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DR MAHIPAL REDDY INDUR ENDOSCOPY CENTRE NIZAMBAD  INDIA
 
Pathology  ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Pathology  ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Immunohistochemistry  ,[object Object],[object Object],[object Object],[object Object],[object Object]
Risk factors of pancreatic cancer ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Clinical presentation ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Clinical presentation ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Diagnosis  ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Diagnosis  ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Staging  ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Staging ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Treatment – surgical resection ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Treatment – surgical resection ,[object Object],[object Object],[object Object],[object Object],[object Object]
Right-side versus Left-side pancreatic resection:  John Hopkins Experience (1984-1999) Right-side (N=564) Left-side (N=52) P value Tumor diameter 3.1cm 4.7cm <0.01 Margin(+) 30% 20% NS LN(+) 73% 59% 0.03 Post-op mortality 2.3% 1.9% NS Overall complication 31% 25% NS Post-op hospital stay 11d 7d NS Median survival  18m 12m NS
For recurrence ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Unresectable disease ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Palliative surgery ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Systemic chemotherapy  ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Chemotherapy – historical  ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Gemcitabine  ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Gemcitabine-based combination
Gemzar+Tarceva vs. Gemzar  ASCO annual meeting 2005, abstr no. 1
 
 
 
Classification  ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Epidemiology  ,[object Object],[object Object],[object Object],[object Object]
Risk factors ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Pathology  ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Growth pattern ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Clinical manifestation  ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Clinical manifestation ,[object Object],[object Object]
Diagnostic evaluation  ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Extrahepatic Cholangiocarcinoma T1 confined to the bile duct T2 invades beyond the wall of the bile duct T3 invades the liver, gallbladder, pancreas, and/or unilateral branches of the portal vein or hepatic artery T4 Invades any of the following: main portal vein or its branches bilaterally, common hepatic artery, or other adjacent structures, such as the colon, stomach, duodenum, or abdominal wall  N1 Regional lymph node metastasis M1 Distant metastasis Stage IA T1 N0 M0 Stage IB T2 N0 M0 Stage IIA T3 N0 M0 Stage IIB T1 – T3 N1 M0 Stage III T4 Any N M0 Stage IV Any T Any N M1
Intrahepatic Cholangiocarcinoma T1 Solitary tumor without vascular invasion T2 Solitary tumor with vascular invasion or multiple tumors none >5 cm  T3 Multiple tumors >5 cm or tumor involving a major branch of the portal or hepatic veins  T4 Tumor(s) with direct invasion of adjacent organs other than the gallbladder or with perforation of visceral peritoneum  N1 Nodal metastases to the hepatoduodenal ligament M1 Any distant metastases Stage I  T1 N0 M0 Stage II T2 N0 M0 Stage IIIA T3 N0 M0 Stage IIIB T4 N0 M0 Stage IIIC Any T N1 M0 Stage IV Any T Any N M1
Treatment  ,[object Object],[object Object],[object Object],[object Object],[object Object]
Multimodality treatment  ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Locally advanced disease ,[object Object],[object Object],[object Object],[object Object],[object Object]
Palliative chemotherapy ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Palliative procedure ,[object Object],[object Object],[object Object],[object Object],[object Object]

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Pancreatic Biliary Cancer by Dr Mahipal reddy

  • 1. DR MAHIPAL REDDY INDUR ENDOSCOPY CENTRE NIZAMBAD INDIA
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  • 15. Right-side versus Left-side pancreatic resection: John Hopkins Experience (1984-1999) Right-side (N=564) Left-side (N=52) P value Tumor diameter 3.1cm 4.7cm <0.01 Margin(+) 30% 20% NS LN(+) 73% 59% 0.03 Post-op mortality 2.3% 1.9% NS Overall complication 31% 25% NS Post-op hospital stay 11d 7d NS Median survival 18m 12m NS
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  • 23. Gemzar+Tarceva vs. Gemzar ASCO annual meeting 2005, abstr no. 1
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  • 35. Extrahepatic Cholangiocarcinoma T1 confined to the bile duct T2 invades beyond the wall of the bile duct T3 invades the liver, gallbladder, pancreas, and/or unilateral branches of the portal vein or hepatic artery T4 Invades any of the following: main portal vein or its branches bilaterally, common hepatic artery, or other adjacent structures, such as the colon, stomach, duodenum, or abdominal wall N1 Regional lymph node metastasis M1 Distant metastasis Stage IA T1 N0 M0 Stage IB T2 N0 M0 Stage IIA T3 N0 M0 Stage IIB T1 – T3 N1 M0 Stage III T4 Any N M0 Stage IV Any T Any N M1
  • 36. Intrahepatic Cholangiocarcinoma T1 Solitary tumor without vascular invasion T2 Solitary tumor with vascular invasion or multiple tumors none >5 cm T3 Multiple tumors >5 cm or tumor involving a major branch of the portal or hepatic veins T4 Tumor(s) with direct invasion of adjacent organs other than the gallbladder or with perforation of visceral peritoneum N1 Nodal metastases to the hepatoduodenal ligament M1 Any distant metastases Stage I T1 N0 M0 Stage II T2 N0 M0 Stage IIIA T3 N0 M0 Stage IIIB T4 N0 M0 Stage IIIC Any T N1 M0 Stage IV Any T Any N M1
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