This document proposes that there is a common cause of Alzheimer's and Parkinson's diseases. It hypothesizes that the accumulation of beta-amyloid and alpha-synuclein proteins leads to the formation of a hybrid protein that alters neuronal activity and causes neurodegeneration. The study aims to create this hybrid protein in vitro, insert it into mice brains, and examine its effects through in vivo experimentation and comparison to control mice in order to better understand the link between the two diseases.

1. Alzheimer's and Parkinson's disease common cause Erick G. Rodríguez Biol.3009

3. The most common progressive neurologic diseases

4. Irreversible loss of neurons in various areas of the brain

5. Caused by the accumulation of proteins

8. Lewybodies and Lewyneurities are made of ubiquitin and α-synuclein.

10. auditory systems

11. eye movement

12. body movementHOPES. (2004). The HOPES Brain Tutorial. Available: http://www.stanford.edu/group/hopes/basics/braintut/ab3.html. Last accessed 29 Jun 2009.

14. EliezerMasliah at the University of California, San Diego

15. β-amyloidand α-synuclein are active proteins in both diseases

16. this two proteins work together to create a hybrid protein with a small hole called a nanopore that alters neuronal activity

19. “In vitro” experimentation to create the hybrid protein

20. Insert hybrid protein into the brains of live mice

22. Make post mortem examination of the mice brains

24. Find inhibitor for the enzymes that produce β-amyloid and α-synucleinproteins

26. Tsigelny I., Crews L., Desplats P., Shaked G., Sharikov Y., Mizuno H., Spencer B., Rockenstein E., Trejo M., Platoshyn O., Yuan J., Masliah E.. (2008). Mechanisms of Hybrid Oligomer Formation in the Pathogenesis of Combined Alzheimer's and Parkinson's Diseases. Available: http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0003135. Last accessed 27 Jun 2009.