Manikandan_antiemetics

Antiemetics Dr.S.Manikandan Department of Pharmacology Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Pondicherry. INDIA.

Vomiting Centre (medulla) Cerebral cortex Anticipatory emesis Smell Sight Thought Vestibular nuclei Motion sickness Pharynx & GIT Chemo & radio therapy Gastroenteritis Chemoreceptor Trigger Zone (CTZ) (Outside BBB) Cancer chemotherapy Opioids Muscarinic, 5 HT 3 & Histaminic H 1 5 HT 3 receptors Dopamine D 2 5 HT 3, ,Opioid Receptors Muscarinic Histaminic H 1 Pathophysiology of Emesis

Now answer this question Which group of drugs can be used as antiemetics ? ,[object Object],[object Object],[object Object],[object Object],[object Object]

Serotonin 5 HT 3 Antagonist ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Drugs Available ,[object Object],[object Object],[object Object],Indications ,[object Object],[object Object]

Adverse Effects ,[object Object],[object Object],[object Object]

Dopamine D 2 Antagonist ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Now answer this question Which is a better antiemetic – Metoclopramide or Domperidone ? ,[object Object],[object Object],[object Object]

Phenothiazines & Butyrophenones ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

H 1 Antihistaminics ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Anticholinergics ,[object Object],Cannabinoids ,[object Object],[object Object]

Now answer this question ,[object Object]

[object Object],[object Object]

Manikandan_antiemetics

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