism of Drugs
- 58. Oxidation - CYP CYP3A4/5
- 66. Phase I and Phase II Reaction Drug Metabolite Metabolite EXCRETION Metabolite Phase I Phase II Phase II Metabolism
- 71. 4. Excretion
- 83. Kinetics of Elimination Zero Order 1st Order conc. Time
Notas del editor
- The pH scale is logarithmic and as a result, each whole pH value below 7 is ten times more acidic than the next higher value. For example, pH 4 is ten times more acidic than pH 5 and 100 times (10 times 10) more acidic than pH 6. The same holds true for pH values above 7, each of which is ten times more alkaline (another way to say basic) than the next lower whole value. For example, pH 10 is ten times more alkaline than pH 9 and 100 times (10 times 10) more alkaline than pH
- A chemical substance that takes on oxygen or gives up electrons to another substance. Read more: Oxidation-Reduction Reaction - examples, body, used, water, process, life, plants, chemical, form, energy, gas, animals, carbon, oxygen, substance, plant, Redox and electron exchanges http://www.scienceclarified.com/Oi-Ph/Oxidation-Reduction-Reaction.html#ixzz0wPXCNZTp Reduction: A process in which a chemical substance gives off oxygen or takes on electrons. Read more: Oxidation-Reduction Reaction - examples, body, used, water, process, life, plants, chemical, form, energy, gas, animals, carbon, oxygen, substance, plant, Redox and electron exchanges http://www.scienceclarified.com/Oi-Ph/Oxidation-Reduction-Reaction.html#ixzz0wPXUgtyL
- Faeces: Liver actively transport drugs and its metabolites into bile (Glucoronides). OATP – orgnic acids and OCT – organic bases. Other lipophillic drugs – by P-gp. Most lucoronides are deconjugated by bacteria and reabsorbed in intestine – enterohepatic circulation. Drugs – erythromycin, rifmpicin and tetracycline etc. Ultimate excretion occurs in urine Milk – not importnt for mother but for fetus. Basic drugs can pass to milk as it has slightly lower pH Drugs – Saliva – Lithium, KI, heavy metals and rifampicin
- Although Cpss cn be calculated, its real value actually varies with individuls – deviation from averge ptients