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Aeromedical evacuation
Hoist Rescue
Sling single?
Double sling?
Stretcher?
Rescue basket?
Respiratory Function in Hoist Rescue:
              Comparing
Slings, Stretcher, and Rescue Basket
        David   Murphy ,     Alan   Garner , and     Rod   Bishop

             From CareFlight NSW, Northmead, NSW, Australia.

 Aviation, Space, and Environmental Medicine x Vol. 82, No. 2 x February 2011

                 CareFlight NSW, Northmead, NSW, Australia
INTRODUCTION
INTRODUCTION




B) double sling   A) single sling
INTRODUCTION




D) rescue basket   C) stretcher
INTRODUCTION
INTRODUCTION
So what happens?                             INTRODUCTION



Suspention trauma and harness-hang syndrome


∗ General feelings of unease
  ∗ Dizzy, sweaty and other signs of shock
  ∗ Increased pulse and breathing rates
∗ Then a sudden drop in pulse & BP
∗ Instant loss of consciousness
∗ If not rescued, death is certain
  ∗ From suffocation due to a closed airway, or
    from lack of blood flow and oxygen to the
    brain.
INTRODUCTION
Suspention trauma and harness-hang syndrome
INTRODUCTION
INTRODUCTION
INTRODUCTION
INTRODUCTION
INTRODUCTION
Sever Asthma

When is a severe acute episode
happening?
• Limited ability to speak
• Pulsus paradoxus > 25mmHg
• Pulse >110/min
• RR >25-30/min
• Flow rates <50% predicted
• O2 saturation <91-92%
• Some consider flow rates < 35% predicted
to be life-threatening
Stepwise approach ( children)

classificati    mild        Mild         Moderate     Severe
on             Intermitte   persistent   persistent   persistent
               nt
Minor          < 1/week     1-3 /week    4-5/week     Continuou
symptoms                                              s

exacerbati     < 1/month 1 /month        2-3/month > 4
on/                                                /month
nocturnal
PEF            >80%         >80%         60-80%       < 60%
between
attacks
               Step 1       Step 2       Step 3       Step 4
Stepwise approach ( adult)

classificati    mild        Mild         Moderate     Severe
on             Intermitte   persistent   persistent   persistent
               nt
Minor          < 2 /week    2-3 /week    4-5 /week    Continuou
symptoms                                              s

exacerbati     <2           2-3          4-5          >5
on/            /month       /month       /month       /month
nocturnal
PEF            >80%         >80%         60-80%       < 60%
between
attacks
               Step 1       Step 2       Step 3       Step 4
Asthma classification
INTRODUCTION
INTRODUCTION
                 >
Rescue Basket (RB) Stretcher
INTRODUCTION
H0 & H1 thesis



H1:Use of the RB would not be associated with impairment of spirometry in healthy
volunteers

H0:Use of the Stretcher would not be associated with impairment of spirometry in
healthy volunteers
METHODS
Winch
simulator
METHODS
Randomized ,Controlled cross-over study
Hypothesis Testing: Case-Crossover Studies


Randomized ,Controlled cross-over
study

∗ Study of “triggers” within an individual
∗ ”Case" and "control" component, but information of both
  components will come from the same individual
∗ ”Case component" = hazard period which is the time period
  right before the disease or event onset
∗ ”Control component" = control period which is a specified time
  interval other than the hazard period
METHODS
Randomized ,Controlled cross-over
study
METHODS
Table of Random Numbers
Sequence - randomization




                           542-04-#38
METHODS
METHODS
METHODS




EasyOne Diagnostic Spirometer
Pulmonary Function
     Testing
Perform test
Types of Spirometers


∗ Bellows spirometers:
  Measure volume; mainly in lung function units

∗ Electronic desk top spirometers:
  Measure flow and volume with real time display

∗ Small hand-held spirometers:
  Inexpensive and quick to use but no print out
Volume Measuring Spirometer
Flow Measuring Spirometer
Desktop Electronic Spirometers
Small Hand-held Spirometers
Actual PFT Performance Technique


∗ Prepare the equipment – find a nurse who knows (or is
  that nose?) what to do.

∗ Patient should be seated with nose clip in place.

∗ The patient needs to practice the exercise before actually
  performing the test. Have the patient breath in and out
  deeply several times.

∗ Ask the patient to breath in as deeply as they can.
Actual PFT Performance Technique


∗ The patient should place their mouth completely over
  the mouthpiece, not inside it.

∗ Ask the patient to blow out as fast and as quick as they
  can for at least six seconds. Enthusiatically coach the
  patient – jump, shout, get down, hoot and holler…
 “Blow, blow, come on, blow more, you can do it!”
Actual PFT Performance Technique


∗ Once the patient has blown out as much as they can,
  ask them to then inhale as deeply as they can.

∗ Repeat the whole test three times. The goal is to get
  a reproducible result that is consistent.

∗ You may need to repeat the test more than three
  times in order to obtain an internally valid test.
Difinitions &
Considerations
Lung Volumes and Capacities


∗ There are four basic lung volumes:
  ∗   Inspiratory reserve volume (IRV)
  ∗   Tidal volume (TV)
  ∗   Expiratory reserve volume (ERV)
  ∗   Residual volume (RV)
∗ In various combinations, these lung volumes then
  form lung capacities.
∗ E.g., Vital capacity = IRV + TV + ERV
Lung Volumes
Normal Spirometry
Obstructive Pattern



■ Decreased FEV1

■ Decreased FVC

■ Decreased FEV1/FVC
      - <70% predicted

■ FEV1 used to follow severity in COPD
Obstructive Lung Disease — Differential
               Diagnosis


 Asthma
 COPD
   - chronic bronchitis
   - emphysema
 Bronchiectasis
 Bronchiolitis
 Upper airway obstruction
Restrictive Pattern



 Decreased FEV1




 Decreased FVC


 FEV1/FVC normal or increased
Restrictive Lung Disease —Differential
               Diagnosis



 Pleural

 Parenchymal

 Chest wall

 Neuromuscular
Spirometry Patterns
Indications for
          Pulmonary Function Testing



∗ Patients 45 years old and older who have ever smoked.


∗ Patients with prolonged or excessive cough or sputum
  production.

∗ Patients with a history of exposure to lung irritants.
Indications for
       Pulmonary Function Testing


∗ Detecting pulmonary disease
  ∗ Pulmonary symptoms – chest pain, orthopnea, cough,
    phlegm production, dyspnea, wheezing

  ∗ Physical findings – Chest wall problems, cyanosis,
    clubbing, decreased breath sounds

  ∗ Abnormal labs/x-rays – ABG, Chest X-Ray
Indications for
           Pulmonary Function Testing


∗ Assessing disease severity and progression
  ∗ Pulmonary disease – COPD, Cystic fibrosis, Interstitial lung
    disease, Sarcoidosis

  ∗ Cardiac disease – CHF, Congenital heart disease, Pulmonary
    hypertension

  ∗ Neuromuscular disease – Amyotrophic lateral sclerosis, Guillain-
    Barre syndrome, Multiple sclerosis, Myasthenia gravis
Indications for
       Pulmonary Function Testing

∗ Pre-operative risk stratification
  ∗ Thoracic surgery


  ∗ Cardiac surgery


  ∗ Organ transplantation


  ∗ General surgical procedures


∗ Evaluating disability and impairment
Contraindications for PFT

Relative contraindications for spirometry include hemoptysis of

unknown origin, pneumothorax, unstable angina pectoris,

recent myocardial infarction, thoracic aneurysms, abdominal

aneurysms, cerebral aneurysms, recent eye surgery (increased

intraocular pressure during forced expiration), recent abdominal

or thoracic surgical procedures, and patients with a history of

syncope associated with forced exhalation.
Normal Values


∗ FVC is the total amount of air a person can exhale,
  usually measured in six seconds.
  ∗   80 – 120% of predicted is a normal value
  ∗   70 – 80% demonstrates mild reduction/restriction
  ∗   50 – 70% demonstrates moderate reduction
  ∗   <50% demonstrates severe reduction


∗ FEV1 is the amount of air a person can exhale in one
  second.
  ∗ 80 – 120% of predicted is a normal value
Normal Values


∗ FEV1/FVC ratio is the percentage of FVC that can be
  expired in one second.
  ∗ 75 – 80% is normal


  ∗ 60 – 80% demonstrates mild obstruction


  ∗ 50 – 60% demonstrates moderate obstruction


  ∗ <50% demonstrates severe obstruction
Normal Values


∗ FEF25-75 reflects small airway function
  ∗ >80% is normal


  ∗ 60 – 80% reflects mild obstruction in the small airways


  ∗ 40 – 60% reflects moderate obstruction


  ∗ <40% reflects severe obstruction
Spirometry Interpretation: So
   what constitutes normal?


∗ Normal values vary and depend on:

  ∗   Height
  ∗   Age
  ∗   Gender
  ∗   Ethnicity
PFT Interpretation
PFT Interpretation


∗ Three steps in interpretation
  ∗ Is the test valid?


  ∗ Interpret the test


  ∗ Classify severity of disease if present
Validity


∗ The test is valid is you have good patient effort and
  the three tests performed are internally consistent.

∗ You may notice a learning curve in that the latter tests
  are better performed than the former.

∗ Make sure that the tests are maximal effort. You
  need to be really aggressive in coaching your patient.
Acceptability Criteria
1 - good start of test : sharp take off

2- Meet end-of-test criteria

3- free from artifacts:

   -Cough or glottis closure during the first second of exhalation

   -Variable effort , submaximal effort

    -Leak

   -Obstructed mouthpiece

   -Have a satisfactory exhalation 6 s of exhalation
Reproducibility Criteria


After 3 acceptable spirograms been obtained

 Are the two largest FVC within 150ml of each other?

 Are the two largest FEV1 within 150ml of each other?

If both of these criteria are met, the test session may be concluded.

If both of these criteria are not met, continue testing until Both of the
   criteria are met with analysis of additional acceptable spirograms; OR
   a total of eight tests have been performed
Interpretation of Spirometry


Step 1. Look at the Flow-Volume loop
Step 2. Look at the FEV1 (Nl ≥ 80% predicted).
Step 3. Look at FVC (Nl ≥ 80%).
Step 4. Look at FEV1/FVC ratio (Nl≥ 75%).
Step 5. Look at FEF25-75% (wide normal range)
Normal Values


∗ FVC is the total amount of air a person can exhale,
  usually measured in six seconds.
  ∗   80 – 120% of predicted is a normal value
  ∗   70 – 80% demonstrates mild reduction/restriction
  ∗   50 – 70% demonstrates moderate reduction
  ∗   <50% demonstrates severe reduction


∗ FEV1 is the amount of air a person can exhale in one
  second.
  ∗ 80 – 120% of predicted is a normal value
Normal Values


∗ FEV1/FVC ratio is the percentage of FVC that can be
  expired in one second.
  ∗ 75 – 80% is normal


  ∗ 60 – 80% demonstrates mild obstruction


  ∗ 50 – 60% demonstrates moderate obstruction


  ∗ <50% demonstrates severe obstruction
Normal Values


∗ FEF25-75 reflects small airway function
  ∗ >80% is normal


  ∗ 60 – 80% reflects mild obstruction in the small airways


  ∗ 40 – 60% reflects moderate obstruction


  ∗ <40% reflects severe obstruction
PFT Interpretation


Assess FVC, FEV1, and FEV1/FVC ratio.
FVC and FEV1 normal, with a normal FEV1/FVC ratio: Normal Test

  FVC low, FEV1 low or normal, and a normal to high FEV1/FVC ratio:--
   Restrictive lung disease



FVC low or normal, FEV1 low, and a low FEV1/FVC ratio:
    Obstructive lung disease
Measurements Obtained from the FVC
             Curve


∗ FEV1---the volume exhaled during the first second of the
  FVC maneuver

∗ FEF 25-75%---the mean expiratory flow during the middle
  half of the FVC maneuver; reflects flow through the small
  (<2 mm in diameter) airways

∗ FEV1/FVC---the ratio of FEV1 to FVC X 100 (expressed as a
  percent); an important value because a reduction of this
  ratio from expected values is specific for obstructive
  rather than restrictive diseases
Spirometry Interpretation:
  Obstructive vs. Restrictive Defect


∗ Obstructive Disorders   ∗ Restrictive Disorders
  ∗   FVC nl or↓            ∗ FVC ↓
  ∗   FEV1 ↓                ∗   FEV1 ↓
  ∗   FEF25-75% ↓           ∗   FEF 25-75% nl to ↓
  ∗   FEV1/FVC ↓            ∗   FEV1/FVC nl to ↑
  ∗   TLC nl or ↑           ∗   TLC ↓
Spirometry Interpretation: What
           do the numbers mean?


∗ FVC                              FEV1
∗ Interpretation of % predicted:   Interpretation of % predicted:

  ∗   80-120% Normal                 ∗   >75% Normal
  ∗   70-79% Mild reduction          ∗   60%-75% Mild obstruction
  ∗   50%-69% Moderate reduction     ∗   50-59% Moderate obstruction
  ∗   <50% Severe reduction          ∗   <49% Severe obstruction
                                         ∗ <25 y.o. add 5% and >60 y.o.
                                           subtract 5
Actual       Predicted   % Predicted
FVC        4.0          4.5         88
FEV1       3.4          4.2         89
FEV1/FVC   85           82          112
FEF25-75

                    Normal
Actual      Predicted   % Predicted
FVC        2.0         4.0         50
FEV1       1.8         3.7         47
FEV1/FVC   90          82          112
FEF25-75

           Restrictive Pattern
Actual    Predicted   % Predicted
FVC        4.0       4.5         88
FEV1       2.4       4.2         58
FEV1/FVC   60        82          76
FEF25-75   2.2       4.4         50

           Obstructive Pattern
Acceptable and Unacceptable
  Spirograms (from ATS, 1994)
PFTs
Normal vs. Obstructive vs. Restrictive
Variable Effort
Early Glottic Closure
Cough
Flow-Volume Loops
Flow-Volume Loops
Special Techniques


∗ Beta Agonist Challenge
∗ Methacholine Challenge
∗ DLCO
Beta Agonist Challenge


∗ Perform this when there is a suspicion that the
  obstructive defect may be reversible –> asthma.

∗ Give the patient a beta agonist treatment (two puffs
  of an albuterol MDI or an albuterol nebulizer) and
  repeat the PFTs several minutes later. If you notice a
  12% or more increase in FEV1, then you have diagnosed
  reversible airway disease/asthma.
Methacholine Challenge


∗ If you have a suspicion that the patient might have Exercise-
  induced bronchospasm (EIB), then refer them to a pulmonary
  lab where they can do provocative testing with methacholine.

∗ If the patient has a decrease in their FEV1/FVC ratio with the
  inhalation of methacholine, then you have diagnosed EIB.

∗ Pretreat before exercise with albuterol or cromolyn.
Diffuse capacity of carbon monoxide in
                 the lung DLCO


∗ After performing the standard PFTs, the patient then inhales
  trace amounts of carbon monoxide.

∗ CO traverses the alveolar capillary beds much more readily than
  CO2 or O2.


∗ As such, most of the CO inhaled should be absorbed.

∗ When it is not, this suggests pulmonary scarring consistent with
  pulmonary fibrosis. Search for a cause.
Diffusing Capacity



 Decreased DLCO                 Increased DLCO
                                  (>120-140% predicted)
      (<80% predicted)
                                   Asthma (or normal)
  Obstructive lung disease
                                   Pulmonary hemorrhage
  Parenchymal disease
                                   Polycythemia
  Pulmonary vascular disease
                                   Left to right shunt
  Anemia
paired T test


    The paired t-test will show whether the

 differences observed in the 2 measures will be

       found reliably in repeated samples.
ANOVA:One way


If we have data measured at the interval level, we

can compare two or more population groups in

terms of their population means using a

technique called analysis of variance, or ANOVA.
Honestly significant difference test (HSD)



 When you do multiple significance tests, the
chance of finding a "significant" difference just
by chance increases. Tukey´s HSD test is one of
several methods of ensuring that the chance of
finding a significant difference in any comparison
(under a null model) is maintained at the alpha
level of the test.
RESULTS
DISCUSSION
DISCUSSION
DISCUSSION
DISCUSSION
DISCUSSION
DISCUSSION
DISCUSSION
DISCUSSION
DISCUSSION
Air Turbulance
DISCUSSION
Major sources of noise generated by a helicopter
DISCUSSION
DISCUSSION

Static Spirometry
DISCUSSION

Dynamic Spirometry
DISCUSSION
DISCUSSION
Body Plethysmography
DISCUSSION

Body Plethysmography
DISCUSSION

helium dilution
DISCUSSION
DISCUSSION
DISCUSSION
THANKS FOR
   YOUR
ATTENTION
    134

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Respiratory function in hoist rescue111

  • 1.
  • 2.
  • 9. Respiratory Function in Hoist Rescue: Comparing Slings, Stretcher, and Rescue Basket David Murphy , Alan Garner , and Rod Bishop From CareFlight NSW, Northmead, NSW, Australia. Aviation, Space, and Environmental Medicine x Vol. 82, No. 2 x February 2011 CareFlight NSW, Northmead, NSW, Australia
  • 11. INTRODUCTION B) double sling A) single sling
  • 15. So what happens? INTRODUCTION Suspention trauma and harness-hang syndrome ∗ General feelings of unease ∗ Dizzy, sweaty and other signs of shock ∗ Increased pulse and breathing rates ∗ Then a sudden drop in pulse & BP ∗ Instant loss of consciousness ∗ If not rescued, death is certain ∗ From suffocation due to a closed airway, or from lack of blood flow and oxygen to the brain.
  • 16. INTRODUCTION Suspention trauma and harness-hang syndrome
  • 21. INTRODUCTION Sever Asthma When is a severe acute episode happening? • Limited ability to speak • Pulsus paradoxus > 25mmHg • Pulse >110/min • RR >25-30/min • Flow rates <50% predicted • O2 saturation <91-92% • Some consider flow rates < 35% predicted to be life-threatening
  • 22.
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  • 25.
  • 26. Stepwise approach ( children) classificati mild Mild Moderate Severe on Intermitte persistent persistent persistent nt Minor < 1/week 1-3 /week 4-5/week Continuou symptoms s exacerbati < 1/month 1 /month 2-3/month > 4 on/ /month nocturnal PEF >80% >80% 60-80% < 60% between attacks Step 1 Step 2 Step 3 Step 4
  • 27. Stepwise approach ( adult) classificati mild Mild Moderate Severe on Intermitte persistent persistent persistent nt Minor < 2 /week 2-3 /week 4-5 /week Continuou symptoms s exacerbati <2 2-3 4-5 >5 on/ /month /month /month /month nocturnal PEF >80% >80% 60-80% < 60% between attacks Step 1 Step 2 Step 3 Step 4
  • 30. INTRODUCTION > Rescue Basket (RB) Stretcher
  • 31. INTRODUCTION H0 & H1 thesis H1:Use of the RB would not be associated with impairment of spirometry in healthy volunteers H0:Use of the Stretcher would not be associated with impairment of spirometry in healthy volunteers
  • 35. Hypothesis Testing: Case-Crossover Studies Randomized ,Controlled cross-over study ∗ Study of “triggers” within an individual ∗ ”Case" and "control" component, but information of both components will come from the same individual ∗ ”Case component" = hazard period which is the time period right before the disease or event onset ∗ ”Control component" = control period which is a specified time interval other than the hazard period
  • 38. Table of Random Numbers Sequence - randomization 542-04-#38
  • 44. Types of Spirometers ∗ Bellows spirometers: Measure volume; mainly in lung function units ∗ Electronic desk top spirometers: Measure flow and volume with real time display ∗ Small hand-held spirometers: Inexpensive and quick to use but no print out
  • 49. Actual PFT Performance Technique ∗ Prepare the equipment – find a nurse who knows (or is that nose?) what to do. ∗ Patient should be seated with nose clip in place. ∗ The patient needs to practice the exercise before actually performing the test. Have the patient breath in and out deeply several times. ∗ Ask the patient to breath in as deeply as they can.
  • 50. Actual PFT Performance Technique ∗ The patient should place their mouth completely over the mouthpiece, not inside it. ∗ Ask the patient to blow out as fast and as quick as they can for at least six seconds. Enthusiatically coach the patient – jump, shout, get down, hoot and holler… “Blow, blow, come on, blow more, you can do it!”
  • 51. Actual PFT Performance Technique ∗ Once the patient has blown out as much as they can, ask them to then inhale as deeply as they can. ∗ Repeat the whole test three times. The goal is to get a reproducible result that is consistent. ∗ You may need to repeat the test more than three times in order to obtain an internally valid test.
  • 53. Lung Volumes and Capacities ∗ There are four basic lung volumes: ∗ Inspiratory reserve volume (IRV) ∗ Tidal volume (TV) ∗ Expiratory reserve volume (ERV) ∗ Residual volume (RV) ∗ In various combinations, these lung volumes then form lung capacities. ∗ E.g., Vital capacity = IRV + TV + ERV
  • 54.
  • 57. Obstructive Pattern ■ Decreased FEV1 ■ Decreased FVC ■ Decreased FEV1/FVC - <70% predicted ■ FEV1 used to follow severity in COPD
  • 58. Obstructive Lung Disease — Differential Diagnosis  Asthma  COPD - chronic bronchitis - emphysema  Bronchiectasis  Bronchiolitis  Upper airway obstruction
  • 59. Restrictive Pattern  Decreased FEV1  Decreased FVC  FEV1/FVC normal or increased
  • 60. Restrictive Lung Disease —Differential Diagnosis  Pleural  Parenchymal  Chest wall  Neuromuscular
  • 62. Indications for Pulmonary Function Testing ∗ Patients 45 years old and older who have ever smoked. ∗ Patients with prolonged or excessive cough or sputum production. ∗ Patients with a history of exposure to lung irritants.
  • 63. Indications for Pulmonary Function Testing ∗ Detecting pulmonary disease ∗ Pulmonary symptoms – chest pain, orthopnea, cough, phlegm production, dyspnea, wheezing ∗ Physical findings – Chest wall problems, cyanosis, clubbing, decreased breath sounds ∗ Abnormal labs/x-rays – ABG, Chest X-Ray
  • 64. Indications for Pulmonary Function Testing ∗ Assessing disease severity and progression ∗ Pulmonary disease – COPD, Cystic fibrosis, Interstitial lung disease, Sarcoidosis ∗ Cardiac disease – CHF, Congenital heart disease, Pulmonary hypertension ∗ Neuromuscular disease – Amyotrophic lateral sclerosis, Guillain- Barre syndrome, Multiple sclerosis, Myasthenia gravis
  • 65. Indications for Pulmonary Function Testing ∗ Pre-operative risk stratification ∗ Thoracic surgery ∗ Cardiac surgery ∗ Organ transplantation ∗ General surgical procedures ∗ Evaluating disability and impairment
  • 66. Contraindications for PFT Relative contraindications for spirometry include hemoptysis of unknown origin, pneumothorax, unstable angina pectoris, recent myocardial infarction, thoracic aneurysms, abdominal aneurysms, cerebral aneurysms, recent eye surgery (increased intraocular pressure during forced expiration), recent abdominal or thoracic surgical procedures, and patients with a history of syncope associated with forced exhalation.
  • 67. Normal Values ∗ FVC is the total amount of air a person can exhale, usually measured in six seconds. ∗ 80 – 120% of predicted is a normal value ∗ 70 – 80% demonstrates mild reduction/restriction ∗ 50 – 70% demonstrates moderate reduction ∗ <50% demonstrates severe reduction ∗ FEV1 is the amount of air a person can exhale in one second. ∗ 80 – 120% of predicted is a normal value
  • 68. Normal Values ∗ FEV1/FVC ratio is the percentage of FVC that can be expired in one second. ∗ 75 – 80% is normal ∗ 60 – 80% demonstrates mild obstruction ∗ 50 – 60% demonstrates moderate obstruction ∗ <50% demonstrates severe obstruction
  • 69. Normal Values ∗ FEF25-75 reflects small airway function ∗ >80% is normal ∗ 60 – 80% reflects mild obstruction in the small airways ∗ 40 – 60% reflects moderate obstruction ∗ <40% reflects severe obstruction
  • 70. Spirometry Interpretation: So what constitutes normal? ∗ Normal values vary and depend on: ∗ Height ∗ Age ∗ Gender ∗ Ethnicity
  • 72. PFT Interpretation ∗ Three steps in interpretation ∗ Is the test valid? ∗ Interpret the test ∗ Classify severity of disease if present
  • 73. Validity ∗ The test is valid is you have good patient effort and the three tests performed are internally consistent. ∗ You may notice a learning curve in that the latter tests are better performed than the former. ∗ Make sure that the tests are maximal effort. You need to be really aggressive in coaching your patient.
  • 74. Acceptability Criteria 1 - good start of test : sharp take off 2- Meet end-of-test criteria 3- free from artifacts: -Cough or glottis closure during the first second of exhalation -Variable effort , submaximal effort -Leak -Obstructed mouthpiece -Have a satisfactory exhalation 6 s of exhalation
  • 75. Reproducibility Criteria After 3 acceptable spirograms been obtained  Are the two largest FVC within 150ml of each other?  Are the two largest FEV1 within 150ml of each other? If both of these criteria are met, the test session may be concluded. If both of these criteria are not met, continue testing until Both of the criteria are met with analysis of additional acceptable spirograms; OR a total of eight tests have been performed
  • 76. Interpretation of Spirometry Step 1. Look at the Flow-Volume loop Step 2. Look at the FEV1 (Nl ≥ 80% predicted). Step 3. Look at FVC (Nl ≥ 80%). Step 4. Look at FEV1/FVC ratio (Nl≥ 75%). Step 5. Look at FEF25-75% (wide normal range)
  • 77. Normal Values ∗ FVC is the total amount of air a person can exhale, usually measured in six seconds. ∗ 80 – 120% of predicted is a normal value ∗ 70 – 80% demonstrates mild reduction/restriction ∗ 50 – 70% demonstrates moderate reduction ∗ <50% demonstrates severe reduction ∗ FEV1 is the amount of air a person can exhale in one second. ∗ 80 – 120% of predicted is a normal value
  • 78. Normal Values ∗ FEV1/FVC ratio is the percentage of FVC that can be expired in one second. ∗ 75 – 80% is normal ∗ 60 – 80% demonstrates mild obstruction ∗ 50 – 60% demonstrates moderate obstruction ∗ <50% demonstrates severe obstruction
  • 79. Normal Values ∗ FEF25-75 reflects small airway function ∗ >80% is normal ∗ 60 – 80% reflects mild obstruction in the small airways ∗ 40 – 60% reflects moderate obstruction ∗ <40% reflects severe obstruction
  • 80. PFT Interpretation Assess FVC, FEV1, and FEV1/FVC ratio. FVC and FEV1 normal, with a normal FEV1/FVC ratio: Normal Test FVC low, FEV1 low or normal, and a normal to high FEV1/FVC ratio:-- Restrictive lung disease FVC low or normal, FEV1 low, and a low FEV1/FVC ratio: Obstructive lung disease
  • 81. Measurements Obtained from the FVC Curve ∗ FEV1---the volume exhaled during the first second of the FVC maneuver ∗ FEF 25-75%---the mean expiratory flow during the middle half of the FVC maneuver; reflects flow through the small (<2 mm in diameter) airways ∗ FEV1/FVC---the ratio of FEV1 to FVC X 100 (expressed as a percent); an important value because a reduction of this ratio from expected values is specific for obstructive rather than restrictive diseases
  • 82. Spirometry Interpretation: Obstructive vs. Restrictive Defect ∗ Obstructive Disorders ∗ Restrictive Disorders ∗ FVC nl or↓ ∗ FVC ↓ ∗ FEV1 ↓ ∗ FEV1 ↓ ∗ FEF25-75% ↓ ∗ FEF 25-75% nl to ↓ ∗ FEV1/FVC ↓ ∗ FEV1/FVC nl to ↑ ∗ TLC nl or ↑ ∗ TLC ↓
  • 83. Spirometry Interpretation: What do the numbers mean? ∗ FVC FEV1 ∗ Interpretation of % predicted: Interpretation of % predicted: ∗ 80-120% Normal ∗ >75% Normal ∗ 70-79% Mild reduction ∗ 60%-75% Mild obstruction ∗ 50%-69% Moderate reduction ∗ 50-59% Moderate obstruction ∗ <50% Severe reduction ∗ <49% Severe obstruction ∗ <25 y.o. add 5% and >60 y.o. subtract 5
  • 84. Actual Predicted % Predicted FVC 4.0 4.5 88 FEV1 3.4 4.2 89 FEV1/FVC 85 82 112 FEF25-75 Normal
  • 85. Actual Predicted % Predicted FVC 2.0 4.0 50 FEV1 1.8 3.7 47 FEV1/FVC 90 82 112 FEF25-75 Restrictive Pattern
  • 86. Actual Predicted % Predicted FVC 4.0 4.5 88 FEV1 2.4 4.2 58 FEV1/FVC 60 82 76 FEF25-75 2.2 4.4 50 Obstructive Pattern
  • 87. Acceptable and Unacceptable Spirograms (from ATS, 1994)
  • 88. PFTs
  • 89. Normal vs. Obstructive vs. Restrictive
  • 92. Cough
  • 95. Special Techniques ∗ Beta Agonist Challenge ∗ Methacholine Challenge ∗ DLCO
  • 96. Beta Agonist Challenge ∗ Perform this when there is a suspicion that the obstructive defect may be reversible –> asthma. ∗ Give the patient a beta agonist treatment (two puffs of an albuterol MDI or an albuterol nebulizer) and repeat the PFTs several minutes later. If you notice a 12% or more increase in FEV1, then you have diagnosed reversible airway disease/asthma.
  • 97. Methacholine Challenge ∗ If you have a suspicion that the patient might have Exercise- induced bronchospasm (EIB), then refer them to a pulmonary lab where they can do provocative testing with methacholine. ∗ If the patient has a decrease in their FEV1/FVC ratio with the inhalation of methacholine, then you have diagnosed EIB. ∗ Pretreat before exercise with albuterol or cromolyn.
  • 98. Diffuse capacity of carbon monoxide in the lung DLCO ∗ After performing the standard PFTs, the patient then inhales trace amounts of carbon monoxide. ∗ CO traverses the alveolar capillary beds much more readily than CO2 or O2. ∗ As such, most of the CO inhaled should be absorbed. ∗ When it is not, this suggests pulmonary scarring consistent with pulmonary fibrosis. Search for a cause.
  • 99. Diffusing Capacity  Decreased DLCO  Increased DLCO (>120-140% predicted) (<80% predicted)  Asthma (or normal)  Obstructive lung disease  Pulmonary hemorrhage  Parenchymal disease  Polycythemia  Pulmonary vascular disease  Left to right shunt  Anemia
  • 100.
  • 101. paired T test The paired t-test will show whether the differences observed in the 2 measures will be found reliably in repeated samples.
  • 102. ANOVA:One way If we have data measured at the interval level, we can compare two or more population groups in terms of their population means using a technique called analysis of variance, or ANOVA.
  • 103. Honestly significant difference test (HSD) When you do multiple significance tests, the chance of finding a "significant" difference just by chance increases. Tukey´s HSD test is one of several methods of ensuring that the chance of finding a significant difference in any comparison (under a null model) is maintained at the alpha level of the test.
  • 105.
  • 106.
  • 107.
  • 108.
  • 109.
  • 110.
  • 120. DISCUSSION Major sources of noise generated by a helicopter
  • 129.
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  • 133.
  • 134. THANKS FOR YOUR ATTENTION 134

Editor's Notes

  1. Early effects are from distributative shock, and develop within a few minutes. Timings are given in a later slide. The fainting process is instant – a test performed by the Suspensiontrauma.info medical staff asked fit and uninjured students to hang in a harness and count upwards, paying them money if they counted highest and remembered the number. They fainted almost between one number and the next, and of 50 volunteers only two remembered a number, but both were wrong.
  2. Case cross over studies are the newest form of epidemiologic design.
  3. Image source: http://en.wikipedia.org/wiki/Main_Page
  4. Image source: http://www.spirxpert.com/index.html
  5. Image source: http://www.spirxpert.com/index.html FEV1 is decreased out of proportion to FVC, which causes the ratio to decrease as well.
  6. This is not a complete list, just some of the most common diseases that should be on your differential for obstructive lung disease.
  7. Image source: http://www.spirxpert.com/index.html FEV1 decreases in proportion to decrease in FVC, so ratio remains normal or even slightly increased
  8. Restrictive lung disease is made up of intrinsic lung disease (causes inflammation and scarring (interstitial lung diseases) or fill the airspaces w/ debris, inflammation (exudate); extrinsic causes are chest wall or pleural diseases that mechanically compress the lung and prevent expansion. Neuromuscular causes decreases ability of respiratory muscles to inflate and deflate the lungs.
  9. Height varies directly with vc VC increases with age up to age 20 years then becomes inversely proportion to age Women usually with lower vc than men
  10. Pulmonary vascular disease = pulmonary emboli, pulmonary HTN. Low DLCO is also a major predictor of desaturation during exercise.