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Fit2Cure: The Future of Health in the Palm of your Hands.
1. Geoffrey H. Siwo, Victoria Lam, Ian Sander & Fit2Cure Players
Fit2Cure Team
Human + Computer Intelligence Democratizing Medical Discovery
DePaul School of Computing and Digital Media, Chicago, IL
FIT2CURE: THE FUTURE OF HEALTH IN THE
PALM OF YOUR HANDS
6. CURRENT MEDICINE CAN’T COPE UP
• > 10,000 diseases
• Same disease in a different patient is not exactly the same
• 95% of diseases have no cure
• >50% of diseases are rare (affects <1 in 1500 people)
• Rising cost of healthcare, shortage of doctors
14. 2003: Undergraduate in Africa doing computational modeling of HIV on a pay-to-go computer
… IN AFRICA
2003 to 2005: organized Bioinformatics
training for fellow students
2010: Students in 2003 group organize First
Virtual Bioinformatics Conference in Africa
15. …IN USA
• 15 year old Jack Andraka develops pancreatic cancer test: 100 times more
sensitive and 28 times cheaper
16. IT’S GOING TO HAPPEN EVERYWHERE AS 3
BILLION MORE PEOPLE JOIN THE INTERNET
19. GalaxyZoo (2007): User base 250,000+
Significant contribution due to program: 1.25
million galaxies classified CAPTCHAS : Number of people using CAPTCHAs in a day: 100
million, Number of words deciphered by humans using
CAPTCHAs in a year: 440 million
Foldit (2008): User base 250,000+ people, best players are non-
scientists, shown that people can fold proteins better than the best
computer algorithms; able to find structure of M-PMV (HIV retroviral
protease) in 3 weeks—which eluded scientist for over a decade
Recently, research groups have been asking interested non-
scientists to help with large scale scientific problems
Usually takes the form of a game or computer program where
citizens are asked to perform tasks better suited to humans than
computer
CITIZEN SCIENCE
21. FILE NDA: FDA
approval (2-3yrs)
Identify disease
Isolate protein involved in disease (2-5yrs)
Find a drug effective against disease protein (2-5yrs)
Preclinical Testing (1-3yrs)
Formulation & Scale-up
FILE IND:
Human clinical trials (2-10yrs)
Fit2Cure
DRUG DISCOVERY AND DEVELOPMENT
23. Fit2CureTM
Competition! +
Social Impact
Compete with friends!
In the future:
For our top scoring players, we
will be donating (real) money to
an approved research center or
rare & neglected disease institute
of your choosing, and in your
name.
24. EMERGENT PATTERNS IN PLAY TRACE
• Expectation-maximization
(EM) based mining of
player data
-user interface design
- novel scientific insights
27. Connecting Fit2Cure to Your
Genetics: Fit2CureMyDisease
• Fit2Cure links personal genome data from the company 23andMe
• Fit2Cure can alert you when you are playing with a protein in which
you have mutations or allergic drug reactions
Fit2CureTM
28.
29. ACKNOWLEDGEMENTS
University of Notre Dame
• Dean Gregory Crawford
• Prof. Richard Taylor
Funding
College of Science Innovation Entrepreneurship Fund (supported by
Charles Edison Fund)
Dynamoid Apps
• Blair Lyons
• Laura Gonzalez
Editor's Notes
Play, learn and discover!
>10,000 diseases, less than 5% have cures, complex genetics of humans (each of us is difererent), drugs don’t work in all people, we have been designing drugs for the average person, no one is average!!
My journey: Solving a scientific problem without a lab- HIV drug resistance (incidentally presented this in Chcago). Forming a Bioinformatics group where we self trained. Give example of Jack Andraka. What if we make it so easy for millions of people? Computing technologies are exponentially growing for more than 100 years. A hope that one day kids in school, even in Africa, will be part of a major discovery for their own disease