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VIPoma
Neck of Pancreas   Anatomy of Pancreas
 
[object Object],[object Object],[object Object],หน้าที่ของตับอ่อน
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Pancreatic Tumor
Exocrine Tumor ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Clinical presentations of pancreatic endocrine tumor Name  ( synonym ) Hormone responsible Clinical symptoms Principle of Medical Treatment Insulinoma  (insulin-producing tumor) or Beta cell tumor Insulin  Whipple triad  - Mental confuse, weakness,fatigue and convulsion , palpitation - Fasting hypoglycemia  - Relief of hypoglycemic symptoms after glucose administation May require immediate potassium replasement and glucose administration
Clinical presentations of pancreatic endocrine tumor Name  ( synonym ) Hormone responsible Clinical symptoms Principle of Medical Treatment Gastrinoma (gastrin-producing tumor; ulcerogenic tumor) or G-cell tumors  Gastrin  Zollinger-Ellison syndrome * Severe gastrointestinal ulcerative disease * Gastric acid hypersecretion * Steatorrhea (fatty diarrhea)  1 .  Stabilize hemodynamic and control bleeding from gastrointestinal ulcers  2 .  Establish a nonacidic gastric pH with the use of  proton pump inhibitors, eg, omeprazole  3 .  Administration of the somatostatin analogue octreotide or chemotherapeutic agent
Clinical presentations of pancreatic endocrine tumor Name  ( synonym ) Hormone responsible Clinical symptoms Principle of Medical Treatment Glucagonoma (glucagon-producing tumor) or Alpha cell tumors Glucagon  ,[object Object],[object Object],[object Object],[object Object],Generally have nutritional depletion and often require blood transfusions, total parenteral nutrition, and preoperative control of hyperglycemia
Clinical presentations of pancreatic endocrine tumor Name  ( synonym ) Hormone responsible Clinical symptoms Principle of Medical Treatment VIPoma (vasoactive intestinal polypeptide) (VIP-producing tumor; diarrheogenic tumor; Verner-Morrison syndrome; pancreatic cholera)  VIP ,[object Object],[object Object],[object Object],[object Object],Primary initial concern in the treatment  of a patient who presents first with VIPoma - associated diarrhea is the  replacement of volume losses and the correction of acid - base and electrolyte abnormalities
Clinical presentations of pancreatic endocrine tumor Name  ( synonym ) Hormone responsible Clinical symptoms Principle of Medical Treatment Somatostatinoma (somatostatin-producing tumor) or Delta cell tumors Somatostatin  ,[object Object],[object Object],[object Object],[object Object],[object Object],Nutritional repletion and control of hyperglycemia are important aspects of good medical care in patients
[object Object],[object Object],[object Object],Investigation
[object Object],[object Object],[object Object],[object Object],Surgical Treatment

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Vi Poma

  • 2. Neck of Pancreas Anatomy of Pancreas
  • 3.  
  • 4.
  • 5.
  • 6.
  • 7. Clinical presentations of pancreatic endocrine tumor Name ( synonym ) Hormone responsible Clinical symptoms Principle of Medical Treatment Insulinoma (insulin-producing tumor) or Beta cell tumor Insulin Whipple triad - Mental confuse, weakness,fatigue and convulsion , palpitation - Fasting hypoglycemia - Relief of hypoglycemic symptoms after glucose administation May require immediate potassium replasement and glucose administration
  • 8. Clinical presentations of pancreatic endocrine tumor Name ( synonym ) Hormone responsible Clinical symptoms Principle of Medical Treatment Gastrinoma (gastrin-producing tumor; ulcerogenic tumor) or G-cell tumors Gastrin Zollinger-Ellison syndrome * Severe gastrointestinal ulcerative disease * Gastric acid hypersecretion * Steatorrhea (fatty diarrhea) 1 . Stabilize hemodynamic and control bleeding from gastrointestinal ulcers 2 . Establish a nonacidic gastric pH with the use of proton pump inhibitors, eg, omeprazole 3 . Administration of the somatostatin analogue octreotide or chemotherapeutic agent
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Notas del editor

  1. ตับอ่อน มีขนาดความยาวประมาณ 6 นิ้ว มีรูปร่างคล้ายปลาดุก เป็นต่อมขนาดใหญ่ ตั้งอยู่ทางด้านหลังของกระเพาะอาหาร ใกล้กับลำไส้เล็กส่วนดูโอดินัม ซึ่งเป็นลำไส้เล็กส่วนต้น
  2. endocrine tumor ผู้ป่วยมักมีอาการอันเนื่องมาจากความผิดปกติของฮอร์โมนที่เนื้องอกสร้างขึ้น การจำแนก endocrine tumor ของตับอ่อนจึงอาศัยชนิดของฮอร์โมนที่ตรวจพบในเลือดหรือในเนื้อเยื่อของ tumor เป็นสำคัญ