Soft tissue sarcomas are rare mesenchymal tumors that can arise in various soft tissues of the body. They are classified based on their cell of origin and differentiation. Treatment involves surgical excision with negative margins, with adjuvant radiation therapy sometimes used to improve local control. Prognosis depends on tumor size, grade, depth and margins of resection, with retroperitoneal and high grade tumors having a worse prognosis due to difficulty obtaining clear margins. Metastatic disease typically spreads to the lungs and has a poor median survival of 8-12 months.

1. Soft Tissue Sarcomas June 8, 2009

3. Location and Type

8. Tumor seeding after biopsy

11. Staging **Does not take into account extremity vs. visceral Staging system predicts survival and risk of metastasis, but not local recurrence M1 N1 Any T Any G Stage IV M0 N0 T2b G3,4 Stage III M0 N0 T2a G3,4 Stage IIB M0 N0 T1a,b G3,4 Stage IIA M0 N0 T2a,b G2,2 Stage IB M0 N0 T1a,b G1,2 Stage IA

12. Survival by stage

17. Local recurrence with post-op brachytherapy

19. Pre-op vs post-op radiotherapy

25. Liposarcoma

26. Survival after resection of primary retroperitoneal sarcoma

31. GIST

32. GIST

33. Extremity sarcomas MFH Synovial sarcoma

35. Sarcoma after mastectomy