Ceorins

Pharmacology of Cephalosporins: General Overview Flavio Guzmán, M.D. http://pharmamotion.com.ar

β - lactams: cell wall inhibitors

β -lactam ring ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Cell wall inhibitors: important features ,[object Object],[object Object],[object Object]

Mechanism of action 1 ,[object Object],[object Object],[object Object]

Cephalosporins: characteristics

Chemical structure of cephalosporins ,[object Object],[object Object]

1st Generation cephalosporins: antibacterial coverage Active mainly against Gram positive cocci. Less active against Gram negative.

Clinical uses of first gen. cephalosporins

2nd generation cephalosporins. Antibiotic coverage ,[object Object]

3rd generation cephalosporins Coverage Increased coverage against Gram negatives. Decreased coverage against Gram +

3rd generation cephalosporins Clinical uses

4th generation cephalosporins Antibacterial coverage Coverage against Gram + and Gram -, good activity against β -lactamase producing bacteria.

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