1. Nuclear receptors
Emilie Lilford
Group 11

2. Biochemical definition of a receptor

3. Chemical change  physiological change  biological
function
Ligand
Receptor

4. Types of receptors and locations:
• Cell surface receptors
• Receptors located in the cytoplasm
• Nuclear receptors

5. Ligands of nuclear receptors

6. Structures of some nuclear receptor ligands and their corresponding
receptors name.

7. Structural organization

9. Sandwich filling model of ligand binding domain (LBD)
LBD

10. DNA binding domain (DBD) – structure of the human progesterone receptor
DBD

11. What is a Domain?
• Independent subunits of proteins.
• Between 25 -500 amino acids in length.
• Independently stable and folded.
• Can diverge and converge.
• Domain represents function.

12. Domains of nuclear receptors
• Zinc fingers
• LBD
• DBD
• N-terminal + C-terminal

13. How nuclear receptors work.