The document evaluates the therapeutic response of metformin HCl alone and in combination with other drugs on glycemic control in diabetic patients. It describes a retrospective and prospective study conducted at TTD Central Hospital and SVIMS involving 320 type 1 and type 2 diabetic patients between October 2006 and March 2007. The study assessed glycemic values, adverse drug reactions, diabetic complications, and demographic data to evaluate the effectiveness of different treatment regimens including metformin alone or in combination with other drugs like glibenclamide, glipizide, pioglitazone, and acarbose. The results showed that combination therapies were more effective at improving glycemic control and had better tolerability compared to individual drugs.

1. EVALUATION OF THERAPEUTIC RESPONSE OF METFORMIN HCl AND ITS RATIONALE COMBINATIONS ON GLYCEMIC VALUE IN DIABETICS C SUJANI B UMA MAHESH B SUNIL GAVASKAR D SIVA SANKAR K V HIMA BINDU K V GOPINATH & B PUSHPA KUMARI DEPARTMENT OF PHARMACOLOGY SRI PADMAVATHI SCHOOL OF PHARMACY TIRUPATI - 517 503 (A.P.) INDIA

4. Plan of Work Design of Study Retrospective and prospective Study Site T.T.D Central hospital, SVIMS Study Period October, 06 to March, 2007

11. Data on diseases

12. Demographic data based on sex (n=320)

13. Demographic data based on age (n=320)

14. Demographic data based on education (n=320)

15. Demographic data based on Occupation

16. Demographic data based on Smoking (n=320)

17. Demographic data based on Alcohol social habit (n=320)

18. Demographic data based on Mean + SD (n=206)

19. Causes of diabetes (n=320)

20. Risk factor - BMI

21. Demographic data based on treatment profile (n=210)

22. Effect of anti-diabetic drug(s) 0n glycemic value (%change)

23. Percentage change in glycemic value of Metformin HCl

24. Percentage change in glycemic value of Metformin + Glibenclamide treatment

25. Percentage change in glycemic value of Metformin + Glipizide treatment

26. Percentage change in glycemic value of Met + Pioz + Acarbose treatment

27. Therapeutic response of anti-diabetic drug(s) on glycemic value

28. Adverse Drug Reactions of Anti-Diabetic Drugs (n=320)

29. Data on diabetic complications