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Aim: Prioritising 5 novel drug targets for P. falciparum Clara Lin Rohan Puri Mushira Che Mokhtar Joyna Chen Eric Kuek Li-eon Billy Po Colleen Chan
Global Malaria Endemicity
Plasmodium falciparum ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
 
Venn Diagram
Criteria for prioritizing drug targets ,[object Object],[object Object],[object Object],[object Object],[object Object]
Criteria for prioritizing drug targets ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Search Criteria (3):Selectivity ,[object Object]
Search Criteria (4): Stage Specificity Life Cycle of Plasmodium sp.
Search Criteria (4): Stage Specificity ,[object Object]
Structure-based drug design ,[object Object],[object Object],[object Object],[object Object],[object Object],Mehlin C. (2005) Comb. Chem&High Throughput screening
Assayability ,[object Object],[object Object],[object Object]
Assign Weights + Combine ,[object Object],[object Object],[object Object],[object Object]
Ranked List of Targets ,[object Object]
5 Selected Drug Targets ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Drug target example: adenosine deaminase ,[object Object],[object Object],[object Object],[object Object],PDB sructure
Conclusion ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

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Abp Final Slides