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Natural Therapies for
Post-Treatment Symptoms

       Chad Aschtgen, ND
Providence Integrative Cancer Care
Presentation Objectives
Upon completion of this activity, you will be able to:
   • Describe the role of lifestyle factors and dietary
     supplements within the context of the comprehensive
     survivor care plan.
   • Identify a variety of supplements that may help to
     mitigate numerous common post-therapy symptoms.
   • Identify numerous indicators of health that may be
     evaluated and addressed in an effort to promote
     wellness and reduce risk of new or recurrent disease.

                                                      2
Presentation Outline
   Survivorship Care Plan – Creating Context
   Focus on Health – Promoting Wellness
   Vitamins & Dietary Supplements
        Symptom Management – Quality of Life

   EVALUATING AND TREATING THE BIOLOGICAL
    TERRAIN
        Risk Reduction – the Role of Supplements

   Dietary Supplement Considerations
                                                    3
   Recommended Resources
Survivorship Care Plan – Context
   Medical Oncology Follow Up
        Surveillance, evaluation and maintenance care
   Family/General Physician Care (PCP)
        Screening for early intervention of other disease
        Evaluation and treatment of injury and disease
   HEALTH, WELLNESS & QUALITY OF LIFE
    FOCUS
        Promoting health/Preventing injury and disease
        Addressing pertinent lifestyle factors
        Dietary supplementation                             4
Multi-Disciplinary / Integrative Approach




                                            5
Multi-Disciplinary / Integrative Approach




                                            6
Multi-Disciplinary / Integrative Approach




                                            7
General Health & Wellness Promotion
   Nutrition
       Vegetables, Fruits, Whole Grains, Herbs/Spices
       Limiting alcohol consumption
   Physical Activity and Exercise – Intensity
       Sweating & brief muscle soreness
   Healthy Weight Management – BMI < 25
   Sleep Management – 7-8 hours/night
   Stress Management & Psycho/Social Health
   Minimize/Eliminate Toxic Exposures                   8
Promoting Wellness & Reducing Risk
                             2007
                    1. Healthy weight
                    2. Physical Activity
                    3.-5. Nutrition x3
                    6. Alcohol
                    7. Processed/
                       preserved foods
                    8. Dietary
                       supplements
                                           9
American Institute for Cancer Research




                                         10
Multivitamins Vs Food – Nutrition




                                                                  11
From Anticancer: A New Way of Life – David Servan-Schreiber, MD
Vitamins & Dietary Supplements
The research results are conflicting




Headlines are confusing:

“Taking Vitamin E Puts Men at Greater Risk for Prostate
Cancer”

“Vitamin D Can Decrease Cancer by Up To 80%”

“Vitamin C Kills Cancer Cells”

“Vitamin C Supplements May be Harmful”                    12
Vitamins & Dietary Supplements
The research results are conflicting




Headlines are confusing:

“Regimens: No Cancer Benefits Seen in Supplements”

“Vitamin E Found to Cut Cancer Risk For Prostate”

“Vitamin A Found to Inhibit Cancer”

“Vitamin D Deficiency Linked to Breast Cancer”       13
Vitamins & Dietary Supplements




                                                                  14
From Anticancer: A New Way of Life – David Servan-Schreiber, MD
Vitamins & Dietary Supplements
Use supplements as you would any medicine–
     for a targeted, therapeutic effect.

     1. Symptom Management
     2. Specific Health Promotion/
          Risk Reduction
  Be conscious of the desired effects and potential risks
     • Is the supplement safe for you?
     • Is the supplement likely effective?
     • Understand appropriate prioritization.
     • Heed general cautions- allergic rxn, drug
         interactions…                                      15
Common Post-Treatment Symptoms




                             16
Common Post-Treatment Symptoms
Many symptoms will resolve on their own… Eventually




                                                 17
Common Post-Treatment Symptoms
      atigue

      Sleep • 7-8 hrs/n

            Protein • 25g/ meal

                     Hydration • 64oz/d


        hey Protein – choose a highly concentrated
        product; 90% Pure Protein
Image credits – all molecular images from Wikimedia commons @ wikipedia.com
                                                                              18
Common Post-Treatment Symptoms
       atigue – What is the cause?



       oEnzyme Q10 – 100mg twice daily

       well tolerated; GI upset

       caution: warfarin, some heart medications


                                                   19
       shwagandha – 500mg twice daily
Photo credit – cliff1066 @ flickr.com
Common Post-Treatment Symptoms
       nsomnia – sleep hygiene



       elatonin – 1-3mg at bedtime

       well tolerated; drowsiness, GI upset

       caution: nifedipine, sedatives, anti-depressants



       alerian root – 500mg at bedtime
Photo credit – oKikos @ flickr.com
                                                          20
Common Post-Treatment Symptoms
       ental fogginess – ‘Chemo Brain’


       See Fatigue and Insomnia



       cetyl L-Carnitine – 1.5-3g twice daily

       GI upset, tart flavor (powder)

       caution: hemodialysis, attention deficit disorder
                                                           21
Photo credit – Michael Wolf @ wikipedia.com
Common Post-Treatment Symptoms
       onstipation

       High fiber foods • 30-40g/d

                Hydration • 64-96oz/day

                            Physical activity • walking 30-45m/day


       iber supplement – 5-15g in 8-12oz water at bedtime
                                                                     22
Photo credit – Ahmad Fuad Morad @ flickr.com
       Pectin, inulin, psyllium, prune or beet powder
Common Post-Treatment Symptoms
iarrhea



robiotics – one capsule/tablet daily

use a high-potency product

containing numerous strains:

    Lactobacilli & Bifidobacteria
                                       23
well tolerated; GI upset
Common Post-Treatment Symptoms
     ot flashes



     itamin E – 400IU 2-3x/daily

     warning: bleeding, GI upset, rash

     caution: blood thinners



     esperidin Methyl Chalcone – 500mg 2-3x daily
Photo credit – Nuts by Adam Wyles @ flickr.com. Citrus by Monica Arellano-Ongpin @ flickr.com
                                                                                                24
Common Post-Treatment Symptoms
eripheral neuropathy



lpha-lipoic acid – 600mg 2-3x/daily

very well tolerated; GI upset, hypoglycemia




                                              25
Common Post-Treatment Symptoms
air, Skin and Nail Support



uminous by Vitanica – one capsule twice daily

Vitamins C, D and E, Biotin, Calcium, Magnesium,
Selenium, Zinc, Silica, Horsetail, Nettles
leaf, Gotu kola herb, Rosemary leaf, and
Oatstraw.


                                                   26
ontinue for 3-6 months then consider
Common Post-Treatment Symptoms
oint Pain – associated with hormone therapy


ish Oil – 2g twice daily of a concentrated product
well tolerated; GI upset, revisiting fish taste

caution: blood thinners


itamin D – possibly, but test first!

atural anti-inflammatories
    curcumin, holy basil, boswellia, rosemary, ginger, oregano, etc
                                                                      27
Factors of Health – Individualized Care
   Inflammation   




   Oxidative stress   




   Glucose / Insulin balance   




   Nutrient status – deficiency and/or excess   




   Coagulation – components of clotting/ bleeding
   Hormone balance / Exposure
   Immune function
   Optimal/Adequate organ function
                                                     28
Evaluating the Biological Terrain
   Inflammation
       Sedimentation Rate
       C-reactive Protein
       Interleukin-6
   Oxidative stress (hepatic)
       Gamma-glutamyl Transferase
   Glucose / Insulin balance
       Hemoglobin A1c/ Glycosylated Hemoglobin
   Nutrient status – deficiency and/or excess
       Vitamin D
       Essential fatty acid profile              29
Targeted Risk Reduction
   Fish oil – 2-5g daily
   Green tea – 500mg of EGCG 2-3x/d
   Curcumin – 3-6g daily; highly absorbable form
   Vitamin E succinate – 400IU daily
   Resveratrol – 175-200mg twice daily
   Vitamin D – 1,000-5,000IU daily as per results
   Coriolus mushroom – 600mg three times daily
                                                    30
Dietary Supplement Considerations
   Quality & Purity is Important
   Specific form of nutrients/botanicals matters
       Vitamin D3 versus D2
       Fish oil; cod liver oil vs whole fish vs concentrates
       Root, leaf, flower
   Raw material and finished product source matters
       Purity, potency and microbial contamination
   Of course “Natural” ≠ Safe
       Nor necessarily effective
   Just as Rx ≠ Safe
                                                                31
Recommended Resources
 Five to Thrive: Your Cutting Edge-Cancer Prevention Plan
    Lise N. Alschuler, ND & Karolyn A. Gazella
 Anticancer: A New Way of Life
    David Servan-Schreiber, MD
 Life Over Cancer: Block Program Integrative Cancer
    Treatment Keith I. Block, MD
 The Cancer Fighting Kitchen
    Rebecca Katz
 The Journey Through Cancer
    Jeremy R. Geffen, MD
 Integrative Medicine: About Herbs, Botanicals & More
    Memorial Sloan-Kettering Cancer Center website
                                                      32
    – http://www.mskcc.org/mskcc/html/11570.cfm
Chad D. Aschtgen, ND, FABNO
Seattle Integrative Oncology                                       www.seattlend.com

Institute of Complementary Medicine                               www.icmedicine.com
Swedish Medical Center Cherry Hill Campus - Jefferson Tower
1600 E. Jefferson St, Ste 603
Seattle, WA 98122
t: 206.726.0034 | f: 206.726.9434


Providence Integrative Cancer Care                            www.providence.org/swsa
at Providence Regional Cancer System
4525 Third Ave SE, Ste 200
Lacey, WA 98503
t: 360.754.3934 ext. 1083 | f: 360.412.8955

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Natural Therapies for Post-Chemo and Radiation Symptoms

  • 1. Natural Therapies for Post-Treatment Symptoms Chad Aschtgen, ND Providence Integrative Cancer Care
  • 2. Presentation Objectives Upon completion of this activity, you will be able to: • Describe the role of lifestyle factors and dietary supplements within the context of the comprehensive survivor care plan. • Identify a variety of supplements that may help to mitigate numerous common post-therapy symptoms. • Identify numerous indicators of health that may be evaluated and addressed in an effort to promote wellness and reduce risk of new or recurrent disease. 2
  • 3. Presentation Outline  Survivorship Care Plan – Creating Context  Focus on Health – Promoting Wellness  Vitamins & Dietary Supplements  Symptom Management – Quality of Life  EVALUATING AND TREATING THE BIOLOGICAL TERRAIN  Risk Reduction – the Role of Supplements  Dietary Supplement Considerations 3  Recommended Resources
  • 4. Survivorship Care Plan – Context  Medical Oncology Follow Up  Surveillance, evaluation and maintenance care  Family/General Physician Care (PCP)  Screening for early intervention of other disease  Evaluation and treatment of injury and disease  HEALTH, WELLNESS & QUALITY OF LIFE FOCUS  Promoting health/Preventing injury and disease  Addressing pertinent lifestyle factors  Dietary supplementation 4
  • 8. General Health & Wellness Promotion  Nutrition  Vegetables, Fruits, Whole Grains, Herbs/Spices  Limiting alcohol consumption  Physical Activity and Exercise – Intensity  Sweating & brief muscle soreness  Healthy Weight Management – BMI < 25  Sleep Management – 7-8 hours/night  Stress Management & Psycho/Social Health  Minimize/Eliminate Toxic Exposures 8
  • 9. Promoting Wellness & Reducing Risk 2007 1. Healthy weight 2. Physical Activity 3.-5. Nutrition x3 6. Alcohol 7. Processed/ preserved foods 8. Dietary supplements 9
  • 10. American Institute for Cancer Research 10
  • 11. Multivitamins Vs Food – Nutrition 11 From Anticancer: A New Way of Life – David Servan-Schreiber, MD
  • 12. Vitamins & Dietary Supplements The research results are conflicting Headlines are confusing: “Taking Vitamin E Puts Men at Greater Risk for Prostate Cancer” “Vitamin D Can Decrease Cancer by Up To 80%” “Vitamin C Kills Cancer Cells” “Vitamin C Supplements May be Harmful” 12
  • 13. Vitamins & Dietary Supplements The research results are conflicting Headlines are confusing: “Regimens: No Cancer Benefits Seen in Supplements” “Vitamin E Found to Cut Cancer Risk For Prostate” “Vitamin A Found to Inhibit Cancer” “Vitamin D Deficiency Linked to Breast Cancer” 13
  • 14. Vitamins & Dietary Supplements 14 From Anticancer: A New Way of Life – David Servan-Schreiber, MD
  • 15. Vitamins & Dietary Supplements Use supplements as you would any medicine– for a targeted, therapeutic effect. 1. Symptom Management 2. Specific Health Promotion/ Risk Reduction Be conscious of the desired effects and potential risks • Is the supplement safe for you? • Is the supplement likely effective? • Understand appropriate prioritization. • Heed general cautions- allergic rxn, drug interactions… 15
  • 17. Common Post-Treatment Symptoms Many symptoms will resolve on their own… Eventually 17
  • 18. Common Post-Treatment Symptoms atigue Sleep • 7-8 hrs/n Protein • 25g/ meal Hydration • 64oz/d hey Protein – choose a highly concentrated product; 90% Pure Protein Image credits – all molecular images from Wikimedia commons @ wikipedia.com 18
  • 19. Common Post-Treatment Symptoms atigue – What is the cause? oEnzyme Q10 – 100mg twice daily well tolerated; GI upset caution: warfarin, some heart medications 19 shwagandha – 500mg twice daily Photo credit – cliff1066 @ flickr.com
  • 20. Common Post-Treatment Symptoms nsomnia – sleep hygiene elatonin – 1-3mg at bedtime well tolerated; drowsiness, GI upset caution: nifedipine, sedatives, anti-depressants alerian root – 500mg at bedtime Photo credit – oKikos @ flickr.com 20
  • 21. Common Post-Treatment Symptoms ental fogginess – ‘Chemo Brain’ See Fatigue and Insomnia cetyl L-Carnitine – 1.5-3g twice daily GI upset, tart flavor (powder) caution: hemodialysis, attention deficit disorder 21 Photo credit – Michael Wolf @ wikipedia.com
  • 22. Common Post-Treatment Symptoms onstipation High fiber foods • 30-40g/d Hydration • 64-96oz/day Physical activity • walking 30-45m/day iber supplement – 5-15g in 8-12oz water at bedtime 22 Photo credit – Ahmad Fuad Morad @ flickr.com Pectin, inulin, psyllium, prune or beet powder
  • 23. Common Post-Treatment Symptoms iarrhea robiotics – one capsule/tablet daily use a high-potency product containing numerous strains: Lactobacilli & Bifidobacteria 23 well tolerated; GI upset
  • 24. Common Post-Treatment Symptoms ot flashes itamin E – 400IU 2-3x/daily warning: bleeding, GI upset, rash caution: blood thinners esperidin Methyl Chalcone – 500mg 2-3x daily Photo credit – Nuts by Adam Wyles @ flickr.com. Citrus by Monica Arellano-Ongpin @ flickr.com 24
  • 25. Common Post-Treatment Symptoms eripheral neuropathy lpha-lipoic acid – 600mg 2-3x/daily very well tolerated; GI upset, hypoglycemia 25
  • 26. Common Post-Treatment Symptoms air, Skin and Nail Support uminous by Vitanica – one capsule twice daily Vitamins C, D and E, Biotin, Calcium, Magnesium, Selenium, Zinc, Silica, Horsetail, Nettles leaf, Gotu kola herb, Rosemary leaf, and Oatstraw. 26 ontinue for 3-6 months then consider
  • 27. Common Post-Treatment Symptoms oint Pain – associated with hormone therapy ish Oil – 2g twice daily of a concentrated product well tolerated; GI upset, revisiting fish taste caution: blood thinners itamin D – possibly, but test first! atural anti-inflammatories curcumin, holy basil, boswellia, rosemary, ginger, oregano, etc 27
  • 28. Factors of Health – Individualized Care  Inflammation   Oxidative stress   Glucose / Insulin balance   Nutrient status – deficiency and/or excess   Coagulation – components of clotting/ bleeding  Hormone balance / Exposure  Immune function  Optimal/Adequate organ function 28
  • 29. Evaluating the Biological Terrain  Inflammation  Sedimentation Rate  C-reactive Protein  Interleukin-6  Oxidative stress (hepatic)  Gamma-glutamyl Transferase  Glucose / Insulin balance  Hemoglobin A1c/ Glycosylated Hemoglobin  Nutrient status – deficiency and/or excess  Vitamin D  Essential fatty acid profile 29
  • 30. Targeted Risk Reduction  Fish oil – 2-5g daily  Green tea – 500mg of EGCG 2-3x/d  Curcumin – 3-6g daily; highly absorbable form  Vitamin E succinate – 400IU daily  Resveratrol – 175-200mg twice daily  Vitamin D – 1,000-5,000IU daily as per results  Coriolus mushroom – 600mg three times daily 30
  • 31. Dietary Supplement Considerations  Quality & Purity is Important  Specific form of nutrients/botanicals matters  Vitamin D3 versus D2  Fish oil; cod liver oil vs whole fish vs concentrates  Root, leaf, flower  Raw material and finished product source matters  Purity, potency and microbial contamination  Of course “Natural” ≠ Safe  Nor necessarily effective  Just as Rx ≠ Safe 31
  • 32. Recommended Resources Five to Thrive: Your Cutting Edge-Cancer Prevention Plan Lise N. Alschuler, ND & Karolyn A. Gazella Anticancer: A New Way of Life David Servan-Schreiber, MD Life Over Cancer: Block Program Integrative Cancer Treatment Keith I. Block, MD The Cancer Fighting Kitchen Rebecca Katz The Journey Through Cancer Jeremy R. Geffen, MD Integrative Medicine: About Herbs, Botanicals & More Memorial Sloan-Kettering Cancer Center website 32 – http://www.mskcc.org/mskcc/html/11570.cfm
  • 33. Chad D. Aschtgen, ND, FABNO Seattle Integrative Oncology www.seattlend.com Institute of Complementary Medicine www.icmedicine.com Swedish Medical Center Cherry Hill Campus - Jefferson Tower 1600 E. Jefferson St, Ste 603 Seattle, WA 98122 t: 206.726.0034 | f: 206.726.9434 Providence Integrative Cancer Care www.providence.org/swsa at Providence Regional Cancer System 4525 Third Ave SE, Ste 200 Lacey, WA 98503 t: 360.754.3934 ext. 1083 | f: 360.412.8955

Notas del editor

  1. Although referencing a few research studies, the presentation is designed to emphasize practical/useful information. Promoting wellness – weight management, glucose/insulin balance, decreased inflammation. Treating symptoms
  2. There is the Summary of Treatment info – then the going forward aspect of the plan: e.g. colonoscopy, mammogram, vaccinations, etc. Ongoing medication management; e.g. diabetes, high blood pressure medications, etc. Endorsement for survivorship care plan And re-engaging with the family care physician
  3. The Lifestyle factors – Our primary tools Also, minimizing exposure to risk factors – tobacco, pollution, excess UV, ionizing radiation, solvents, etc.
  4. Nutrition: Energy dense/sugary foods, plant (non-starchy) foods and animal foods Survivors [should] follow the recommendations for cancer prevention!!
  5. I often ask my patients why they are taking a certain supplement and often they state that they don’t know!
  6. Whole foods, primarily plant based diet with a wide variety of food choices and abundant herbs and spices.
  7. Gastrointestinal toxicity Neurological toxicity
  8. Nutrition, sleep, physical activity, etc.
  9. Meat and dairy products, beans, avocado 2 weeks
  10. Beta blocker (atenolol, metoprolol) 2-4 weeks
  11. Pineal gland
  12. Gastrointestinal toxicity
  13. Lactobacilli (L. casei HA-108; L. paracasei HA-196; L. acidophilus HA-122; L. rhamnosus HA-111; L. rhamnosus HA-114; L. salivarius HA-118)Bifidobacteria (B. breve HA-129; B. bifidum HA-132; B. longum HA-135; B. infantis HA-116) Wheat, corn, barley, peanuts, soybean, egg white, milk

  14. Plant-derived oils (wheat germ, soybean, sunflower, almond, safflower, corn), wheat germ, liver, eggs, nuts and seeds, green leafy vegetables, whole grains
  15. Many of these can be addressed by nutrition and exercise Others need an individualized approach Common supplements with overlapping benefit
  16. Need to expand this; consider multiple slides.