K5 Lipogel is a lightly perfumed, hydroquinone-free formulation, having an effective whitening action on the brown skin spots due to excessive sun exposure, age, oral contraceptives, use of photosensitizing products, freckles and pigmentation around scars caused by acne or surgical intervention. K5 Lipogel does not undergo microbiological contamination because it is made of 99% of lipidic ingredients that do not offer a proper culture media for microbial growth. Epicutaneous patch tests (15 minutes and 24 hours) have showed good tolerability of K5. K5 Lipogel is currently notified as a cosmetic product in Italy and it can be immediately sold all over Europe.

2. INTRODUCTION
• For some people, a clearer skin is a hope for
racial redemption, for others it represents a
way of chasing eternal youth
• To achieve this goal, many agree to
jeopardize their health (abuse of dangerous
substances) or spend a lot of money (peeling,
laser, ...)
• A product that combines efficiency, excellent
tolerability, safety and handling costs is
absolutely innovative

3. Do you feel comfortable with your skin?

4. What’s behind the Skin Color?
Did you know that different pigments determine the skin color?
• MELANINS (eumelanin and feomelanine) yellow, brown to black;
• HEMOGLOBIN pink and oxygenated;
• CAROTENE yellow – orange nuances.
Under normal conditions, melanins determines the skin color. The melanocyte, a
dendritic cell that resides in the basal layer of the epidermis, is the seat of melanin
synthesis. Pheomelanin and eumelanin derived from the same initial pathway. The
enzyme tyrosinase catalyzes the conversion of tyrosine to DOPA and subsequently
into DOPA-quinone.
The synthesis of melanin is related to 2 conditions:
1. type of racial and constitutional factors (phototype);
2. exposure to external agents (ultraviolet radiation).

6. The Pigmentation Disorders
Often a change in the skin color is the manifestation of an ectodermal
extracutaneous disorder. This is an unsightly condition of interest,
dermatologically characterized by hypopigmentation (leucoderma) or
hyperpigmentation.
There are different forms of hyperpigmentation:
• The hyperpigmentation caused by accumulation of melanin
(hypermelanosis) or originated from darkening causes (blood, exogenous
pigment, carotene);
• Hypermelanosis congenital: neurofibromatosis, xeroderma pigmentosum
and Mongolian spots;
• Hypermelanosis acquired: secondary to systemic diseases, drugs, UV,
post-traumatic results or treatments;
Melasma is the most common form!

7. Melasma: the most common pigmentation disorder
WHAT IS MELASMA?
Melasma (Chloasma, mask of pregnancy) is a localized facial hyperpigmentation more
common in women, triggered by exposure to sunlight and hormonal changes.
CAUSES: genetic predisposition - oral contraceptives
BODY PARTS AFFECTED: Forehead – Temples – Cheeks - Upper lip.
How localized hypermelanosis has been cured? What about new treatments?
Historically, the most used substance in treatment is hydroquinone, in concentrations ranging
from 2% to 4%, or higher in association with sunscreens. The classic formulation of Kligman
contained hydroquinone, tretinoin and a corticosteroid with low activity. Concentrations of
hydroquinone up to 8% -10% have been created to lighten the skin of black race individuals,
but they turned out to be very dangerous for the human health.
Also due to its indiscriminate use and to its CARCENOGIC effects, hydroquinone is no longer
available and has been banned by the European Union (The 24th Directive 2000/6/EC).

8. K5 Lipogel by FRIULCHEM
K5 Lipogel is the combination of 3 active ingredients:
1. PIDOBENZONE
The second-generation worldwide patented depigmenting agent, healthy and free of collateral
risks. PIDOBENZONE has shown depigmenting activity by providing valuable clinical results in the
treatment of limited hypermelanosis.
After 3-4 weeks of treatment, you can already observe appreciable clinical results.
2. Salicylic Acid
A gentle exfoliating keratolytic action is a prerequisite for the penetration and efficacy of
depigmentation.
Kligman (master of photoaging) in its formula inserted tretinoin, to which salicylic acid is certainly
preferable for the absence of photosensitizing action.
3. SOLAR FILTER (SFP 10)
Prevention is better than cure! During the winter months in the northern areas, melasma regresses
spontaneously. Therefore, the best treatment is to protect from sun exposure.

9. K5 Lipogel can help!
K5 Lipogel is a lightly perfumed, allergène-free formulation,
having an effective whitening action on the brown skin spots
due to excessive sun exposure, age, oral contraceptives, use of
photosensitizing products, freckles and pigmentation around
scars caused by acne or surgical intervention.
K5 Lipogel does not undergo microbiological contamination
because it is made of 99% of lipidic ingredients that do not offer
a proper culture media for microbial growth.
Epicutaneous patch tests (15 minutes and 24 hours) have
showed good tolerability of K5.
5 Lipogel is currently notified as a cosmetic product in Italy and it
can be immediately sold all over Europe

10. Some statistics on K5 treatment…

12. PIDOBENZONE (2nd Generation) vs.
HYDROQUINONE (1st Generation)
They are molecules with a common base, but thanks to a chemical group
(esterification) their behavior is different!
Over the years, innovation in the scientific research and continuous studies
on skin protection have developed second-generation molecules and
alternative treatments that better satisfy human needs. Thus, better results
and no side effects have increased compliance.
In other words:
• people feel better and happier;
• chemical research can really change and improve people's lives,
• clinicians and dermatologists have a new tool that cannot be ignored.

13. Learn more on www.fc-store.com
Discuss about it on twitter.com/K5Lipogel
&
spread the word!