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OBESITY IN FAMILY PRACTICE MANAGEMENT OF OBESITY IN FAMILY PRACTICE
DR. G. C. DHAR. MD., DTM&H FRSTM&H (UK), MCFP (CANADA)
IN 1998, THE WORLD HEALTH ORGANIZATION DESIGNATED OBESITY AS A GLOBAL EPIDEMIC
WHAT TO DO ? OBESITY EPIDEMIC!
SEDENTARY  LIFESTYLE & EXCESSIVE EATING
L U X U R Y  L I F E !
?
TREATMENT OF OBESITY CONSISTS OF 2 STEPS ,[object Object],[object Object]
WHAT IS OBESITY? ,[object Object]
OBESITY NOW IS NOT A PROBLEM OF HIGH INCOME COUNTRIES IT IS NOW DRAMATICALLY INCREASING IN MIDDLE AND LOW INCOME COUNTRIES
CURRENT SITUATION ,[object Object],[object Object]
IN BANGLADESH ,[object Object],[object Object],[object Object],[object Object]
IMPORTANT FACTORS FOR BANGLADESH ,[object Object],[object Object],[object Object]
CLASSIFICATION OF OBESITY ACCORDING TO  BMI ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
WHAT IS BMI? BODY WEIGHT IN KG DIVIDED BY HEIGHT IN METER SQUARE
ALTHOUGH WE DEFINE OBESITY BY BMI BMI EXACTLY DOES NOT REFLECT THE ACTUAL ADIPOSITY
BECAUSE ,[object Object],[object Object],[object Object]
 
VISCERAL OR CENTRAL OBESITY IS RISKY MEASURED BY  WAIST CIRCUMFERENCE WAIST CIRCUMFERENCE
HOW TO MEASURE WAIST CIRCUMFERENCE? ,[object Object],[object Object],[object Object],[object Object]
 
 
 
NORMAL WAIST CIRCUMFERENCE ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
HIGHER WAIST CIRCUMFERENCE IS AN INDEPENDENT RISK FACTOR HIGH CONTENT OF VISCERAL FAT = HIGHER METABOLIC RISK
 
 
NOT ALL PATEINTS WITH ABDOMINAL OBESITY ARE IN RISK STOP!!!
ABDOMINAL FAT SHOULD BE DEFFERENTIATED INTO VISCERAL FAT & SUBCUTANEOUS FAT H O W ?
PRACTICAL TIP FOR PHYSICIAN ,[object Object],[object Object],[object Object],[object Object]
PERIPHERAL FAT e.g. AROUND HIP CONTAINS MORE PUFA AND MORE PHYSIOLOGIC
MODERN MARKER OF OBESITY WAIST HIP RATIO (WHR)
WHAT IS WAIST HIP RATIO? ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
OTHER MEASUREMENTS FOR OBESITY ,[object Object],[object Object],[object Object],[object Object],[object Object]
BODY MASS INDEX(BMI) WAIST CIRCUMFERENCE The two important screening methods of obesity accepted worldwide
CAUSES OF OBESITY ,[object Object],[object Object],[object Object],[object Object],[object Object]
1. LIFESTYLE AND DIET ,[object Object]
 
1. LIFESTYLE AND DIET cont’d ,[object Object],[object Object],[object Object]
1. LIFESTYLE AND DIET cont’d  ,[object Object],[object Object],[object Object],[object Object]
 
2. ENVIRONMENTAL FACTORS ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
3. GENETIC FACTORS ,[object Object],[object Object],[object Object],[object Object]
4. HORMONAL DISEASES ,[object Object],[object Object],[object Object]
5. CERTAIN MEDICATIONS ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
CHILDHOOD OBESITY DO YOU KNOW? ,[object Object],[object Object],[object Object],[object Object],[object Object]
CHILDHOOD OBESITY FOR CHILDREN FROM 2-20 YEARS, BMI MEASUREMENT IS DIFFERENT FROM THOSE OF ADULTS
CHILDHOOD OBESITY
HOW TO MEASURE CHILD HOOD OBESITY?
BMI FOR CHILDREN  AGE AND GENDER SPECIFIC
OBTAIN ACCURATE WEIGHT & HEIGHT MEASUREMENT
CALCULATE BMI IN THE SAME WAY AS ADULT
BMI NUMBER IS PLOTTED ON THE BMI-FOR-AGE GROWTH CHART TO OBTAIN PERCENTILE RANKING. DIFFERENT CHART FOR BOYS AND GIRLS
 
 
CLASSIFICATION OF CHILDHOOD OBESITY ,[object Object],[object Object],[object Object],[object Object]
WHY OBESITY IS RISKY? ,[object Object],[object Object],[object Object],[object Object]
OTHER COMPLICATIONS OF OBESITY ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
KEY PATHOPHYSIOLOGICAL MECHANISMS FOR THE DEVELOPEMENT OF OBESITY RELATED DISEASES
ENDOTHELIAL DYSFUNCTION ATHEROSCLEROSIS INFLAMMATION
INCREASED ABDOMINAL OBESITY ,[object Object],[object Object]
INCREASED LEVEL OF FREE FATTY ACIDS ,[object Object],[object Object]
FAT IS NO MORE AN INERT ORGAN ,[object Object],[object Object]
ADIPOCYTOKINES OR ADIPOKINES ,[object Object],[object Object]
IMPORTANT ADIPOKINES ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
TNF-ALPHA Generally together with IL1 & IL6, increases the synthesis of C Reactive Protein
INTERLUKIN-6 (IL-6) Increases C reactive Protein
LEPTIN ,[object Object],[object Object]
C-Reactive Protein (CRP) Number one inflammatory marker
ANGIOTENSIN ,[object Object],[object Object]
PLASMINOGEN ACTIVATOR INHIBITOR 1 (PAI-1) ,[object Object],[object Object]
RESISTIN Plays both in inflammation and insulin resistance
ADIPONECTIN ,[object Object],[object Object],[object Object]
WHY  INFLAMMATION IS SO IMPORTANT?
ACUTE INFLAMMATION ,[object Object]
CHRONIC INFLAMMATION ,[object Object],[object Object],[object Object]
WHAT CRP DOES? ,[object Object],[object Object],[object Object],[object Object],[object Object]
 
INFLAMMATION AND T2DM ,[object Object],[object Object],[object Object]
HOW TO MANAGE?
BEFORE GOING TO TREAT OBESITY ,[object Object],[object Object]
RISK FACTORS ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
High absolute risk for obesity related disease ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
LABORATORY TESTS  ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
TREATMENT OF OBESITY ,[object Object],[object Object],[object Object]
GOAL FOR OBESITY TREATMENT ,[object Object],[object Object]
WHAT IS THE AIM OF HEALTHIER WEIGHT? ,[object Object],[object Object],[object Object],[object Object]
NON-PHARMACOLOGICAL TREATMENT ,[object Object],[object Object],[object Object]
DIETARY CHANGE
1. DIETARY CHANGE  TARGET LOW CALORIE DIET ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
TARGET: LOW CALORIE DIET CAUTION! Must not be less than 800kcal/day
WHAT HAPPENS WHEN CALORIES REDUCED  BELOW MAINTENANCE?
RECENT INSTITUTE OF MEDICINE (IOM) GUIDELINES ACCEPTABLE MACRONUTRIENT DISTRIBUTION RANGE (MDR)
WHAT IS MDR?
TIGHT RESTRICTION ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
EAT ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
EXAMPLE OF LCD ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
E G G  I N  O B E S I T Y
EGG ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
EGG cont’d ,[object Object],[object Object]
EGG cont’d REFERENCES ,[object Object],[object Object],[object Object]
2. PHYSICAL ACTIVITY ,[object Object],[object Object],[object Object]
PHYSICAL ACTIVITY SHOULD BE STARTED GRADUALLY. walking 10min/day-3days in a week, increase gradually up to 45min/day-7days/week
ACSM's Guidelines for Exercise Testing and Prescription -- Sixth Edition, page 26 Virtually all sedentary individuals can begin a moderate exercise program safely.
3. BEHAVIOR MODIFICATIONS ,[object Object],[object Object],[object Object]
PHARMACOLOGICAL TREATMENT IS INDICATED IF ,[object Object],[object Object],[object Object]
Non-pharmacological treatment should be continued together with pharmacological agents
TWO DRUGS CURRENTLY APPROVED BY FDA SIBUTRAMINE ORLISTAT
SIBUTRAMINE ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
ORLISTAT ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
THESE ARE FOR LONG TERM USE If weight reduction is not achieved 2kg in 4 weeks, drug should be discontinued
NEWER PHARMACOLOGICAL AGENT Endocannabinoid (ECS) receptor blocker
RIMONABANT ,[object Object],[object Object],[object Object],[object Object],[object Object]
SURGICAL TREATMENT OF OBESITY ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
BARIATRIC SURGERY 1 ,[object Object],[object Object],[object Object],[object Object]
BARIATRIC SURGERY 2 ,[object Object],[object Object],[object Object],[object Object],[object Object]
Contraindications to Treatment  of overweight & obesity ,[object Object],[object Object],[object Object],[object Object]
PRACTICAL TIPS FOR FAMILY PHYSICIANS ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
MANAGEMENT OPTION I ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
MANAGEMENT OPTION II ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
MANAGEMENT OPTION III ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
PRACTICAL TIPS FOR CHILDHOOD OBESITY ,[object Object],[object Object],[object Object],[object Object],[object Object]
PRACTICAL TIPS FOR CHILDHOOD OBESITY-con’d ,[object Object],[object Object]
DOCTORS! WHERE WE STAND? WITH OBESITY?
 
NO!!
NO!!
NO!!
NO!
N O !
Y E S !
YES!!
YES!!
YES!!
YES!
BE ACTIVE KEEP HEALTHY
References: ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
T H A N K  Y O U!

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