1. Respiratory distress syndrome (RDS) Mbbs.weebly.com

2. RDS = HMD RDS: Respiratory distress syndrome HMD: Hyaline membrane disease

6. Constituents of PS

8. Capillary permeability↑ Pulmonary hypertension Hyaline membrane formation R->L shunting

9. Hyaline membrane

10. Hyaline membrane

12. Chest retraction

13. Laboratory examinations 1. foam test （胃液泡沫稳定试验〕 2. measurement of the levels of PS amniotic fluid or tracheal aspirate L / S (lecithin / sphingomyeline)  2  maturity of lungs 3. blood gas : pH  , PaO 2  , PaCO 2  , HCO 3 -  (mixed acidosis)

15. Severe RDS- white lung

16. Echocardiography Color flow Doppler  PDA and PPHN PDA = Patent ductus arteriosus( 动脉导管未闭 ) PPHN ＝ Persistent Pulmonary Hypertension of newborn ( 新生儿持续性肺动脉高压 )

18. X-ray of Wet Lung

19. Defect in the diaphragm

20. X-ray of diaphragmatic hernia

21. Infant of diaphragmatic hernia

25. CPAP

27. Conventional mechanical ventilation

28. Pulmonary air leak

29. PS replacement therapy PS

31. PS treated RDS

34. Hypoxic Ischemic Encephalopathy (HIE)

38. Lesions of HIE

39. Pathogenesis Alteration of cerebral blood flow

42. Clinical manifestation

45. CT scanning of HIE

49. Intracranial hemorrhage of the newborn

52. Where is germinal matrix ?

54. Etiology and pathogenesis 3. Birth trauma Laceration of tentorium cerebelli,falx cerebri and cerebral superficial vein  Rupture of cerebral vein  Subdural hemorrhage(SDH)

55. Subdural hemorrhage ( SDH)

61. Periventricular- Intraventricular Hemorrhage CT ultrasound PVH IVH PVH-IVH

63. Intraparenchymal Hemorrhagel (IPH) hemorrhage  liquefied  cyst formation  porencephalic cysts ( 脑穿通性囊肿 )

68. Questions?

69. Thank You!