1. BHM
A Reliable And Innovative Partner
Of Chemistry From China
Yang Ping
(Project Leader/Senior Organic Chemist)
Email:ping.yang@honghui-meditech.com
Tel:+86-10-61253848-801
Fax:+86-10-61253882
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2. Company Overviews
• Business
– A CRO in chemistry outsourcing
– Catalog compounds
– No internal drug discovery program
• Location
– Medicine Valley 1 in CBP, South of Beijing
• History
– Dec. 2002: established
– Oct. 2003: lab in use
• Ownership
– private
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3. Management Team
• Ye Liu CEO
– PhD in chemistry, Uppsala Univ., Sweden
– >10 years working experience in European drug industries
• Research Scientist in Pharmacia & Upjohn,
• Head of chemistry department, Karo Bio
• Jinchang Wu VP Research
– PhD in chemistry, Uppsala Univ., Sweden
• Research Scientist in Pharmacia; Senior scientist in Astra
• Professor of Jilin Univ.
• Yang Cai CSO
– PhD in chemistry, Osaka Univ., Japan
• Post Doc at Ciby-geigy,
• Professor of Beijing Univ.
• Liping Shao VP Administration
– PhD in chemistry, Uppsala Univ. Sweden
• Senior Scientist of Swedish Work-protection Institute
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4. Staff
• Number of employees
– 90
• Number of chemists
– 67
– 70% with Master’s degree and 1-5
year working experience
• Number of Ph.D. chemists
– 9
• Support staff
– 14
– Analytical, shipping, administrative,
procurement, etc.
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5. Infrastructure
• Square footage of facility and Labs
– 2200 M2
• Number of hoods / walk in hoods
– 70 / 12
• Capacity for expansion
– Another 1200 M2 available at the same floor
– Estimated time for lab renovation: 3 months
• Library and online services
– Own small library
– Multi-licenses & easier access to online databases
– Crossfire, SciFinder, ACD
• Computer access
– Internet and intranet
– Video and tele-comference accessories
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6. Equipments
• R&D lab • Kilo lab
– Table top hoods with – Walk in hoods with
international standard international standard
– Low temperature – 2X20 L, 5X50 L & 100 L
circulators glass reactors
– Dry operational box – 250 L reactor and
accessories
– Parr hydrogenator ( (1L
and 3L) – 10 L, 20 L and 2x50 L
evaporators with pump
– Autoclave (2000psi) and chiller
– Free-dryer – Workup unit
– Speedvac – Vacuum drying oven
– Microwave reactor – Column for large scale
– Biotage SP1 chromatography
– parallel synthesis facilities
for focused-libraries
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7. Instruments
• Analytical instruments
– NMR: 300 MHz, with multinuclear probe, Bruker
– LCMS: 2 Agilent
– GC: 2 Agilent
– HPLC: 2 Analytical Agilent
2 Preparative Agilent
with UV, PDA, ELS detector
with some chiral columns
– Free-dryer
– UV-VIS Shimadzu
– FT-IR Shimadzu
– Polarimeter
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8. Capabilities
• Organic synthesis • Chiral chemistry
– From milligrams to kilograms
– Asymmetrical synthesis
– Multistep and structural
complex synthesis – Enzymatic resolution
– All category of biological – Ciral resolution
interested compounds
• Med-Chem • Areas of Specialty
– Hits to lead – Nucleoside
– Lead optimization – Peptide mimics
– SAR study – Heterocyclics
• Combi-chem – Palladium chemistry
– focused libraries
– Parallel synthesis – Steroids/ non-steroids
– Scaffolds & building blocks hormones
• Processing and manufacturing – Boric acid
– Route discovery and – CNS (5-HT, Dopamine, etc)
optimization
– Large scale preparation
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9. Project Management
• Project management
– Project leader Collaborative
• with PhD Committee
• Project planning and Senior
Project Leader
Senior
Project leader
progress monitoring BHM Client
• communication Project leader Project leader
BHM Client
– Project teams
• FTEs fully assigned to
Chemistry Chemistry
Team 1 team1
client’s project
Chemistry Chemistry
• Multiple ways/levels for Team 2 Team 2
communication
Supporting team Supporting team
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10. Project Management
• Communication practices
– Weekly progress report by E-mail
– Tele/video conference biweekly/monthly (facility available)
– Face to face project meeting on client’s request
• Procurement and shipment
– Chemicals procurement
• Cheap chemicals available in China
• Readily available chemicals from international provider (Aldrich
etc.)
– Documents for the shipment
• Ready substances with spectrums, compound specifications
• Safe & reliable package with content list & declaration paper
• Protocol (experimental procedures, packet list) submitted by E-mail
– Timelines for delivery
• 3-5 days from Beijing to USA and Europe (by FEDEX or EMS)
• Routine for customs clearance for Import/export
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11. Intellectual Property (IP)
• Management of IP
– Critical for our success (Clients and Honghui)
– All IP rights belong to client (rewards on process IP)
• Systems to protect client IP
– CDA with every employee; IP assignment right to BHM
– BHM fulfils obligation to clients
• Protocols to manage IP
– Firewall between projects of different clients
– Project’s specific password
– Separate project team meetings for different projects
– PGP encryption used in email communications or adopt
clients security system per request
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12. Safety
• Procedures
– Rules, documents, equipments, inspection
– Lab coats, eye-glasses, gloves, showers & eye washers
– Smoke detectors, extinguishers & auto anti-fire system
• Waste disposal
– Separated by types; removal by a special service company
• Use of hoods
– All reactions & work-ups
• Training
– 3 Days for new employees
– Annual follow-up for every chemist
• Safety personnel
– Responsible persons at 3 level: Company; lab and team
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13. BHM – A Competitive Resource For You
• Training-for highly capable chemists
– Initial training with supervisor
• Safety, lab routine, databases, documentation, project practices
– Continuous training by company
• Literature follow-up, internal/invited seminars, special
courses/training programs, scientific meetings/conferences
• Efficient organization
– Senior manage with overseas experience
– Team leader with strong background
– Assembling the right team
• Result oriented management
– Quality and timely delivery to our clients
– Keeping track of in-house goals and milestones
– Incentive income based on performance
– Overtime possible in the evening & weekend if needed
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14. BHM – A Competitive Resource For You
• Quality
– Purity: 95% routinely; 98% per request
– Identification/characterization
• Spectra included with each compound delivered
• H1 NMR, LCMS & HPLC (UV-detector)
• Communication
• Skillful communicators with clients
• Reporting system highly evaluated by clients
• English as the working language for protocol, notebook,
reports and communications
• References/current clients
• “it is a pleasure to work with you guys, your service is very
professional and your team is nice to work with”
(comments from one client)
• J&J PRD, Astra, Phenomix, Karo Bio, Sunesis, Biotica,
Acadia & 7TM…
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15. FTE Based Service
• Full Time Equivalent dedicated only in client’s
project
• Experienced bench chemists with MS. Degree or
equivalent & team leader with PhD
• 240 working days (48 weeks) per year
• Each FTE succeeded about 80-100 “full” steps
• Regular project meetings via tele/video
conference
16. Price list
• Yearly Rate of FTE for R&D program
– 60,000 USD/Year
Chemists of Master’s degree or equivalent
• Yearly Rate of FTE for scale-up processing
– Mutually agreed price per offer
17. Price clarifications
• Price including
– Compensation & facility costs
– Consumable materials
• Solvents, silica gel, SPE columns, vials etc.
– Characterization and analysis
• NMR, LC-MS, HPLC, GC
– Packing and delivery cost
– Protocols and reports
• Price excluding
– Chemicals & reagents
