1. Professor Bernard Launois Department of Surgery University of Rennes

2. CLASSIFICATION OF EXTRA-HEPATIC BILE DUCT CANCER

43. PROXIMAL BILE DUCT CANCER OPERATIVE PROCEDURES ACCORDING TO TUMOR LOCATION Correlation coefficient rho = 0,6695 p < 0,01

44. OPERATIVE PROCEDURES ACCORDING TO TNM CLASSIFICATION Correlation coefficient rho = 0,4133 p < 0,01

45. PROXIMAL BILE DUCT CANCER OPERATIVE PROCEDURES ACCORDING TO TNM STAGING Correlation coefficient rho = 0,4926 p < 0,01

49. Klatskin Tumor Overall survival Month

50. Klatskin Tumor Survival according to age Month years > 60 years < 60-70 years

51. Klatskin Tumor Survival according to histology Month Noudular Infiltrant Papillomatosis

52. Klatskin Tumor Survival according to location

53. Klatskin Tumor Survival according to TNM classification Month

54. Klatskin Tumor Survival according to lymph node involvement

55. Klatskin Tumor Survival according to liver metastases Month Month

56. Klatskin Tumor Survival according to TNM staging Month

57. Klatskin Tumor Survival according to type of surgery Month Tumor resection Transplantation Hepatic and vascular resection Hepatectomy

58. Cirrhosis : 21571 Cancers : 4046 Acute hepatic failure : 3483 Patient Survival according to the Indication 01/1988 - 06/2001 62 66 71 75 81 37 42 49 57 74 55 56 58 60 64 0 20 40 60 80 100 1 2 3 4 5 6 7 8 9 10 (%) Yrs Total Log Rank test p = 0.0001 p Log Rank : Acute Hepatic Failure vs Cirrhosis : 0.0001 Cancers vs Cirrhosis : 0.0001 Acute Hepatic Failure vs Cancers : 0.0001 (Wilcoxon test)