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Nikiforov
1. Yuri E. Nikiforov Department of Pathology University of Cincinnati Genetic Alterations Involved in the Transition from Well Differentiated to Poorly Differentiated and Anaplastic Thyroid Carcinomas Endocrine Pathology Companion Meeting
5. SOS B-RAF RAS GRB2 SOS Signaling Pathways Activated by BRAF in Thyroid Tumors Y1015 Y1062 Y1096 MEK ERK c-Jun, Fos , c- Myc , Elk-1 PLC γ Enigma SHC FRS2 P P P RET P P P
6. Kinase domain Spectrum of BRAF Point Mutations in Various Tumors Phe Gly Leu Val 594 595 598 601 596 599 Val Glu Leu 585 Gly 465 Gly 465 Gly 463 RBD C Ala The Lys Ser P P
7. Prevalence of BRAF Mutations in Thyroid Tumors Nikiforova et al. 2003 Cohen et al., 2003 Xu et al., 2003 Namba et al., 2003 Fukashima et al., 2003 Trovisco et al., 2004
8. BRAF Mutations Present in Both Well Differentiated and Poorly Differentiated Carcinoma Areas Nikiforova et al. (2003) DNA DNA BRAF + BRAF + PC,WD PDC
9. BRAF Mutations in Poorly Differentiated and Anaplastic Carcinomas Nikiforova et al. (2003)
13. Mechanism of RAS Activation by Point Mutation GAPs SOS GDSs CDC25 C3G Downstream Effectors Mutations codons 12/13 or 61 RAS RAS GTP GDP H 2 O Pi GTP GDP
14. Molecular Pathways Activated by RAS B-RAF BAD Apoptosis Y1062 RAS GRB2 SOS PLC Ral /Cdc42 DAG PKC AKT Rho Rac MEK ERK PI3K JNK P70S6K MEKK1 BCL c-Jun, Fos , c- Myc , Elk-1 SHC FRS2 RET P P P P
16. RAS in Progression of Thyroid Tumors: Case report of AC with areas of FC AC RAS codon 61 CAA CGA + + p53 codon 189 GCC GTC - + Asakawa & Kobayashi (2002) Mutations found: FC
36. Nikiforov Lab Marina Nikiforova Zhaowen Zhu Raffaele Ciampi Christy Caudill Manoj Gandhi Acknowledgements James Fagin University of Cincinnati Todd Kroll Emory University Giovanni Tallini