1. Carol Andrea Casallas
Residente Farmacología Clínica

2. 1886 1958 1963 1970-1984 1995 2005
Boswell-Smith V, et al. Phosphodiesterase inhibitors. British Journal of Pharmacology (2006) 147, S252–S257
Vezzosi D, et al. Phosphodiesterases in endocrine physiology and disease. European Journal of Endocrinology (2011) 165 177–188

3. α β γ
Adenil Ciclasa
GMPc AMPc Enzimas Efectoras
Canales Iónicos
PKA
5’GMP 5’AMP Transcripción Genética
Diferenciación
Proliferación
Boswell-Smith V, et al. Phosphodiesterase inhibitors. British Journal of Pharmacology (2006) 147, S252–S257
Vezzosi D, et al. Phosphodiesterases in endocrine physiology and disease. European Journal of Endocrinology (2011) 165 177–188

4. Son 11Familias: PDE 3 PDE 4 PDE 5
• 3 Selectivos AMPc
Vasodialtación. Cel. Inflamatoria Vasodilatador
(4,7,8). Broncodilatación Broncodialtación Pentoxifilina
• 3 Selectivos GMPc Antiagregación PDE4 (a4)- PDE7 Sildenafil
(5,6,9). Inotropico (+) Teofilina
• 5 Ambos Milrinone Roflumilast
Cilostazol
(1,2,3,10,11)
Boswell-Smith V, et al. Phosphodiesterase inhibitors. British Journal of Pharmacology (2006) 147, S252–S257
Vezzosi D, et al. Phosphodiesterases in endocrine physiology and disease. European Journal of Endocrinology (2011) 165 177–188

5. Boswell-Smith V, et al. Phosphodiesterase inhibitors. British Journal of Pharmacology (2006) 147, S252–S257
Vezzosi D, et al. Phosphodiesterases in endocrine physiology and disease. European Journal of Endocrinology (2011) 165 177–188

6. Boswell-Smith V, et al. Phosphodiesterase inhibitors. British Journal of Pharmacology (2006) 147, S252–S257
Vezzosi D, et al. Phosphodiesterases in endocrine physiology and disease. European Journal of Endocrinology (2011) 165 177–188

7. Boswell-Smith V, et al. Phosphodiesterase inhibitors. British Journal of Pharmacology (2006) 147, S252–S257
Vezzosi D, et al. Phosphodiesterases in endocrine physiology and disease. European Journal of Endocrinology (2011) 165 177–188

8. Boswell-Smith V, et al. Phosphodiesterase inhibitors. British Journal of Pharmacology (2006) 147, S252–S257
Vezzosi D, et al. Phosphodiesterases in endocrine physiology and disease. European Journal of Endocrinology (2011) 165 177–188