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Type 2 Diabetes & Surgical Disease

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George S. Ferzli
George S. Ferzli
Health & Medicine
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Type 2 Diabetes: A Surgical Disease??? ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],1.Pacheco D, et al. The effects of duodenal-jejunal exclusion on hormonal regulation of glucose metabolism in Goto-Kakizaki rats. Am J Surgery; 194 (2007):221-224 2. Rubino F. Bariatric Surgery:effects on glucose homeostasis. Curr Opin Clin Nutr Metab Care 9:497-507
Historic Perspective ,[object Object],[object Object],[object Object],[object Object],[object Object],Rubino F. Bariatric Surgery:effects on glucose homeostasis. Curr Opin Clin Nutr Metab Care 9:497-507 Friedman NM et al. The amelioration of diabetes mellitus following subtotal gastrectomy. Surg Gynecol Obstetr 1955; 100:201-204 .
Historic Perspective ,[object Object],[object Object],Rubino F. Bariatric Surgery:effects on glucose homeostasis. Curr OpiClin Nutr Metab Care 9:497-507 Bittner R. Homeostasis of glucose and gastric resection: the influence of food passage through the duodenum. Z Gastroenterology 1981; 19:698-707.
Should patients with type 2 DM be considered for surgical treatment regardless of their BMI ? ,[object Object],[object Object],[object Object],[object Object],[object Object]
DJ Bypass & Glucose Metabolism ,[object Object],[object Object],[object Object],[object Object],[object Object],Pacheco D, et al. The effects of duodenal-jejunal exclusion on hormonal regulation of glucose metabolism in Goto-Kakizaki rats. Am J Surgery; 194 (2007):221-224
 
Animal Model of DJ bypass and Glycemic Control ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Pacheco D, et al. The effects of duodenal-jejunal exclusion on hormonal regulation of glucose metabolism in Goto-Kakizaki rats. Am J Surgery; 194 (2007):221-224
 
Results of DJ Bypass on Glycemic Control ,[object Object],[object Object],[object Object],[object Object],[object Object]
Leptin??? ,[object Object],[object Object],[object Object],Pacheco D, et al. The effects of duodenal-jejunal exclusion on hormonal regulation of glucose metabolism in Goto-Kakizaki rats. Am J Surgery; 194 (2007):221-224
Reversal of Insulin Resistance by Leptin

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Type 2 Diabetes & Surgical Disease

Editor's Notes

  1. This raises an interesting question?????
  2. To make a joke: it’s funny that in 1955 this was published in Obstetrics journal….OB/GYN’s were 50 years ahead of general surgeons!!!!!
  3. To make a joke: it’s funny that in 1955 this was published in Obstetrics journal….OB/GYN’s were 50 years ahead of general surgeons!!!!!
  4. This would revolutionize bariatric surgery
  5. Hypothesis regarding the possible contribution of the proximal intestine to the alterations of glucose metabolism in type 2 diabetes